6747c29fc6b0548cf7f73e3547499260  248148.pdf
3640ae0b86ad85d687463298e2429270b849d64f  248148.pdf
f22fc3313d843c24b55fbf9e4850bc1166bd5ab567a296ab92e2686b77440132  248148.pdf

Title:          Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours
Subject:        Clinical and Translational Oncology, https://doi.org/10.1007/s12094-021-02558-0
Keywords:       Gene fusions,Molecular oncology,Mutations,Neoplasm,Target therapies
Author:         P. Garrido 
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows)
CreationDate:   Tue Feb 23 04:24:01 2021 CET
ModDate:        Fri Mar  4 13:39:29 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1162940 bytes
Optimized:      yes
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    616  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    619  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes    622  0
FDOYWG+MyriadPro-SemiboldSemiCnIt    Type 1C           WinAnsi          yes yes yes    624  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes    626  0
PIHTBO+STIX-Regular                  Type 1C           Custom           yes yes yes    629  0
STIX-Italic                          Type 1C           WinAnsi          yes no  yes    631  0
DBCNND+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    633  0
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    638  0
Springnew-Regular                    Type 1C           WinAnsi          yes no  yes    640  0
VLSEHC+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    405  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes    402  0
TTVCBO+MyriadPro-BoldSemiCnIt        Type 1C           WinAnsi          yes yes yes    410  0
Springnew-Regular                    Type 1C           WinAnsi          yes no  yes    414  0
ERGOSN+STIX-Bold                     Type 1C           WinAnsi          yes yes yes    456  0
DSUFGS+MyriadPro-BoldIt              Type 1C           WinAnsi          yes yes yes    510  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-03-05 02:45:25 CET
 RepresentationInformation: 248148.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-03-04 14:03:36 CET
  Size: 1162940
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Anatomopathological aspects
        Children: 
         Item: 
          Title: Biology of NTRK
         Item: 
          Title: Methods of detecting NTRK fusions
          Children: 
           Item: 
            Title: Immunohistochemistry
           Item: 
            Title: Fluorescence in situ hybridization
           Item: 
            Title: Massive parallel sequencing or next-generation sequence
           Item: 
            Title: Reverse transcription polymerase chain reaction
         Item: 
          Title: Organisational aspects
          Children: 
           Item: 
            Title: Workflow
           Item: 
            Title: Optimal biological specimens
           Item: 
            Title: Quality control
           Item: 
            Title: Results reporting
       Item: 
        Title: Clinical aspects
        Children: 
         Item: 
          Title: Larotrectinib
         Item: 
          Title: Entrectinib
         Item: 
          Title: New generation inhibitors
         Item: 
          Title: Infantile fibrosarcoma
       Item: 
        Title: Strategies to optimise the detection of NTRK fusions in adult and paediatric patients by tumour type
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgments 
       Item: 
        Title: References
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 969
      ImageHeight: 733
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 969
      ImageHeight: 1276
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 2079
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: VLSEHC+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: FDOYWG+MyriadPro-SemiboldSemiCnIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: FDOYWG+MyriadPro-SemiboldSemiCnIt
       Flags: Nonsymbolic, Italic
       FontBBox: -156, -250, 1096, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PIHTBO+STIX-Regular
      FontSubset: true
      FirstChar: 26
      LastChar: 250
      FontDescriptor: 
       FontName: PIHTBO+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 32
      LastChar: 169
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ERGOSN+STIX-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: ERGOSN+STIX-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: DBCNND+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DBCNND+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TTVCBO+MyriadPro-BoldSemiCnIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: TTVCBO+MyriadPro-BoldSemiCnIt
       Flags: Nonsymbolic, Italic
       FontBBox: -197, -250, 1145, 978
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DSUFGS+MyriadPro-BoldIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DSUFGS+MyriadPro-BoldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -201, -250, 1225, 987
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: VLSEHC+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: VLSEHC+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c015 91.163280, 2018/06/22-11:31:03        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
            xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <xmp:CreateDate>2021-02-23T08:54:01+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2022-03-04T13:39:29+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2022-03-04T13:39:29+01:00</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows)</pdf:Producer>
         <pdf:Keywords>Gene fusions,Molecular oncology,Mutations,Neoplasm,Target therapies</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s12094-021-02558-0</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer International Publishing</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Clinical and Translational Oncology, https://doi.org/10.1007/s12094-021-02558-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Gene fusions</rdf:li>
               <rdf:li>Molecular oncology</rdf:li>
               <rdf:li>Mutations</rdf:li>
               <rdf:li>Neoplasm</rdf:li>
               <rdf:li>Target therapies</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Multidisciplinary consensus on optimising the detection of NTRK gene alterations in tumours</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>P. Garrido </rdf:li>
               <rdf:li>R. Hladun </rdf:li>
               <rdf:li>E. de Álava </rdf:li>
               <rdf:li>R. Álvarez </rdf:li>
               <rdf:li>F. Bautista </rdf:li>
               <rdf:li>F. López-Ríos </rdf:li>
               <rdf:li>R. Colomer </rdf:li>
               <rdf:li>F. Rojo </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s12094-021-02558-0</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s12094-021-02558-0</prism:url>
         <prism:doi>10.1007/s12094-021-02558-0</prism:doi>
         <prism:issn>1699-3055</prism:issn>
         <prism:volume>23</prism:volume>
         <prism:number>8</prism:number>
         <prism:startingPage>1529</prism:startingPage>
         <prism:endingPage>1541</prism:endingPage>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Clinical and Translational Oncology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s12094-021-02558-0</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:d3dd0b51-0cf9-442f-a516-2715c95ad70a</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:30296d5d-a8a0-4f10-afa5-7f729aaca1e1</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:0778ca3a-2632-42f8-9408-1d7d72ba4a92</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2021-06-21T22:19:24+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:5eb33a50-305c-4b0d-8305-b4a108d87981</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2021-06-21T22:20:05+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>P. Garrido</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5899-6125</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1529
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 94, 634, 107, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1530
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 278, 659, 283, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 54, 584, 59, 569
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 244, 559, 249, 544
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 54, 534, 59, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 64, 534, 69, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 54, 496, 59, 481
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 54, 396, 59, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 65, 396, 70, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 400, 621, 405, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 395, 509, 401, 494
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 441, 221, 446, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 471, 171, 476, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
     Thumb: true
    Page: 
     Label: 1531
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 253, 570, 258, 555
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 119, 545, 130, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 133, 445, 143, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 149, 445, 159, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 98, 395, 108, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 124, 332, 134, 317
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 216, 282, 226, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 160, 245, 166, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 8
      Annotation: 
       Subtype: Link
       Rect: 175, 245, 180, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 186, 245, 196, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 201, 245, 212, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 113, 207, 124, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 250, 182, 260, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 265, 182, 276, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 512, 545, 522, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 528, 545, 538, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 473, 507, 483, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 488, 507, 498, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 533, 482, 538, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 8
      Annotation: 
       Subtype: Link
       Rect: 532, 470, 537, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 413, 420, 423, 405
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 428, 420, 438, 405
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 443, 420, 453, 405
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
     Thumb: true
    Page: 
     Label: 1532
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 97, 336, 107, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 206, 223, 216, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 95, 161, 100, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 105, 161, 115, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 390, 674, 400, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 454, 649, 464, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 468, 649, 478, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 432, 561, 437, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 443, 561, 453, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 459, 561, 469, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 475, 561, 485, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 505, 249, 515, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 351, 236, 361, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 473, 236, 483, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 441, 224, 451, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 528, 224, 538, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
     Thumb: true
    Page: 
     Label: 1533
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 460, 124, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 129, 460, 139, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 267, 435, 272, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 8
      Annotation: 
       Subtype: Link
       Rect: 281, 435, 286, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 51, 423, 61, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 253, 335, 263, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 268, 335, 278, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 196, 260, 206, 245
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 235, 248, 245, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 203, 223, 213, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 446, 736, 456, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 345, 661, 355, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
     Thumb: true
    Page: 
     Label: 1534
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 94, 635, 105, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 54, 560, 64, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 191, 485, 202, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 505, 736, 511, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 441, 611, 451, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 456, 611, 466, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 439, 449, 449, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 454, 449, 464, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 384, 336, 394, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 399, 336, 409, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 434, 111, 444, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
     Thumb: true
    Page: 
     Label: 1535
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 273, 711, 283, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 54, 624, 64, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 207, 574, 217, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 181, 436, 191, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 196, 436, 206, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 201, 374, 211, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 276, 86, 286, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 306, 486, 316, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 328, 424, 338, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 372, 424, 377, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 478, 311, 488, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 430, 236, 440, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 348, 174, 359, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
     Thumb: true
    Page: 
     Label: 1536
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 87, 511, 92, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 97, 511, 107, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 231, 486, 236, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 241, 486, 251, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 256, 486, 266, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 224, 424, 235, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 54, 311, 64, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 515, 674, 525, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 397, 549, 407, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 368, 336, 373, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 380, 286, 385, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 498, 99, 503, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 512, 99, 517, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 521, 99, 526, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 531, 99, 541, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 306, 86, 316, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
     Thumb: true
    Page: 
     Label: 1537
     Sequence: 9
     Thumb: true
    Page: 
     Label: 1538
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 111, 374, 121, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 126, 374, 137, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 100, 715, 109, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 113, 715, 121, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 126, 715, 134, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 322, 700, 331, 687
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 335, 700, 344, 687
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 479, 700, 487, 687
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 491, 700, 500, 687
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 235, 675, 243, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 496, 675, 505, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 295, 650, 303, 637
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 519, 650, 528, 637
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 532, 650, 540, 637
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 223, 625, 232, 612
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 519, 625, 528, 612
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 291, 600, 299, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 228, 575, 237, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 219, 550, 228, 537
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
     Thumb: true
    Page: 
     Label: 1539
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 392, 626, 542, 613
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1540
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 115, 626, 289, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 616, 231, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 596, 289, 583
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 586, 251, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 636, 544, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 626, 357, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 369, 546, 544, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 536, 426, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 483, 526, 544, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 516, 544, 503
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 506, 398, 493
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 354, 206, 544, 193
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 196, 544, 183
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 186, 340, 173
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 527, 176, 544, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 166, 544, 153
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 156, 451, 143
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1541
     Sequence: 13
     Thumb: true
  Checksum: 475e7d2b
   Type: CRC32
  Checksum: 6747c29fc6b0548cf7f73e3547499260
   Type: MD5
  Checksum: 3640ae0b86ad85d687463298e2429270b849d64f
   Type: SHA-1