cf970c3d251bd18a92987547f84fe0be  pmc_32964683.pdf
8301b6bc8a4cb819b690061cfef33d72e6baa5c7  pmc_32964683.pdf
ce2ff0b6681c36820e94daa27dc262bfafc33ad1d517e4a54c800137ae31880a  pmc_32964683.pdf

Title:           Renal function dynamics following co‐administration of sacubitril/valsartan and empagliflozin in patients with heart failure and type 2 diabetes
Subject:         
Keywords:        10.1002/ehf2.12965 and Heart failure with reduced ejection fraction (HFrEF); Type 2 diabetes mellitus; Sacubitril/valsartan; SGLT2i; Renal function; Renal safety profile
Author:          Rafael Espriella, Antoni Bayés‐Genís, Herminio Morillas, Rafael Bravo, Verónica Vidal, Eduardo Núñez, Enrique Santas, Gema Miñana, Juan Sanchis, Lorenzo Fácila, Francisco Torres, Jose Luis Górriz, Alfonso Valle, Julio Núñez
Creator:         Arbortext Advanced Print Publisher 9.0.114/W Unicode
Producer:        Acrobat Distiller 10.0.0 (Windows)
CreationDate:    Fri Dec 11 17:54:09 2020 CET
ModDate:         Mon Dec 14 04:10:48 2020 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           9
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       3505617 bytes
Optimized:       yes
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HBMBII+AdvTT9d59b7b4                 Type 1C           WinAnsi          yes yes no     140  0
HBMBMA+AdvTT2ffda40f.B               Type 1C           WinAnsi          yes yes no     145  0
HBMBIJ+AdvTT9d59b7b4+20              Type 1C           Custom           yes yes yes    150  0
HBMBJK+AdvTT9d59b7b4+fb              Type 1C           Custom           yes yes yes    137  0
HBMBJL+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     157  0
HBMBJM+AdvTTa749c674.I               Type 1C           WinAnsi          yes yes no     160  0
HBMBKN+AdvTTa749c674.I+20            Type 1C           Custom           yes yes yes    122  0
HBMBKO+AdvTTd35102ee.B               Type 1C           WinAnsi          yes yes no     144  0
HBMBKP+AdvTT182ff89e+22              Type 1C           Custom           yes yes yes    146  0
HBMBLP+AdvTT06f3545d.I               Type 1C           WinAnsi          yes yes no     159  0
HBMBOA+AdvTT73b978ed.I+03            Type 1C           Custom           yes yes yes      2  0
HBMBPB+AdvTTd35102ee.B+20            Type 1C           Custom           yes yes yes     28  0
HBMCAC+AdvTT721fcc5a.B               Type 1C           WinAnsi          yes yes no      35  0
HBMCAD+AdvTT61d28366                 Type 1C           WinAnsi          yes yes no      29  0
HBMCAE+AdvTT97b0a7bc.I               Type 1C           WinAnsi          yes yes no      19  0
HBMCAF+AdvTT61d28366+fb              Type 1C           Custom           yes yes yes     34  0
HBMCBF+AdvTT61d28366+20              Type 1C           Custom           yes yes yes     18  0
HBMCCG+AdvTTa36d0062.I               Type 1C           WinAnsi          yes yes no      74  0
HBNJBK+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no      47  0
HBNJCL+AdvTTd35102ee.B+fb            Type 1C           Custom           yes yes yes     98  0
HBOBEK+AdvTT0c4b9ea1.BI              Type 1C           WinAnsi          yes yes no      83  0
HBOBEL+AdvTTa36d0062.I+20            Type 1C           Custom           yes yes yes     95  0
HBOBEM+AdvTTa36d0062.I+fb            Type 1C           Custom           yes yes yes     69  0
HBOBGM+AdvTTf696b0bf.B               Type 1C           WinAnsi          yes yes no      58  0
HBOBGN+AdvTTe6661573                 Type 1C           WinAnsi          yes yes no      72  0
HBOBGO+AdvTTe6661573+fb              Type 1C           Custom           yes yes yes    102  0
HBOBHP+AdvTTe6661573+20              Type 1C           Custom           yes yes yes     75  0
HBOBIA+AdvTTee482667.B               Type 1C           WinAnsi          yes yes no      76  0
HBOBIB+AdvTTe6661573+01              Type 1C           Custom           yes yes yes     63  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:01:37 CEST
 RepresentationInformation: pmc_32964683.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:47:29 CEST
  Size: 3505617
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 163
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
   Info: 
    Title: Renal function dynamics following co‐administration of sacubitril/valsartan and empagliflozin in patients with heart failure and type 2 diabetes
    Author: Rafael Espriella, Antoni Bayés‐Genís, Herminio Morillas, Rafael Bravo, Verónica Vidal, Eduardo Núñez, Enrique Santas, Gema Miñana, Juan Sanchis, Lorenzo Fácila, Francisco Torres, Jose Luis Górriz, Alfonso Valle, Julio Núñez
    Subject: 
    Keywords: 10.1002/ehf2.12965 and Heart failure with reduced ejection fraction (HFrEF); Type 2 diabetes mellitus; Sacubitril/valsartan; SGLT2i; Renal function; Renal safety profile
    Creator: Arbortext Advanced Print Publisher 9.0.114/W Unicode
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Fri Dec 11 17:54:09 CET 2020
    ModDate: Mon Dec 14 04:10:48 CET 2020
   ID: 0xac24b78655e2a44e6a8c8bcd6825d8bc, 0x631ad2e31163d39b6995a99bc2ca8587
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 4025
      ImageHeight: 2399
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 4025
      ImageHeight: 1358
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 4025
      ImageHeight: 2659
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 4025
      ImageHeight: 2127
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HBMBOA+AdvTT73b978ed.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBMBOA+AdvTT73b978ed.I+03
       Flags: Symbolic
       FontBBox: -812, -281, 1135, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBOBEM+AdvTTa36d0062.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HBOBEM+AdvTTa36d0062.I+fb
       Flags: Symbolic
       FontBBox: -166, -208, 833, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBOBGN+AdvTTe6661573
      FontSubset: true
      FirstChar: 40
      LastChar: 248
      FontDescriptor: 
       FontName: HBOBGN+AdvTTe6661573
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -229, 916, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBJK+AdvTT9d59b7b4+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HBMBJK+AdvTT9d59b7b4+fb
       Flags: Symbolic
       FontBBox: 9, 0, 739, 677
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMCCG+AdvTTa36d0062.I
      FontSubset: true
      FirstChar: 40
      LastChar: 239
      FontDescriptor: 
       FontName: HBMCCG+AdvTTa36d0062.I
       Flags: Serif, Nonsymbolic
       FontBBox: -145, -229, 947, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBOBHP+AdvTTe6661573+20
      FontSubset: true
      FirstChar: 1
      LastChar: 144
      FontDescriptor: 
       FontName: HBOBHP+AdvTTe6661573+20
       Flags: Symbolic
       FontBBox: -218, -156, 1552, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMBII+AdvTT9d59b7b4
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: HBMBII+AdvTT9d59b7b4
       Flags: Serif, Nonsymbolic
       FontBBox: -31, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBOBIA+AdvTTee482667.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: HBOBIA+AdvTTee482667.B
       Flags: Nonsymbolic
       FontBBox: -72, -229, 937, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBKO+AdvTTd35102ee.B
      FontSubset: true
      FirstChar: 46
      LastChar: 122
      FontDescriptor: 
       FontName: HBMBKO+AdvTTd35102ee.B
       Flags: Serif, Nonsymbolic
       FontBBox: -41, -177, 875, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBMA+AdvTT2ffda40f.B
      FontSubset: true
      FirstChar: 49
      LastChar: 55
      FontDescriptor: 
       FontName: HBMBMA+AdvTT2ffda40f.B
       Flags: Nonsymbolic
       FontBBox: -83, -187, 875, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBKP+AdvTT182ff89e+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBMBKP+AdvTT182ff89e+22
       Flags: Symbolic
       FontBBox: -41, -270, 1177, 1020
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMCBF+AdvTT61d28366+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBMCBF+AdvTT61d28366+20
       Flags: Symbolic
       FontBBox: -218, -114, 1614, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMCAE+AdvTT97b0a7bc.I
      FontSubset: true
      FirstChar: 80
      LastChar: 110
      FontDescriptor: 
       FontName: HBMCAE+AdvTT97b0a7bc.I
       Flags: Nonsymbolic
       FontBBox: -135, -229, 1000, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBOBEK+AdvTT0c4b9ea1.BI
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: HBOBEK+AdvTT0c4b9ea1.BI
       Flags: Nonsymbolic
       FontBBox: -156, -229, 958, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBIJ+AdvTT9d59b7b4+20
      FontSubset: true
      FirstChar: 1
      LastChar: 144
      FontDescriptor: 
       FontName: HBMBIJ+AdvTT9d59b7b4+20
       Flags: Symbolic
       FontBBox: -218, -156, 1322, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMBPB+AdvTTd35102ee.B+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBMBPB+AdvTTd35102ee.B+20
       Flags: Symbolic
       FontBBox: -218, -166, 1364, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMBJL+AdvTT7b515deb
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: HBMBJL+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMCAD+AdvTT61d28366
      FontSubset: true
      FirstChar: 37
      LastChar: 177
      FontDescriptor: 
       FontName: HBMCAD+AdvTT61d28366
       Flags: Nonsymbolic
       FontBBox: -52, -229, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBLP+AdvTT06f3545d.I
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: HBMBLP+AdvTT06f3545d.I
       Flags: Nonsymbolic
       FontBBox: -104, -187, 937, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBOBEL+AdvTTa36d0062.I+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBOBEL+AdvTTa36d0062.I+20
       Flags: Symbolic
       FontBBox: -218, -156, 1541, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMBJM+AdvTTa749c674.I
      FontSubset: true
      FirstChar: 40
      LastChar: 250
      FontDescriptor: 
       FontName: HBMBJM+AdvTTa749c674.I
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -187, 937, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMCAF+AdvTT61d28366+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HBMCAF+AdvTT61d28366+fb
       Flags: Symbolic
       FontBBox: 19, 0, 822, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBNJCL+AdvTTd35102ee.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBNJCL+AdvTTd35102ee.B+fb
       Flags: Symbolic
       FontBBox: 9, 0, 781, 677
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBMCAC+AdvTT721fcc5a.B
      FontSubset: true
      FirstChar: 49
      LastChar: 108
      FontDescriptor: 
       FontName: HBMCAC+AdvTT721fcc5a.B
       Flags: Nonsymbolic
       FontBBox: -41, -229, 947, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBOBGO+AdvTTe6661573+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HBOBGO+AdvTTe6661573+fb
       Flags: Symbolic
       FontBBox: 0, 0, 864, 739
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBNJBK+AdvP4C4E51
      FontSubset: true
      FirstChar: 62
      LastChar: 62
      FontDescriptor: 
       FontName: HBNJBK+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBMBKN+AdvTTa749c674.I+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HBMBKN+AdvTTa749c674.I+20
       Flags: Symbolic
       FontBBox: -218, -156, 1312, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBOBGM+AdvTTf696b0bf.B
      FontSubset: true
      FirstChar: 82
      LastChar: 115
      FontDescriptor: 
       FontName: HBOBGM+AdvTTf696b0bf.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 937, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBOBIB+AdvTTe6661573+01
      FontSubset: true
      FirstChar: 1
      LastChar: 155
      FontDescriptor: 
       FontName: HBOBIB+AdvTTe6661573+01
       Flags: Symbolic
       FontBBox: -72, -229, 958, 1000
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" xmlns:fn="http://www.w3.org/2005/xpath-functions" x:xmptk="Adobe XMP Core 5.4-c005 78.147326, 2012/08/23-13:03:03"><rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" rdf:about=""><jav:journal_article_version>VoR</jav:journal_article_version><prism:doi>10.1002/ehf2.12965</prism:doi></rdf:Description></rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 3792
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 120, 144, 181, 151
      Annotation: 
       Subtype: Link
       Rect: 206, 33, 341, 40
    Page: 
     Label: 3793
     Sequence: 2
    Page: 
     Label: 3794
     Sequence: 3
    Page: 
     Label: 3795
     Sequence: 4
    Page: 
     Label: 3796
     Sequence: 5
    Page: 
     Label: 3797
     Sequence: 6
    Page: 
     Label: 3798
     Sequence: 7
    Page: 
     Label: 3799
     Sequence: 8
    Page: 
     Label: 3800
     Sequence: 9
  Checksum: c57b21be
   Type: CRC32
  Checksum: cf970c3d251bd18a92987547f84fe0be
   Type: MD5
  Checksum: 8301b6bc8a4cb819b690061cfef33d72e6baa5c7
   Type: SHA-1
  Checksum: ce2ff0b6681c36820e94daa27dc262bfafc33ad1d517e4a54c800137ae31880a
   Type: SHA-256