a9057ad0624434455811df4d15eb9055 Biomed_Pharmacother-2021-143-112126.pdf 159959b9b02c76f9d9736419280670254464b4f2 Biomed_Pharmacother-2021-143-112126.pdf ac0fd16a89170e05940061c65270df802e52d692a5ee887c12b2867a80803f84 Biomed_Pharmacother-2021-143-112126.pdf Title: Intestinal inflammation-associated hypersensitivity is attenuated in a DSS model of colitis in Sigma-1 knockout C57BL/6 mice Subject: Biomedicine & Pharmacotherapy, 143 (2021) 112126. doi:10.1016/j.biopha.2021.112126 Keywords: Colitis,Hyperalgesia,Hypersensitivity,Intestinal inflammation,Pain,Sigma 1 receptor Author: Sergio López-Estévez Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 30th August 2021 ModDate: Tue Aug 31 07:20:40 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2723826 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CQJOMT+CharisSIL CID TrueType Identity-H yes yes yes 748 0 VXCJFZ+Univers Type 1C Builtin yes yes yes 750 0 CMKOLS+CharisSIL-Italic CID TrueType Identity-H yes yes yes 753 0 QRWTQO+TimesNewRomanPS-ItalicMT CID TrueType Identity-H yes yes yes 756 0 MATBFN+STIX-Regular Type 1C Custom yes yes yes 759 0 EOLCKM+CharisSIL-Bold CID TrueType Identity-H yes yes yes 762 0 RECUMR+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 765 0 NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 767 0 TPFXPP+CharisSIL CID TrueType Identity-H yes yes yes 771 0 KEPREY+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 121 0 LOXFPX+CharisSIL-Italic CID TrueType Identity-H yes yes yes 116 0 NBXCFK+STIX-Italic Type 1C Custom yes yes yes 125 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 127 0 KOYXAT+ArialUnicodeMS CID TrueType Identity-H yes yes yes 145 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:47:07 CEST RepresentationInformation: Biomed_Pharmacother-2021-143-112126.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:51:33 CEST Size: 2723826 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Intestinal inflammation-associated hypersensitivity is attenuated in a DSS model of colitis in Sigma-1 knockout C57BL/6 mice Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Animals Destination: mk:H2_1 Item: Title: 2.2 Colitis induction Destination: mk:H2_2 Item: Title: 2.3 Evaluation of referred mechanical hypersensitivity: von Frey test Destination: mk:H2_3 Item: Title: 2.4 Experimental protocol Destination: mk:H2_4 Item: Title: 2.5 Samples collection Destination: mk:H2_5 Item: Title: 2.6 Clinical and macroscopic assessment of inflammation Destination: mk:H2_6 Item: Title: 2.7 Histological studies Destination: mk:H2_7 Item: Title: 2.8 Serum haptoglobin Destination: mk:H2_8 Item: Title: 2.9 Gene expression using Quantitative Reverse Transcription-PCR Destination: mk:H2_9 Item: Title: 2.10 Protein expression using Western blot Destination: mk:H2_10 Item: Title: 2.11 Statistical analysis Destination: mk:H2_11 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Colitis development in WT and σ1R KO mice Destination: mk:H2_12 Item: Title: 3.2 Inflammatory markers are differentially regulated in WT and σ1R KO mice during colitis Destination: mk:H2_13 Item: Title: 3.3 Colitis-associated mechanical hypersensitivity is attenuated in σ1R KO mice Destination: mk:H2_14 Item: Title: 3.4 Expression of colonic sensory-related markers is modulated during DSS-induced colitis Destination: mk:H2_15 Item: Title: 3.5 ERK expression within the spinal cord is not affected by colitis Destination: mk:H2_16 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: Funding Destination: mk:H1_5 Item: Title: CRediT authorship contribution statement Destination: mk:H1_6 Item: Title: Conflict of interest statement Destination: creditlink2 Item: Title: References Destination: mk:HH2_1 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: CMKOLS+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: KOYXAT+ArialUnicodeMS Encoding: Identity-H ToUnicode: true Font: BaseFont: QRWTQO+TimesNewRomanPS-ItalicMT Encoding: Identity-H ToUnicode: true Font: BaseFont: EOLCKM+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: CQJOMT+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: RECUMR+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MATBFN+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 13 FontDescriptor: FontName: MATBFN+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KEPREY+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: KEPREY+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NBXCFK+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NBXCFK+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VXCJFZ+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: VXCJFZ+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: CMKOLS+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CMKOLS+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: QRWTQO+TimesNewRomanPS-ItalicMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QRWTQO+TimesNewRomanPS-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -498, -307, 1120, 1023 FontFile2: true Font: BaseFont: EOLCKM+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: EOLCKM+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: CQJOMT+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CQJOMT+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: RECUMR+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RECUMR+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: KOYXAT+ArialUnicodeMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KOYXAT+ArialUnicodeMS Flags: Nonsymbolic FontBBox: -1011, -279, 2260, 1074 FontFile2: true XMP: application/pdf 10.1016/j.biopha.2021.112126 Elsevier Masson SAS Biomedicine & Pharmacotherapy, 143 (2021) 112126. doi:10.1016/j.biopha.2021.112126 Colitis Hyperalgesia Hypersensitivity Intestinal inflammation Pain Sigma 1 receptor Intestinal inflammation-associated hypersensitivity is attenuated in a DSS model of colitis in Sigma-1 knockout C57BL/6 mice Sergio López-Estévez Georgia Gris Beatriz de la Puente Alicia Carceller Vicente Martínez journal Biomedicine & Pharmacotherapy © 2021 The Author(s). Published by Elsevier Masson SAS. 0753-3322 143 1 November 2021 2021-11-01 112126 112126 10.1016/j.biopha.2021.112126 https://doi.org/10.1016/j.biopha.2021.112126 2010-04-23 true 10.1016/j.biopha.2021.112126 elsevier.com sciencedirect.com VoR 10.1016/j.biopha.2021.112126 noindex 2010-04-23 true 30th August 2021 sciencedirect.com elsevier.com Elsevier 2021-08-31T07:20:40+02:00 2021-08-30T15:33:33 2021-08-31T07:20:40+02:00 True 30th August 2021 Acrobat Distiller 8.1.0 (Windows) Colitis,Hyperalgesia,Hypersensitivity,Intestinal inflammation,Pain,Sigma 1 receptor uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:47e722a8-31e7-4edf-9620-ebf0d40b80fe http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 137, 576, 143, 587 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 144, 571, 216, 582 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 216, 571, 413, 582 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 119, 563, 125, 574 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 126, 563, 133, 574 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 133, 563, 140, 574 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 141, 566, 145, 571 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 141, 558, 145, 569 Flags: Print Destination: 701 Annotation: Subtype: Link Rect: 268, 209, 286, 217 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 422, 261, 440, 269 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 468, 240, 486, 248 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 98, 104, 178, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 274, 667, 397, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 188, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 212, 748, 381, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 39, 49, 131, 56 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 87, 647, 105, 655 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 74, 626, 96, 634 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 223, 605, 250, 613 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 193, 584, 208, 592 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 257, 563, 286, 571 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 214, 521, 229, 529 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 99, 134, 128, 142 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 338, 678, 365, 686 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 369, 657, 396, 665 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 486, 636, 502, 644 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 466, 615, 486, 623 Flags: Print Destination: 5 Annotation: Subtype: Link Rect: 478, 395, 498, 403 Flags: Print Destination: 5 Annotation: Subtype: Link Rect: 531, 133, 547, 141 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 384, 60, 400, 68 Flags: Print Destination: 46 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 151, 475, 167, 483 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 270, 196, 286, 204 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 129, 113, 145, 121 Flags: Print Destination: 46 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 175, 730, 196, 738 Flags: Print Destination: 12 Annotation: Subtype: Link Rect: 113, 626, 136, 634 Flags: Print Destination: 12 Annotation: Subtype: Link Rect: 179, 563, 199, 571 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 217, 532, 237, 540 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 121, 490, 142, 498 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 306, 699, 326, 707 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 309, 626, 329, 634 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 480, 502, 500, 510 Flags: Print Destination: 17 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 263, 432, 283, 439 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 125, 348, 145, 356 Flags: Print Destination: 23 Annotation: Subtype: Link Rect: 229, 327, 249, 335 Flags: Print Destination: 23 Annotation: Subtype: Link Rect: 153, 254, 173, 262 Flags: Print Destination: 23 Annotation: Subtype: Link Rect: 309, 379, 329, 387 Flags: Print Destination: 23 Annotation: Subtype: Link Rect: 471, 358, 491, 366 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 473, 264, 493, 272 Flags: Print Destination: 29 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 250, 439, 272, 446 Flags: Print Destination: 34 Annotation: Subtype: Link Rect: 222, 271, 243, 279 Flags: Print Destination: 34 Annotation: Subtype: Link Rect: 445, 480, 465, 488 Flags: Print Destination: 39 Annotation: Subtype: Link Rect: 382, 343, 420, 351 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 404, 280, 420, 288 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 499, 270, 515, 278 Flags: Print Destination: 46 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 250, 122, 266, 130 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 274, 101, 288, 109 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 37, 91, 49, 99 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 87, 70, 114, 78 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 543, 112, 557, 120 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 306, 101, 330, 109 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 529, 80, 545, 88 Flags: Print Destination: 46 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 140, 283, 167, 291 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 37, 252, 75, 260 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 242, 189, 276, 197 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 531, 293, 546, 301 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 355, 283, 370, 291 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 366, 273, 402, 281 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 437, 252, 495, 260 Flags: Print Destination: 46 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 213, 357, 240, 365 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 244, 315, 273, 323 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 239, 263, 255, 271 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 270, 252, 286, 260 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 37, 231, 53, 239 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 166, 127, 193, 135 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 270, 85, 286, 93 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 500, 315, 515, 323 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 335, 273, 351, 281 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 413, 273, 428, 281 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 473, 242, 500, 250 Flags: Print Destination: 46 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 71, 441, 178, 447 Flags: Print Annotation: Subtype: Link Rect: 53, 417, 179, 423 Flags: Print Annotation: Subtype: Link Rect: 202, 401, 274, 407 Flags: Print Annotation: Subtype: Link Rect: 53, 393, 109, 399 Flags: Print Annotation: Subtype: Link Rect: 183, 369, 275, 375 Flags: Print Annotation: Subtype: Link Rect: 53, 361, 109, 367 Flags: Print Annotation: Subtype: Link Rect: 103, 345, 229, 351 Flags: Print Annotation: Subtype: Link Rect: 264, 329, 286, 336 Flags: Print Annotation: Subtype: Link Rect: 53, 321, 194, 328 Flags: Print Annotation: Subtype: Link Rect: 241, 305, 286, 312 Flags: Print Annotation: Subtype: Link Rect: 53, 297, 116, 304 Flags: Print Annotation: Subtype: Link Rect: 181, 281, 284, 288 Flags: Print Annotation: Subtype: Link Rect: 53, 273, 284, 280 Flags: Print Annotation: Subtype: Link Rect: 53, 265, 215, 272 Flags: Print Annotation: Subtype: Link Rect: 160, 249, 274, 256 Flags: Print Annotation: Subtype: Link Rect: 54, 241, 77, 248 Flags: Print Annotation: Subtype: Link Rect: 82, 202, 230, 208 Flags: Print Annotation: Subtype: Link Rect: 251, 186, 283, 192 Flags: Print Annotation: Subtype: Link Rect: 54, 178, 152, 184 Flags: Print Annotation: Subtype: Link Rect: 191, 162, 281, 168 Flags: Print Annotation: Subtype: Link Rect: 54, 154, 96, 160 Flags: Print Annotation: Subtype: Link Rect: 210, 130, 282, 136 Flags: Print Annotation: Subtype: Link Rect: 54, 122, 109, 128 Flags: Print Annotation: Subtype: Link Rect: 82, 90, 209, 96 Flags: Print Annotation: Subtype: Link Rect: 211, 74, 283, 80 Flags: Print Annotation: Subtype: Link Rect: 54, 66, 109, 73 Flags: Print Annotation: Subtype: Link Rect: 447, 732, 519, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 393, 730 Flags: Print Annotation: Subtype: Link Rect: 402, 692, 523, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 455, 674 Flags: Print Annotation: Subtype: Link Rect: 358, 628, 482, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 550, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 535, 619 Flags: Print Annotation: Subtype: Link Rect: 323, 604, 347, 611 Flags: Print Annotation: Subtype: Link Rect: 351, 572, 498, 579 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 464, 555 Flags: Print Annotation: Subtype: Link Rect: 351, 509, 477, 515 Flags: Print Annotation: Subtype: Link Rect: 351, 477, 493, 483 Flags: Print Annotation: Subtype: Link Rect: 364, 453, 485, 459 Flags: Print Annotation: Subtype: Link Rect: 351, 429, 498, 435 Flags: Print Annotation: Subtype: Link Rect: 382, 397, 503, 403 Flags: Print Annotation: Subtype: Link Rect: 351, 373, 470, 380 Flags: Print Annotation: Subtype: Link Rect: 358, 341, 480, 348 Flags: Print Annotation: Subtype: Link Rect: 398, 309, 525, 316 Flags: Print Annotation: Subtype: Link Rect: 494, 278, 539, 284 Flags: Print Annotation: Subtype: Link Rect: 323, 270, 412, 276 Flags: Print Annotation: Subtype: Link Rect: 499, 238, 544, 244 Flags: Print Annotation: Subtype: Link Rect: 323, 230, 396, 236 Flags: Print Annotation: Subtype: Link Rect: 393, 198, 520, 204 Flags: Print Annotation: Subtype: Link Rect: 373, 166, 520, 172 Flags: Print Annotation: Subtype: Link Rect: 438, 142, 546, 148 Flags: Print Annotation: Subtype: Link Rect: 323, 134, 346, 140 Flags: Print Annotation: Subtype: Link Rect: 368, 102, 491, 109 Flags: Print Annotation: Subtype: Link Rect: 522, 70, 555, 77 Flags: Print Annotation: Subtype: Link Rect: 323, 62, 412, 69 Flags: Print Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 239, 716, 284, 722 Flags: Print Annotation: Subtype: Link Rect: 54, 708, 112, 714 Flags: Print Annotation: Subtype: Link Rect: 133, 684, 273, 690 Flags: Print Annotation: Subtype: Link Rect: 251, 660, 284, 666 Flags: Print Annotation: Subtype: Link Rect: 54, 652, 168, 658 Flags: Print Annotation: Subtype: Link Rect: 132, 628, 279, 635 Flags: Print Annotation: Subtype: Link Rect: 221, 604, 266, 611 Flags: Print Annotation: Subtype: Link Rect: 54, 596, 138, 603 Flags: Print Annotation: Subtype: Link Rect: 221, 572, 266, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 129, 571 Flags: Print Annotation: Subtype: Link Rect: 141, 533, 263, 539 Flags: Print Annotation: Subtype: Link Rect: 499, 716, 545, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 399, 714 Flags: Print Annotation: Subtype: Link Rect: 477, 676, 549, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 373, 674 Flags: Print Annotation: Subtype: Link Rect: 508, 644, 554, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 636, 400, 643 Flags: Print Annotation: Subtype: Link Rect: 323, 628, 555, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 548, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 530, 619 Flags: Print Annotation: Subtype: Link Rect: 455, 588, 549, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 358, 587 Flags: Print Annotation: Subtype: Link Rect: 491, 557, 537, 563 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 405, 555 Flags: Print Checksum: 7c6ed7c1 Type: CRC32 Checksum: a9057ad0624434455811df4d15eb9055 Type: MD5 Checksum: 159959b9b02c76f9d9736419280670254464b4f2 Type: SHA-1 Checksum: ac0fd16a89170e05940061c65270df802e52d692a5ee887c12b2867a80803f84 Type: SHA-256