641322e0da09e417b977cd817865a652  pmc_32831895.pdf
2904f4ccdc68c40cd410516ae742fbbb07428f7f  pmc_32831895.pdf
5f99e00d56a0044f55f1f27db1b3f870981519e26f18a33859f575e447536656  pmc_32831895.pdf

Title:           Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats
Subject:         Nutrition & Metabolism, 2020, doi:10.1186/s12986-020-00492-6
Keywords:        Obesity,Microbiome,Exercise,Hypothalamus,White adipose tissue,Cafeteria diet
Author:          Sarah-Jane Leigh
Creator:         Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:        Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Sun Aug 16 05:52:24 2020 CEST
ModDate:         Tue Aug 18 13:38:52 2020 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1753753 bytes
Optimized:       no
PDF version:     1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     20  0
OOMCJA+GgmvsxAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no      18  0
OOMFGA+NjjsbpAdvTTe45e47d2           Type 1C           WinAnsi          yes yes no      19  0
OOMFHB+DtnjlnAdvTTb5929f4c           Type 1C           WinAnsi          yes yes no      66  0
OOMFMA+MbcrgjAdvTT99c4c969           Type 1C           WinAnsi          yes yes no      21  0
OOMFNA+QwqpydAdvTT1b53b5fb.I         Type 1C           WinAnsi          yes yes no      68  0
OOMKBH+GlhkhhAdvTT7329fd89.I         Type 1C           WinAnsi          yes yes no      22  0
OOMKGJ+NqvwjfAdvTT86d47313+20        Type 1C           WinAnsi          yes yes no      15  0
OOMKFI+VjqpwyAdvTT86d47313           Type 1C           WinAnsi          yes yes no      16  0
OOMKFJ+VkcyvlAdvTT8861b38f.I         Type 1C           WinAnsi          yes yes no      17  0
OOMKIK+BhnbbtAdvTT86d47313+03        Type 1C           Custom           yes yes yes    176  0
OOMKJK+XbrjkkAdvTT86d47313+22        Type 1C           Custom           yes yes yes    177  0
OOMPBP+XstxtcAdvTTb5929f4c+20        Type 1C           WinAnsi          yes yes no      69  0
OOMPEP+TrxdxnAdvTTe45e47d2+20        Type 1C           WinAnsi          yes yes no     276  0
OONNIJ+LcntswAdvTT99c4c969+20        Type 1C           WinAnsi          yes yes no      67  0
OONNLJ+CywhmkAdvTTb5929f4c+22        Type 1C           Custom           yes yes no     162  0
OONNOK+PgpvnbAdvTTaf7f9f4f.B+20      Type 1C           WinAnsi          yes yes no     205  0
OONNNJ+YfsffvAdvTTb5929f4c+03        Type 1C           Custom           yes yes yes    206  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:02:51 CEST
 RepresentationInformation: pmc_32831895.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:47:17 CEST
  Size: 1753753
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 496
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: sectionAbs1
      Children: 
       Item: 
        Title: Background
        Destination: sectionASec1
       Item: 
        Title: Methods
        Destination: sectionASec2
       Item: 
        Title: Results
        Destination: sectionASec3
       Item: 
        Title: Conclusions
        Destination: sectionASec4
     Item: 
      Title: Introduction
      Destination: sectionSec1
     Item: 
      Title: Materials and methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Subjects and diet manipulation
        Destination: sectionSec3
       Item: 
        Title: Treadmill exercise
        Destination: sectionSec4
       Item: 
        Title: Sample collection
        Destination: sectionSec5
       Item: 
        Title: Protein and triglyceride measurements
        Destination: sectionSec6
       Item: 
        Title: RNA extraction and gene expression assays
        Destination: sectionSec7
       Item: 
        Title: Statistical analyses
        Destination: sectionSec8
       Item: 
        Title: Fecal DNA extraction, microbiome community sequencing and statistical analyses
        Destination: sectionSec9
     Item: 
      Title: Results
      Destination: sectionSec10
      Children: 
       Item: 
        Title: Energy intake, body weight and composition, and WAT gene expression
        Destination: sectionSec11
       Item: 
        Title: Microbial species diversity and microbiome composition
        Destination: sectionSec12
       Item: 
        Title: Predicted microbiome function
        Destination: sectionSec13
       Item: 
        Title: WAT and hypothalamic gene expression
        Destination: sectionSec14
       Item: 
        Title: Associations between variables of interest and microbiome
        Destination: sectionSec15
     Item: 
      Title: Discussion
      Destination: sectionSec16
     Item: 
      Title: Conclusions
      Destination: sectionSec17
     Item: 
      Title: Supplementary information
      Destination: sectionSec18
     Item: 
      Title: Abbreviations
      Destination: sectionabr1
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar1
     Item: 
      Title: Consent for publication
      Destination: sectionFPar2
     Item: 
      Title: Competing interests
      Destination: sectionFPar3
     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
      Destination: ArtNote2
   Info: 
    Title: Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats
    Author: Sarah-Jane Leigh
    Subject: Nutrition & Metabolism, 2020, doi:10.1186/s12986-020-00492-6
    Keywords: Obesity,Microbiome,Exercise,Hypothalamus,White adipose tissue,Cafeteria diet
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sun Aug 16 05:52:24 CEST 2020
    ModDate: Tue Aug 18 13:38:52 CEST 2020
   ID: 0x59d71d1cdf72e5309fcd4aa1d117c58f, 0x805d9737f7b1afd1f0e1699ab298b718
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 176
      ImageHeight: 182
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 688
      ImageHeight: 126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 54
      ImageHeight: 103
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 2011
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 2315
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 1907
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 2054
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OOMFHB+DtnjlnAdvTTb5929f4c
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: OOMFHB+DtnjlnAdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OONNLJ+CywhmkAdvTTb5929f4c+22
      FontSubset: true
      FirstChar: 21
      LastChar: 22
      FontDescriptor: 
       FontName: OONNLJ+CywhmkAdvTTb5929f4c+22
       Flags: Nonsymbolic
       FontBBox: -10, -218, 1083, 812
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: OONNIJ+LcntswAdvTT99c4c969+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: OONNIJ+LcntswAdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -447, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMFNA+QwqpydAdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: OOMFNA+QwqpydAdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMPBP+XstxtcAdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: OOMPBP+XstxtcAdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -447, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OONNOK+PgpvnbAdvTTaf7f9f4f.B+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: OONNOK+PgpvnbAdvTTaf7f9f4f.B+20
       Flags: Nonsymbolic
       FontBBox: -468, -197, 1656, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OONNNJ+YfsffvAdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: OONNNJ+YfsffvAdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOMKGJ+NqvwjfAdvTT86d47313+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: OOMKGJ+NqvwjfAdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -354, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMKFI+VjqpwyAdvTT86d47313
      FontSubset: true
      FirstChar: 32
      LastChar: 239
      FontDescriptor: 
       FontName: OOMKFI+VjqpwyAdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMKIK+BhnbbtAdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: OOMKIK+BhnbbtAdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -364, -250, 906, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOMKFJ+VkcyvlAdvTT8861b38f.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: OOMKFJ+VkcyvlAdvTT8861b38f.I
       Flags: Serif, Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMKJK+XbrjkkAdvTT86d47313+22
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: OOMKJK+XbrjkkAdvTT86d47313+22
       Flags: Symbolic
       FontBBox: -166, -250, 1031, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOMCJA+GgmvsxAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: OOMCJA+GgmvsxAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMFGA+NjjsbpAdvTTe45e47d2
      FontSubset: true
      FirstChar: 32
      LastChar: 177
      FontDescriptor: 
       FontName: OOMFGA+NjjsbpAdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOMPEP+TrxdxnAdvTTe45e47d2+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: OOMPEP+TrxdxnAdvTTe45e47d2+20
       Flags: Nonsymbolic
       FontBBox: -447, -197, 1302, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMFMA+MbcrgjAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: OOMFMA+MbcrgjAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOMKBH+GlhkhhAdvTT7329fd89.I
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: OOMKBH+GlhkhhAdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.139439, 2010/09/27-13:37:26        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>Obesity,Microbiome,Exercise,Hypothalamus,White adipose tissue,Cafeteria diet</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1186/s12986-020-00492-6</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nutrition &amp; Metabolism</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nutrition &amp; Metabolism, 2020, doi:10.1186/s12986-020-00492-6</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Obesity</rdf:li>
               <rdf:li>Microbiome</rdf:li>
               <rdf:li>Exercise</rdf:li>
               <rdf:li>Hypothalamus</rdf:li>
               <rdf:li>White adipose tissue</rdf:li>
               <rdf:li>Cafeteria diet</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Sarah-Jane Leigh</rdf:li>
               <rdf:li>Nadeem O. Kaakoush</rdf:li>
               <rdf:li>Rosa M. Escorihuela</rdf:li>
               <rdf:li>R. Frederick Westbrook</rdf:li>
               <rdf:li>Margaret J. Morris</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:ModifyDate>2020-08-18T13:38:52+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2020-08-18T13:38:52+02:00</xmp:MetadataDate>
         <xmp:CreateDate>2020-08-16T11:52:24+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:40671657-d2ce-479c-aae2-84ddaaff8d0d</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:d4fa1982-49f3-4db3-acbf-7e6f979d28e8</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:40671657-d2ce-479c-aae2-84ddaaff8d0d</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-08-18T15:55:05+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/">
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Margaret J. Morris</author:name>
                  <author:orcid>http://orcid.org/0000-0003-2285-5117</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>editorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag EditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Editor information: contains the name of each editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>seriesEditorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Series editor information: contains the name of each series editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>EditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/editorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>editor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>SeriesEditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>seriesEditor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 496, 635, 538, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 528, 547, 536, 556
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 73, 518, 80
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 338, 65, 477, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 165, 183, 172
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 215, 669, 220, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 59, 645, 64, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 282, 633, 287, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 133, 621, 138, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 157, 597, 162, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 90, 561, 95, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 59, 501, 64, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 141, 477, 146, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 240, 441, 245, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 252, 441, 262, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 196, 417, 206, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 158, 405, 168, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 254, 405, 264, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 207, 333, 217, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 59, 237, 69, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 231, 213, 240, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 248, 213, 257, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 136, 129, 146, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 117, 117, 127, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 275, 93, 285, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 307, 297, 317, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 129, 152, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 115, 81, 125, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 168, 57, 178, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 525, 465, 535, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 506, 453, 516, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 469, 369, 479, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 341, 345, 351, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 308, 321, 317, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 346, 309, 356, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 369, 261, 379, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 431, 189, 440, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 307, 93, 317, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 279, 645, 283, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 46
      Annotation: 
       Subtype: Link
       Rect: 369, 669, 374, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 46
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 250, 693, 255, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 253, 681, 258, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 85, 621, 90, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 234, 609, 239, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 258, 585, 263, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 46
      Annotation: 
       Subtype: Link
       Rect: 93, 549, 98, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 46
      Annotation: 
       Subtype: Link
       Rect: 188, 429, 193, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: 46
      Annotation: 
       Subtype: Link
       Rect: 246, 417, 251, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 168, 357, 172, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 46
      Annotation: 
       Subtype: Link
       Rect: 353, 669, 358, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 491, 633, 496, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 439, 537, 443, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 396, 453, 400, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 324, 441, 329, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 506, 393, 511, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 220, 561, 225, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 107, 549, 112, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 151, 465, 155, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 280, 465, 285, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 136, 315, 141, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 160, 303, 165, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 248, 291, 253, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 281, 279, 285, 288
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 152, 165, 157, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 50
      Annotation: 
       Subtype: Link
       Rect: 401, 525, 406, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 50
      Annotation: 
       Subtype: Link
       Rect: 465, 513, 470, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 50
      Annotation: 
       Subtype: Link
       Rect: 331, 153, 336, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 486, 81, 491, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 51
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 199, 117, 204, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 128, 93, 133, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 127, 69, 131, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 322, 129, 327, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 468, 117, 473, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 304, 57, 309, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 159, 489, 169, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 186, 225, 196, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 197, 201, 207, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 157, 189, 167, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 228, 117, 238, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 158, 105, 167, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 59, 81, 69, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 75, 81, 85, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 364, 489, 374, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 380, 489, 390, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 434, 477, 444, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 347, 357, 356, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 441, 177, 451, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 392, 165, 401, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 344, 81, 354, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 406, 81, 416, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 422, 81, 432, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 424, 57, 434, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 133, 105, 143, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 155, 69, 165, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 253, 57, 263, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 669, 101, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 275, 525, 285, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 172, 477, 182, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 188, 477, 198, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 234, 429, 244, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 134, 405, 144, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 76, 285, 86, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 170, 261, 180, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 59, 129, 69, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 101, 117, 111, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 144, 93, 154, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 478, 477, 532, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 468, 381, 475
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
  Checksum: 79472f6b
   Type: CRC32
  Checksum: 641322e0da09e417b977cd817865a652
   Type: MD5
  Checksum: 2904f4ccdc68c40cd410516ae742fbbb07428f7f
   Type: SHA-1
  Checksum: 5f99e00d56a0044f55f1f27db1b3f870981519e26f18a33859f575e447536656
   Type: SHA-256