8094a4f179d0e6842afaed2ec376b13c pmc_32928792.pdf b19eb31e6574c56ad2202c7e2f5c441db98285bc pmc_32928792.pdf f4144037b1493fcb9780bac1514c34cde99606b01778387303be7bdf2fe1f853 pmc_32928792.pdf Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Sep 11 16:18:32 2020 CEST ModDate: Fri Sep 11 16:18:33 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 591781 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JJOAFQ+BookAntiqua-Bold CID TrueType Identity-H yes yes yes 445 0 ISCPRS+ArialMT CID TrueType Identity-H yes yes yes 460 0 ZMQSVK+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes yes 447 0 OVACCG+HelveticaNeueLTStd-BdCn Type 1C Custom yes yes yes 448 0 HGPODU+HelveticaNeueLTStd-Roman Type 1C Custom yes yes yes 449 0 QYEOEC+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 461 0 UECMIU+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 462 0 GPYDPW+Helvetica-Condensed-Bold Type 1C Custom yes yes yes 473 0 FLOXBY+NewBaskerville-Roman Type 1C WinAnsi yes yes yes 474 0 UECMIU+HelveticaNeueLTStd-CnO Type 1C WinAnsi yes yes yes 525 0 QYEOEC+HelveticaNeueLTStd-Cn Type 1C WinAnsi yes yes yes 527 0 OVACCG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 529 0 DIKLZC+Symbol Type 1C Custom yes yes yes 346 0 UECMIU+HelveticaNeueLTStd-CnO Type 1C WinAnsi yes yes yes 29 0 QYEOEC+HelveticaNeueLTStd-Cn Type 1C WinAnsi yes yes yes 31 0 OVACCG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 33 0 UECMIU+HelveticaNeueLTStd-CnO Type 1C WinAnsi yes yes yes 80 0 QYEOEC+HelveticaNeueLTStd-Cn Type 1C WinAnsi yes yes yes 82 0 OVACCG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 84 0 UECMIU+HelveticaNeueLTStd-CnO Type 1C WinAnsi yes yes yes 354 0 QYEOEC+HelveticaNeueLTStd-Cn Type 1C WinAnsi yes yes yes 352 0 OVACCG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 353 0 CJAFLE+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 368 0 UECMIU+HelveticaNeueLTStd-CnO Type 1C WinAnsi yes yes yes 363 0 QYEOEC+HelveticaNeueLTStd-Cn Type 1C WinAnsi yes yes yes 362 0 OVACCG+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 361 0 ZCMNVK+NewBaskerville-Italic Type 1C WinAnsi yes yes yes 369 0 ZCMNVK+FrutigerLTStd-Bold Type 1C WinAnsi yes yes yes 373 0 XZNBTO+HelveticaNeueLTStd-It Type 1C Custom yes yes yes 374 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:06:46 CET RepresentationInformation: pmc_32928792.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-10-05 03:37:09 CEST Size: 591781 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 542 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Efficacy and safety of insulin glargine 300 U/mL (Gla-300) during hospitalization and therapy intensification at discharge in patients with insufficiently controlled type 2 diabetes: results of the phase IV COBALTA trial Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Study design and participants Item: Title: Study treatment Item: Title: Study endpoints Item: Title: Statistical methods Item: Title: Results Children: Item: Title: Study population Item: Title: Study treatment Item: Title: Glycemic control Item: Title: Weight and body mass index Item: Title: Hyperglycemia and hypoglycemia Children: Item: Title: Hyperglycemia Item: Title: Anytime hypoglycemia Item: Title: Nocturnal hypoglycemia Item: Title: Severe hypoglycemia Item: Title: Hyperglycemia and hypoglycemia subanalyses Item: Title: Rehospitalizations and visits to emergency rooms Item: Title: Adverse events Item: Title: Patient-reported outcomes Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Sep 11 16:18:32 CEST 2020 ModDate: Fri Sep 11 16:18:33 CEST 2020 ID: 0x00dfa9ff6321e94ba47ea2c6ef00ae01, 0xbf5ade4cb2acfb448afa82e8a0823904 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: CJAFLE+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: ISCPRS+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: JJOAFQ+BookAntiqua-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: OVACCG+HelveticaNeueLTStd-BdCn FontSubset: true FirstChar: 31 LastChar: 122 FontDescriptor: FontName: OVACCG+HelveticaNeueLTStd-BdCn Flags: Nonsymbolic FontBBox: -164, -224, 1066, 961 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HGPODU+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 27 LastChar: 248 FontDescriptor: FontName: HGPODU+HelveticaNeueLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -214, 1076, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZCMNVK+NewBaskerville-Italic FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ZCMNVK+NewBaskerville-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -138, -274, 1347, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ZCMNVK+FrutigerLTStd-Bold FontSubset: true FirstChar: 67 LastChar: 83 FontDescriptor: FontName: ZCMNVK+FrutigerLTStd-Bold Flags: Nonsymbolic FontBBox: -166, -250, 1000, 935 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: XZNBTO+HelveticaNeueLTStd-It FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: XZNBTO+HelveticaNeueLTStd-It Flags: Nonsymbolic, Italic FontBBox: -166, -214, 1106, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GPYDPW+Helvetica-Condensed-Bold FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: GPYDPW+Helvetica-Condensed-Bold Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FLOXBY+NewBaskerville-Roman FontSubset: true FirstChar: 32 LastChar: 239 FontDescriptor: FontName: FLOXBY+NewBaskerville-Roman Flags: Serif, Nonsymbolic FontBBox: -205, -272, 1207, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: DIKLZC+Symbol FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: DIKLZC+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QYEOEC+HelveticaNeueLTStd-Cn FontSubset: true FirstChar: 28 LastChar: 250 FontDescriptor: FontName: QYEOEC+HelveticaNeueLTStd-Cn Flags: Nonsymbolic FontBBox: -164, -212, 1000, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UECMIU+HelveticaNeueLTStd-CnO FontSubset: true FirstChar: 31 LastChar: 116 FontDescriptor: FontName: UECMIU+HelveticaNeueLTStd-CnO Flags: Nonsymbolic, Italic FontBBox: -171, -272, 1068, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZMQSVK+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: ZMQSVK+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: CJAFLE+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CJAFLE+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: ISCPRS+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ISCPRS+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Font: BaseFont: JJOAFQ+BookAntiqua-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JJOAFQ+BookAntiqua-Bold Flags: Serif, Symbolic FontBBox: -134, -337, 1193, 1021 FontFile2: true XMP: doi:bmjdrc-2020-001518 application/pdf 2020-09-11T15:18:32+01:00 2020-09-11T15:18:33+01:00 2020-09-11T15:18:33+01:00 Adobe InDesign 14.0 (Windows) uuid:2a6edcc5-5313-46a6-9d4a-bbcc8d728e54 xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:336d9e5d-d96c-894a-b87a-28772ea4851c proof:pdf xmp.iid:ef64b5d9-bdcf-6d4f-a746-78a495b1e8a4 xmp.did:bcaf19cd-4dc2-c643-8990-11b98603de15 xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign CC 14.0 (Windows) / 2020-09-11T15:18:32+01:00 576702de-2b22-4705-ac88-cb87b1afb49f Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 40, 34, 65, 18 Annotation: Subtype: Link Rect: 220, 567, 229, 555 Annotation: Subtype: Link Rect: 423, 567, 432, 555 Annotation: Subtype: Link Rect: 274, 554, 283, 541 Annotation: Subtype: Link Rect: 435, 554, 444, 541 Annotation: Subtype: Link Rect: 527, 554, 536, 541 Annotation: Subtype: Link Rect: 43, 317, 120, 307 Annotation: Subtype: Link Rect: 42, 307, 106, 297 Annotation: Subtype: Link Rect: 40, 197, 135, 174 Annotation: Subtype: Link Rect: 479, 75, 490, 63 ActionDest: 207 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 256, 735, 260, 723 ActionDest: 207 Annotation: Subtype: Link Rect: 78, 687, 94, 675 ActionDest: 207 Annotation: Subtype: Link Rect: 73, 663, 84, 651 ActionDest: 239 Annotation: Subtype: Link Rect: 79, 627, 94, 615 ActionDest: 207 Annotation: Subtype: Link Rect: 62, 591, 71, 579 ActionDest: 239 Annotation: Subtype: Link Rect: 171, 519, 203, 507 ActionDest: 207 Annotation: Subtype: Link Rect: 91, 459, 107, 447 ActionDest: 239 Annotation: Subtype: Link Rect: 109, 423, 125, 411 ActionDest: 239 Annotation: Subtype: Link Rect: 106, 351, 113, 339 ActionDest: 239 Annotation: Subtype: Link Rect: 184, 315, 191, 303 ActionDest: 239 Annotation: Subtype: Link Rect: 77, 255, 95, 243 ActionDest: 239 Annotation: Subtype: Link Rect: 120, 207, 136, 195 ActionDest: 239 Annotation: Subtype: Link Rect: 253, 183, 270, 171 ActionDest: 239 Annotation: Subtype: Link Rect: 489, 686, 553, 674 Annotation: Subtype: Link Rect: 306, 674, 390, 662 Annotation: Subtype: Link Rect: 489, 492, 553, 480 Annotation: Subtype: Link Rect: 306, 480, 374, 468 Annotation: Subtype: Link Rect: 525, 419, 553, 407 Annotation: Subtype: Link Rect: 306, 407, 415, 395 Annotation: Subtype: Link Rect: 364, 185, 491, 173 Annotation: Subtype: Link Rect: 427, 160, 553, 149 Annotation: Subtype: Link Rect: 306, 148, 312, 137 Annotation: Subtype: Link Rect: 473, 100, 480, 88 ActionDest: 239 Annotation: Subtype: Link Rect: 311, 88, 438, 76 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 70, 483, 87, 471 ActionDest: 239 Annotation: Subtype: Link Rect: 271, 375, 278, 363 ActionDest: 239 Annotation: Subtype: Link Rect: 397, 621, 526, 609 Annotation: Subtype: Link Rect: 405, 597, 435, 585 ActionDest: 103 Annotation: Subtype: Link Rect: 457, 597, 553, 585 Annotation: Subtype: Link Rect: 306, 585, 340, 573 Annotation: Subtype: Link Rect: 324, 516, 459, 504 Annotation: Subtype: Link Rect: 368, 408, 499, 396 Annotation: Subtype: Link Rect: 458, 289, 553, 276 Annotation: Subtype: Link Rect: 306, 276, 336, 264 Annotation: Subtype: Link Rect: 455, 207, 498, 195 ActionDest: 103 Annotation: Subtype: Link Rect: 525, 207, 553, 195 Annotation: Subtype: Link Rect: 306, 195, 406, 183 Annotation: Subtype: Link Rect: 311, 171, 351, 159 ActionDest: 103 Annotation: Subtype: Link Rect: 374, 171, 502, 159 Annotation: Subtype: Link Rect: 363, 111, 495, 99 Annotation: Subtype: Link Rect: 516, 63, 553, 51 ActionDest: 103 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 61, 161, 190, 149 Annotation: Subtype: Link Rect: 188, 124, 231, 113 ActionDest: 103 Annotation: Subtype: Link Rect: 260, 124, 288, 113 Annotation: Subtype: Link Rect: 42, 112, 140, 100 Annotation: Subtype: Link Rect: 186, 75, 230, 63 ActionDest: 103 Annotation: Subtype: Link Rect: 260, 75, 288, 63 Annotation: Subtype: Link Rect: 42, 63, 138, 51 Annotation: Subtype: Link Rect: 428, 397, 553, 385 Annotation: Subtype: Link Rect: 306, 385, 312, 373 Annotation: Subtype: Link Rect: 358, 301, 490, 289 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 143, 312, 174, 300 ActionDest: 130 Annotation: Subtype: Link Rect: 142, 287, 170, 275 ActionDest: 130 Annotation: Subtype: Link Rect: 91, 88, 120, 76 ActionDest: 130 Annotation: Subtype: Link Rect: 99, 63, 128, 52 ActionDest: 130 Annotation: Subtype: Link Rect: 311, 515, 345, 503 ActionDest: 130 Annotation: Subtype: Link Rect: 515, 491, 546, 479 ActionDest: 130 Annotation: Subtype: Link Rect: 461, 455, 491, 443 ActionDest: 130 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 113, 351, 243, 339 Annotation: Subtype: Link Rect: 88, 219, 116, 207 ActionDest: 154 Annotation: Subtype: Link Rect: 157, 148, 281, 135 Annotation: Subtype: Link Rect: 546, 172, 553, 160 ActionDest: 239 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 205, 651, 235, 639 ActionDest: 239 Annotation: Subtype: Link Rect: 150, 603, 156, 591 ActionDest: 239 Annotation: Subtype: Link Rect: 141, 555, 147, 543 ActionDest: 239 Annotation: Subtype: Link Rect: 83, 543, 90, 531 ActionDest: 239 Annotation: Subtype: Link Rect: 229, 531, 245, 519 ActionDest: 239 Annotation: Subtype: Link Rect: 148, 507, 154, 495 ActionDest: 239 Annotation: Subtype: Link Rect: 165, 435, 216, 423 ActionDest: 239 Annotation: Subtype: Link Rect: 75, 375, 81, 363 ActionDest: 239 Annotation: Subtype: Link Rect: 75, 339, 107, 327 ActionDest: 239 Annotation: Subtype: Link Rect: 134, 195, 151, 183 ActionDest: 239 Annotation: Subtype: Link Rect: 219, 135, 235, 123 ActionDest: 239 Annotation: Subtype: Link Rect: 112, 99, 141, 87 ActionDest: 239 Annotation: Subtype: Link Rect: 349, 687, 370, 675 ActionDest: 239 Annotation: Subtype: Link Rect: 518, 663, 525, 651 ActionDest: 239 Annotation: Subtype: Link Rect: 451, 507, 458, 495 ActionDest: 334 Annotation: Subtype: Link Rect: 401, 471, 408, 459 ActionDest: 334 Annotation: Subtype: Link Rect: 339, 399, 346, 387 ActionDest: 334 Annotation: Subtype: Link Rect: 442, 327, 459, 315 ActionDest: 239 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 459, 350, 543, 341 Annotation: Subtype: Link Rect: 306, 340, 347, 331 Annotation: Subtype: Link Rect: 393, 279, 534, 270 Annotation: Subtype: Link Rect: 349, 252, 465, 242 Annotation: Subtype: Link Rect: 412, 242, 529, 233 Annotation: Subtype: Link Rect: 381, 232, 498, 223 Annotation: Subtype: Link Rect: 339, 223, 455, 214 Annotation: Subtype: Link Rect: 348, 213, 464, 204 Annotation: Subtype: Link Rect: 480, 163, 521, 154 Annotation: Subtype: Link Rect: 322, 121, 370, 112 Annotation: Subtype: Link Rect: 484, 95, 542, 86 Annotation: Subtype: Link Rect: 322, 87, 344, 78 Annotation: Subtype: Link Rect: 481, 70, 511, 61 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 200, 729, 284, 721 Annotation: Subtype: Link Rect: 276, 695, 286, 686 Annotation: Subtype: Link Rect: 57, 687, 96, 678 Annotation: Subtype: Link Rect: 210, 652, 257, 644 Annotation: Subtype: Link Rect: 196, 618, 276, 609 Annotation: Subtype: Link Rect: 166, 584, 196, 575 Annotation: Subtype: Link Rect: 158, 558, 205, 549 Annotation: Subtype: Link Rect: 226, 533, 268, 524 Annotation: Subtype: Link Rect: 212, 490, 255, 481 Annotation: Subtype: Link Rect: 57, 438, 105, 430 Annotation: Subtype: Link Rect: 102, 404, 149, 395 Annotation: Subtype: Link Rect: 131, 378, 206, 370 Annotation: Subtype: Link Rect: 206, 336, 278, 327 Annotation: Subtype: Link Rect: 215, 284, 287, 276 Annotation: Subtype: Link Rect: 204, 241, 257, 233 Annotation: Subtype: Link Rect: 188, 199, 261, 190 Annotation: Subtype: Link Rect: 250, 147, 281, 139 Annotation: Subtype: Link Rect: 57, 139, 79, 130 Annotation: Subtype: Link Rect: 123, 105, 196, 96 Annotation: Subtype: Link Rect: 57, 79, 130, 70 Annotation: Subtype: Link Rect: 139, 62, 188, 53 Annotation: Subtype: Link Rect: 497, 738, 533, 729 Annotation: Subtype: Link Rect: 322, 729, 352, 721 Annotation: Subtype: Link Rect: 368, 704, 440, 695 Annotation: Subtype: Link Rect: 476, 678, 549, 669 Annotation: Subtype: Link Rect: 403, 644, 442, 635 Annotation: Subtype: Link Rect: 409, 575, 482, 567 Annotation: Subtype: Link Rect: 438, 550, 481, 541 Annotation: Subtype: Link Rect: 322, 515, 370, 507 Annotation: Subtype: Link Rect: 440, 490, 487, 481 Annotation: Subtype: Link Rect: 355, 464, 403, 455 Annotation: Subtype: Link Rect: 536, 438, 542, 430 Annotation: Subtype: Link Rect: 322, 430, 397, 421 Annotation: Subtype: Link Rect: 431, 396, 478, 387 Annotation: Subtype: Link Rect: 505, 370, 552, 361 Annotation: Subtype: Link Rect: 380, 327, 426, 318 Annotation: Subtype: Link Rect: 353, 293, 436, 284 Annotation: Subtype: Link Rect: 452, 276, 493, 267 Annotation: Subtype: Link Rect: 461, 241, 491, 233 Annotation: Subtype: Link Rect: 495, 207, 543, 198 Annotation: Subtype: Link Rect: 322, 156, 370, 147 Annotation: Subtype: Link Rect: 499, 130, 553, 121 Annotation: Subtype: Link Rect: 322, 122, 374, 113 Annotation: Subtype: Link Rect: 542, 105, 548, 96 Annotation: Subtype: Link Rect: 322, 96, 397, 87 Annotation: Subtype: Link Rect: 443, 70, 536, 62 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 217, 727, 278, 718 Annotation: Subtype: Link Rect: 57, 717, 75, 708 Annotation: Subtype: Link Rect: 454, 730, 501, 721 Annotation: Subtype: Link Rect: 463, 696, 510, 687 Checksum: 841f1dd8 Type: CRC32 Checksum: 8094a4f179d0e6842afaed2ec376b13c Type: MD5 Checksum: b19eb31e6574c56ad2202c7e2f5c441db98285bc Type: SHA-1