6d22c04e88ff888f91e486073a8839f9 combio_a2021m4v4p448.pdf be44f9d4d5146f63f4c57746f7ddd8c2b794e92f combio_a2021m4v4p448.pdf c49ab2d3ff8062d6244e3b7b631ed6014e8da0eb9941581345c90b66785d6158 combio_a2021m4v4p448.pdf Title: The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm Subject: Communications Biology, doi:10.1038/s42003-021-01968-8 Keywords: Author: Daniel Yero Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Apr 1 09:24:27 2021 CEST ModDate: Wed Sep 15 18:20:04 2021 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 3157326 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HOPMEG+AdvOTea1a7398 Type 1C WinAnsi 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object 'bm_CR73' cannot be found Offset: 3104531 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR74' cannot be found Offset: 3104531 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR75' cannot be found Offset: 3104531 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR76' cannot be found Offset: 3104531 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 936 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the p攀爀椀瀀氀愀猀洩㸾൥湤潢樍㤰㘠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠㜯䑥獴⣾＀䄀ㄩ⽆‰⽆楲獴‹㈸‰⁒⽌慳琠㤲㤠〠刯乥硴‹ㄷ‰⁒⽐慲敮琠㤰㔠〠刯呩瑬攨Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Ttg2DPae contains a large hydrophobic cavity that binds four acyl tails Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: The Ttg2D/MlaC fold: a new two-domain architecture and SBP structural cluster Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Evolution of sequence and structural diversity of the MlaC family Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Ttg2DPae binds two diacyl glycerophospholipids and cardiolipin, to our knowledge representing a novel phospholipid trafficking 洀攀挀栀愀渀椀猀洀 愀洀漀渀最 䜀爀愀洀ⴀ渀攀最愀琀椀瘀攀 戀愀挀琀攀爀椀愩㸾൥湤潢樍㤳㌠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䈀㌩⽆‰⽎數琠㤳㈠〠刯偡牥湴‹〶‰⁒⽐牥瘠㤳㐠〠刯呩瑬攨Evolution of sequence and structural diversity of the MlaC family Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Ttg2DPae binds two diacyl glycerophospholipids or cardiolipin in the periplasm of P. aeruginosa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: The Ttg2’system provides P. aeruginosa with a mechanism of resistance to membrane-damaging agents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: The Ttg2’system is associated to P. aeruginosa’s intrinsic resistance to low antibiotic concentrations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Bacterial strains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Expression, purification, and preparation of Ttg2DPae protein variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Ttg2DPae structure resolution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Delipidation of purified recombinant Ttg2DPae Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Native MS analysis and identification of bound phospholipids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Cardiolipin binding to Ttg2DPae by native MS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Generation of markerless ttg2 mutants in MDR P. aeruginosa strains and complementations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: OM permeabilization assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Susceptibility to antibiotics and membrane-damaging agents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Biofilm formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Bioinformatic analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Statistics and reproducibility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Competing interests Destination: 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Daura Springer US Communications Biology, doi:10.1038/s42003-021-01968-8 10.1038/s42003-021-01968-8 http://dx.doi.org/10.1038/s42003-021-01968-8 journal Communications Biology © 2021, The Author(s) 2399-3642 10.1038/s42003-021-01968-8 springer.com springerlink.com 2010-04-23 True 10.1038/s42003-021-01968-8 springer.com springerlink.com Springer 2021-09-15T18:20:04+02:00 2021-04-01T12:54:27+05:30 2021-09-15T18:20:04+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:4a834f55-db5b-40b4-86ea-b82f24fd8fe8 uuid:2283e68a-5570-4a93-847d-37af9f3c881f default 1 converted uuid:f8c1c8c4-c677-4df6-bd24-23d802124b05 converted to PDF/A-2b pdfToolbox 2021-04-01T12:55:24+05:30 2 B Daniel Yero http://orcid.org/0000-0002-6234-4082 Lionel Costenaro http://orcid.org/0000-0002-6157-6682 Oscar Conchillo-Solé http://orcid.org/0000-0003-4266-246X Marta Vilaseca http://orcid.org/0000-0002-1666-1300 Isidre Gibert http://orcid.org/0000-0003-1442-2258 Xavier Daura 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