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application/pdf PDFMetadata: Objects: 666 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Primary samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Whole-exome sequencing (WES) and data processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: RNA sequencing (RNA-Seq) and data processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Flow cytometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Determination of IL-10 in plasma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: B and T lymphocytes co-cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: CLL cells show limited and non-recurrent genetic changes at clinical progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Effector memory CD8+ T cells co-expressing inhibitory receptors accumulate at CLL progression while they remain steady over time in patients with stable disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Terminally exhausted CD8+ T cells (T-betdim/−EomeshiPD1hi) accumulate at CLL progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: T cells acquire a distinct transcriptional profile at CLL progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: CLL cells from patients at clinical progression have enhanced capacity to induce PD1 expression in CD8+ T cells via soluble factors including IL-10 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Supplementary Information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Authors’s contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Declarations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Info: Title: Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia Author: Isabel Jiménez Subject: Biomarker Research, 2021, doi:10.1186/s40364-021-00290-z Keywords: CLL,Immune evasion,Clinical progression,T cell exhaustion Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 14 18:10:52 CEST 2021 ModDate: Thu May 20 13:48:47 CEST 2021 ID: 0xbebfdb34d32c6226187aca3926ebb171, 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application/pdf 10.1186/s40364-021-00290-z Biomarker Research Biomarker Research, 2021, doi:10.1186/s40364-021-00290-z CLL Immune evasion Clinical progression T cell exhaustion Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia Isabel Jiménez Bárbara Tazón-Vega Pau Abrisqueta Juan C. Nieto Sabela Bobillo Carles Palacio-García Júlia Carabia Rafael Valdés-Mas Magdalena Munuera Lluís Puigdefàbregas Genís Parra Anna Esteve-Codina Clara Franco-Jarava Gloria Iacoboni María José Terol José Antonio García-Marco Marta Crespo Francesc Bosch 2021-05-20T13:48:47+02:00 2021-05-20T13:48:47+02:00 2021-05-15T00:10:52+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:8315f422-4e67-4ba1-9dbc-d34b3601acd1 uuid:df132a0b-7312-4c00-8f06-c4498560151d default 1 converted uuid:8315f422-4e67-4ba1-9dbc-d34b3601acd1 converted to PDF/A-2b pdfToolbox 2021-05-15T03:02:03+08:00 2 B Francesc Bosch http://orcid.org/0000-0001-9241-2886 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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