98c66493dc61b12d5a675aca39fd84b8 236092.pdf f6ba22391fbf1e70e4fe889724fd8bd1577d9ca8 236092.pdf 7fccd415ccae93d9bd3b829efc87aafb0e5ed58559f060f712372fd4af563035 236092.pdf Title: Aneuploidy in Cancer: Lessons from Acute Lymphoblastic Leukemia Subject: Trends in Cancer, 7 (2021) 37-47. doi:10.1016/j.trecan.2020.08.008 Keywords: aneuploidy; mitosis; chromosome segregation; hematological neoplasms; B cell acute lymphoblastic leukemia Author: Oscar Molina Creator: Elsevier CreationDate: Wed Dec 16 01:30:20 2020 CET ModDate: Wed Dec 16 01:33:31 2020 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 602.929 x 782.929 pts Page rot: 0 File size: 1866106 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DLKLFM+AdvTTb0eaa911 Type 1C WinAnsi yes yes no 710 0 DLKLFN+AdvOTb8f60ac3 Type 1C WinAnsi yes yes no 712 0 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IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Aneuploidy in Cancer: Lessons from Acute Lymphoblastic Leukemia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Aneuploidy in Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Aneuploidy Is Caused by Chromosome Segregation Defects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Improper Kinetochore–Microtubule Attachments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Defects in Chromosome Cohesion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Defective Spindle-Assembly Checkpoint Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Supernumerary Centrosomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Consequences of Aneuploidy and the 'Aneuploidy Paradox' in Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Aneuploidy in Hematological Neoplasms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Etiology of Aneuploidy in Childhood B-ALL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Concluding Remarks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1491 ImageHeight: 2145 ColorSpace: RGB BitsPerSample: 8 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Annotation: Subtype: Link Rect: 252, 235, 291, 241 Annotation: Subtype: Link Rect: 252, 227, 412, 233 Annotation: Subtype: Link Rect: 252, 219, 412, 225 Annotation: Subtype: Link Rect: 252, 211, 274, 217 Annotation: Subtype: Link Rect: 252, 203, 413, 209 Annotation: Subtype: Link Rect: 252, 195, 408, 201 Annotation: Subtype: Link Rect: 252, 187, 412, 193 Annotation: Subtype: Link Rect: 252, 179, 412, 185 Annotation: Subtype: Link Rect: 252, 171, 412, 177 Annotation: Subtype: Link Rect: 252, 163, 412, 169 Annotation: Subtype: Link Rect: 252, 155, 413, 161 Annotation: Subtype: Link Rect: 252, 147, 395, 153 Annotation: Subtype: Link Rect: 252, 139, 412, 145 Annotation: Subtype: Link Rect: 252, 131, 384, 137 Annotation: Subtype: Link Rect: 252, 123, 413, 129 Annotation: Subtype: Link Rect: 252, 115, 375, 121 Annotation: Subtype: Link Rect: 252, 107, 413, 113 Annotation: Subtype: Link Rect: 252, 100, 412, 105 Annotation: Subtype: Link Rect: 252, 92, 323, 98 Annotation: Subtype: Link Rect: 252, 84, 412, 90 Annotation: Subtype: Link Rect: 252, 76, 342, 82 Page: Label: 47 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 68, 661, 228, 667 Annotation: Subtype: Link Rect: 68, 653, 228, 659 Annotation: Subtype: Link Rect: 68, 645, 157, 651 Annotation: Subtype: Link Rect: 67, 637, 228, 643 Annotation: Subtype: Link Rect: 67, 630, 228, 635 Annotation: Subtype: Link Rect: 67, 622, 197, 627 Annotation: Subtype: Link Rect: 68, 614, 228, 620 Annotation: Subtype: Link Rect: 68, 606, 228, 612 Annotation: Subtype: Link Rect: 68, 598, 97, 604 Annotation: Subtype: Link Rect: 67, 590, 228, 596 Annotation: Subtype: Link Rect: 67, 582, 228, 588 Annotation: Subtype: Link Rect: 67, 574, 144, 580 Annotation: Subtype: Link Rect: 67, 566, 228, 572 Annotation: Subtype: Link Rect: 67, 558, 228, 564 Annotation: Subtype: Link Rect: 67, 550, 124, 556 Annotation: Subtype: Link Rect: 68, 542, 228, 548 Annotation: Subtype: Link Rect: 68, 534, 221, 540 Annotation: Subtype: Link Rect: 67, 526, 228, 532 Annotation: Subtype: Link Rect: 67, 518, 228, 524 Annotation: Subtype: Link Rect: 67, 510, 148, 516 Annotation: Subtype: Link Rect: 68, 502, 228, 508 Annotation: Subtype: Link Rect: 68, 494, 228, 500 Annotation: Subtype: Link Rect: 68, 486, 170, 492 Annotation: Subtype: Link Rect: 68, 478, 228, 484 Annotation: Subtype: Link Rect: 68, 470, 211, 476 Annotation: Subtype: Link Rect: 67, 462, 228, 468 Annotation: Subtype: Link Rect: 67, 454, 228, 460 Annotation: Subtype: Link Rect: 67, 446, 169, 452 Annotation: Subtype: Link Rect: 67, 438, 228, 444 Annotation: Subtype: Link Rect: 67, 430, 228, 436 Annotation: Subtype: Link Rect: 67, 422, 228, 428 Annotation: Subtype: Link Rect: 67, 414, 146, 420 Annotation: Subtype: Link Rect: 67, 406, 228, 412 Annotation: Subtype: Link Rect: 67, 398, 228, 404 Annotation: Subtype: Link Rect: 67, 390, 228, 396 Annotation: Subtype: Link Rect: 67, 382, 193, 388 Annotation: Subtype: Link Rect: 68, 374, 228, 380 Annotation: Subtype: Link Rect: 68, 366, 228, 372 Annotation: Subtype: Link Rect: 68, 359, 119, 364 Annotation: Subtype: Link Rect: 67, 351, 228, 357 Annotation: Subtype: Link Rect: 67, 343, 209, 349 Annotation: Subtype: Link Rect: 67, 335, 228, 341 Annotation: Subtype: Link Rect: 67, 327, 228, 333 Annotation: Subtype: Link Rect: 67, 319, 186, 325 Annotation: Subtype: Link Rect: 67, 311, 228, 317 Annotation: Subtype: Link Rect: 67, 303, 228, 309 Annotation: Subtype: Link Rect: 67, 295, 182, 301 Annotation: Subtype: Link Rect: 67, 287, 228, 293 Annotation: Subtype: Link Rect: 67, 279, 228, 285 Annotation: Subtype: Link Rect: 67, 271, 110, 277 Annotation: Subtype: Link Rect: 67, 263, 228, 269 Annotation: Subtype: Link Rect: 67, 255, 228, 261 Annotation: Subtype: Link Rect: 67, 247, 225, 253 Annotation: Subtype: Link Rect: 67, 239, 228, 245 Annotation: Subtype: Link Rect: 67, 231, 228, 237 Annotation: Subtype: Link Rect: 67, 223, 228, 229 Annotation: Subtype: Link Rect: 67, 215, 164, 221 Annotation: Subtype: Link Rect: 67, 207, 228, 213 Annotation: Subtype: Link Rect: 67, 199, 228, 205 Annotation: Subtype: Link Rect: 67, 191, 183, 197 Annotation: Subtype: Link Rect: 252, 661, 413, 667 Annotation: Subtype: Link Rect: 252, 653, 412, 659 Annotation: Subtype: Link Rect: 252, 645, 342, 651 Annotation: Subtype: Link Rect: 252, 637, 413, 643 Annotation: Subtype: Link Rect: 252, 630, 412, 635 Annotation: Subtype: Link Rect: 252, 622, 388, 627 Annotation: Subtype: Link Rect: 252, 614, 412, 620 Annotation: Subtype: Link Rect: 252, 606, 413, 612 Annotation: Subtype: Link Rect: 252, 598, 413, 604 Annotation: Subtype: Link Rect: 252, 590, 298, 596 Annotation: Subtype: Link Rect: 252, 582, 412, 588 Annotation: Subtype: Link Rect: 252, 574, 413, 580 Annotation: Subtype: Link Rect: 252, 566, 330, 572 Annotation: Subtype: Link Rect: 252, 558, 412, 564 Annotation: Subtype: Link Rect: 252, 550, 397, 556 Annotation: Subtype: Link Rect: 252, 542, 412, 548 Annotation: Subtype: Link Rect: 252, 534, 412, 540 Annotation: Subtype: Link Rect: 252, 526, 281, 532 Annotation: Subtype: Link Rect: 252, 518, 413, 524 Annotation: Subtype: Link Rect: 252, 510, 413, 516 Annotation: Subtype: Link Rect: 252, 502, 291, 508 Annotation: Subtype: Link Rect: 252, 494, 412, 500 Annotation: Subtype: Link Rect: 252, 486, 368, 492 Annotation: Subtype: Link Rect: 252, 478, 413, 484 Annotation: Subtype: Link Rect: 252, 470, 413, 476 Annotation: Subtype: Link Rect: 252, 462, 413, 468 Annotation: Subtype: Link Rect: 252, 454, 275, 460 Annotation: Subtype: Link Rect: 252, 446, 413, 452 Annotation: Subtype: Link Rect: 252, 438, 413, 444 Annotation: Subtype: Link Rect: 252, 430, 275, 436 Annotation: Subtype: Link Rect: 252, 422, 413, 428 Annotation: Subtype: Link Rect: 252, 414, 393, 420 Annotation: Subtype: Link Rect: 252, 406, 412, 412 Annotation: Subtype: Link Rect: 252, 398, 412, 404 Annotation: Subtype: Link Rect: 252, 390, 413, 396 Annotation: Subtype: Link Rect: 252, 382, 413, 388 Annotation: Subtype: Link Rect: 252, 374, 387, 380 Annotation: Subtype: Link Rect: 252, 366, 413, 372 Annotation: Subtype: Link Rect: 252, 359, 412, 364 Annotation: Subtype: Link Rect: 252, 351, 412, 357 Annotation: Subtype: Link Rect: 252, 343, 412, 349 Annotation: Subtype: Link Rect: 252, 335, 370, 341 Annotation: Subtype: Link Rect: 252, 327, 413, 333 Annotation: Subtype: Link Rect: 252, 319, 413, 325 Annotation: Subtype: Link Rect: 252, 311, 400, 317 Annotation: Subtype: Link Rect: 252, 303, 412, 309 Annotation: Subtype: Link Rect: 252, 295, 412, 301 Annotation: Subtype: Link Rect: 252, 287, 324, 293 Annotation: Subtype: Link Rect: 252, 279, 413, 285 Annotation: Subtype: Link Rect: 252, 271, 412, 277 Annotation: Subtype: Link Rect: 252, 263, 413, 269 Annotation: Subtype: Link Rect: 252, 255, 392, 261 Annotation: Subtype: Link Rect: 252, 247, 412, 253 Annotation: Subtype: Link Rect: 252, 239, 412, 245 Annotation: Subtype: Link Rect: 252, 231, 413, 237 Annotation: Subtype: Link Rect: 252, 223, 412, 229 Annotation: Subtype: Link Rect: 252, 215, 390, 221 Annotation: Subtype: Link Rect: 252, 207, 413, 213 Annotation: Subtype: Link Rect: 252, 199, 412, 205 Annotation: Subtype: Link Rect: 252, 191, 296, 197 Checksum: c881b968 Type: CRC32 Checksum: 98c66493dc61b12d5a675aca39fd84b8 Type: MD5 Checksum: f6ba22391fbf1e70e4fe889724fd8bd1577d9ca8 Type: SHA-1