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Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: 2.1 Subjects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.2 Clinical and cognitive evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.3 MRI acquisition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.4 MRI analysis of lesions and global atrophy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.5 Thalamus volume measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: 2.5.1 Manual delineations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.5.2 Automated segmentation methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.6 Normalization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: 2.6.1 Contrast-to-noise ratio Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 2.7 Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Children: Item: Title: 3.1 Subject characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 3.2 Analysis of volumetric agreement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Children: Item: Title: 3.2.1 Intraclass correlation analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 3.2.2 Bland-Altman scatter plots and analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 3.3 Reproducibility of manual thalamus outlining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 3.4 Relation of thalamus volume measures with cognition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Children: Item: Title: 3.4.1 Thalamus volumes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 3.4.2 Consistency of discrimination between cognitively impaired and preserved patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 3.4.3 Analysis of correlations with cognition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 3.4.4 Analysis of correlations with performance scores on separate cognitive domains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Children: Item: Title: 4.1 Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: 4.2 Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Acknowledgement of financial support and other Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Appendix A Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Info: Title: Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study Author: Jessica Burggraaff Subject: NeuroImage: Clinical, 29 (2021) 102549. 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NeuroImage: Clinical, 29 (2021) 102549. doi:10.1016/j.nicl.2020.102549 Multiple Sclerosis MRI Cognition Thalamus Deep grey matter Atrophy Segmentation Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study Jessica Burggraaff Yao Liu Juan C. Prieto Jorge Simoes Alexandra de Sitter Serena Ruggieri Iman Brouwer Birgit I. Lissenberg-Witte Mara A. Rocca Paola Valsasina Stefan Ropele Claudio Gasperini Antonio Gallo Deborah Pareto Jaume Sastre-Garriga Christian Enzinger Massimo Filippi Nicola De Stefano Olga Ciccarelli Hanneke E. Hulst Mike P. Wattjes Frederik Barkhof Bernard M.J. Uitdehaag Hugo Vrenken Charles R.G. Guttmann journal NeuroImage: Clinical © 2020 The Authors. 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