03f12791a7ae310dce89d023cdab331a pmc_32635668.pdf 075306486e8faf3a5b88d3aaed7e57ebfc336203 pmc_32635668.pdf a0e2276c6316a6aa63985dbf54632bf928f44c0fbe2233dcf1db665568b48067 pmc_32635668.pdf Title: Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers Subject: The arsenal against different types of cancers has increased impressively in the last decade. The detailed knowledge of the tumor microenvironment enables it to be manipulated in order to help the immune system fight against tumor cells by using specific checkpoint inhibitors, cell-based treatments, targeted antibodies, and immune stimulants. In fact, it is widely known that the first immunotherapeutic tools as immune stimulants for cancer treatment were bacteria and still are; specifically, the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG) continues to be the treatment of choice for preventing cancer recurrence and progression in non-invasive bladder cancer. BCG and also other mycobacteria or their components are currently under study for the immunotherapeutic treatment of different malignancies. This review focuses on the preclinical and clinical assays using mycobacteria to treat non-urological cancers, providing a wide knowledge of the beneficial applications of these microorganisms to manipulate the tumor microenvironment aiming at tumor clearance. Keywords: BCG; non-tuberculous mycobacteria; adjuvant; immunotherapy; mycobacteria antigens Author: Estela Noguera-Ortega, Sandra Guallar-Garrido and Esther Julián Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sun Jul 5 13:07:06 2020 CEST ModDate: Sun Jul 5 13:07:06 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1435665 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PAERZC+URWPalladioL-Ital Type 1 Custom yes yes no 98 0 VQZLAA+URWPalladioL-Bold Type 1 Custom yes yes no 99 0 AIQCCL+VnURWPalladioL-Bold Type 1 Custom yes yes no 100 0 XXBVHD+URWPalladioL-Roma Type 1 Custom yes yes no 101 0 ESYGMN+VnURWPalladioL Type 1 Custom yes yes no 102 0 WOCYLK+Rpxr Type 1 Builtin yes yes no 103 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT 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Linotype,Italic TrueType WinAnsi yes yes no 365 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 366 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 367 0 Times New Roman TrueType WinAnsi no no no 368 0 ABCDEE+Palatino Linotype,BoldItalic TrueType WinAnsi yes yes no 369 0 Times New Roman CID TrueType Identity-H yes no yes 370 0 GBLQZB+Rpxi Type 1 Builtin yes yes no 887 0 NUUXUW+VnURWPalladioL-Italic Type 1 Custom yes yes no 939 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 995 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:42:07 CEST RepresentationInformation: pmc_32635668.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:46:56 CEST Size: 1435665 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true 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