dfa99155ecdbdb221d593d03f83f4a09 pmc_33113930.pdf 29214bc2f9e13b3c7b5cbb655c2ae3cabbfee175 pmc_33113930.pdf 44ea8956a849a1cc1dc61da0047882a46e8fff7f75759abbb359eb352e255e96 pmc_33113930.pdf Title: Incidence of Melanoma in Catalonia, Spain, Is Rapidly Increasing in the Elderly Population. A Multicentric Cohort Study Subject: The incidence of melanoma has been increasing worldwide during recent decades. The objective of the study was to analyse the trends in incidence for in situ and invasive melanoma in the Spanish region of Catalonia during the period of 2008–2017. We designed a cross-sectional study with an age-period-cohort analysis of melanoma patient data from the Network of Melanoma Centres in Catalonia. Our database covered a population of over seven million and included a total of 8626 patients with incident melanoma. The main outcome measures were crude and age-standardised incidence rates to the European 2013 standard population. Joinpoint regression models were used to evaluate the population trends. We observed an increase in the age-standardised incidence rate (per 100,000 population) of all melanoma subtypes from 11.56 in 2008 to 13.78 in 2017 with an average annual percent change (AAPC) of 3.5%. This incidence increase was seen exclusively in the older population. Moreover, the stratified analysis showed a statistically significant increase in the age-standardised incidence rate for invasive (AAPC 2.1%) and in situ melanoma (AAPC 6.5%). In conclusion, the incidence of melanoma has continued to increase in the elderly population over recent decades, with a rapidly increasing trend of in situ melanomas and the lentigo maligna subtype. Keywords: melanoma; incidence; population-based study; epidemiology; Spain; skin cancer Author: Sebastian Podlipnik, Cristina Carrera, Aram Boada, Nina Richarz, Joaquim Marcoval, Josep Ramon Ferreres, Domingo Bodet, Rosa María Martí, Sonia Segura, Mireia Sabat, Joan Dalmau, Mónica Quintana, Antoni Azon, Neus Curcó, Manel Formigon, María Rosa Olivella-Garcés, Pedro Zaballos, Joaquim Sola, Loida Galvany, Carola Baliu-Piqué, Marta Alegre, Paola Pasquali,Josep Malvehy and Susana Puig Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Oct 23 09:04:44 2020 CEST ModDate: Fri Oct 23 09:04:44 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 633431 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PTTYAT+URWPalladioL-Ital Type 1 Custom yes yes no 44 0 OARNFY+URWPalladioL-Bold Type 1 Custom yes yes no 45 0 JRRMBS+URWPalladioL-Roma Type 1 Custom yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 52 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 67 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 68 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 HPTNQB+URWPalladioL-BoldItal Type 1 Custom yes yes no 151 0 LEFEDA+Helvetica Type 1C WinAnsi yes yes no 155 0 GIOWGQ+Helvetica-Bold Type 1C WinAnsi yes yes no 156 0 QZOCRG+Helvetica TrueType WinAnsi yes yes yes 198 0 GVQBXN+Helvetica-Bold TrueType WinAnsi yes yes yes 199 0 AQIXPF+Helvetica Type 1C Custom yes yes no 214 0 FNUVVH+Helvetica-Bold Type 1C WinAnsi yes yes no 215 0 AIOPCN+Helvetica TrueType WinAnsi yes yes yes 242 0 EXLHQC+Helvetica-Bold TrueType WinAnsi yes yes yes 243 0 WEIJUK+CMSY9 Type 1 Builtin yes yes no 356 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-23 02:37:00 CET RepresentationInformation: pmc_33113930.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-30 03:48:08 CET Size: 633431 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの Item: Title: きちぴづひどちぬぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつび Item: Title: げづびふぬぴび Item: Title: いどびっふびびどはの Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: WEIJUK+CMSY9 FontSubset: true FirstChar: 13 LastChar: 13 FontDescriptor: FontName: WEIJUK+CMSY9 Flags: Symbolic FontBBox: -29, -958, 1146, 777 FontFile: true Font: BaseFont: HPTNQB+URWPalladioL-BoldItal FontSubset: true FirstChar: 78 LastChar: 80 FontDescriptor: FontName: HPTNQB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PTTYAT+URWPalladioL-Ital FontSubset: true FirstChar: 39 LastChar: 121 FontDescriptor: FontName: PTTYAT+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OARNFY+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 243 FontDescriptor: FontName: OARNFY+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JRRMBS+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: JRRMBS+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 217, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 168, 640, 179, 654 Annotation: Subtype: Link Rect: 196, 640, 207, 654 Annotation: Subtype: Link Rect: 301, 640, 312, 654 Annotation: Subtype: Link Rect: 243, 572, 254, 586 Annotation: Subtype: Link Rect: 332, 572, 343, 586 Annotation: Subtype: Link Rect: 466, 142, 518, 161 Annotation: Subtype: Link Rect: 180, 38, 253, 50 Annotation: Subtype: Link Rect: 413, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 203, 485, 210, 493 ActionDest: 305 Annotation: Subtype: Link Rect: 494, 471, 501, 480 ActionDest: 305 Annotation: Subtype: Link Rect: 504, 471, 511, 480 ActionDest: 305 Annotation: Subtype: Link Rect: 115, 444, 122, 453 ActionDest: 305 Annotation: Subtype: Link Rect: 125, 444, 132, 453 ActionDest: 305 Annotation: Subtype: Link Rect: 397, 444, 409, 453 ActionDest: 305 Annotation: Subtype: Link Rect: 409, 444, 421, 453 ActionDest: 305 Annotation: Subtype: Link Rect: 294, 417, 306, 426 ActionDest: 305 Annotation: Subtype: Link Rect: 381, 390, 393, 399 ActionDest: 305 Annotation: Subtype: Link Rect: 120, 349, 127, 358 ActionDest: 305 Annotation: Subtype: Link Rect: 228, 309, 239, 318 ActionDest: 305 Annotation: Subtype: Link Rect: 503, 295, 515, 304 ActionDest: 305 Annotation: Subtype: Link Rect: 491, 268, 503, 277 ActionDest: 305 Annotation: Subtype: Link Rect: 503, 268, 515, 277 ActionDest: 305 Annotation: Subtype: Link Rect: 396, 241, 408, 250 ActionDest: 305 Annotation: Subtype: Link Rect: 409, 241, 420, 250 ActionDest: 337 Annotation: Subtype: Link Rect: 276, 131, 288, 140 ActionDest: 337 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 240, 675, 252, 684 ActionDest: 337 Annotation: Subtype: Link Rect: 491, 594, 503, 603 ActionDest: 337 Annotation: Subtype: Link Rect: 271, 553, 283, 562 ActionDest: 337 Annotation: Subtype: Link Rect: 294, 472, 306, 481 ActionDest: 337 Annotation: Subtype: Link Rect: 490, 432, 502, 441 ActionDest: 337 Annotation: Subtype: Link Rect: 503, 432, 515, 441 ActionDest: 337 Annotation: Subtype: Link Rect: 441, 418, 452, 427 ActionDest: 337 Annotation: Subtype: Link Rect: 277, 305, 284, 317 ActionDest: 148 Annotation: Subtype: Link Rect: 243, 278, 250, 290 ActionDest: 148 Annotation: Subtype: Link Rect: 301, 278, 308, 290 ActionDest: 148 Annotation: Subtype: Link Rect: 427, 265, 434, 277 ActionDest: 208 Annotation: Subtype: Link Rect: 353, 130, 360, 142 ActionDest: 166 Annotation: Subtype: Link Rect: 379, 130, 386, 142 ActionDest: 208 Annotation: Subtype: Link Rect: 508, 76, 515, 88 ActionDest: 166 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 324, 713, 331, 725 ActionDest: 234 Annotation: Subtype: Link Rect: 218, 659, 225, 671 ActionDest: 234 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 508, 713, 515, 725 ActionDest: 166 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 470, 296, 482, 305 ActionDest: 337 Annotation: Subtype: Link Rect: 485, 296, 497, 305 ActionDest: 337 Annotation: Subtype: Link Rect: 397, 282, 409, 292 ActionDest: 337 Annotation: Subtype: Link Rect: 441, 242, 453, 251 ActionDest: 337 Annotation: Subtype: Link Rect: 484, 215, 496, 224 ActionDest: 337 Annotation: Subtype: Link Rect: 439, 201, 451, 210 ActionDest: 337 Annotation: Subtype: Link Rect: 121, 188, 133, 197 ActionDest: 337 Annotation: Subtype: Link Rect: 216, 174, 228, 183 ActionDest: 337 Annotation: Subtype: Link Rect: 291, 120, 303, 129 ActionDest: 337 Annotation: Subtype: Link Rect: 503, 93, 515, 102 ActionDest: 337 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 305, 715, 317, 724 ActionDest: 337 Annotation: Subtype: Link Rect: 230, 661, 242, 670 ActionDest: 337 Annotation: Subtype: Link Rect: 457, 634, 469, 643 ActionDest: 337 Annotation: Subtype: Link Rect: 253, 594, 265, 603 ActionDest: 337 Annotation: Subtype: Link Rect: 503, 567, 515, 576 ActionDest: 337 Annotation: Subtype: Link Rect: 92, 540, 104, 549 ActionDest: 305 Annotation: Subtype: Link Rect: 105, 540, 117, 549 ActionDest: 337 Annotation: Subtype: Link Rect: 146, 445, 158, 454 ActionDest: 337 Annotation: Subtype: Link Rect: 321, 418, 332, 427 ActionDest: 337 Annotation: Subtype: Link Rect: 289, 405, 296, 414 ActionDest: 305 Annotation: Subtype: Link Rect: 299, 405, 306, 414 ActionDest: 305 Annotation: Subtype: Link Rect: 306, 405, 318, 414 ActionDest: 337 Annotation: Subtype: Link Rect: 327, 324, 339, 333 ActionDest: 352 Annotation: Subtype: Link Rect: 368, 256, 380, 265 ActionDest: 352 Annotation: Subtype: Link Rect: 383, 256, 395, 265 ActionDest: 352 Annotation: Subtype: Link Rect: 356, 215, 368, 225 ActionDest: 352 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 377, 484, 414, 495 Annotation: Subtype: Link Rect: 420, 484, 456, 495 Annotation: Subtype: Link Rect: 302, 459, 340, 470 Annotation: Subtype: Link Rect: 346, 459, 382, 470 Annotation: Subtype: Link Rect: 199, 421, 237, 431 Annotation: Subtype: Link Rect: 243, 421, 279, 431 Annotation: Subtype: Link Rect: 340, 394, 377, 405 Annotation: Subtype: Link Rect: 479, 355, 516, 366 Annotation: Subtype: Link Rect: 171, 304, 209, 315 Annotation: Subtype: Link Rect: 149, 266, 187, 276 Annotation: Subtype: Link Rect: 418, 239, 455, 250 Annotation: Subtype: Link Rect: 462, 239, 498, 250 Annotation: Subtype: Link Rect: 422, 200, 459, 211 Annotation: Subtype: Link Rect: 211, 175, 421, 186 Annotation: Subtype: Link Rect: 306, 110, 343, 121 Annotation: Subtype: Link Rect: 100, 72, 137, 82 Annotation: Subtype: Link Rect: 143, 72, 179, 82 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 287, 714, 325, 725 Annotation: Subtype: Link Rect: 331, 714, 367, 725 Annotation: Subtype: Link Rect: 351, 701, 456, 712 Annotation: Subtype: Link Rect: 302, 651, 339, 661 Annotation: Subtype: Link Rect: 328, 624, 366, 635 Annotation: Subtype: Link Rect: 396, 599, 433, 609 Annotation: Subtype: Link Rect: 406, 585, 519, 596 Annotation: Subtype: Link Rect: 97, 572, 468, 583 Annotation: Subtype: Link Rect: 166, 533, 274, 544 Annotation: Subtype: Link Rect: 406, 495, 519, 506 Annotation: Subtype: Link Rect: 97, 482, 160, 493 Annotation: Subtype: Link Rect: 242, 444, 279, 454 Annotation: Subtype: Link Rect: 266, 404, 303, 415 Annotation: Subtype: Link Rect: 278, 378, 315, 390 Annotation: Subtype: Link Rect: 322, 378, 358, 390 Annotation: Subtype: Link Rect: 464, 340, 502, 351 Annotation: Subtype: Link Rect: 140, 315, 177, 325 Annotation: Subtype: Link Rect: 458, 288, 496, 299 Annotation: Subtype: Link Rect: 478, 262, 515, 273 Annotation: Subtype: Link Rect: 100, 224, 137, 235 Annotation: Subtype: Link Rect: 172, 186, 209, 196 Annotation: Subtype: Link Rect: 285, 159, 323, 170 Annotation: Subtype: Link Rect: 478, 146, 516, 157 Annotation: Subtype: Link Rect: 100, 134, 136, 144 Annotation: Subtype: Link Rect: 153, 95, 191, 105 Annotation: Subtype: Link Rect: 372, 69, 410, 80 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 265, 728, 303, 738 Annotation: Subtype: Link Rect: 309, 728, 345, 738 Annotation: Subtype: Link Rect: 224, 702, 262, 712 Annotation: Subtype: Link Rect: 349, 637, 387, 648 Annotation: Subtype: Link Rect: 182, 599, 220, 609 Annotation: Subtype: Link Rect: 226, 599, 262, 609 Annotation: Subtype: Link Rect: 76, 526, 166, 557 Annotation: Subtype: Link Rect: 234, 520, 424, 531 Checksum: 7cbbb6ec Type: CRC32 Checksum: dfa99155ecdbdb221d593d03f83f4a09 Type: MD5 Checksum: 29214bc2f9e13b3c7b5cbb655c2ae3cabbfee175 Type: SHA-1