e5766198537d28158bfc58e5f73e8e5c pmc_32695090.pdf b3bd54beca0a9134b489072c2de9e486bed2ddd2 pmc_32695090.pdf 5e1474e83bc8a3eacaa55f4d847c92241102a77225159b7b48b4d63307f4558e pmc_32695090.pdf Title: The Respiratory Microbiome in Cystic Fibrosis: Compartment Patterns and Clinical Relationships in Early Stage Disease Subject: We compared the bacterial microbiomes lodged in the bronchial tree, oropharynx and nose of patients with early stage cystic fibrosis (CF) not using chronic antibiotics, determining their relationships with lung function and exacerbation frequency. Keywords: cystic fibrosis, microbiome, exacerbation, lung function, Staphylococcus aureus Author: Marian Garcia-Nuñez and Eduard Monsó Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Tue Jun 30 09:59:25 2020 CEST ModDate: Tue Jun 30 09:59:25 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 9861067 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NAYEZI+MinionPro-Regular Type 1 Custom yes yes no 28 0 CVFLWZ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 29 0 TPUTFW+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 30 0 XEHEPU+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 35 0 WQSHYB+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 36 0 QGABAY+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 37 0 VXWSEY+RBLMI Type 1 Builtin yes yes no 38 0 IPBOPZ+MinionPro-It Type 1 Custom yes yes no 96 0 FOINRE+MTSYN Type 1 Builtin yes yes no 98 0 AVEJCE+MTGU Type 1 Builtin yes yes no 158 0 ZKLQCJ+MinionPro-Bold Type 1 Custom yes yes no 201 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:19:08 CET RepresentationInformation: pmc_32695090.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-27 03:46:46 CEST Size: 9861067 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 568 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The Respiratory Microbiome in Cystic Fibrosis: Compartment Patterns and Clinical Relationships in Early Stage Disease Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Design and Patients Item: Title: Sociodemographic and Clinical Measurements Item: Title: Sample Acquisition and Processing Item: Title: DNA Extraction Item: Title: PCR Amplification and Sequencing of 16S rRNA Gene Item: Title: Sequence Analysis Item: Title: Identification of Procedural Contaminants Item: Title: Data Analysis Item: Title: Results Children: Item: Title: Patient Characteristics Item: Title: Sequencing Item: Title: Topographical Analyses Item: Title: Longitudinal Study Item: Title: Bronchial Microbiome and Clinical Patterns Item: Title: Discussion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Info: Title: The Respiratory Microbiome in Cystic Fibrosis: Compartment Patterns and Clinical Relationships in Early Stage Disease Author: Marian Garcia-Nuñez and Eduard Monsó Subject: We compared the bacterial microbiomes lodged in the bronchial tree, oropharynx and nose of patients with early stage cystic fibrosis (CF) not using chronic antibiotics, determining their relationships with lung function and exacerbation frequency. Keywords: cystic fibrosis, microbiome, exacerbation, lung function, Staphylococcus aureus Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Tue Jun 30 10:29:25 CEST 2020 ModDate: Tue Jun 30 10:29:25 CEST 2020 ID: 0x33cb5bc7a66876a8921580c2071139f0, 0x33cb5bc7a66876a8921580c2071139f0 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: IPBOPZ+MinionPro-It FontSubset: true FirstChar: 3 LastChar: 243 FontDescriptor: FontName: IPBOPZ+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FOINRE+MTSYN FontSubset: true FirstChar: 0 LastChar: 67 FontDescriptor: FontName: FOINRE+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: XEHEPU+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 134 FontDescriptor: FontName: XEHEPU+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WQSHYB+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: WQSHYB+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QGABAY+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: QGABAY+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VXWSEY+RBLMI FontSubset: true FirstChar: 49 LastChar: 62 FontDescriptor: FontName: VXWSEY+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: ZKLQCJ+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: ZKLQCJ+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NAYEZI+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: NAYEZI+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CVFLWZ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: CVFLWZ+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TPUTFW+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: TPUTFW+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: AVEJCE+MTGU FontSubset: true FirstChar: 34 LastChar: 109 FontDescriptor: FontName: AVEJCE+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true XMP: cystic fibrosis, microbiome, exacerbation, lung function, Staphylococcus aureus pdfTeX-1.40.15 1.5 application/pdf The Respiratory Microbiome in Cystic Fibrosis: Compartment Patterns and Clinical Relationships in Early Stage Disease We compared the bacterial microbiomes lodged in the bronchial tree, oropharynx and nose of patients with early stage cystic fibrosis (CF) not using chronic antibiotics, determining their relationships with lung function and exacerbation frequency. 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