d0472d44076a416c451b7678644a646d  pmc_33225898.pdf
09f8679648af8dd7720122a6d6d608d11691aafc  pmc_33225898.pdf
93b4f8ef2a908793307544fd8f437aa0ffe2d48fd9f85301dd2b8eebf42f509f  pmc_33225898.pdf

Title:           MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data
Subject:         BMC Bioinformatics, https://doi.org/10.1186/s12859-020-03768-z
Keywords:        Loss of chromosome Y;SNP array;Bioconductor
Author:           Juan R. González
Creator:         Adobe InDesign 15.0 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Tue Nov 17 16:08:39 2020 CET
ModDate:         Mon Nov 23 10:21:36 2020 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           17
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1709650 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     34  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     53  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes    154  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     54  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     35  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     36  0
GOVIXR+MyriadPro-LightIt             Type 1C           WinAnsi          yes yes yes    153  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes     37  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  yes    285  0
OUOKTB+WarnockPro-Regular2           Type 1C           Custom           yes yes no      78  0
OUOKTB+WarnockPro-It2                Type 1C           Custom           yes yes no      79  0
OUOKTB+MTSYN                         Type 1C           Custom           yes yes no      80  0
OUOKTB+MTMI                          Type 1C           Custom           yes yes no      81  0
CLMDCR+MyriadPro-SemiboldIt          Type 1C           WinAnsi          yes yes yes    113  0
HPSUPS+MTSY                          Type 1C           Custom           yes yes yes    133  0
WarnockPro-Light                     Type 1C           WinAnsi          yes no  yes    232  0
YGMFYH+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes    272  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:00:43 CEST
 RepresentationInformation: pmc_33225898.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:47:37 CEST
  Size: 1709650
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 434
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusions: 
       Item: 
        Title: Background
       Item: 
        Title: Implementation
        Children: 
         Item: 
          Title: mLOY calling
         Item: 
          Title: LRR, mLRR-Y, BAF and B-deviation
         Item: 
          Title: Quality control
         Item: 
          Title: MADloy software
         Item: 
          Title: Experimental validation
         Item: 
          Title: Statistical analyses
         Item: 
          Title: Simulation studies
         Item: 
          Title: EGCUT data
         Item: 
          Title: TCGA data
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Improved detection of mLOY status
         Item: 
          Title: mLOY improves the statistical power of association studies
         Item: 
          Title: Application of MADloy on finding transcriptomic signatures of mLOY
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: Availability and requirements
       Item: 
        Title: Acknowledgments
       Item: 
        Title: References
   Info: 
    Title: MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data
    Author:  Juan R. González
    Subject: BMC Bioinformatics, https://doi.org/10.1186/s12859-020-03768-z
    Keywords: Loss of chromosome Y;SNP array;Bioconductor
    Creator: Adobe InDesign 15.0 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Tue Nov 17 16:08:39 CET 2020
    ModDate: Mon Nov 23 10:21:36 CET 2020
   ID: 0x0a49915c2039ea3d1219003d7767b05b, 0x8aa1537cfca823af39ffb050e8971dc6
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 82
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 663
      ImageHeight: 101
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 42
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1181
      ImageHeight: 2200
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 523
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1418
      ImageHeight: 1092
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 874
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HPSUPS+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HPSUPS+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -175, -515, 1437, 929
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: OUOKTB+WarnockPro-Regular2
      FontSubset: true
      FirstChar: 29
      LastChar: 32
      FontDescriptor: 
       FontName: OUOKTB+WarnockPro-Regular2
       Flags: Symbolic, AllCap
       FontBBox: 0, -16, 500, 700
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: OUOKTB+WarnockPro-It2
      FontSubset: true
      FirstChar: 22
      LastChar: 32
      FontDescriptor: 
       FontName: OUOKTB+WarnockPro-It2
       Flags: Symbolic, SmallCap
       FontBBox: -22, -191, 783, 708
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: OUOKTB+MTSYN
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: OUOKTB+MTSYN
       Flags: Symbolic, AllCap
       FontBBox: 0, -83, 724, 583
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: YGMFYH+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: YGMFYH+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: OUOKTB+MTMI
      FontSubset: true
      FirstChar: 30
      LastChar: 32
      FontDescriptor: 
       FontName: OUOKTB+MTMI
       Flags: Symbolic, AllCap
       FontBBox: 0, -177, 344, 676
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: CLMDCR+MyriadPro-SemiboldIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: CLMDCR+MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GOVIXR+MyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GOVIXR+MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2020-11-17T15:08:39</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.0 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2020-11-23T10:21:36+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2020-11-23T10:21:36+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Loss of chromosome Y;SNP array;Bioconductor</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12859-020-03768-z</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Bioinformatics, https://doi.org/10.1186/s12859-020-03768-z</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Loss of chromosome Y</rdf:li>
               <rdf:li>SNP array</rdf:li>
               <rdf:li>Bioconductor</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Juan R. González</rdf:li>
               <rdf:li> Marcos López-Sánchez</rdf:li>
               <rdf:li> Alejandro Cáceres</rdf:li>
               <rdf:li> Pere Puig</rdf:li>
               <rdf:li> Tonu Esko</rdf:li>
               <rdf:li> Luis A. Pérez-Jurado</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12859-020-03768-z</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12859-020-03768-z</prism:url>
         <prism:doi>10.1186/s12859-020-03768-z</prism:doi>
         <prism:issn>1471-2105</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BMC Bioinformatics</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12859-020-03768-z</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:a26d5d29-9f03-45d9-abbc-59bcb589706f</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:eedbe3cc-c3c4-4174-b848-2d12ac7b2e1c</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:a26d5d29-9f03-45d9-abbc-59bcb589706f</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-11-21T09:47:18Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Juan R. González</author:name>
                  <author:orcid>http://orcid.org/0000-0003-3267-2146</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 145, 580, 157, 567
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 263, 168, 268, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 521, 76, 538, 68
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 68, 279, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 448, 68, 538, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 60, 227, 52
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 690, 139, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 145, 690, 150, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 335, 647, 340, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 438, 647, 443, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 211, 633, 216, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 319, 633, 324, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 120, 591, 125, 579
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 130, 591, 135, 579
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 337, 577, 347, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 352, 577, 362, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 201, 421, 211, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 236, 336, 246, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 202, 294, 207, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 399, 166, 409, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 193, 124, 203, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 151, 81, 161, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 167, 81, 176, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 408, 605, 418, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 286, 477, 296, 465
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 446, 393, 456, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 462, 378, 472, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 175, 303, 180, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 209, 303, 214, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 289, 303, 294, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 144, 104, 149, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 268, 447, 272, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 337, 447, 342, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 434, 447, 444, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 401, 405, 411, 393
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 220, 152, 477, 140
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 138, 320, 126
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 179, 110, 477, 97
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 95, 161, 83
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 120, 81, 392, 69
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 214, 393, 387, 380
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 188, 364, 197, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 228, 294, 477, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 279, 132, 267
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 326, 138, 336, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 204, 124, 214, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 192, 549, 201, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 350, 534, 360, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 310, 520, 320, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 308, 393, 318, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 159, 209, 226, 197
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 347, 181, 357, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 183, 110, 193, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 142, 480, 343, 467
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 325, 267, 394, 255
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 134, 239, 139, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 340, 225, 345, 213
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 355, 168, 360, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
     Thumb: true
    Page: 
     Sequence: 8
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 372, 690, 377, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 149
      Annotation: 
       Subtype: Link
       Rect: 133, 619, 138, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 403, 577, 408, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 295, 548, 300, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 383, 435, 388, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 423, 421, 428, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 138, 364, 143, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 393, 647, 398, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 172
      Annotation: 
       Subtype: Link
       Rect: 289, 633, 294, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 172
      Annotation: 
       Subtype: Link
       Rect: 160, 407, 165, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 220
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 270, 647, 275, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 405, 492, 410, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 253, 633, 258, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 289, 477, 294, 465
       Flags: Print
       AppearanceDictionary: true
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 332, 378, 337, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 296, 90, 301, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 201
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 266, 118, 271, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 201
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 412, 463, 417, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 213, 350, 223, 337
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 168, 166, 178, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 120, 109, 130, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 345, 81, 350, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 354, 81, 359, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
     Thumb: true
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 467, 591, 472, 579
       Flags: Print
       AppearanceDictionary: true
       Destination: 236
      Annotation: 
       Subtype: Link
       Rect: 379, 548, 388, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 222, 261, 391, 247
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 140, 424, 131
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 357, 508, 458, 499
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 499, 141, 490
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 168, 490, 368, 481
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 350, 448, 401, 439
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 243, 523, 337, 514
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 432, 487, 465, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 478, 225, 469
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 183, 307, 302, 298
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 243, 244, 348, 235
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 9b6d4e54
   Type: CRC32
  Checksum: d0472d44076a416c451b7678644a646d
   Type: MD5
  Checksum: 09f8679648af8dd7720122a6d6d608d11691aafc
   Type: SHA-1
  Checksum: 93b4f8ef2a908793307544fd8f437aa0ffe2d48fd9f85301dd2b8eebf42f509f
   Type: SHA-256