5c5500813435ed2fed89581dc1ea4572 pmc_32674272.pdf a1ff69de9ca0773eba779c65d7a2783c0d768da2 pmc_32674272.pdf 3e0ca18fad2484ab0b688eda10ebcdafdc0586e9e2e59959a1b851d5af78c6dd pmc_32674272.pdf Title: Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti Subject: This pilot study was conducted to analyze the quality of the antimicrobials sold in the street markets in Port-au-Prince, Haiti. A total of 258 packs containing antimicrobials were bought in 28 street markets in Port-au-Prince (Haiti). Tablets and contents of capsules included in 196 packs were analyzed using a Raman handheld spectrometer (NanoRAM of BWTEK, Model: BWS456-785) during the first quarter of 2019. Three out of 11 antimicrobials (Amoxicillin, Metronidazole, and Cotrimoxazole) had a high spectral match with an HQI 90 to the respective authentic medicine for more than 95% of their tablets/capsules. For six antimicrobials (Tetracycline, Erythromycin, Cloxacillin, Azithromycin, Clarithromycin, and the combination Amoxicillin + Clavulanic Acid) none of their tablets/capsules showed a sufficient spectral match with the authentic medicine. This finding indicates that these products sold in the markets did not contain the labeled drug and/or contained a degraded drug. In addition to the fact that prescription antimicrobials can be purchased in street markets, the present field study found that for most of them (including “Watch” antimicrobials according to the AWaRe classification) were substandard, which contributes to the present antimicrobials resistance epidemic. Keywords: pharmaceutical quality; antimicrobial resistance; substandard medicines; Haiti; street markets; AWaRe classification Author: Théodule Jean-Baptiste, John F. 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