a73cc9d9ed4a3b50fe71edf250178d80 s41598-021-92381-y.pdf 5cb84ee42c204deb77f8de498ad6cd5551e44fb5 s41598-021-92381-y.pdf d6033c2c104233fbd8d9a2356d7da80d116bd895ad0938383659d84558a707f9 s41598-021-92381-y.pdf Title: Assessment of the gene mosaicism burden in blood and its implications for immune disorders Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-92381-y Author: Manuel Solís-Moruno Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jun 15 08:45:33 2021 CEST ModDate: Tue Jun 15 11:19:39 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1378793 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XTKUEW+Wingdings-Regular Type 1C WinAnsi yes yes yes 512 0 MinionPro-It Type 1C WinAnsi yes no yes 35 0 MinionPro-Regular Type 1C Custom yes no yes 34 0 Corbel-Bold2 TrueType WinAnsi yes no yes 513 0 JLLLHW+Corbel-Bold CID TrueType Identity-H yes yes yes 37 0 Corbel2 TrueType WinAnsi yes no yes 38 0 GOBYRC+Corbel CID TrueType Identity-H yes yes yes 39 0 MinionPro-Bold Type 1C Custom yes no yes 36 0 Corbel2 TrueType WinAnsi yes no yes 43 0 QARVBI+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 282 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:49:38 CEST RepresentationInformation: s41598-021-92381-y.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:51:16 CEST Size: 1378793 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 579 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Assessment of the gene mosaicism burden in blood and its implications for immune disorders Children: Item: Title: Material and methods Children: Item: Title: Ethical approval. Item: Title: Samples. Item: Title: Sequencing and genomic analysis. Item: Title: Results Children: Item: Title: Detection of somatic pathogenic variants from WES in PID patients. Item: Title: Filtering strategies for the identification of true causal variants. Item: Title: Mosaicism abundance detection in whole blood. Item: Title: Cell type distribution of somatic variants in S5 patient. Item: Title: Discussion Item: Title: Conclusions Item: Title: References Item: Title: Acknowledgements Info: Title: Assessment of the gene mosaicism burden in blood and its implications for immune disorders Author: Manuel Solís-Moruno Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-92381-y Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jun 15 09:15:33 CEST 2021 ModDate: Tue Jun 15 11:19:39 CEST 2021 ID: 0x8de0f485c338d98b0ece88e9bbe79b38, 0xfd1d80b06bf47898fbc741ed842949ad Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 1478 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 639 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 666 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: JLLLHW+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: GOBYRC+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: XTKUEW+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XTKUEW+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: Corbel-Bold2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 32 LastChar: 224 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: QARVBI+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: QARVBI+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: GOBYRC+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GOBYRC+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: JLLLHW+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JLLLHW+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2021-06-15T12:15:33+05:30 Springer 2021-06-15T11:19:39+02:00 2021-06-15T11:19:39+02:00 application/pdf https://doi.org/10.1038/s41598-021-92381-y Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-92381-y Assessment of the gene mosaicism burden in blood and its implications for immune disorders Manuel Solís-Moruno Anna Mensa-Vilaró Laura Batlle-Masó Irene Lobón Núria Bonet Tomàs Marquès-Bonet Juan I. 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