3a2d0dcd31a67a2a00efe8114233948d 255433.pdf a8518b3093e37628aea8c26589844483d2c95af9 255433.pdf 9399577d7214fd771b3dd7fd55f48208347807624ac5d2c122b66561e6d8bdcb 255433.pdf Title: High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain Subject: Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD. Keywords: diabetes mellitus; haemodialysis; diabetic foot syndrome; foot ulcer; amputation; all-cause mortality; cardiovascular mortality; survival Author: Montserrat Dòria, Àngels Betriu, Montserrat Belart, Verónica Rosado, Marta Hernández, Felipe Sarro, Jordi Real, Esmeralda Castelblanco, Linda Roxana Pacheco, Elvira Fernández, Josep Franch-Nadal, Mònica Gratacòs and Dídac Mauricio Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Mar 29 09:39:17 2021 CEST ModDate: Fri Apr 9 04:59:51 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 705209 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VEAELY+VnURWPalladioL Type 1 Custom yes yes no 10 0 YYSHVL+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 NSSIKB+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 ZIHPSW+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 YKIHBZ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 LGTZLE+CMSY10 Type 1 Builtin yes yes no 84 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 91 0 GBKNIF+Arial CID TrueType Identity-H yes yes yes 105 0 GBKNKH+Arial,Italic TrueType WinAnsi yes yes no 111 0 GBKKLO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 114 0 GBKKMA+PalatinoLinotype TrueType WinAnsi yes yes no 117 0 GBKKMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 120 0 GBKNIE+Arial,Bold CID TrueType Identity-H yes yes yes 123 0 GBKNIF+Arial CID TrueType Identity-H yes yes yes 136 0 GBKNKH+Arial,Italic TrueType WinAnsi yes yes no 142 0 GBKKLO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 145 0 GBKKMA+PalatinoLinotype TrueType WinAnsi yes yes no 148 0 GBKKMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 151 0 GBKNIE+Arial,Bold CID TrueType Identity-H yes yes yes 154 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-05 02:44:51 CET RepresentationInformation: 255433.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-04 08:53:16 CET Size: 705209 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 329 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Studied Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Outcomes at 5-Years Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Predictors of All-Cause Mortality and CV Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Overall Dialysis Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: DM Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain Author: Montserrat Dòria, Àngels Betriu, Montserrat Belart, Verónica Rosado, Marta Hernández, Felipe Sarro, Jordi Real, Esmeralda Castelblanco, Linda Roxana Pacheco, Elvira Fernández, Josep Franch-Nadal, Mònica Gratacòs and Dídac Mauricio Subject: Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD. 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