4fab13beed4852a690e0182fecddf835 pharmaceutics_a2021v13n9p1336.pdf a74d35ea1bc56bb20c77e4491785bf2f7ddcce19 pharmaceutics_a2021v13n9p1336.pdf 2d8eaa4f19612d9fe60198fb715a338bbff88f6d770d1ef1519768a0c58c46d8 pharmaceutics_a2021v13n9p1336.pdf Title: Wharton’s Jelly Mesenchymal Stromal Cells and Derived Extracellular Vesicles as Post-Myocardial Infarction Therapeutic Toolkit: An Experienced View Subject: Outstanding progress has been achieved in developing therapeutic options for reasonably alleviating symptoms and prolonging the lifespan of patients suffering from myocardial infarction (MI). Current treatments, however, only partially address the functional recovery of post-infarcted myocardium, which is in fact the major goal for effective primary care. In this context, we largely investigated novel cell and TE tissue engineering therapeutic approaches for cardiac repair, particularly using multipotent mesenchymal stromal cells (MSC) and natural extracellular matrices, from pre-clinical studies to clinical application. A further step in this field is offered by MSC-derived extracellular vesicles (EV), which are naturally released nanosized lipid bilayer-delimited particles with a key role in cell-to-cell communication. Herein, in this review, we further describe and discuss the rationale, outcomes and challenges of our evidence-based therapy approaches using Wharton’s jelly MSC and derived EV in post-MI management. Keywords: biomanufacturing; cardiac tissue engineering; clinical translation; extracellular vesicles; mesenchymal stromal cells; myocardial infarction; Wharton’s jelly Author: Noelia Muñoz-Domínguez, Santiago Roura, Cristina Prat-Vidal and Joaquim Vives Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Aug 26 10:26:28 2021 CEST ModDate: Thu Aug 26 10:30:27 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1369810 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OPNYWB+VnURWPalladioL Type 1 Custom yes yes no 10 0 AWUBXU+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 HCYGTC+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 IXXSNN+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 IQNYER+CMSY10 Type 1 Builtin yes yes no 28 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 IAFAOG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 41 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 69 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 73 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 77 0 ZXDKIP+EURM10 Type 1 Builtin yes yes no 89 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 101 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 105 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 109 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 113 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 146 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 150 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 154 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 158 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-10 03:06:45 CET RepresentationInformation: pharmaceutics_a2021v13n9p1336.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-01-28 10:57:04 CET Size: 1369810 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 465 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Foundations of an Advanced Post-Myocardial Infarction Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Wharton’s Jelly Mesenchymal Stromal Cells: The Active Ingredient Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Cardiac Extracellular Matrices: The Supportive Vehicles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Evidence-Based Pre-Clinical Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: PeriCord: A Valuable CASE in Scalability and GMP Biomanufacturing of Cardiac Bioimplants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Mesenchymal Stromal Cell-Secreted Extracellular Vesicles: The Envisioned Alternative Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: MSC-EV-Based Products: Clinical Perspectives and Biomanufacturing Challenges Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: Wharton’s Jelly Mesenchymal Stromal Cells and Derived Extracellular Vesicles as Post-Myocardial Infarction Therapeutic Toolkit: An Experienced View Author: Noelia Muñoz-Domínguez, Santiago Roura, Cristina Prat-Vidal and Joaquim Vives Subject: Outstanding progress has been achieved in developing therapeutic options for reasonably alleviating symptoms and prolonging the lifespan of patients suffering from myocardial infarction (MI). Current treatments, however, only partially address the functional recovery of post-infarcted myocardium, which is in fact the major goal for effective primary care. In this context, we largely investigated novel cell and TE tissue engineering therapeutic approaches for cardiac repair, particularly using multipotent mesenchymal stromal cells (MSC) and natural extracellular matrices, from pre-clinical studies to clinical application. A further step in this field is offered by MSC-derived extracellular vesicles (EV), which are naturally released nanosized lipid bilayer-delimited particles with a key role in cell-to-cell communication. Herein, in this review, we further describe and discuss the rationale, outcomes and challenges of our evidence-based therapy approaches using Wharton’s jelly MSC and derived EV in post-MI management. 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