af97036b5323f4925302be7d17ef3680  kidintrep_a2021v6p1088.pdf
f129858b32572661ffc8a1204de697c9cb04745f  kidintrep_a2021v6p1088.pdf
5c25269aac65667c134e77562ab5f02232602b7f76422d1948aab52b60febb86  kidintrep_a2021v6p1088.pdf

Title:          Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
Subject:        Kidney International Reports, 6 (2021) 1088-1098. doi:10.1016/j.ekir.2021.01.029
Author:         Gema Ariceta
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Mon Dec 31 23:45:16 1 LMT
ModDate:        Fri Apr  2 07:03:35 2021 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      612 x 792 pts (letter)
Page rot:       0
File size:      1504921 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EGLAEE+AdvOT3bf1a849.B               Type 1C           WinAnsi          yes yes no     707  0
EGLAEF+AdvOT0de51fd2                 Type 1C           WinAnsi          yes yes no     710  0
EGLAFG+AdvOT0de51fd2+20              Type 1C           WinAnsi          yes yes no     713  0
EGLAFH+AdvOTa84cfff1.I               Type 1C           WinAnsi          yes yes no     715  0
EGLAFI+AdvOT0de51fd2+fb              Type 1C           Custom           yes yes yes    708  0
EGLAFJ+AdvPSSym                      Type 1C           WinAnsi          yes yes no     726  0
EGLAFK+AdvOT7bedbc7e                 Type 1C           WinAnsi          yes yes no     728  0
EGLAFL+AdvOT7bedbc7e+fb              Type 1C           Custom           yes yes yes    722  0
EGLAFM+AdvOT7bedbc7e+20              Type 1C           WinAnsi          yes yes no     724  0
EGLCCE+AdvOT0a81dd96.B               Type 1C           WinAnsi          yes yes no     455  0
EGLCCF+AdvOTb4959fff                 Type 1C           WinAnsi          yes yes no     456  0
EGLCCG+AdvOTb4959fff+20              Type 1C           WinAnsi          yes yes no     462  0
EGLCCH+AdvOT0c7211e1.I               Type 1C           WinAnsi          yes yes no     458  0
EGLAJL+AdvOT372b1957.I               Type 1C           WinAnsi          yes yes no     454  0
EGLAJM+AdvP4C4E74                    Type 1C           Custom           yes yes yes    467  0
EGLCEH+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     481  0
EGLDFC+AdvOTb4959fff+fb              Type 1C           Custom           yes yes yes    480  0
EGLDGC+AdvOT8817665d                 Type 1C           WinAnsi          yes yes no     504  0
EGLDHD+AdvOTaf810ba6                 Type 1C           WinAnsi          yes yes no     489  0
EGLDHE+AdvOTaf810ba6+fb              Type 1C           Custom           yes yes yes    487  0
EGLDHF+AdvOT2c6df7a6                 Type 1C           WinAnsi          yes yes no     488  0
EGLDHG+AdvPS3FDD77                   Type 1C           WinAnsi          yes yes no     498  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-04-05 02:28:57 CEST
 RepresentationInformation: kidintrep_a2021v6p1088.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-04-04 09:20:54 CEST
  Size: 1504921
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Improperly formed date
   Offset: 1492048
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fna' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fna' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnb' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnc' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnd' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnd' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fna' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnb' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnc' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fna' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnb' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnc' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fna' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnb' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnc' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found
   Offset: 1478275
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found
   Offset: 1478275
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 780
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
      Children: 
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
        Children: 
         Item: 
          Title: Literature Review
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
         Item: 
          Title: PHYOX1 Study Design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
         Item: 
          Title: PHYOX1 Safety Analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
         Item: 
          Title: Statistical Analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
        Children: 
         Item: 
          Title: Literature Review: Patients With Congenital LDHAD Do not Show Signs of Liver Manifestations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: Literature Review: Alterations in Lactate, Pyruvate, and CK Levels in Patients With LDHAD
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: PHYOX1: HVs Treated With Single-Dose Nedosiran Showed no Alterations in Plasma Lactate, Pyruvate, or CK Levels
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: PHYOX1: No Drug-Related Musculoskeletal AEs Were Observed in the Single-Dose Nedosiran Group
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
       Item: 
        Title: Disclosure
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
       Item: 
        Title: Supplementary Material
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
   Info: 
    Title: Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
    Author: Gema Ariceta
    Subject: Kidney International Reports, 6 (2021) 1088-1098. doi:10.1016/j.ekir.2021.01.029
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
   ID: 0x115eb5545b66d536f5dc0f1fb8f33c2a, 0xbd0d79a2d3c77144a9826d4e5fc9b64f
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1595
      ImageHeight: 902
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1346
      ImageHeight: 732
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2095
      ImageHeight: 873
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2092
      ImageHeight: 857
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2092
      ImageHeight: 840
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1325
      ImageHeight: 2080
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EGLDFC+AdvOTb4959fff+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EGLDFC+AdvOTb4959fff+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGLCEH+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: EGLCEH+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAEE+AdvOT3bf1a849.B
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: EGLAEE+AdvOT3bf1a849.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 989, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAFI+AdvOT0de51fd2+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EGLAFI+AdvOT0de51fd2+fb
       Flags: Symbolic
       FontBBox: 0, 0, 520, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGLAEF+AdvOT0de51fd2
      FontSubset: true
      FirstChar: 40
      LastChar: 243
      FontDescriptor: 
       FontName: EGLAEF+AdvOT0de51fd2
       Flags: Nonsymbolic
       FontBBox: -10, -250, 989, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAJL+AdvOT372b1957.I
      FontSubset: true
      FirstChar: 45
      LastChar: 116
      FontDescriptor: 
       FontName: EGLAJL+AdvOT372b1957.I
       Flags: Nonsymbolic
       FontBBox: -93, -270, 1031, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLCCE+AdvOT0a81dd96.B
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: EGLCCE+AdvOT0a81dd96.B
       Flags: Nonsymbolic
       FontBBox: -72, -250, 885, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLDHE+AdvOTaf810ba6+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EGLDHE+AdvOTaf810ba6+fb
       Flags: Symbolic
       FontBBox: 9, 0, 437, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGLCCF+AdvOTb4959fff
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: EGLCCF+AdvOTb4959fff
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLDHF+AdvOT2c6df7a6
      FontSubset: true
      FirstChar: 37
      LastChar: 121
      FontDescriptor: 
       FontName: EGLDHF+AdvOT2c6df7a6
       Flags: Nonsymbolic
       FontBBox: -41, -208, 822, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAFG+AdvOT0de51fd2+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: EGLAFG+AdvOT0de51fd2+20
       Flags: Nonsymbolic
       FontBBox: -166, -125, 979, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLDHD+AdvOTaf810ba6
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: EGLDHD+AdvOTaf810ba6
       Flags: Nonsymbolic
       FontBBox: -41, -218, 833, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLCCH+AdvOT0c7211e1.I
      FontSubset: true
      FirstChar: 65
      LastChar: 78
      FontDescriptor: 
       FontName: EGLCCH+AdvOT0c7211e1.I
       Flags: Nonsymbolic
       FontBBox: -41, -260, 1031, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAFH+AdvOTa84cfff1.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: EGLAFH+AdvOTa84cfff1.I
       Flags: Nonsymbolic
       FontBBox: -41, -270, 1135, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLCCG+AdvOTb4959fff+20
      FontSubset: true
      FirstChar: 147
      LastChar: 150
      FontDescriptor: 
       FontName: EGLCCG+AdvOTb4959fff+20
       Flags: Nonsymbolic
       FontBBox: -156, -104, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAFL+AdvOT7bedbc7e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EGLAFL+AdvOT7bedbc7e+fb
       Flags: Symbolic
       FontBBox: 0, 0, 781, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGLDHG+AdvPS3FDD77
      FontSubset: true
      FirstChar: 91
      LastChar: 91
      FontDescriptor: 
       FontName: EGLDHG+AdvPS3FDD77
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1145, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAJM+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 188
      FontDescriptor: 
       FontName: EGLAJM+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGLAFM+AdvOT7bedbc7e+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: EGLAFM+AdvOT7bedbc7e+20
       Flags: Nonsymbolic
       FontBBox: -135, -343, 1000, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAFJ+AdvPSSym
      FontSubset: true
      FirstChar: 170
      LastChar: 170
      FontDescriptor: 
       FontName: EGLAFJ+AdvPSSym
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLAFK+AdvOT7bedbc7e
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: EGLAFK+AdvOT7bedbc7e
       Flags: Serif, Nonsymbolic
       FontBBox: -62, -291, 937, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGLDGC+AdvOT8817665d
      FontSubset: true
      FirstChar: 35
      LastChar: 36
      FontDescriptor: 
       FontName: EGLDGC+AdvOT8817665d
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1000, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.ekir.2021.01.029</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Gema Ariceta</rdf:li>
               <rdf:li>Kelly Barrios</rdf:li>
               <rdf:li>Bob D. Brown</rdf:li>
               <rdf:li>Bernd Hoppe</rdf:li>
               <rdf:li>Ralf Rosskamp</rdf:li>
               <rdf:li>Craig B. Langman</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>lactate dehydrogenase A</rdf:li>
               <rdf:li>nedosiran</rdf:li>
               <rdf:li>primary hyperoxaluria</rdf:li>
               <rdf:li>RNA interference</rdf:li>
               <rdf:li>small interfering RNA</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Kidney International Reports, 6 (2021) 1088-1098. doi:10.1016/j.ekir.2021.01.029</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Inc</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Kidney International Reports</prism:publicationName>
         <prism:copyright>© 2021 International Society of Nephrology. Published by Elsevier Inc.</prism:copyright>
         <prism:issn>2468-0249</prism:issn>
         <prism:volume>6</prism:volume>
         <prism:number>4</prism:number>
         <prism:coverDisplayDate>April 2021</prism:coverDisplayDate>
         <prism:pageRange>1088-1098</prism:pageRange>
         <prism:startingPage>1088</prism:startingPage>
         <prism:endingPage>1098</prism:endingPage>
         <prism:doi>10.1016/j.ekir.2021.01.029</prism:doi>
         <prism:url>https://doi.org/10.1016/j.ekir.2021.01.029</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.ekir.2021.01.029</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.ekir.2021.01.029</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>2th April 2021</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:ModifyDate>2021-04-02T10:33:35+05:30</xap:ModifyDate>
         <xap:MetadataDate>2021-04-02T10:33:35+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>2th April 2021</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:4b31ca2e-8bda-4085-abc6-27080dd2cad5</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:96b0335c-7843-4199-85ba-7d0b664b62d9</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1088
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 142, 641, 147, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 149, 641, 153, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 226, 641, 230, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 309, 641, 314, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 388, 641, 393, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 395, 641, 400, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 483, 641, 488, 652
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 164, 627, 169, 638
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 171, 627, 176, 638
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 216, 322, 375, 331
      Annotation: 
       Subtype: Link
       Rect: 105, 289, 276, 298
      Annotation: 
       Subtype: Link
       Rect: 89, 217, 93, 228
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 95, 217, 99, 228
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 184, 173, 226, 184
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 152, 165, 164, 176
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 463, 113, 466, 124
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 469, 113, 472, 124
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 382, 61, 386, 72
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 388, 61, 392, 72
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 167, 79, 281, 87
      Annotation: 
       Subtype: Link
       Rect: 484, 704, 562, 719
    Page: 
     Label: 1089
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 68, 403, 72, 414
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 74, 403, 78, 414
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 80, 377, 84, 388
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 86, 377, 90, 388
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 269, 338, 273, 349
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 275, 338, 279, 349
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 283, 260, 287, 271
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 290, 260, 293, 271
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 271, 209, 279, 220
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 170, 229, 181
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 144, 66, 155
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 485, 442, 504, 453
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 530, 325, 538, 336
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 320, 294, 357, 305
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 503, 286, 523, 297
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 462, 209, 470, 220
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 555, 183, 562, 194
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 423, 87, 501, 98
    Page: 
     Label: 1090
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 245, 649, 264, 660
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 189, 532, 197, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 199, 532, 206, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 103, 442, 110, 453
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 112, 442, 120, 453
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 504, 670, 562, 681
      Annotation: 
       Subtype: Link
       Rect: 317, 657, 334, 668
      Annotation: 
       Subtype: Link
       Rect: 439, 437, 556, 448
       Destination: 644
      Annotation: 
       Subtype: Link
       Rect: 362, 372, 473, 383
       Destination: 644
    Page: 
     Label: 1091
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 205, 298, 212, 309
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 157, 53, 177, 64
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 329, 397, 367, 408
       Destination: 41
      Annotation: 
       Subtype: Link
       Rect: 513, 260, 521, 271
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 505, 139, 539, 150
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 545, 144, 552, 155
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 555, 144, 562, 155
       Destination: null
    Page: 
     Label: 1092
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 87, 509, 95, 520
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 97, 509, 105, 520
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 107, 509, 115, 520
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 117, 509, 125, 520
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 98, 458, 105, 469
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 191, 316, 230, 326
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 218, 225, 252, 236
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 375, 709, 426, 720
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 320, 683, 374, 694
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 503, 618, 542, 629
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 455, 379, 489, 390
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 355, 230, 359, 241
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 361, 230, 365, 241
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 191, 679, 194, 686
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 205, 668, 207, 675
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 209, 668, 211, 675
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 121, 648, 124, 655
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 224, 636, 227, 643
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 212, 616, 214, 623
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 122, 602, 126, 608
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 71, 570, 76, 577
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 241, 562, 245, 569
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 246, 562, 251, 569
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 252, 562, 257, 569
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 122, 554, 126, 561
       Destination: null
    Page: 
     Label: 1093
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 191, 503, 198, 514
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 176, 360, 195, 371
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 339, 490, 347, 501
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 490, 427, 501
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 477, 425, 485, 436
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 687, 557, 694
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 676, 557, 683
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 667, 557, 674
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 645, 557, 652
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 634, 557, 641
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 625, 557, 632
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 603, 557, 610
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 592, 557, 599
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 556, 583, 559, 590
       Destination: null
    Page: 
     Label: 1094
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 286, 376, 293, 387
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 510, 363, 518, 374
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 520, 363, 528, 374
       Destination: null
    Page: 
     Label: 1095
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 159, 145, 167, 156
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 167, 93, 175, 104
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 434, 80, 442, 91
       Destination: null
    Page: 
     Label: 1096
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 437, 546, 445, 557
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 362, 533, 370, 544
       Destination: null
    Page: 
     Label: 1097
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 567, 293, 576
      Annotation: 
       Subtype: Link
       Rect: 48, 554, 73, 563
      Annotation: 
       Subtype: Link
       Rect: 48, 514, 176, 523
      Annotation: 
       Subtype: Link
       Rect: 66, 424, 293, 432
      Annotation: 
       Subtype: Link
       Rect: 66, 413, 167, 421
      Annotation: 
       Subtype: Link
       Rect: 66, 399, 293, 407
      Annotation: 
       Subtype: Link
       Rect: 66, 388, 293, 396
      Annotation: 
       Subtype: Link
       Rect: 66, 377, 84, 385
      Annotation: 
       Subtype: Link
       Rect: 66, 363, 293, 371
      Annotation: 
       Subtype: Link
       Rect: 66, 352, 293, 360
      Annotation: 
       Subtype: Link
       Rect: 66, 341, 293, 349
      Annotation: 
       Subtype: Link
       Rect: 66, 330, 134, 338
      Annotation: 
       Subtype: Link
       Rect: 66, 316, 293, 324
      Annotation: 
       Subtype: Link
       Rect: 66, 305, 293, 313
      Annotation: 
       Subtype: Link
       Rect: 66, 294, 258, 302
      Annotation: 
       Subtype: Link
       Rect: 66, 280, 293, 288
      Annotation: 
       Subtype: Link
       Rect: 66, 269, 293, 277
      Annotation: 
       Subtype: Link
       Rect: 66, 258, 278, 266
      Annotation: 
       Subtype: Link
       Rect: 66, 244, 293, 252
      Annotation: 
       Subtype: Link
       Rect: 66, 233, 141, 241
      Annotation: 
       Subtype: Link
       Rect: 66, 219, 293, 227
      Annotation: 
       Subtype: Link
       Rect: 66, 208, 158, 216
      Annotation: 
       Subtype: Link
       Rect: 170, 183, 293, 191
      Annotation: 
       Subtype: Link
       Rect: 66, 172, 150, 180
      Annotation: 
       Subtype: Link
       Rect: 66, 158, 293, 166
      Annotation: 
       Subtype: Link
       Rect: 66, 148, 293, 155
      Annotation: 
       Subtype: Link
       Rect: 66, 137, 293, 145
      Annotation: 
       Subtype: Link
       Rect: 66, 126, 96, 134
      Annotation: 
       Subtype: Link
       Rect: 67, 111, 293, 119
      Annotation: 
       Subtype: Link
       Rect: 67, 100, 293, 108
      Annotation: 
       Subtype: Link
       Rect: 67, 89, 161, 97
      Annotation: 
       Subtype: Link
       Rect: 67, 75, 293, 83
      Annotation: 
       Subtype: Link
       Rect: 67, 64, 293, 72
      Annotation: 
       Subtype: Link
       Rect: 67, 53, 251, 61
      Annotation: 
       Subtype: Link
       Rect: 336, 736, 562, 744
      Annotation: 
       Subtype: Link
       Rect: 336, 725, 548, 733
      Annotation: 
       Subtype: Link
       Rect: 336, 709, 562, 717
      Annotation: 
       Subtype: Link
       Rect: 336, 699, 562, 706
      Annotation: 
       Subtype: Link
       Rect: 336, 688, 493, 696
      Annotation: 
       Subtype: Link
       Rect: 336, 672, 562, 680
      Annotation: 
       Subtype: Link
       Rect: 336, 661, 562, 669
      Annotation: 
       Subtype: Link
       Rect: 336, 650, 480, 658
      Annotation: 
       Subtype: Link
       Rect: 336, 635, 562, 643
      Annotation: 
       Subtype: Link
       Rect: 336, 624, 541, 632
      Annotation: 
       Subtype: Link
       Rect: 336, 608, 562, 616
      Annotation: 
       Subtype: Link
       Rect: 336, 597, 562, 605
      Annotation: 
       Subtype: Link
       Rect: 336, 586, 421, 594
      Annotation: 
       Subtype: Link
       Rect: 336, 572, 562, 580
      Annotation: 
       Subtype: Link
       Rect: 336, 561, 562, 569
      Annotation: 
       Subtype: Link
       Rect: 336, 550, 562, 558
      Annotation: 
       Subtype: Link
       Rect: 336, 539, 562, 547
      Annotation: 
       Subtype: Link
       Rect: 336, 528, 366, 536
      Annotation: 
       Subtype: Link
       Rect: 336, 514, 562, 522
      Annotation: 
       Subtype: Link
       Rect: 336, 503, 562, 511
      Annotation: 
       Subtype: Link
       Rect: 336, 492, 366, 500
      Annotation: 
       Subtype: Link
       Rect: 336, 478, 562, 486
      Annotation: 
       Subtype: Link
       Rect: 336, 467, 562, 475
      Annotation: 
       Subtype: Link
       Rect: 336, 456, 458, 464
      Annotation: 
       Subtype: Link
       Rect: 336, 442, 562, 450
      Annotation: 
       Subtype: Link
       Rect: 336, 431, 562, 439
      Annotation: 
       Subtype: Link
       Rect: 336, 420, 562, 428
      Annotation: 
       Subtype: Link
       Rect: 336, 409, 353, 417
      Annotation: 
       Subtype: Link
       Rect: 336, 395, 562, 403
      Annotation: 
       Subtype: Link
       Rect: 336, 384, 562, 392
      Annotation: 
       Subtype: Link
       Rect: 336, 373, 406, 381
      Annotation: 
       Subtype: Link
       Rect: 336, 359, 562, 367
      Annotation: 
       Subtype: Link
       Rect: 336, 348, 504, 356
      Annotation: 
       Subtype: Link
       Rect: 336, 334, 562, 342
      Annotation: 
       Subtype: Link
       Rect: 336, 323, 562, 331
      Annotation: 
       Subtype: Link
       Rect: 336, 312, 551, 320
      Annotation: 
       Subtype: Link
       Rect: 336, 298, 562, 306
      Annotation: 
       Subtype: Link
       Rect: 336, 287, 562, 295
      Annotation: 
       Subtype: Link
       Rect: 336, 276, 472, 284
      Annotation: 
       Subtype: Link
       Rect: 336, 262, 562, 270
      Annotation: 
       Subtype: Link
       Rect: 336, 251, 562, 259
      Annotation: 
       Subtype: Link
       Rect: 336, 240, 562, 248
      Annotation: 
       Subtype: Link
       Rect: 336, 229, 562, 237
      Annotation: 
       Subtype: Link
       Rect: 336, 218, 416, 226
      Annotation: 
       Subtype: Link
       Rect: 336, 204, 562, 212
      Annotation: 
       Subtype: Link
       Rect: 336, 193, 562, 201
      Annotation: 
       Subtype: Link
       Rect: 336, 182, 562, 190
      Annotation: 
       Subtype: Link
       Rect: 336, 171, 562, 179
      Annotation: 
       Subtype: Link
       Rect: 336, 161, 375, 168
      Annotation: 
       Subtype: Link
       Rect: 336, 146, 562, 154
      Annotation: 
       Subtype: Link
       Rect: 336, 136, 562, 143
      Annotation: 
       Subtype: Link
       Rect: 336, 125, 487, 133
      Annotation: 
       Subtype: Link
       Rect: 336, 111, 562, 118
      Annotation: 
       Subtype: Link
       Rect: 336, 100, 562, 108
      Annotation: 
       Subtype: Link
       Rect: 336, 89, 410, 97
      Annotation: 
       Subtype: Link
       Rect: 336, 75, 562, 83
      Annotation: 
       Subtype: Link
       Rect: 336, 64, 562, 72
      Annotation: 
       Subtype: Link
       Rect: 336, 53, 556, 61
    Page: 
     Label: 1098
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 67, 736, 293, 744
      Annotation: 
       Subtype: Link
       Rect: 67, 725, 293, 733
      Annotation: 
       Subtype: Link
       Rect: 67, 714, 236, 722
      Annotation: 
       Subtype: Link
       Rect: 67, 700, 293, 708
      Annotation: 
       Subtype: Link
       Rect: 67, 689, 293, 697
      Annotation: 
       Subtype: Link
       Rect: 67, 678, 293, 686
      Annotation: 
       Subtype: Link
       Rect: 67, 667, 121, 675
      Annotation: 
       Subtype: Link
       Rect: 67, 653, 293, 661
      Annotation: 
       Subtype: Link
       Rect: 67, 642, 293, 650
      Annotation: 
       Subtype: Link
       Rect: 67, 631, 164, 639
      Annotation: 
       Subtype: Link
       Rect: 67, 617, 293, 625
      Annotation: 
       Subtype: Link
       Rect: 67, 606, 293, 614
      Annotation: 
       Subtype: Link
       Rect: 67, 595, 183, 603
      Annotation: 
       Subtype: Link
       Rect: 67, 581, 293, 589
      Annotation: 
       Subtype: Link
       Rect: 67, 570, 293, 578
      Annotation: 
       Subtype: Link
       Rect: 67, 559, 200, 567
      Annotation: 
       Subtype: Link
       Rect: 67, 545, 293, 553
      Annotation: 
       Subtype: Link
       Rect: 67, 534, 293, 542
      Annotation: 
       Subtype: Link
       Rect: 67, 523, 234, 531
      Annotation: 
       Subtype: Link
       Rect: 67, 508, 293, 516
      Annotation: 
       Subtype: Link
       Rect: 67, 497, 293, 505
      Annotation: 
       Subtype: Link
       Rect: 67, 486, 293, 494
      Annotation: 
       Subtype: Link
       Rect: 67, 475, 293, 483
      Annotation: 
       Subtype: Link
       Rect: 67, 464, 150, 472
      Annotation: 
       Subtype: Link
       Rect: 67, 450, 293, 458
      Annotation: 
       Subtype: Link
       Rect: 67, 439, 293, 447
      Annotation: 
       Subtype: Link
       Rect: 67, 429, 293, 436
      Annotation: 
       Subtype: Link
       Rect: 67, 418, 154, 426
      Annotation: 
       Subtype: Link
       Rect: 67, 403, 293, 411
      Annotation: 
       Subtype: Link
       Rect: 67, 392, 293, 400
      Annotation: 
       Subtype: Link
       Rect: 67, 381, 291, 389
      Annotation: 
       Subtype: Link
       Rect: 67, 366, 293, 374
      Annotation: 
       Subtype: Link
       Rect: 67, 355, 293, 363
      Annotation: 
       Subtype: Link
       Rect: 67, 344, 255, 352
      Annotation: 
       Subtype: Link
       Rect: 67, 330, 293, 338
      Annotation: 
       Subtype: Link
       Rect: 67, 319, 293, 327
      Annotation: 
       Subtype: Link
       Rect: 67, 308, 174, 316
      Annotation: 
       Subtype: Link
       Rect: 336, 736, 562, 744
      Annotation: 
       Subtype: Link
       Rect: 336, 725, 562, 733
      Annotation: 
       Subtype: Link
       Rect: 336, 714, 484, 722
      Annotation: 
       Subtype: Link
       Rect: 336, 700, 562, 708
      Annotation: 
       Subtype: Link
       Rect: 336, 689, 562, 697
      Annotation: 
       Subtype: Link
       Rect: 336, 678, 562, 686
      Annotation: 
       Subtype: Link
       Rect: 336, 667, 562, 675
      Annotation: 
       Subtype: Link
       Rect: 336, 656, 366, 664
      Annotation: 
       Subtype: Link
       Rect: 336, 641, 562, 649
      Annotation: 
       Subtype: Link
       Rect: 336, 630, 562, 638
      Annotation: 
       Subtype: Link
       Rect: 336, 619, 488, 627
      Annotation: 
       Subtype: Link
       Rect: 336, 603, 562, 611
      Annotation: 
       Subtype: Link
       Rect: 336, 592, 562, 600
      Annotation: 
       Subtype: Link
       Rect: 336, 581, 410, 589
      Annotation: 
       Subtype: Link
       Rect: 336, 566, 562, 574
      Annotation: 
       Subtype: Link
       Rect: 336, 555, 562, 563
      Annotation: 
       Subtype: Link
       Rect: 336, 544, 433, 552
      Annotation: 
       Subtype: Link
       Rect: 336, 528, 562, 536
      Annotation: 
       Subtype: Link
       Rect: 336, 517, 562, 525
      Annotation: 
       Subtype: Link
       Rect: 336, 506, 562, 514
      Annotation: 
       Subtype: Link
       Rect: 336, 495, 410, 503
      Annotation: 
       Subtype: Link
       Rect: 336, 480, 562, 488
      Annotation: 
       Subtype: Link
       Rect: 336, 469, 562, 477
      Annotation: 
       Subtype: Link
       Rect: 336, 458, 562, 466
      Annotation: 
       Subtype: Link
       Rect: 336, 447, 562, 455
      Annotation: 
       Subtype: Link
       Rect: 336, 436, 475, 444
      Annotation: 
       Subtype: Link
       Rect: 514, 389, 562, 397
      Annotation: 
       Subtype: Link
       Rect: 336, 378, 489, 386
      Annotation: 
       Subtype: Link
       Rect: 536, 331, 562, 339
      Annotation: 
       Subtype: Link
       Rect: 336, 320, 489, 328
  Checksum: 3013cf6c
   Type: CRC32
  Checksum: af97036b5323f4925302be7d17ef3680
   Type: MD5
  Checksum: f129858b32572661ffc8a1204de697c9cb04745f
   Type: SHA-1