b9da8f2e331349d7e4b4c3970404bb13 pmc_32768001.pdf e6c1ef36a1217f837ce5ebc5e2a2651afdf8e577 pmc_32768001.pdf b96a553cab3e8b1efac90ff2fa452e1a13a51b094b96066d5a4bc39cb5bbd92d pmc_32768001.pdf Title: ECCO2R therapy in the ICU: consensus of a European round table meeting Subject: Critical Care, 2020, doi:10.1186/s13054-020-03210-z Keywords: Acute respiratory distress syndrome,Chronic obstructive pulmonary disease,CO2 removal,Consensus,Driving pressure,ECCO2R,Gas exchange,Lung protective ventilation,Tidal volume,Therapy experience Author: Alain Combes Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Aug 3 22:50:14 2020 CEST ModDate: Fri Aug 7 12:22:06 2020 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 918667 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 25 0 KCBJKL+YycyplAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 19 0 KCBNDG+WpnmfpAdvTTe45e47d2 Type 1C WinAnsi yes yes no 20 0 KCBNDH+DqqgsrAdvTTb5929f4c Type 1C WinAnsi yes yes no 21 0 KCBNJG+JlglxyAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 22 0 KCBNKH+ScnprfAdvTT99c4c969 Type 1C WinAnsi yes yes no 24 0 KCBOMB+CrjxdqAdvTT7329fd89.I Type 1C WinAnsi yes yes no 26 0 KCBPCD+FnjxstAdvTT86d47313 Type 1C WinAnsi yes yes no 16 0 KCBPCE+VxrnwdAdvTT86d47313+20 Type 1C WinAnsi yes yes no 17 0 KCBPBB+SkykvhAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 9 0 KCBPBC+JlssxpAdvTTb5929f4c+22 Type 1C Custom yes yes yes 18 0 KCBPDE+SfwrkdAdvTT8861b38f.I Type 1C WinAnsi yes yes no 23 0 KCBPGE+NqxhlnAdvTT86d47313+22 Type 1C Custom yes yes yes 191 0 KCCBLH+PtxpgbAdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 282 0 KCCBLI+SlnlgxAdvTTe45e47d2+22 Type 1C Custom yes yes yes 283 0 KCCBOI+GtsddjAdvTTb5929f4c+25 Type 1C Custom yes yes yes 295 0 KCCCBI+JmngbyAdvTTb5929f4c+03 Type 1C Custom yes yes yes 325 0 KCCCGH+NwlwwmAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 389 0 KCCCNF+QkdvgdAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 391 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:03:46 CEST RepresentationInformation: pmc_32768001.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:47:12 CEST Size: 918667 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 419 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: sectionAbs1 Children: Item: Title: Background Destination: sectionASec1 Item: Title: Methods Destination: sectionASec2 Item: Title: Results Destination: sectionASec3 Item: Title: Conclusions Destination: sectionASec4 Item: Title: Background Destination: sectionSec1 Item: Title: Methods Destination: sectionSec2 Children: Item: Title: Research questions and objectives Destination: sectionSec3 Item: Title: Data collection and analysis Destination: sectionSec4 Item: Title: Results Destination: sectionSec5 Children: Item: Title: Attendee clinical experience Destination: sectionSec6 Item: Title: Indications and rationale for ECCO2R based on pre-meeting survey Destination: sectionSec7 Item: Title: Use of ECCO2R therapy in patients with ARDS Destination: sectionSec8 Item: Title: Use of ECCO2R therapy in patients with ae-COPD Destination: sectionSec9 Item: Title: Anticoagulation strategy for patients receiving ECCO2R Destination: sectionSec10 Item: Title: Discussion Destination: sectionSec11 Children: Item: Title: Limitations Destination: sectionSec12 Item: Title: Conclusions Destination: sectionSec13 Item: Title: Supplementary information Destination: sectionSec14 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Acknowledgements Destination: section1 Item: Title: Authors’ contributions Destination: section2 Item: Title: Authors’ information Destination: sectionFPar1 Item: Title: Funding Destination: section3 Item: Title: Availability of data and materials Destination: section4 Item: Title: Ethics approval and consent to participate Destination: sectionFPar2 Item: Title: Consent for publication Destination: sectionFPar3 Item: Title: Competing interests Destination: sectionFPar4 Item: Title: Author details Destination: section5 Item: Title: References Destination: sectionBib1 Item: Title: Publisher’s Note Destination: ArtNote2 Info: Title: ECCO2R therapy in the ICU: consensus of a European round table meeting Author: Alain Combes Subject: Critical Care, 2020, doi:10.1186/s13054-020-03210-z Keywords: Acute respiratory distress syndrome,Chronic obstructive pulmonary disease,CO2 removal,Consensus,Driving pressure,ECCO2R,Gas exchange,Lung protective ventilation,Tidal volume,Therapy experience Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Aug 03 22:50:14 CEST 2020 ModDate: Fri Aug 07 12:22:06 CEST 2020 ID: 0x39e7e6df839778f5b247208d562a88ec, 0xbdec667a558aba23a808efef079a1f86 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: KCCCBI+JmngbyAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: KCCCBI+JmngbyAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCCCGH+NwlwwmAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: KCCCGH+NwlwwmAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCCBOI+GtsddjAdvTTb5929f4c+25 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: KCCBOI+GtsddjAdvTTb5929f4c+25 Flags: Symbolic FontBBox: -10, -302, 833, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCCCNF+QkdvgdAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: KCCCNF+QkdvgdAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBPBB+SkykvhAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 110 FontDescriptor: FontName: KCBPBB+SkykvhAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBPCD+FnjxstAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 126 FontDescriptor: FontName: KCBPCD+FnjxstAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBPCE+VxrnwdAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: KCBPCE+VxrnwdAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBPBC+JlssxpAdvTTb5929f4c+22 FontSubset: true FirstChar: 1 LastChar: 139 FontDescriptor: FontName: KCBPBC+JlssxpAdvTTb5929f4c+22 Flags: Symbolic FontBBox: -10, -218, 1083, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCBJKL+YycyplAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: KCBJKL+YycyplAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBNDG+WpnmfpAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: KCBNDG+WpnmfpAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBNDH+DqqgsrAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 252 FontDescriptor: FontName: KCBNDH+DqqgsrAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBNJG+JlglxyAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: KCBNJG+JlglxyAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBPDE+SfwrkdAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 110 FontDescriptor: FontName: KCBPDE+SfwrkdAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCBNKH+ScnprfAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: KCBNKH+ScnprfAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KCBOMB+CrjxdqAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: KCBOMB+CrjxdqAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCCBLH+PtxpgbAdvTTe45e47d2+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: KCCBLH+PtxpgbAdvTTe45e47d2+20 Flags: Nonsymbolic FontBBox: -447, -197, 1302, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCCBLI+SlnlgxAdvTTe45e47d2+22 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: KCCBLI+SlnlgxAdvTTe45e47d2+22 Flags: Symbolic FontBBox: -10, -229, 1020, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCBPGE+NqxhlnAdvTT86d47313+22 FontSubset: true FirstChar: 1 LastChar: 139 FontDescriptor: FontName: KCBPGE+NqxhlnAdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -250, 1031, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Acute respiratory distress syndrome,Chronic obstructive pulmonary disease,CO2 removal,Consensus,Driving pressure,ECCO2R,Gas exchange,Lung protective ventilation,Tidal volume,Therapy experience Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13054-020-03210-z Critical Care Critical Care, 2020, doi:10.1186/s13054-020-03210-z Acute respiratory distress syndrome Chronic obstructive pulmonary disease CO2 removal Consensus Driving pressure ECCO2R Gas exchange Lung protective ventilation Tidal volume Therapy experience ECCO2R therapy in the ICU: consensus of a European round table meeting Alain Combes Georg Auzinger Gilles Capellier Damien Cheyron Ian Clement Guglielmo Consales Wojciech Dabrowski David Bels Francisco Javier González Molina Ortiz Antje Gottschalk Matthias P. Hilty David Pestaña Eduardo Sousa Redmond Tully Jacques Goldstein Kai Harenski 2020-08-07T12:22:06+02:00 2020-08-07T12:22:06+02:00 2020-08-04T04:50:14+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:0bcd9ca3-4fc3-43ce-8419-e0618417b2f9 uuid:04da85ae-e600-481c-bafd-b3f64c691a94 default 1 converted uuid:0bcd9ca3-4fc3-43ce-8419-e0618417b2f9 converted to PDF/A-2b pdfToolbox 2020-08-04T06:19:37+08:00 2 B Alain Combes http://orcid.org/0000-0002-6030-3957 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 126, 599, 135, 608 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 228, 179, 235 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 255, 345, 260, 355 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 266, 345, 271, 355 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 146, 261, 151, 271 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 158, 261, 168, 271 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 223, 201, 233, 211 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 126, 165, 136, 175 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 142, 165, 152, 175 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 158, 165, 168, 175 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 59, 105, 69, 115 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 77, 105, 87, 115 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 93, 105, 103, 115 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 124, 93, 134, 103 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 141, 93, 151, 103 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 217, 69, 222, 79 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 403, 405, 408, 415 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 336, 393, 346, 403 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 355, 393, 365, 403 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 373, 393, 383, 403 Flags: Print AppearanceDictionary: true Destination: 91 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 150, 585, 221, 594 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 513, 231, 522 Flags: Print AppearanceDictionary: true Destination: 67 Annotation: Subtype: Link Rect: 78, 489, 88, 498 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 431, 645, 436, 654 Flags: Print AppearanceDictionary: true Destination: 5 Annotation: Subtype: Link Rect: 431, 441, 441, 450 Flags: Print AppearanceDictionary: true Destination: 91 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 134, 477, 143, 486 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 440, 597, 450, 606 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 455, 597, 465, 606 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 373, 477, 378, 486 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 406, 477, 411, 486 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 404, 261, 409, 270 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 394, 213, 398, 222 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 338, 165, 348, 174 Flags: Print AppearanceDictionary: true Destination: 91 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 86, 345, 91, 354 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 223, 273, 228, 282 Flags: Print AppearanceDictionary: true Destination: 87 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 251, 681, 256, 690 Flags: Print AppearanceDictionary: true Destination: 88 Annotation: Subtype: Link Rect: 186, 585, 191, 594 Flags: Print AppearanceDictionary: true Destination: 88 Annotation: Subtype: Link Rect: 90, 441, 95, 450 Flags: Print AppearanceDictionary: true Destination: 89 Annotation: Subtype: Link Rect: 333, 633, 338, 642 Flags: Print AppearanceDictionary: true Destination: 89 Annotation: Subtype: Link Rect: 466, 501, 471, 510 Flags: Print AppearanceDictionary: true Destination: 89 Annotation: Subtype: Link Rect: 341, 393, 351, 402 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 428, 141, 437, 150 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 364, 57, 369, 66 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 378, 57, 388, 66 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 397, 57, 407, 66 Flags: Print AppearanceDictionary: true Destination: 91 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 211, 309, 220, 318 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 307, 297, 317, 306 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 495, 249, 504, 258 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 457, 225, 467, 234 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 473, 225, 483, 234 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 525, 93, 535, 102 Flags: Print AppearanceDictionary: true Destination: 90 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 282, 573, 287, 582 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 224, 561, 234, 570 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 159, 525, 168, 534 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 139, 381, 148, 390 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 153, 381, 163, 390 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 280, 333, 285, 342 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 161, 285, 165, 294 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 171, 285, 181, 294 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 148, 177, 158, 186 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 165, 177, 175, 186 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 59, 105, 69, 114 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 74, 105, 83, 114 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 475, 330, 480, 340 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 410, 318, 420, 328 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 426, 318, 436, 328 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 442, 318, 452, 328 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 478, 270, 532, 278 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 261, 380, 269 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Thumb: true Page: Sequence: 10 Thumb: true Checksum: cbfaca0a Type: CRC32 Checksum: b9da8f2e331349d7e4b4c3970404bb13 Type: MD5 Checksum: e6c1ef36a1217f837ce5ebc5e2a2651afdf8e577 Type: SHA-1 Checksum: b96a553cab3e8b1efac90ff2fa452e1a13a51b094b96066d5a4bc39cb5bbd92d Type: SHA-256