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PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: H3K79me2/3 controls enhancer–nobreakpromoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in’MLLⴀ萀䄀䘀㐀 氀攀甀欀攀洀椀愀 挀攀氀氀猩㸾൥湤潢樍㤵〠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀ㄩ⽆‰⽎數琠㤶㈠〠刯偡牥湴‹㐹‰⁒⽔楴汥⣾＀䄀戀猀琀爀愀挀琩㸾൥湤潢樍㤵ㄠ〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀㘩⽆‰⽐慲敮琠㤴㤠〠刯偲敶‹㔲‰⁒⽔楴汥⣾＀刀攀昀攀爀攀渀挀攀猩㸾൥湤潢樍㤵㈠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䴀ㄩ⽆‰⽎數琠㤵ㄠ〠刯偡牥湴‹㐹‰⁒⽐牥瘠㤵㌠〠刯呩瑬攨ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Cell culture and cell lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Cell culture drug treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Primograft Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Patient samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Flow cytometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: siRNA knockdown Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: SEM PROM1/CD133’shRNA lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Colony-forming assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Cell cycle analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Western blotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: qRT-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Poly(A) RNA purification and sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Gene expression analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Single-cell gene expression analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: ChIP-qPCR and ChIP-seq Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: ATAC-seq Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Sequence analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Capture-C Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Children: Item: Title: MLLr leukemia cell lines and primary ALL blasts show heterogeneous expression of PROM1/CD133 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: CD133 is important for MLL-AF4 ALL leukemogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: MLL-AF4 directly binds to and regulates PROM1 expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: MLL-AF4 controls PROM1 expression via H3K79me2/„3 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: PROM1 is regulated by H3K79me2/3 enhancers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: PROM1 is polycomb-repressed in CD133− acute leukemia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: PROM1/TAPT1 H3K79me2/3 enhancers are inactive in CD133− leukemia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: MLL and PRC2 regulate PROM1/CD133 expression during lymphopoiesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Children: Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Compliance with ethical standards Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: References Destination: 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Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41375-020-0808-y H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells Laura Godfrey Nicholas T. Crump Sorcha O’Byrne I-Jun Lau Siobhan Rice Joe R. Harman Thomas Jackson Natalina Elliott Gemma Buck Christopher Connor Ross Thorne David J. H. F. Knapp Olaf Heidenreich Paresh Vyas Pablo Menendez Sarah Inglott Philip Ancliff Huimin Geng Irene Roberts Anindita Roy Thomas A. Milne Springer US Leukemia, doi:10.1038/s41375-020-0808-y 10.1038/s41375-020-0808-y http://dx.doi.org/10.1038/s41375-020-0808-y journal Leukemia © 2020, The Author(s) 1476-5551 10.1038/s41375-020-0808-y springer.com springerlink.com 2010-04-23 True 10.1038/s41375-020-0808-y springer.com springerlink.com Springer 2020-12-15T17:35:28+05:30 2020-12-15T17:35:28+05:30 2020-12-15T17:35:00+05:30 True VoR uuid:8ad7e5c9-39f0-487a-8e76-94f0c01c723e uuid:8f7b9725-b538-4759-8344-baa813aa5fd3 default 1 converted uuid:46337e9a-6673-44cf-8490-b3184841443b converted to PDF/A-2b pdfToolbox 2020-12-15T17:35:28+05:30 2 B Nicholas T. 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