1e4b32ce9736d7b9614091b86d0c2653 pmc_33101610.pdf 458fa3092259ee4dc02c6b7fb0600102b22907c5 pmc_33101610.pdf 54535cbd4b0b017d28f7a80aa91605a1932782e85257911c40a0062bf5303f91 pmc_33101610.pdf Title: Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor Subject: Computational and Structural Biotechnology Journal, 18 (2020) 2723-2732. doi:10.1016/j.csbj.2020.09.028 Author: Gemma Navarro Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Wed Oct 7 18:01:16 2020 CEST ModDate: Wed Oct 7 18:01:51 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2053508 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DFOOPI+AdvGulliv-R Type 1C Custom yes yes no 880 0 DFOPBI+AdvCORRESAST Type 1C Custom yes yes yes 887 0 DFOPBJ+AdvGulliv-I Type 1C WinAnsi yes yes no 888 0 DFOPCK+AdvGulliv-F Type 1C WinAnsi yes yes no 891 0 DFOPCL+AdvPSMP13 Type 1C WinAnsi yes yes no 892 0 DFOPCM+AdvPSSym Type 1C Custom yes yes no 895 0 DFOPCN+AdvGulliv-B Type 1C WinAnsi yes yes no 896 0 DFPAAI+AdvPSUnv Type 1C WinAnsi yes yes no 902 0 DFPADI+AdvP4C4E74 Type 1C Custom yes yes yes 495 0 DFPAEJ+AdvPi1 Type 1C WinAnsi yes yes no 496 0 DFPAGK+AdvPSMP12 Type 1C WinAnsi yes yes no 504 0 DFPAGL+AdvGulli-BI Type 1C WinAnsi yes yes no 503 0 DFPAGM+AdvP4C4E46 Type 1C Custom yes yes no 505 0 DFPAFJ+AdvPSMP10 Type 1C WinAnsi yes yes no 506 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-17 02:31:04 CET RepresentationInformation: pmc_33101610.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-02 03:35:53 CET Size: 2053508 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf005' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf010' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf015' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf020' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf005' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf020' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf010' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf020' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf015' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf015' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf015' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf010' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'laf025' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0005' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0010' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0015' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0020' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0025' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0030' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0035' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0040' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0050' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0055' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0065' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0070' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0085' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0090' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0095' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0105' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0065' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0115' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0120' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0125' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para22' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para25' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0130' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para29' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0140' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para31' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0145' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0150' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para34' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0125' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0020' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0050' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para41' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lb0030' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para43' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0135' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced 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ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para58' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para59' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para60' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para61' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para62' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid 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2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para69' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para70' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para71' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para72' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para73' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para74' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para75' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para76' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para77' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para78' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect 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PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para85' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para86' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para87' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para88' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para89' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: 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Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para96' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para97' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para98' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para99' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para100' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para101' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para102' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para103' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para104' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para105' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect 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ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para112' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para113' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para114' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para115' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para116' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para117' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para118' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para119' cannot be found Offset: 2019111 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para120' cannot be found Offset: 2019111 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 963 FreeObjects: 91 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor Destination: 1 Children: Item: Title: 1 Introduction Destination: 1 Item: Title: 2 Materials and methods Destination: 1 Children: Item: Title: 2.1 Reagents Destination: 1 Item: Title: 2.2 Cell culture and transient transfection Destination: 1 Item: Title: 2.3 Homogeneous HTRF binding assays Destination: 1 Item: Title: 2.4 Covalent labeling of cells expressing pHALO-tagged receptors Destination: 1 Item: Title: 2.5 Non-radioactive homogeneous time-resolved FRET-based binding assays Destination: 1 Item: Title: 2.6 Signal detection and data analysis Destination: 1 Item: Title: 2.7 cAMP determination Destination: 1 Item: Title: 2.8 ERK1/2 phosphorylation assays Destination: 1 Item: Title: 2.9 β-Arrestin 2 recruitment Destination: 1 Item: Title: 2.10 Dynamic mass redistribution assays (DMR) Destination: 1 Item: Title: 2.11 Calculation of bias factor Destination: 1 Item: Title: 2.12 Computational methods Destination: 1 Item: Title: 2.13 Statistical analysis Destination: 1 Item: Title: 3 Results and discussion Destination: 1 Children: Item: Title: 3.1 Ligand binding experiments Destination: 1 Item: Title: 3.2 Molecular models of agonist binding Destination: 1 Item: Title: 3.3 Agonist-induced signaling responses Destination: 1 Item: Title: 3.4 Addressing biased agonism Destination: 1 Item: Title: 3.5 Molecular mechanisms of agonist-induced receptor activation Destination: 1 Item: Title: 4 Conclusion Destination: 1 Item: Title: 5 Notes Destination: 1 Item: Title: Funding Destination: 1 Item: Title: CRediT authorship contribution statement Destination: 1 Item: Title: Appendix A Supplementary data Destination: 1 Item: Title: References Destination: 1 Info: Title: Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor Author: Gemma Navarro Subject: Computational and Structural Biotechnology Journal, 18 (2020) 2723-2732. doi:10.1016/j.csbj.2020.09.028 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FontDescriptor: FontName: DFPAFJ+AdvPSMP10 Flags: Nonsymbolic FontBBox: 0, -302, 989, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DFOPCK+AdvGulliv-F FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: DFOPCK+AdvGulliv-F Flags: Serif, Nonsymbolic FontBBox: -104, -250, 1406, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DFOPCL+AdvPSMP13 FontSubset: true FirstChar: 68 LastChar: 118 FontDescriptor: FontName: DFOPCL+AdvPSMP13 Flags: Serif, Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DFOPCM+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: DFOPCM+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true XMP: application/pdf doi:10.1016/j.csbj.2020.09.028 Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor Gemma Navarro Angel Gonzalez Stefano Campanacci Rafael Rivas-Santisteban Irene Reyes-Resina Nil Casajuana-Martin Arnau Cordomí Leonardo Pardo Rafael Franco G protein coupled receptors Adenosine A2A receptor Functional selectivity G protein binding β-Arrestin recruitment Molecular dynamic simulations Computational and Structural Biotechnology Journal, 18 (2020) 2723-2732. doi:10.1016/j.csbj.2020.09.028 The Authors journal Computational and Structural Biotechnology Journal © 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. 2001-0370 18 2020 2723-2732 2723 2732 10.1016/j.csbj.2020.09.028 https://doi.org/10.1016/j.csbj.2020.09.028 2010-04-23 true 10.1016/j.csbj.2020.09.028 elsevier.com sciencedirect.com VoR 10.1016/j.csbj.2020.09.028 noindex 2010-04-23 true 7.0 elsevier.com sciencedirect.com sciencedirect.com elsevier.com Elsevier 2020-10-07T21:31:51+05:30 2020-10-07T21:31:16+05:30 2020-10-07T21:31:51+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:dfb95011-f680-425b-86bc-e5dffe1ff511 uuid:dcad5d35-9134-4f16-9af2-69181d69a944 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 2723 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 37, 601, 37, 614 Destination: null Annotation: Subtype: Link Rect: 501, 586, 529, 614 Annotation: Subtype: Link Rect: 37, 562, 37, 572 Destination: null Annotation: Subtype: Link Rect: 120, 567, 124, 577 Destination: null Annotation: Subtype: 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