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referenced object 'link_B6' cannot be found Offset: 553644 MIMEtype: application/pdf PDFMetadata: Objects: 249 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Anti-HMGCR Specificity of HALIP: A Confirmatory Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2. Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: 2.1. Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: 2.1.1. Sera Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.1.2. IIF Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.2. Purification of Human Anti-HMGCR Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.3. Colocalization of Human and Rabbit Polyclonal Anti-HMGCR Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.4. Absorption of the Anti-HMGCR Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 3.1. Immunofluorescence Pattern of the Purified Human Anti-HMGCR Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3.2. Immunofluorescence Pattern of the Colocalization Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Data Availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Conflicts of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Info: Title: HDJIR_6292631 1..4 Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Jul 16 07:52:06 CEST 2020 ModDate: Wed Jul 29 15:01:38 CEST 2020 ID: 0x248379dedd7a879f3ec5411b27e886e9, 0xab2a2e4c4b34898de43df81ef80a2170 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 844 ImageHeight: 527 BitsPerSample: 8 BitsPerSampleUnit: integer 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770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEAOIO+WdydyqMinionProIt FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: DEAOIO+WdydyqMinionProIt Flags: Nonsymbolic FontBBox: -1187, -260, 1312, 822 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: VVHCLM+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VVHCLM+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfAnti-HMGCR Specificity of HALIP: A Confirmatory StudyBaucells, AndrésMartínez, Maria AngelesAlvarado-Cardenas, MarceloMariscal, AnaísMartinez-Martinez, LauraJuárez, CándidoSelva-O’Callaghan, AlbertA distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. 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