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'bm_CR37' cannot be found Offset: 945368 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 945368 MIMEtype: application/pdf PDFMetadata: Objects: 666 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Cell lines and treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Dynamic BH3 profiling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Cell death analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Protein extraction and quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Immunoprecipitation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Immunoblotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Development of RMS orthoxenograft mouse model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Drug treatment in ERMS RMSX1 orthoxenograft tumor model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: PDX cell isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Novel chemotherapy combinations with BH3 mimetics to increase RMS cytotoxicity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Vincristine promotes MCL-1-mediated resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Effective therapeutic combination in’vivo of vincristine with the MCL-1 inhibitor S63845 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Info: Title: Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma 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true Font: BaseFont: JMPEBG+AdvOTa9103878+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: JMPEBG+AdvOTa9103878+20 Flags: Nonsymbolic FontBBox: -166, -218, 968, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMPEHN+AdvOTf0bf83d5.I FontSubset: true FirstChar: 41 LastChar: 119 FontDescriptor: FontName: JMPEHN+AdvOTf0bf83d5.I Flags: Serif, Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41419-020-02887-y Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance Clara Alcon Albert Manzano-Muñoz Estela Prada Jaume Mora Aroa Soriano Gabriela Guillén Soledad Gallego Josep Roma Josep Samitier Alberto Villanueva Joan Montero Springer US Cell Death and Disease, doi:10.1038/s41419-020-02887-y 10.1038/s41419-020-02887-y http://dx.doi.org/10.1038/s41419-020-02887-y journal Cell Death and Disease © 2020, The Author(s) 2041-4889 10.1038/s41419-020-02887-y springer.com springerlink.com 2010-04-23 True 10.1038/s41419-020-02887-y springer.com springerlink.com Springer 2020-08-15T13:36:48+02:00 2020-08-14T22:48:42+05:30 2020-08-15T13:36:48+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:0c452b3a-aeea-40f2-b9f6-a33bf3bbad17 uuid:8a9c576b-5bdf-4ca2-a25c-140ead27da06 default 1 converted uuid:61333c9a-c34d-4edd-8eea-87ec9a71dbc7 converted to PDF/A-2b pdfToolbox 2020-08-14T22:49:35+05:30 2 B Albert Manzano-Muñoz http://orcid.org/0000-0003-4039-7391 Estela Prada http://orcid.org/0000-0003-4611-1120 Aroa Soriano http://orcid.org/0000-0001-9659-1471 Gabriela Guillén http://orcid.org/0000-0001-5632-2672 Soledad Gallego http://orcid.org/0000-0002-4712-9624 Josep Roma http://orcid.org/0000-0001-7692-6123 Alberto Villanueva http://orcid.org/0000-0001-5164-0006 Joan Montero http://orcid.org/0000-0002-9192-4836 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object 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