d413746d1b66b32bc80062cdeb120373 processes_a2021v9n11p1873.pdf 4ae9a9e471dc81f40ceb0b138b4d421c43592b77 processes_a2021v9n11p1873.pdf 4378e76679346238c21cb3b9c82461120c22e9016a7606ab74266ba20e82c54f processes_a2021v9n11p1873.pdf Title: The Dark Side of Platinum Based Cytostatic Drugs: From Detection to Removal Subject: The uncontrolled release of pharmaceutical drugs into the environment raised serious concerns in the last decades as they can potentially exert adverse effects on living organisms even at the low concentrations at which they are typically found. Among them, platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. In this review, the studies on environmental occurrence, transformation, potential ecotoxicity, and possible treatment for the removal of platinum cytostatic compounds are revised. The analysis of the literature highlighted the generally low total platinum concentration values (from a few tens of ng L-1 to a few hundred g L-1) found in hospital effluents. Additionally, several studies highlighted how hospitals are sources of a minor fraction of the total Pt CDs found in the environment due to the slow excretion rate which is longer than the usual treatment durations. Only some data about the impact of the exposure to low levels of Pt CDs on the health of flora and fauna are present in literature. In some cases, adverse effects have been shown to occur in living organisms, even at low concentrations. Further ecotoxicity data are needed to support or exclude their chronic effects on the ecosystem. Finally, fundamental understanding is required on the platinum drugs removal by MBR, AOPs, technologies, and adsorption. Keywords: cytostatic drugs; water treatment; environmental remediation; emerging pollutants Author: Yessica Roque-Diaz, Martina Sanadar, Dong Han, Montserrat López-Mesas, Manuel Valiente, Marilena Tolazzi, Andrea Melchior and Daniele Veclani Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Oct 21 10:51:12 2021 CEST ModDate: Fri Oct 22 07:22:27 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 26 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3133688 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNKDOL+VnURWPalladioL Type 1 Custom yes yes no 10 0 XNSZMW+EURM10 Type 1 Builtin yes yes no 15 0 KAKXVQ+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 AKEWFO+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 JRFBVD+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 VVYUGW+CMSY10 Type 1 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Size: 3133688 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 791 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Action Mechanism, Speciation and Determinations Analysis of Pt-Based CDs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Reactivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Prediction of Platinum-Based CDs Release into the Environment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Analytical Techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Biological Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Environmental Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Working Environments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Predicted Behavior in the Aquatic and Related Environments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Ecotoxicological Potency Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Impact of Water Treatment Technologies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Children: Item: Title: Membrane Bioreactors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Advanced Oxidation Processes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Adsorption Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: The Dark Side of Platinum Based Cytostatic Drugs: From Detection to Removal Author: Yessica Roque-Diaz, Martina Sanadar, Dong Han, Montserrat López-Mesas, Manuel Valiente, Marilena Tolazzi, Andrea Melchior and Daniele Veclani Subject: The uncontrolled release of pharmaceutical drugs into the environment raised serious concerns in the last decades as they can potentially exert adverse effects on living organisms even at the low concentrations at which they are typically found. Among them, platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. In this review, the studies on environmental occurrence, transformation, potential ecotoxicity, and possible treatment for the removal of platinum cytostatic compounds are revised. The analysis of the literature highlighted the generally low total platinum concentration values (from a few tens of ng L-1 to a few hundred g L-1) found in hospital effluents. Additionally, several studies highlighted how hospitals are sources of a minor fraction of the total Pt CDs found in the environment due to the slow excretion rate which is longer than the usual treatment durations. Only some data about the impact of the exposure to low levels of Pt CDs on the health of flora and fauna are present in literature. In some cases, adverse effects have been shown to occur in living organisms, even at low concentrations. Further ecotoxicity data are needed to support or exclude their chronic effects on the ecosystem. Finally, fundamental understanding is required on the platinum drugs removal by MBR, AOPs, technologies, and adsorption. 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