3539b5187e8461f6e50dc05ee5eed7c3 pmc_32807815.pdf 1213272298a1c38a5486bfbf7b384c28bd2c2766 pmc_32807815.pdf f632cd3574edbc8b6d25edb71625b4d033731d8552e7d2507b6ce904c5be3194 pmc_32807815.pdf Title: Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-70814-4 Author: Leonardo Sarlabous Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Aug 11 10:18:54 2020 CEST ModDate: Tue Aug 11 20:52:43 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 5356344 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MYESVI+Wingdings-Regular Type 1C WinAnsi yes yes yes 518 0 MinionPro-Regular Type 1C Custom yes no yes 70 0 Corbel-Bold2 TrueType WinAnsi yes no yes 72 0 INVNBY+Corbel-Bold CID TrueType Identity-H yes yes yes 73 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 347 0 Corbel2 TrueType WinAnsi yes no yes 74 0 DNMOJI+Corbel CID TrueType Identity-H yes yes yes 75 0 MinionPro-It Type 1C Custom yes no yes 71 0 MinionPro-Bold Type 1C Custom yes no yes 95 0 RSWXXG+MTSYN4 Type 1C Custom yes yes yes 107 0 RSWXXG+MinionPro-It14 Type 1C Custom yes yes no 108 0 RSWXXG+MinionPro-It16 Type 1C Custom yes yes no 109 0 RSWXXG+MinionPro-It15 Type 1C Custom yes yes no 110 0 RSWXXG+CMEX10 Type 1C Custom yes yes no 111 0 RSWXXG+MinionPro-Regular2 Type 1C Custom yes yes no 112 0 RSWXXG+MTMI Type 1C Custom yes yes no 113 0 RSWXXG+MinionPro-It17 Type 1C Custom yes yes no 114 0 RSWXXG+MTSYN6 Type 1C Custom yes yes yes 115 0 RSWXXG+MinionPro-It5 Type 1C Custom yes yes no 116 0 RSWXXG+MinionPro-It13 Type 1C Custom yes yes no 117 0 RSWXXG+MinionPro-Regular7 Type 1C Custom yes yes no 118 0 RSWXXG+MinionPro-It12 Type 1C Custom yes yes no 119 0 RSWXXG+MTMI3 Type 1C Custom yes yes no 120 0 RSWXXG+MinionPro-It26 Type 1C Custom yes yes no 121 0 RSWXXG+MinionPro-It18 Type 1C Custom yes yes no 122 0 RSWXXG+MinionPro-It2 Type 1C Custom yes yes no 123 0 RSWXXG+MTSYN5 Type 1C Custom yes yes yes 124 0 RSWXXG+MinionPro-It11 Type 1C Custom yes yes no 125 0 RSWXXG+MinionPro-It9 Type 1C Custom yes yes no 126 0 RSWXXG+MinionPro-It8 Type 1C Custom yes yes no 127 0 RSWXXG+MinionPro-It10 Type 1C Custom yes yes no 128 0 RSWXXG+MinionPro-It7 Type 1C Custom yes yes no 129 0 RSWXXG+MTSYN3 Type 1C Custom yes yes yes 130 0 RSWXXG+MinionPro-Regular4 Type 1C Custom yes yes no 131 0 RSWXXG+MinionPro-It6 Type 1C Custom yes yes no 132 0 RSWXXG+CMEX103 Type 1C Custom yes yes no 133 0 RSWXXG+MinionPro-Regular8 Type 1C Custom yes yes no 134 0 RSWXXG+MinionPro-It27 Type 1C Custom yes yes no 135 0 RSWXXG+MinionPro-Regular3 Type 1C Custom yes yes no 136 0 RSWXXG+MTSYN2 Type 1C Custom yes yes yes 137 0 RSWXXG+MTMI2 Type 1C Custom yes yes no 138 0 RSWXXG+MTSYN Type 1C Custom yes yes yes 139 0 RSWXXG+CMEX104 Type 1C Custom yes yes no 140 0 RSWXXG+MTSYN10 Type 1C Custom yes yes yes 141 0 RSWXXG+MinionPro-It4 Type 1C Custom yes yes no 142 0 RSWXXG+MinionPro-It3 Type 1C Custom yes yes no 143 0 RSWXXG+MTSYN9 Type 1C Custom yes yes yes 144 0 RSWXXG+MinionPro-It24 Type 1C Custom yes yes no 145 0 RSWXXG+MinionPro-It25 Type 1C Custom yes yes no 146 0 RSWXXG+MinionPro-Regular5 Type 1C Custom yes yes no 147 0 RSWXXG+CMEX102 Type 1C Custom yes yes no 148 0 RSWXXG+MinionPro-It21 Type 1C Custom yes yes no 149 0 RSWXXG+MTSYN8 Type 1C Custom yes yes yes 150 0 RSWXXG+MinionPro-It22 Type 1C Custom yes yes no 151 0 RSWXXG+MTSYN7 Type 1C Custom yes yes yes 152 0 RSWXXG+MinionPro-It23 Type 1C Custom yes yes no 153 0 RSWXXG+MinionPro-Regular6 Type 1C Custom yes yes no 154 0 RSWXXG+MinionPro-It20 Type 1C Custom yes yes no 155 0 RSWXXG+MinionPro-It19 Type 1C Custom yes yes no 156 0 RSWXXG+MTSYN11 Type 1C Custom yes yes yes 317 0 RSWXXG+MinionPro-It28 Type 1C Custom yes yes no 318 0 RSWXXG+MinionPro-Regular9 Type 1C Custom yes yes no 319 0 RSWXXG+CMEX105 Type 1C Custom yes yes no 320 0 BUZFHM+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 420 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:41:06 CEST RepresentationInformation: pmc_32807815.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:47:15 CEST Size: 5356344 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 595 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation Children: Item: Title: Anchor 2 Item: Title: Anchor 3 Item: Title: Methods Children: Item: Title: Defining complex patient ventilator interactions. Item: Title: Data acquisition and data analysis. Item: Title: Study population. Item: Title: Visual validation of CP-VI. Item: Title: Sample entropy. Item: Title: Automatic CP-VI detection. Item: Title: Statistical analysis. Item: Title: Optimization procedure (selection of m, r, and Th). Item: Title: Results Children: Item: Title: Visual CP-VI analysis by experts. Item: Title: Detecting CP-VI with SE. Item: Title: Optimization of SE settings, Th detection using a repeated holdout cross-validation procedure. Item: Title: Discussion Item: Title: Conclusion Item: Title: References Item: Title: Acknowledgments Info: Title: Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation Author: Leonardo Sarlabous Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-70814-4 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Aug 11 10:48:54 CEST 2020 ModDate: Tue Aug 11 20:52:43 CEST 2020 ID: 0xa43ca963d3ea148044e12d3dadd5d75b, 0xb3067426de063223dcc73f61e645fa07 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2011 ImageHeight: 1174 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 455 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 1500 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2011 ImageHeight: 996 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1698 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2011 ImageHeight: 1121 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: INVNBY+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: DNMOJI+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: RSWXXG+MinionPro-It10 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It10 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It7 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It7 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN3 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN3 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-Regular4 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular4 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It6 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It6 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+CMEX103 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+CMEX103 Flags: Symbolic FontBBox: 0, -2359, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MYESVI+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MYESVI+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-Regular8 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular8 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It27 FontSubset: true FirstChar: 23 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It27 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-Regular3 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular3 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN2 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN2 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MTMI2 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTMI2 Flags: Symbolic, AllCap FontBBox: 0, -177, 344, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+CMEX104 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+CMEX104 Flags: Symbolic FontBBox: 0, -2359, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN10 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN10 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It4 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It4 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It3 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It3 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN9 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN9 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It24 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It24 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It25 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It25 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-Regular5 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular5 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+CMEX102 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+CMEX102 Flags: Symbolic FontBBox: 0, -2359, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It21 FontSubset: true FirstChar: 24 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It21 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN8 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN8 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It22 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It22 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN7 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN7 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It23 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It23 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-Regular6 FontSubset: true FirstChar: 23 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular6 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It20 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It20 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It19 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It19 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN11 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN11 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It28 FontSubset: true FirstChar: 26 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It28 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-Regular9 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular9 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+CMEX105 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: RSWXXG+CMEX105 Flags: Symbolic FontBBox: 0, -2359, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MTSYN4 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN4 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It14 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It14 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It16 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It16 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It15 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It15 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+CMEX10 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: RSWXXG+CMEX10 Flags: Symbolic FontBBox: 0, -2359, 1387, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-Regular2 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: RSWXXG+MinionPro-Regular2 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTMI FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: RSWXXG+MTMI Flags: Symbolic, AllCap FontBBox: 0, -177, 344, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It17 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It17 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN6 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN6 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It5 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It5 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It13 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It13 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-Regular7 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-Regular7 Flags: Symbolic, SmallCap FontBBox: 0, -163, 796, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It12 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It12 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTMI3 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTMI3 Flags: Symbolic, AllCap FontBBox: 0, -177, 344, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It26 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It26 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It18 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It18 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It2 FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: RSWXXG+MinionPro-It2 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MTSYN5 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MTSYN5 Flags: Symbolic FontBBox: 0, -954, 987, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSWXXG+MinionPro-It11 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It11 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It9 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It9 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RSWXXG+MinionPro-It8 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: RSWXXG+MinionPro-It8 Flags: Symbolic FontBBox: -103, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true TrueType: Font: BaseFont: BUZFHM+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: BUZFHM+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-Bold2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: DNMOJI+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DNMOJI+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: INVNBY+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: INVNBY+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2020-08-11T13:48:54+05:30 Springer 2020-08-11T20:52:43+02:00 2020-08-11T20:52:43+02:00 application/pdf https://doi.org/10.1038/s41598-020-70814-4 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-020-70814-4 Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation Leonardo Sarlabous José Aquino-Esperanza Rudys Magrans Candelaria de Haro Josefina López-Aguilar Carles Subirà Montserrat Batlle Montserrat Rué Gemma Gomà Ana Ochagavia Rafael Fernández Lluís Blanch 10.1038/s41598-020-70814-4 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-020-70814-4 10.1038/s41598-020-70814-4 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-020-70814-4 noindex springer.com springerlink.com VoR uuid:ce9fbd82-ed1a-484f-b2ee-e0ad8ec91542 uuid:a0f939a1-bebd-4bb8-a8cb-191edd9fb442 default 1 converted uuid:218abc97-2208-4804-8885-7fd6e009aa7a converted to PDF/A-2b pdfToolbox 2020-08-11T13:49:52+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 543, 230, 546, 217 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 549, 230, 552, 217 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 486, 210, 489, 197 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 492, 210, 495, 197 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 394, 200, 397, 187 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 399, 200, 401, 187 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 403, 200, 406, 187 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 407, 200, 410, 187 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 234, 190, 237, 177 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 238, 190, 241, 177 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 242, 190, 245, 177 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 246, 190, 249, 177 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 250, 190, 256, 177 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 271, 180, 276, 167 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 481, 656, 556, 638 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 282, 714, 285, 702 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 286, 714, 289, 702 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 291, 714, 293, 702 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 295, 714, 298, 702 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 299, 714, 305, 702 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 296, 704, 301, 692 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 304, 704, 310, 692 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 319, 654, 324, 642 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 451, 624, 456, 612 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 459, 624, 465, 612 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 537, 604, 543, 592 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 546, 604, 552, 592 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 245, 574, 251, 562 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 250, 544, 256, 532 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 257, 544, 263, 532 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 462, 544, 468, 532 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 288, 534, 294, 522 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 369, 534, 375, 522 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 376, 534, 382, 522 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 461, 534, 467, 522 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 274, 524, 280, 512 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 234, 494, 240, 482 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 241, 494, 247, 482 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 250, 494, 256, 482 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 319, 484, 325, 472 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 462, 484, 468, 472 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 471, 484, 477, 472 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 368, 474, 371, 462 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 373, 474, 378, 462 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 548, 444, 554, 432 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 190, 342, 196, 330 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 197, 342, 203, 330 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 204, 342, 209, 330 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 211, 342, 216, 330 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 227, 302, 230, 290 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 434, 292, 436, 280 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 466, 292, 471, 280 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 254, 230, 256, 218 Flags: Print AppearanceDictionary: true Destination: 407 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 448, 296, 454, 284 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 325, 286, 330, 274 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 312, 224, 315, 212 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 316, 224, 322, 212 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 522, 113, 528, 100 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 224, 93, 229, 80 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 231, 93, 236, 80 Flags: Print AppearanceDictionary: true Destination: 407 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 440, 486, 445, 474 Flags: Print AppearanceDictionary: true Destination: 407 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 372, 393, 376, 381 Flags: Print AppearanceDictionary: true Destination: 305 Annotation: Subtype: Link Rect: 216, 303, 222, 291 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 245, 221, 251, 209 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 222, 181, 227, 169 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 362, 171, 368, 159 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 371, 171, 377, 159 Flags: Print AppearanceDictionary: true Destination: 427 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 447, 236, 453, 224 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 454, 236, 460, 224 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 193, 206, 197, 194 Flags: Print AppearanceDictionary: true Destination: 337 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 213, 322, 217, 310 Flags: Print AppearanceDictionary: true Destination: 350 Annotation: Subtype: Link Rect: 213, 271, 218, 258 Flags: Print AppearanceDictionary: true Destination: 361 Annotation: Subtype: Link Rect: 485, 150, 490, 138 Flags: Print AppearanceDictionary: true Destination: 378 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 333, 117, 338, 105 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 355, 107, 361, 95 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 362, 107, 368, 95 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 369, 107, 375, 95 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 378, 107, 383, 95 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 499, 97, 505, 85 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 506, 97, 512, 85 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 513, 97, 519, 85 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 522, 97, 527, 85 Flags: Print AppearanceDictionary: true Destination: 427 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 468, 354, 474, 342 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 475, 354, 481, 342 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 546, 354, 552, 342 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 224, 274, 230, 262 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 208, 254, 213, 242 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 217, 84, 222, 72 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 343, 84, 349, 72 Flags: Print AppearanceDictionary: true Destination: 407 Annotation: Subtype: Link Rect: 350, 84, 356, 72 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 357, 84, 363, 72 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 189, 74, 194, 62 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 196, 74, 201, 62 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 204, 74, 210, 62 Flags: Print AppearanceDictionary: true Destination: 427 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 333, 654, 339, 642 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 340, 654, 346, 642 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 450, 654, 456, 642 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 532, 654, 538, 642 Flags: Print AppearanceDictionary: true Destination: 427 Annotation: Subtype: Link Rect: 229, 644, 234, 632 Flags: Print AppearanceDictionary: true Destination: 427 Thumb: true Page: Sequence: 11 Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 365, 593, 523, 581 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 563, 443, 551 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 357, 453, 516, 441 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 3f7c9134 Type: CRC32 Checksum: 3539b5187e8461f6e50dc05ee5eed7c3 Type: MD5 Checksum: 1213272298a1c38a5486bfbf7b384c28bd2c2766 Type: SHA-1