2c2803d2c4014f186f109bb408bb1ce5 PIIS0092867421008916.pdf effe4a5da98ade0098a50cc27fff894ad9b3216c PIIS0092867421008916.pdf e2e123cc3bd729cdec945ee594714d01af23068af36c9050c580b1f33a60ec8c PIIS0092867421008916.pdf Title: Ancient and modern genomes unravel the evolutionary history of the rhinoceros family Subject: Cell, Corrected proof. doi:10.1016/j.cell.2021.07.032 Author: Shanlin Liu Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Aug 19 15:26:22 2021 CEST ModDate: Thu Aug 19 15:28:18 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 29 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 6234756 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MGEIGK+AdvPSHN-H Type 1C WinAnsi yes yes no 2252 0 MGEIGL+AdvPSHN-M Type 1C MacRoman yes yes 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object 'mmc5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'mmc1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'cor2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff35' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fn1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'cor3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fn2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'mmc4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff33' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor2' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc5' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff30' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff2' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff34' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff27' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mmc4' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff31' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff28' cannot be found ID: PDF-HUL-122 Offset: 6181112 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff35' 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Outlines: Item: Title: CELL12139_proof.pdf Children: Item: Title: Ancient and modern genomes unravel the evolutionary history of the rhinoceros family Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: Resolving the rhinoceros phylogeny Destination: slink3 Item: Title: Gene flow among species Destination: slink4 Item: Title: Timing of divergence between species Destination: slink5 Item: Title: Drivers of low genetic diversity Destination: slink6 Item: Title: Demography and mutational load Destination: slink7 Item: Title: Discussion Destination: flink8 Children: Item: Title: Limitations of the study Destination: slink9 Item: Title: Supplemental information Destination: falink10 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: acklink2 Item: Title: Declaration of interests Destination: acklink3 Item: Title: Supporting citations Destination: flink11 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink12 Children: Item: Title: Key resources table Destination: slink13 Item: Title: Resource availability Destination: slink14 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Experimental model and subject details Destination: slink15 Children: Item: Title: Source organisms Destination: tlink4 Item: Title: Method details Destination: slink16 Children: Item: Title: DNA isolation and sequencing Destination: tlink5 Item: Title: Genome assembly and annotation Destination: tlink6 Item: Title: Genome alignment and phylogenetic inference Destination: tlink7 Item: Title: Molecular dating Destination: tlink8 Item: Title: Alignment tool selection Destination: tlink9 Item: Title: Gene flow Destination: tlink10 Item: Title: Heterozygosity estimation Destination: tlink11 Item: Title: Demographic inference and Runs of Homozygosity (ROH) estimation Destination: tlink12 Item: Title: Genetic load and identification for rhinoceros specific frameshift mutation Destination: tlink13 Item: Title: Test of heterozygosity, PSMC and ROH estimation for the non-modern rhino samples Destination: tlink14 Item: Title: Quantification and statistical analysis Destination: slink17 Item: Title: Additional resources Destination: slink18 Info: Title: Ancient and modern genomes unravel the evolutionary history of the rhinoceros family Author: Shanlin Liu Subject: Cell, Corrected proof. doi:10.1016/j.cell.2021.07.032 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Aug 19 15:56:22 CEST 2021 ModDate: Thu Aug 19 15:58:18 CEST 2021 ID: 0xf7acba1b1433db2d39e5ad204f45c363, 0x0d2a397213e087419bfccaec1469d6f4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG 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FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MFHAAA+AdvPS4731B1 FontSubset: true FirstChar: 37 LastChar: 82 FontDescriptor: FontName: MFHAAA+AdvPS4731B1 Flags: Nonsymbolic FontBBox: 0, -208, 1572, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGEIGM+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: MGEIGM+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: MFGOAH+ArialNarrow-Bold FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: MFGOAH+ArialNarrow-Bold Flags: Nonsymbolic FontBBox: -137, -307, 1000, 1109 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: MFGOAF+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MFGOAF+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true XMP: application/pdf doi:10.1016/j.cell.2021.07.032 Ancient and modern genomes unravel the evolutionary history of the rhinoceros family Shanlin Liu Michael V. Westbury Nicolas Dussex Kieren J. Mitchell Mikkel-Holger S. Sinding Peter D. Heintzman David A. Duchêne Joshua D. Kapp Johanna von Seth Holly Heiniger Fátima Sánchez-Barreiro Ashot Margaryan Remi André-Olsen Binia De Cahsan Guanliang Meng Chentao Yang Lei Chen Tom van der Valk Yoshan Moodley Kees Rookmaaker Michael W. Bruford Oliver Ryder Cynthia Steiner Linda G.R. Bruins-van Sonsbeek Sergey Vartanyan Chunxue Guo Alan Cooper Pavel Kosintsev Irina Kirillova Adrian M. Lister Tomas Marques-Bonet Shyam Gopalakrishnan Robert R. Dunn Eline D. Lorenzen Beth Shapiro Guojie Zhang Pierre-Olivier Antoine Love Dalén M. Thomas P. Gilbert Rhinoceros, Perissodactyl, Conservation genomics, Phylogenomics, Genomic diversity. Cell, Corrected proof. doi:10.1016/j.cell.2021.07.032 Elsevier Inc. journal Cell © 2021 The Authors. Published by Elsevier Inc. 0092-8674 10.1016/j.cell.2021.07.032 https://doi.org/10.1016/j.cell.2021.07.032 P 7.0 10.1016/j.cell.2021.07.032 noindex true Elsevier 2021-08-19T18:56:22+05:30 2021-08-19T18:58:18+05:30 2021-08-19T18:58:18+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:f8aabe32-4b1f-4dde-8d8b-f820939330e2 uuid:cc764403-1906-49b7-a642-c091fffa1790 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 354, 531, 459, 541 Annotation: Subtype: Link Rect: 354, 519, 441, 529 Annotation: Subtype: Link Rect: 354, 507, 446, 517 Annotation: Subtype: Link Rect: 100, 48, 260, 56 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 100, 605, 106, 614 Destination: null Annotation: Subtype: Link Rect: 106, 605, 112, 614 Destination: null Annotation: Subtype: Link Rect: 112, 605, 121, 614 Destination: null Annotation: Subtype: Link Rect: 121, 605, 124, 614 Destination: null Annotation: Subtype: Link Rect: 214, 605, 218, 614 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