c320a6960c06c9cf821d1bbdfe3c9478 249131.pdf 45da356d63cb76bd490ced245d39ec589081e19c 249131.pdf 3fcf9972baec4281917f74573da42b9115caba2ee1ec74b71e01cc39e6fd1916 249131.pdf Title: Extrapolation: Experience gained from original biologics Subject: Drug Discovery Today, 26 (2021) 2003-2013. doi:10.1016/j.drudis.2021.05.006 Author: Luisa-Fernanda Rojas-Chavarro Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Sat Aug 21 14:49:35 2021 CEST ModDate: Sat Aug 21 14:50:05 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 612.283 x 793.701 pts Page rot: 0 File size: 729243 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CGMCJJ+AdvOTc243060c Type 1C WinAnsi yes yes no 910 0 CGMCJK+AdvPSMPi6 Type 1C WinAnsi yes yes no 907 0 CGMCMK+AdvPSSym Type 1C Custom yes yes no 917 0 CGMCGP+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 888 0 CGMCHA+AdvCORRESAST Type 1C Custom yes yes yes 889 0 CGMCIA+AdvOT46dcae81 Type 1C WinAnsi yes yes no 890 0 CGMCIB+AdvOTa554f99f.B Type 1C WinAnsi yes yes no 891 0 CGMCIC+AdvOTa554f99f.B+fb Type 1C Custom yes yes yes 885 0 CGMCID+AdvOTa554f99f.B+20 Type 1C WinAnsi yes yes no 893 0 CGMCIE+AdvOTf8f9f135 Type 1C WinAnsi yes yes no 894 0 CGMCIF+AdvOTf8f9f135+fb Type 1C Custom yes yes yes 901 0 CGMCIG+AdvOTf8f9f135+20 Type 1C WinAnsi yes yes no 902 0 CGMCJH+AdvPSMP10 Type 1C WinAnsi yes yes no 908 0 CGMCJI+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 909 0 CGMCPK+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 612 0 CGMCPL+AdvPSMy-R Type 1C WinAnsi yes yes no 614 0 CGMDBL+AdvPSMP13 Type 1C WinAnsi yes yes no 623 0 CGMDBM+AdvOT96bfafc3.I Type 1C WinAnsi yes yes no 619 0 CGMDCM+AdvOT46dcae81+fb Type 1C Custom yes yes yes 625 0 CGMDIL+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 626 0 CGMDIM+AdvP4C4E74 Type 1C Custom yes yes no 627 0 CGMOGK+Calibri Type 1C Custom yes yes yes 629 0 CGMPBH+Calibri-Bold Type 1C WinAnsi yes yes no 630 0 CGMPCI+AdvPSHEL-O Type 1C WinAnsi yes yes no 628 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-18 02:33:36 CET RepresentationInformation: 249131.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-17 23:58:01 CET Size: 729243 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para2' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para22' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para25' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para29' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para31' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para34' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para41' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para43' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para46' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para47' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para48' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para49' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para50' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para51' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para52' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para53' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para54' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para55' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para56' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para57' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para58' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para59' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para60' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para61' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para62' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para63' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para64' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para65' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para66' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para67' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para68' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para69' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para70' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para71' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para72' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para73' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para74' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para75' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para76' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para77' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para78' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para79' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para80' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para81' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para82' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para83' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para84' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para85' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para86' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para87' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para88' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para89' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para90' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para91' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para92' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para93' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para94' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para95' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para96' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para97' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para98' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para99' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para100' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para101' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para102' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para103' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para104' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para105' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para106' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para107' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para108' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para109' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para110' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para111' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para112' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para113' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para114' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para115' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para116' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para117' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para118' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para119' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para120' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para121' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para122' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para123' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para124' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para125' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para126' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para127' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para128' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para129' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para130' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para131' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para132' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para133' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para134' cannot be found Offset: 696735 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para135' cannot be found 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FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGMCIB+AdvOTa554f99f.B FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: CGMCIB+AdvOTa554f99f.B Flags: Serif, Nonsymbolic FontBBox: -93, -250, 1072, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGMCID+AdvOTa554f99f.B+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: CGMCID+AdvOTa554f99f.B+20 Flags: Nonsymbolic FontBBox: -187, -187, 1312, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGMCIE+AdvOTf8f9f135 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: CGMCIE+AdvOTf8f9f135 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 937 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.drudis.2021.05.006 Extrapolation: Experience gained from original biologics Luisa-Fernanda Rojas-Chavarro Fernando de Mora Adalimumab Biologic Biosimilar Canakinumab Darbepoetin Extrapolation Manufacturing change Omalizumab Trastuzumab Drug Discovery Today, 26 (2021) 2003-2013. doi:10.1016/j.drudis.2021.05.006 The Author(s) journal Drug Discovery Today © 2021 The Author(s). Published by Elsevier Ltd. 1359-6446 26 8 August 2021 2003-2013 2003 2013 10.1016/j.drudis.2021.05.006 https://doi.org/10.1016/j.drudis.2021.05.006 2010-04-23 true 10.1016/j.drudis.2021.05.006 elsevier.com sciencedirect.com VoR 10.1016/j.drudis.2021.05.006 noindex 2010-04-23 true elsevier.com sciencedirect.com sciencedirect.com elsevier.com Elsevier 2021-08-21T18:20:05+05:30 2021-08-21T18:19:35+05:30 2021-08-21T18:20:05+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:436f305f-5923-44f6-9a33-f136f4a00a1b uuid:bd9a2854-6914-4437-a8c7-9709e460d75c http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 2003 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 42, 628, 42, 638 Destination: null Annotation: Subtype: Link Rect: 42, 569, 42, 597 Destination: null Annotation: Subtype: Link Rect: 42, 519, 42, 533 Destination: null Annotation: Subtype: Link Rect: 363, 524, 368, 537 Destination: 826 Annotation: Subtype: Link Rect: 42, 492, 42, 500 Destination: null 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