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application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1146 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: TREM2 expression in the brain and biological fluids in prion diseases Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Material and methods Children: Item: Title: Antibodies and reagents Item: Title: Brain samples Item: Title: Cerebrospinal fluid and plasma samples Item: Title: CSF and plasma tests Item: Title: Animal experimentation Item: Title: Western blotting Item: Title: Real-time polymerase chain reaction (qPCR) Item: Title: Immunohistochemistry Item: Title: Immunofluorescence Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: TREM2 and ADAM10 expression in the brain of sCJD patients Item: Title: Regional and temporal TREM2 expression in the brain of sCJD mouse models Item: Title: sTREM2 in the CSF of prion diseases Item: Title: sTREM2 in the plasma of sCJD Item: Title: Discussion Item: Title: Acknowledgements Item: Title: References Info: Title: TREM2 expression in the brain and biological fluids in prion diseases Author: Daniela Diaz-Lucena Subject: Acta Neuropathologica, https://doi.org/10.1007/s00401-021-02296-1 Keywords: TREM2,Prion diseases,Creutzfeldt-Jakob disease,Microglia,Cerebrospinal fluid,Plasma Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Wed Apr 21 05:18:18 CEST 2021 ModDate: Thu May 06 19:50:02 CEST 2021 ID: 0xf45f728c0c6ca8459ce6627c5fc1f9c3, 0x86e0d7995024c74fbdfb966b0f6ce04a Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 2320 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Berlin Heidelberg Acta Neuropathologica, https://doi.org/10.1007/s00401-021-02296-1 TREM2 Prion diseases Creutzfeldt-Jakob disease Microglia Cerebrospinal fluid Plasma TREM2 expression in the brain and biological fluids in prion diseases Daniela Diaz-Lucena Niels Kruse Katrin Thüne Matthias Schmitz Anna Villar-Piqué Jose Eriton Gomes da Cunha Peter Hermann Óscar López-Pérez Pol Andrés-Benito Anna Ladogana Miguel Calero Enric Vidal Joachim Riggert Hailey Pineau Valerie Sim Henrik Zetterberg Kaj Blennow Jose Antonio del Río Alba Marín-Moreno Juan Carlos Espinosa Juan María Torres Raquel Sánchez-Valle Brit Mollenhauer Isidre Ferrer Inga Zerr Franc Llorens 10.1007/s00401-021-02296-1 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00401-021-02296-1 10.1007/s00401-021-02296-1 1432-0533 141 6 841 859 journal Acta Neuropathologica The Author(s) 2010-04-23 true 10.1007/s00401-021-02296-1 noindex springer.com springerlink.com VoR uuid:cab8cc94-b472-41ff-ba47-99f51126359d 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