521759d4345416576871b4fbd57f79a1 pmc_33226181.pdf 8dfe7fc4a8ffdc5deb323d421fafb420409d3b50 pmc_33226181.pdf 822b491b637bbd2adbbd19fa5df23419155bbb43841013b32d721660c9cb332c pmc_33226181.pdf Title: Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Apr 24 11:11:40 2021 CEST ModDate: Sat Apr 24 11:12:06 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1061395 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BGMBLK+Lato-Italic Type 1C WinAnsi yes yes no 469 0 BGMBBL+Lato-Regular Type 1C WinAnsi yes yes no 472 0 BGMBHJ+Lato-Bold Type 1C WinAnsi yes yes no 475 0 BGMBKJ+STIXTwoMath Type 1C Custom yes yes yes 478 0 BGMCMF+Lato-Black Type 1C WinAnsi yes yes no 155 0 BGMCLE+STIXTwoText-Italic Type 1C Custom yes yes yes 158 0 BGMCMG+STIXTwoText Type 1C Custom yes yes yes 25 0 BGMHOF+STIXTwoText-BoldItalic Type 1C Custom yes yes yes 163 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:00:42 CEST RepresentationInformation: pmc_33226181.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:47:37 CEST Size: 1061395 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 536 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer’s disease: A paired CSF and plasma study Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | INTRODUCTION Destination: section..1.1 Item: Title: 2 | MATERIALS AND METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study cases Destination: subsection..1.2.1 Item: Title: 2.2 | Plasma collection Destination: subsection..1.2.2 Item: Title: 2.3 | CSF collection via lumbar puncture Destination: subsection..1.2.3 Item: Title: 2.4 | Analysis of proNGF and neuroserpin Destination: subsection..1.2.4 Item: Title: 2.5 | Analysis of metallo-proteases Destination: subsection..1.2.5 Item: Title: 2.6 | Analysis of tPA Destination: subsection..1.2.6 Item: Title: 2.7 | Statistical analysis Destination: subsection..1.2.7 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Increased proNGF levels in plasma and CSF from individuals with aDS and DSAD Destination: subsection..1.3.1 Item: Title: 3.2 | Neuroserpin and tPA levels in plasma and CSF from individuals with DS and DSAD Destination: subsection..1.3.2 Item: Title: 3.3 | Analysis of metalloproteases in plasma and CSF from individuals with aDS and DSAD Destination: subsection..1.3.3 Item: Title: 3.4 | Specificity of NGF pathway markers to AD in DS Destination: subsection..1.3.4 Item: Title: 3.5 | Associations between NGF metabolism-related proteins and core biomarkers of AD Destination: subsection..1.3.5 Item: Title: 3.6 | Effects of sex on the plasma and CSF expression of NGF metabolism-related proteins Destination: subsection..1.3.6 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICTS OF INTEREST Destination: section*.6 Item: Title: REFERENCES Destination: section*.8 Item: Title: SUPPORTING INFORMATION Destination: section*.10 Info: Title: Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study Author: Subject: 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