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Item: Title: Variables. Item: Title: RNA extraction. Item: Title: Genome-wide transcriptome study. Item: Title: qRT-PCR. Item: Title: ISH. Item: Title: Statistical methods. Item: Title: Expression profile. Item: Title: Enrichment pathways analysis. Item: Title: Ethical issues. Item: Title: Results Children: Item: Title: Differential expression study. Children: Item: Title: GWTS study. Item: Title: qRT-PCR study. Item: Title: ISH. Item: Title: Cognition evaluation. Item: Title: Expression profile. Item: Title: Pathway enrichment analysis. Item: Title: Discussion Children: Item: Title: Limitations. Item: Title: Conclusions Item: Title: References Item: Title: Acknowledgements Info: Title: Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment Author: Elena Muiño Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-86349-1 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Mar 19 08:08:30 CET 2021 ModDate: Fri Mar 19 11:44:08 CET 2021 ID: 0x94ecb7395f9eef00dedc018604ca2723, 0x9471507a9ee46151daccb7ff695b30ef Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1067 ImageHeight: 1352 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2012 ImageHeight: 1224 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1063 ImageHeight: 1361 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: ACJWON+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: VCAXWX+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: NLOLON+Code2000 Encoding: Identity-H ToUnicode: true Font: BaseFont: ACJWON+Corbel-BoldItalic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: EROGTS+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EROGTS+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: Corbel2 FirstChar: 32 LastChar: 250 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: XIMOYT+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: XIMOYT+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic2 Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: ACJWON+Corbel-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ACJWON+Corbel-BoldItalic Flags: Symbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Font: BaseFont: NLOLON+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NLOLON+Code2000 Flags: Serif, Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true Font: BaseFont: VCAXWX+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VCAXWX+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: ACJWON+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ACJWON+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2021-03-19T12:08:30+05:30 Springer 2021-03-19T11:44:08+01:00 2021-03-19T11:44:08+01:00 application/pdf https://doi.org/10.1038/s41598-021-86349-1 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-86349-1 Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment Elena Muiño Olga Maisterra Joan Jiménez-Balado Natalia Cullell Caty Carrera Nuria P. 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