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Keywords: atherosclerosis, PCSK9 (proprotein convertase subtilisin kexin type 9), lipoprotein receptors, inflammation, lipid loading, LDL—cholesterol Author: Maria Borrell-Pages Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Mar 17 09:00:04 2021 CET ModDate: Wed Mar 17 09:41:36 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1377972 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 43 0 ZLOTGF+HelveticaNeueLTStd-LtIt Type 1C WinAnsi yes yes no 45 0 BCIPMH+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 50 0 CNAVPH+MinionPro-Regular Type 1C Custom yes yes no 52 0 BLOTRV+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 25 0 TAQMLJ+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 30 0 FUNDMM+MinionPro-Bold Type 1C Custom yes yes no 81 0 SMXEOC+MTSY Type 1C Custom yes yes no 83 0 VQKLYF+MTGU Type 1C Custom yes yes no 124 0 CBMNMC+MinionPro-It Type 1C WinAnsi yes yes no 158 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-03 02:39:17 CET RepresentationInformation: 255449.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-02 16:21:40 CET Size: 1377972 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 472 FreeObjects: 18 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: PCSK9 Modulates Macrophage's Lipid-Uptake Receptors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: PCSK9 Modulates Vascular Inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: PCSK9 Participates in Plaque Formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Role of PCSK9 in Inflammation in the Adaptive Immune System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: PCSK9'S Role in Familial Hypercholesterolemia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: PCSK9 and Platelet Thrombosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Concluding Remarks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Info: Title: PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation Author: Maria Borrell-Pages Subject: The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits observed in patients that have followed PCSK9-targeted therapies. Keywords: atherosclerosis, PCSK9 (proprotein convertase subtilisin kexin type 9), lipoprotein receptors, inflammation, lipid loading, LDL cholesterol Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Mar 17 09:30:04 CET 2021 ModDate: Wed Mar 17 10:11:36 CET 2021 ID: 0xe818242b9caaa6b32dc84a2c491532e0, 0x7db436331511e142b8281bfaa3ed77d3 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1335 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1074 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: FUNDMM+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: FUNDMM+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 660, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BCIPMH+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 117 FontDescriptor: FontName: BCIPMH+HelveticaNeueLTStd-MdIt Flags: Nonsymbolic FontBBox: -27, -205, 891, 714 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: SMXEOC+MTSY FontSubset: true FirstChar: 3 LastChar: 67 FontDescriptor: FontName: SMXEOC+MTSY Flags: Symbolic FontBBox: 0, -205, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CNAVPH+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: CNAVPH+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 855 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BLOTRV+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: BLOTRV+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -9, -214, 870, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VQKLYF+MTGU FontSubset: true FirstChar: 97 LastChar: 107 FontDescriptor: FontName: VQKLYF+MTGU Flags: Symbolic FontBBox: 0, -206, 519, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ZLOTGF+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 40 LastChar: 252 FontDescriptor: FontName: ZLOTGF+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 907 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: TAQMLJ+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 149 FontDescriptor: FontName: TAQMLJ+HelveticaNeueLTStd-Lt Flags: Serif, Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CBMNMC+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: CBMNMC+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 1003, 712 FontFile3: true Encoding: WinAnsiEncoding XMP: 2021-03-17T13:30:04+05:30 LaTeX with hyperref package + hypdvips 2021-03-17T14:11:36+05:30 2021-03-17T14:11:36+05:30 application/pdf The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits observed in patients that have followed PCSK9-targeted therapies. 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