7b712c7c8b904a889e1b061001fbe249 pmc_33352565.pdf 3bfaad14ddd2c88e93272a9cff38ec769609c87b pmc_33352565.pdf f63e7032982b802f0e9ca7d2b6d4068baa47504fc2c4382e1140a35d578fbfbf pmc_33352565.pdf Title: Spices to Control COVID-19 Symptoms: Yes, but Not Only… Subject: There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway. Author: Bousquet J.; Czarlewski W.; Zuberbier T.; Mullol J.; Blain H.; Cristol J.-P.; De La Torre R.; Le Moing V.; Pizarro Lozano N.; Bedbrook A.; Agache I.; Akdis C.A.; Canonica G.W.; Cruz A.A.; Fiocchi A.; Fonseca J.A.; Fonseca S.; Gemicioğlu B.; Haahtela T.; Iaccarino G.; Ivancevich J.C.; Jutel M.; Klimek L.; Kuna P.; Larenas-Linnemann D.E.; Melén E.; Okamoto Y.; Papadopoulos N.G.; Pfaar O.; Reynes J.; Rolland Y.; Rouadi P.W.; Samolinski B.; Sheikh A.; Toppila-Salmi S.; Valiulis A.; Choi H.-J.; Kim H.J.; Anto J.M. 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Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway. 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2020-12-22T15:06:09+01:00 application/pdf Bousquet J.; Czarlewski W.; Zuberbier T.; Mullol J.; Blain H.; Cristol J.-P.; De La Torre R.; Le Moing V.; Pizarro Lozano N.; Bedbrook A.; Agache I.; Akdis C.A.; Canonica G.W.; Cruz A.A.; Fiocchi A.; Fonseca J.A.; Fonseca S.; Gemicioğlu B.; Haahtela T.; Iaccarino G.; Ivancevich J.C.; Jutel M.; Klimek L.; Kuna P.; Larenas-Linnemann D.E.; Melén E.; Okamoto Y.; Papadopoulos N.G.; Pfaar O.; Reynes J.; Rolland Y.; Rouadi P.W.; Samolinski B.; Sheikh A.; Toppila-Salmi S.; Valiulis A.; Choi H.-J.; Kim H.J.; Anto J.M. Spices to Control COVID-19 Symptoms: Yes, but Not Only… Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.<br /> Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.<br /> Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway. Nuclear factor (erythroid-derived 2)-like 2 Transient receptor potential ankyrin 1 Transient receptor potential vanillin 1 COVID-19 Spices Fermented vegetables True https://www.karger.com/Article/FullText/513538#copyright Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 464, 451, 469, 437 ActionDest: 270 Annotation: Subtype: Link Rect: 390, 425, 395, 411 ActionDest: 270 Annotation: Subtype: Link Rect: 400, 425, 406, 411 ActionDest: 270 Annotation: Subtype: Link Rect: 403, 400, 408, 386 ActionDest: 270 Annotation: Subtype: Link Rect: 417, 285, 422, 271 ActionDest: 270 Annotation: Subtype: Link Rect: 428, 285, 433, 271 ActionDest: 270 Annotation: Subtype: Link Rect: 370, 272, 375, 258 ActionDest: 270 Annotation: Subtype: Link Rect: 541, 208, 546, 194 ActionDest: 270 Annotation: Subtype: Link Rect: 307, 157, 313, 143 ActionDest: 270 Annotation: Subtype: Link Rect: 391, 132, 396, 118 ActionDest: 270 Page: Sequence: 3 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