8c8f66afae1645576fd5513e6e88cbb4 pmc_32751857.pdf 116f8479e3a44b5fd23d9aa50541ddd0f8ef4f0e pmc_32751857.pdf c1e57f5eca4e11aadb9d885b1877aa33b9c099d391b761fdc2f1ecd5257e1947 pmc_32751857.pdf Title: Alveolar Type II Cells or Mesenchymal Stem Cells: Comparison of Two Different Cell Therapies for the Treatment of Acute Lung Injury in Rats Subject: The use of cell therapies has recently increased for the treatment of pulmonary diseases. Mesenchymal stem/stromal cells (MSCs) and alveolar type II cells (ATII) are the main cell-based therapies used for the treatment of acute respiratory distress syndrome (ARDS). Many pre-clinical studies have shown that both therapies generate positive outcomes; however, the differences in the efficiency of MSCs or ATII for reducing lung damage remains to be studied. We compared the potential of both cell therapies, administering them using the same route and dose and equal time points in a sustained acute lung injury (ALI) model. We found that the MSCs and ATII cells have similar therapeutic effects when we tested them in a hydrochloric acid and lipopolysaccharide (HCl-LPS) two-hit ALI model. Both therapies were able to reduce proinflammatory cytokines, decrease neutrophil infiltration, reduce permeability, and moderate hemorrhage and interstitial edema. Although MSCs and ATII cells have been described as targeting different cellular and molecular mechanisms, our data indicates that both cell therapies are successful for the treatment of ALI, with similar beneficial results. Understanding direct cell crosstalk and the factors released from each cell will open the door to more accurate drugs being able to target specific pathways and offer new curative options for ARDS. Keywords: cell therapy; alveolar type II cells; mesenchymal stem cells; acute lung injury; ARDS; ALI Author: Raquel Guillamat-Prats, Marta Camprubí-Rimblas, Ferranda Puig, Raquel Herrero, Neus Tantinyà, Anna Serrano-Mollar and Antonio Artigas Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Jul 31 10:30:24 2020 CEST ModDate: Fri Jul 31 10:30:24 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2147981 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CAXHRR+URWPalladioL-Ital Type 1 Custom yes yes no 116 0 TFCGZO+URWPalladioL-Bold Type 1 Custom yes yes no 117 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 118 0 CUAJJQ+Pxbsy Type 1 Builtin yes yes no 119 0 PYPZKK+VnURWPalladioL-Bold Type 1 Custom yes yes no 120 0 WXLTBV+URWPalladioL-Roma Type 1 Custom yes yes no 121 0 KORLVE+VnURWPalladioL Type 1 Custom yes yes no 122 0 FATHTC+Rpxr Type 1 Builtin yes yes no 123 0 YNQWUZ+Pxsy Type 1 Builtin yes yes no 124 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 129 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 146 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 147 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 148 0 ABCDEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 239 0 ABCDEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 240 0 ABCDEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 241 0 ABCDEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 242 0 TimesNewRomanPSMT TrueType WinAnsi no no no 243 0 LEVXPH+EURM10 Type 1 Builtin yes yes no 273 0 GBLQZB+Rpxi Type 1 Builtin yes yes no 274 0 YICMPF+Rpcxr Type 1 Builtin yes yes no 283 0 ABCDEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 329 0 ABCDEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 330 0 ABCDEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 331 0 ABCDEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 332 0 TimesNewRomanPSMT TrueType WinAnsi no no no 333 0 ABCDEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 361 0 ABCDEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 362 0 ABCDEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 363 0 TimesNewRomanPSMT TrueType WinAnsi no no no 364 0 ABCDEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 398 0 ABCDEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 399 0 ABCDEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 400 0 ABCDEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 401 0 TimesNewRomanPSMT TrueType WinAnsi no no no 402 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-04-19 02:32:31 CEST RepresentationInformation: pmc_32751857.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-04-18 13:28:42 CEST Size: 2147981 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぇひはふばびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰えぃぬぜ〴ぜ〰ちのつぜ〴ぜ〰がぐこぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぁがぉぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぉのてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぶづはぬちひぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづびづのっとべねちぬぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰くびぴづはっべぴづび〬ぜ〴ぜ〰ぃとはのつひはっべぴづび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Children: Item: Title: ぁのどねちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぇひはふばびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰えぃぬぜ〴ぜ〰ちのつぜ〴ぜ〰がぐこぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぁがぉぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぉのてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぶづはぬちひぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづびづのっとべねちぬぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰くびぴづはっべぴづび〬ぜ〴ぜ〰ぃとはのつひはっべぴづび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぅへばづひどねづのぴちぬぜ〴ぜ〰ぇひはふばびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰えぃぬぜ〴ぜ〰ちのつぜ〴ぜ〰がぐこぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぁがぉぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぉのてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぶづはぬちひぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづびづのっとべねちぬぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰くびぴづはっべぴづび〬ぜ〴ぜ〰ぃとはのつひはっべぴづび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: えぃぬぜ〴ぜ〰ちのつぜ〴ぜ〰がぐこぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぁがぉぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぉのてふびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぶづはぬちひぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづびづのっとべねちぬぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰くびぴづはっべぴづび〬ぜ〴ぜ〰ぃとはのつひはっべぴづび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁぬぶづはぬちひぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづびづのっとべねちぬぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰くびぴづはっべぴづび〬ぜ〴ぜ〰ぃとはのつひはっべぴづび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぉびはぬちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐふひどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きづびづのっとべねちぬぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰くびぴづはっべぴづび〬ぜ〴ぜ〰ぃとはのつひはっべぴづび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつどばはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぅのつばはどのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰うぬふどつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: えどびぴはぬはでどっちぬぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㤩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: ぐひはぴづどのぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰けふちのぴどてどっちぴどはのぜ〴ぜ〰てひはねぜ〴ぜ〰がふのでぜ〴ぜ〰えはねはでづのちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㄰ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰あはぴとぜ〴ぜ〰あづぬぬぜ〴ぜ〰ごとづひちばどづびぜ〴ぜ〰どのぜ〴ぜ〰あはつべぜ〴ぜ〰ちのつぜ〴ぜ〰がふのでぜ〴ぜ〰しづどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰きこぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰いどねどのどびとづつぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴ぜ〰ちてぴづひぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きこぃぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ごとづひちばどづびぜ〴ぜ〰ぉねばひはぶづつぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴ぜ〰ちのつぜ〴ぜ〰げづびぴはひづぜ〴ぜ〰がふのでぜ〴ぜ〰ぁひっとどぴづっぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰あはぴとぜ〴ぜ〰あづぬぬぜ〴ぜ〰ごとづひちばどづびぜ〴ぜ〰どのぜ〴ぜ〰あはつべぜ〴ぜ〰ちのつぜ〴ぜ〰がふのでぜ〴ぜ〰しづどでとぴぜ〴ぜ〰ちのつぜ〴ぜ〰あひはのっとはちぬぶづはぬちひぜ〴ぜ〰がちぶちでづぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰きこぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰いどねどのどびとづつぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴ぜ〰ちてぴづひぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きこぃぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ごとづひちばどづびぜ〴ぜ〰ぉねばひはぶづつぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴ぜ〰ちのつぜ〴ぜ〰げづびぴはひづぜ〴ぜ〰がふのでぜ〴ぜ〰ぁひっとどぴづっぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きこぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰いどねどのどびとづつぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴ぜ〰ちてぴづひぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きこぃぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ごとづひちばどづびぜ〴ぜ〰ぉねばひはぶづつぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴ぜ〰ちのつぜ〴ぜ〰げづびぴはひづぜ〴ぜ〰がふのでぜ〴ぜ〰ぁひっとどぴづっぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きこぃぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぉぉぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ごとづひちばどづびぜ〴ぜ〰ぉねばひはぶづつぜ〴ぜ〰がふのでぜ〴ぜ〰いちねちでづぜ〴ぜ〰ちのつぜ〴ぜ〰げづびぴはひづぜ〴ぜ〰がふのでぜ〴ぜ〰ぁひっとどぴづっぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: LEVXPH+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: LEVXPH+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: GBLQZB+Rpxi FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: GBLQZB+Rpxi Flags: Symbolic FontBBox: -162, -280, 856, 733 FontFile: true Font: BaseFont: CAXHRR+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: CAXHRR+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TFCGZO+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: TFCGZO+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LZDGTK+Rpxb FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: LZDGTK+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: CUAJJQ+Pxbsy FontSubset: true FirstChar: 121 LastChar: 122 FontDescriptor: FontName: CUAJJQ+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: PYPZKK+VnURWPalladioL-Bold FontSubset: true FirstChar: 160 LastChar: 189 FontDescriptor: FontName: PYPZKK+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WXLTBV+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: WXLTBV+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KORLVE+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: KORLVE+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FATHTC+Rpxr FontSubset: true FirstChar: 11 LastChar: 61 FontDescriptor: FontName: FATHTC+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: YNQWUZ+Pxsy FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: YNQWUZ+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 162, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 210, 640, 221, 654 Annotation: Subtype: Link Rect: 368, 640, 379, 654 Annotation: Subtype: Link Rect: 159, 626, 170, 640 Annotation: Subtype: Link Rect: 375, 626, 386, 640 Annotation: Subtype: Link Rect: 181, 613, 193, 626 Annotation: Subtype: Link Rect: 466, 413, 518, 432 Annotation: Subtype: Link Rect: 420, 78, 427, 87 ActionDest: 473 Annotation: Subtype: Link Rect: 430, 78, 437, 87 ActionDest: 473 Annotation: Subtype: Link Rect: 154, 38, 228, 50 Annotation: Subtype: Link Rect: 415, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 493, 743, 500, 752 ActionDest: 473 Annotation: Subtype: Link Rect: 503, 742, 515, 752 ActionDest: 473 Annotation: Subtype: Link Rect: 358, 729, 370, 738 ActionDest: 473 Annotation: Subtype: Link Rect: 373, 729, 385, 738 ActionDest: 507 Annotation: Subtype: Link Rect: 130, 702, 142, 711 ActionDest: 507 Annotation: Subtype: Link Rect: 145, 702, 157, 711 ActionDest: 507 Annotation: Subtype: Link Rect: 174, 675, 186, 684 ActionDest: 507 Annotation: Subtype: Link Rect: 189, 675, 201, 684 ActionDest: 507 Annotation: Subtype: Link Rect: 478, 661, 490, 671 ActionDest: 507 Annotation: Subtype: Link Rect: 491, 661, 503, 671 ActionDest: 507 Annotation: Subtype: Link Rect: 503, 661, 515, 671 ActionDest: 507 Annotation: Subtype: Link Rect: 108, 634, 120, 644 ActionDest: 507 Annotation: Subtype: Link Rect: 121, 634, 133, 644 ActionDest: 507 Annotation: Subtype: Link Rect: 133, 634, 145, 644 ActionDest: 507 Annotation: Subtype: Link Rect: 385, 607, 397, 617 ActionDest: 507 Annotation: Subtype: Link Rect: 398, 607, 410, 617 ActionDest: 507 Annotation: Subtype: Link Rect: 413, 607, 425, 617 ActionDest: 507 Annotation: Subtype: Link Rect: 212, 567, 224, 576 ActionDest: 507 Annotation: Subtype: Link Rect: 224, 567, 236, 576 ActionDest: 507 Annotation: Subtype: Link Rect: 237, 567, 249, 576 ActionDest: 507 Annotation: Subtype: Link Rect: 320, 526, 332, 535 ActionDest: 507 Annotation: Subtype: Link Rect: 335, 526, 347, 535 ActionDest: 541 Annotation: Subtype: Link Rect: 379, 513, 391, 522 ActionDest: 541 Annotation: Subtype: Link Rect: 394, 513, 406, 522 ActionDest: 541 Annotation: Subtype: Link Rect: 217, 486, 224, 495 ActionDest: 473 Annotation: Subtype: Link Rect: 224, 486, 231, 495 ActionDest: 473 Annotation: Subtype: Link Rect: 232, 486, 244, 495 ActionDest: 507 Annotation: Subtype: Link Rect: 244, 486, 256, 495 ActionDest: 541 Annotation: Subtype: Link Rect: 453, 486, 465, 495 ActionDest: 473 Annotation: Subtype: Link Rect: 466, 486, 478, 495 ActionDest: 507 Annotation: Subtype: Link Rect: 478, 486, 490, 495 ActionDest: 507 Annotation: Subtype: Link Rect: 491, 486, 503, 495 ActionDest: 541 Annotation: Subtype: Link Rect: 503, 486, 515, 495 ActionDest: 541 Annotation: Subtype: Link Rect: 388, 445, 400, 454 ActionDest: 541 Annotation: Subtype: Link Rect: 403, 445, 415, 454 ActionDest: 541 Annotation: Subtype: Link Rect: 196, 405, 208, 414 ActionDest: 541 Annotation: Subtype: Link Rect: 208, 405, 220, 414 ActionDest: 577 Annotation: Subtype: Link Rect: 223, 405, 235, 414 ActionDest: 577 Annotation: Subtype: Link Rect: 125, 378, 137, 387 ActionDest: 541 Annotation: Subtype: Link Rect: 137, 378, 149, 387 ActionDest: 577 Annotation: Subtype: Link Rect: 473, 337, 480, 346 ActionDest: 473 Annotation: Subtype: Link Rect: 481, 337, 488, 346 ActionDest: 473 Annotation: Subtype: Link Rect: 491, 337, 503, 346 ActionDest: 507 Annotation: Subtype: Link Rect: 503, 337, 515, 346 ActionDest: 577 Annotation: Subtype: Link Rect: 110, 297, 122, 306 ActionDest: 507 Annotation: Subtype: Link Rect: 123, 297, 135, 306 ActionDest: 507 Annotation: Subtype: Link Rect: 135, 297, 147, 306 ActionDest: 507 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 437, 720, 444, 732 ActionDest: 233 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 286, 619, 298, 628 ActionDest: 577 Annotation: Subtype: Link Rect: 468, 441, 480, 450 ActionDest: 507 Annotation: Subtype: Link Rect: 470, 236, 477, 247 ActionDest: 233 Annotation: Subtype: Link Rect: 347, 222, 355, 234 ActionDest: 233 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 405, 699, 412, 711 ActionDest: 233 Annotation: Subtype: Link Rect: 368, 618, 375, 630 ActionDest: 233 Annotation: Subtype: Link Rect: 123, 567, 135, 576 ActionDest: 507 Annotation: Subtype: Link Rect: 369, 416, 376, 427 ActionDest: 233 Annotation: Subtype: Link Rect: 127, 98, 134, 110 ActionDest: 294 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 108, 670, 115, 682 ActionDest: 322 Annotation: Subtype: Link Rect: 394, 657, 401, 668 ActionDest: 322 Annotation: Subtype: Link Rect: 213, 629, 220, 641 ActionDest: 322 Annotation: Subtype: Link Rect: 109, 589, 116, 601 ActionDest: 322 Annotation: Subtype: Link Rect: 131, 562, 138, 574 ActionDest: 322 Annotation: Subtype: Link Rect: 288, 535, 295, 547 ActionDest: 322 Annotation: Subtype: Link Rect: 382, 494, 389, 506 ActionDest: 322 Annotation: Subtype: Link Rect: 349, 440, 356, 452 ActionDest: 322 Annotation: Subtype: Link Rect: 271, 357, 278, 369 ActionDest: 354 Annotation: Subtype: Link Rect: 180, 317, 187, 328 ActionDest: 354 Annotation: Subtype: Link Rect: 256, 222, 263, 234 ActionDest: 354 Annotation: Subtype: Link Rect: 128, 152, 135, 164 ActionDest: 294 Annotation: Subtype: Link Rect: 145, 139, 152, 151 ActionDest: 393 Annotation: Subtype: Link Rect: 228, 125, 235, 137 ActionDest: 393 Annotation: Subtype: Link Rect: 202, 98, 209, 110 ActionDest: 393 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 237, 699, 244, 711 ActionDest: 393 Annotation: Subtype: Link Rect: 293, 659, 300, 671 ActionDest: 393 Annotation: Subtype: Link Rect: 224, 632, 231, 644 ActionDest: 393 Page: Sequence: 9 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 306, 274, 312, 285 ActionDest: 294 Annotation: Subtype: Link Rect: 331, 103, 338, 112 ActionDest: 473 Annotation: Subtype: Link Rect: 339, 102, 346, 112 ActionDest: 473 Annotation: Subtype: Link Rect: 346, 103, 358, 112 ActionDest: 507 Annotation: Subtype: Link Rect: 359, 103, 371, 112 ActionDest: 541 Annotation: Subtype: Link Rect: 292, 75, 304, 85 ActionDest: 577 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 299, 675, 311, 684 ActionDest: 541 Annotation: Subtype: Link Rect: 311, 675, 323, 684 ActionDest: 541 Annotation: Subtype: Link Rect: 324, 675, 336, 684 ActionDest: 577 Annotation: Subtype: Link Rect: 114, 648, 126, 657 ActionDest: 577 Annotation: Subtype: Link Rect: 127, 648, 139, 657 ActionDest: 577 Annotation: Subtype: Link Rect: 139, 648, 151, 657 ActionDest: 577 Annotation: Subtype: Link Rect: 305, 621, 317, 630 ActionDest: 577 Annotation: Subtype: Link Rect: 318, 621, 330, 630 ActionDest: 577 Annotation: Subtype: Link Rect: 330, 621, 342, 630 ActionDest: 577 Annotation: Subtype: Link Rect: 359, 472, 370, 481 ActionDest: 507 Annotation: Subtype: Link Rect: 371, 472, 383, 481 ActionDest: 507 Annotation: Subtype: Link Rect: 384, 472, 395, 481 ActionDest: 577 Annotation: Subtype: Link Rect: 503, 459, 515, 468 ActionDest: 507 Annotation: Subtype: Link Rect: 181, 405, 188, 414 ActionDest: 473 Annotation: Subtype: Link Rect: 191, 405, 203, 414 ActionDest: 473 Annotation: Subtype: Link Rect: 203, 405, 215, 414 ActionDest: 507 Annotation: Subtype: Link Rect: 216, 405, 228, 414 ActionDest: 541 Annotation: Subtype: Link Rect: 228, 405, 240, 414 ActionDest: 541 Annotation: Subtype: Link Rect: 241, 405, 253, 414 ActionDest: 577 Annotation: Subtype: Link Rect: 256, 405, 268, 414 ActionDest: 577 Annotation: Subtype: Link Rect: 441, 337, 453, 346 ActionDest: 577 Annotation: Subtype: Link Rect: 453, 337, 465, 346 ActionDest: 577 Annotation: Subtype: Link Rect: 415, 310, 427, 319 ActionDest: 541 Annotation: Subtype: Link Rect: 428, 310, 440, 319 ActionDest: 577 Annotation: Subtype: Link Rect: 217, 283, 229, 292 ActionDest: 507 Annotation: Subtype: Link Rect: 229, 283, 241, 292 ActionDest: 577 Annotation: Subtype: Link Rect: 120, 215, 132, 225 ActionDest: 541 Annotation: Subtype: Link Rect: 132, 215, 144, 225 ActionDest: 541 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 236, 427, 274, 437 Annotation: Subtype: Link Rect: 280, 427, 316, 437 Annotation: Subtype: Link Rect: 213, 401, 250, 412 Annotation: Subtype: Link Rect: 257, 401, 293, 412 Annotation: Subtype: Link Rect: 370, 375, 408, 386 Annotation: Subtype: Link Rect: 414, 375, 450, 386 Annotation: Subtype: Link Rect: 393, 349, 431, 360 Annotation: Subtype: Link Rect: 279, 323, 317, 334 Annotation: Subtype: Link Rect: 100, 285, 137, 295 Annotation: Subtype: Link Rect: 378, 259, 416, 270 Annotation: Subtype: Link Rect: 242, 220, 280, 231 Annotation: Subtype: Link Rect: 136, 169, 174, 179 Annotation: Subtype: Link Rect: 317, 130, 354, 140 Annotation: Subtype: Link Rect: 341, 91, 379, 102 Annotation: Subtype: Link Rect: 385, 91, 421, 102 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 100, 715, 137, 725 Annotation: Subtype: Link Rect: 143, 715, 179, 725 Annotation: Subtype: Link Rect: 200, 676, 237, 686 Annotation: Subtype: Link Rect: 243, 676, 280, 686 Annotation: Subtype: Link Rect: 296, 651, 334, 661 Annotation: Subtype: Link Rect: 477, 637, 515, 648 Annotation: Subtype: Link Rect: 234, 612, 271, 622 Annotation: Subtype: Link Rect: 145, 573, 182, 583 Annotation: Subtype: Link Rect: 150, 534, 187, 544 Annotation: Subtype: Link Rect: 390, 495, 428, 506 Annotation: Subtype: Link Rect: 240, 457, 278, 467 Annotation: Subtype: Link Rect: 385, 417, 422, 428 Annotation: Subtype: Link Rect: 428, 417, 464, 428 Annotation: Subtype: Link Rect: 136, 379, 174, 389 Annotation: Subtype: Link Rect: 180, 379, 216, 389 Annotation: Subtype: Link Rect: 100, 341, 137, 351 Annotation: Subtype: Link Rect: 143, 341, 179, 351 Annotation: Subtype: Link Rect: 479, 314, 516, 325 Annotation: Subtype: Link Rect: 100, 276, 137, 286 Annotation: Subtype: Link Rect: 358, 249, 396, 260 Annotation: Subtype: Link Rect: 382, 211, 420, 222 Annotation: Subtype: Link Rect: 406, 185, 444, 196 Annotation: Subtype: Link Rect: 249, 146, 287, 157 Annotation: Subtype: Link Rect: 432, 107, 470, 118 Annotation: Subtype: Link Rect: 369, 69, 407, 80 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 280, 714, 318, 725 Annotation: Subtype: Link Rect: 324, 714, 360, 725 Annotation: Subtype: Link Rect: 318, 675, 356, 686 Annotation: Subtype: Link Rect: 362, 675, 398, 686 Annotation: Subtype: Link Rect: 217, 638, 255, 648 Annotation: Subtype: Link Rect: 231, 599, 269, 609 Annotation: Subtype: Link Rect: 325, 559, 363, 570 Annotation: Subtype: Link Rect: 369, 559, 405, 570 Annotation: Subtype: Link Rect: 243, 508, 280, 519 Annotation: Subtype: Link Rect: 234, 469, 271, 480 Annotation: Subtype: Link Rect: 369, 418, 406, 428 Annotation: Subtype: Link Rect: 451, 378, 488, 389 Annotation: Subtype: Link Rect: 360, 340, 397, 351 Annotation: Subtype: Link Rect: 403, 340, 439, 351 Annotation: Subtype: Link Rect: 478, 314, 516, 325 Annotation: Subtype: Link Rect: 100, 302, 136, 312 Annotation: Subtype: Link Rect: 200, 263, 237, 273 Annotation: Subtype: Link Rect: 243, 263, 280, 273 Annotation: Subtype: Link Rect: 200, 224, 237, 234 Annotation: Subtype: Link Rect: 243, 224, 280, 234 Annotation: Subtype: Link Rect: 100, 199, 137, 209 Annotation: Subtype: Link Rect: 143, 199, 179, 209 Annotation: Subtype: Link Rect: 443, 172, 481, 183 Annotation: Subtype: Link Rect: 224, 134, 261, 144 Annotation: Subtype: Link Rect: 136, 108, 174, 118 Annotation: Subtype: Link Rect: 439, 69, 477, 80 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 465, 727, 502, 738 Annotation: Subtype: Link Rect: 312, 688, 349, 699 Annotation: Subtype: Link Rect: 100, 651, 137, 661 Annotation: Subtype: Link Rect: 143, 651, 179, 661 Annotation: Subtype: Link Rect: 226, 624, 263, 635 Annotation: Subtype: Link Rect: 395, 585, 433, 596 Annotation: Subtype: Link Rect: 439, 585, 475, 596 Annotation: Subtype: Link Rect: 239, 559, 277, 570 Annotation: Subtype: Link Rect: 283, 559, 319, 570 Annotation: Subtype: Link Rect: 224, 534, 262, 544 Annotation: Subtype: Link Rect: 479, 508, 516, 519 Annotation: Subtype: Link Rect: 220, 470, 258, 480 Annotation: Subtype: Link Rect: 384, 443, 422, 454 Annotation: Subtype: Link Rect: 478, 404, 515, 415 Annotation: Subtype: Link Rect: 219, 366, 257, 376 Annotation: Subtype: Link Rect: 263, 366, 299, 376 Annotation: Subtype: Link Rect: 255, 341, 292, 351 Annotation: Subtype: Link Rect: 299, 341, 335, 351 Annotation: Subtype: Link Rect: 147, 315, 185, 325 Annotation: Subtype: Link Rect: 191, 315, 227, 325 Annotation: Subtype: Link Rect: 76, 273, 166, 304 Annotation: Subtype: Link Rect: 234, 267, 407, 278 Checksum: 1f722e14 Type: CRC32 Checksum: 8c8f66afae1645576fd5513e6e88cbb4 Type: MD5 Checksum: 116f8479e3a44b5fd23d9aa50541ddd0f8ef4f0e Type: SHA-1