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IFDKAD+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFCMAH+AdvOT7d6df7ab.I+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IFCMAH+AdvOT7d6df7ab.I+03 Flags: Symbolic FontBBox: -62, -270, 906, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IFCLPE+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: IFCLPE+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFCLPF+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IFCLPF+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41467-021-22491-8 Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Itziar Rojas Sonia Moreno-Grau Niccolo Tesi Benjamin Grenier-Boley Victor Andrade Iris E. Jansen Nancy L. Pedersen Najada Stringa Anna Zettergren Isabel Hernández Laura Montrreal Carmen Antúnez Anna Antonell Rick M. Tankard Joshua C. Bis Rebecca Sims Céline Bellenguez Inés Quintela Antonio González-Perez Miguel Calero Emilio Franco-Macías Juan Macías Rafael Blesa Laura Cervera-Carles Manuel Menéndez-González Ana Frank-García Jose Luís Royo Fermin Moreno Raquel Huerto Vilas Miquel Baquero Mónica Diez-Fairen Carmen Lage Sebastián García-Madrona Pablo García-González Emilio Alarcón-Martín Sergi Valero Oscar Sotolongo-Grau Abbe Ullgren Adam C. Naj Afina W. Lemstra Alba Benaque Alba Pérez-Cordón Alberto Benussi Alberto Rábano Alessandro Padovani Alessio Squassina Alexandre de Mendonça Alfonso Arias Pastor Almar A. L. Kok Alun Meggy Ana Belén Pastor Ana Espinosa Anaïs Corma-Gómez Angel Martín Montes Ángela Sanabria Anita L. DeStefano Anja Schneider Annakaisa Haapasalo Anne Kinhult Ståhlbom Anne Tybjærg-Hansen Annette M. Hartmann Annika Spottke Arturo Corbatón-Anchuelo Arvid Rongve Barbara Borroni Beatrice Arosio Benedetta Nacmias Børge G. Nordestgaard Brian W. Kunkle Camille Charbonnier Carla Abdelnour Carlo Masullo Carmen Martínez Rodríguez Carmen Muñoz-Fernandez Carole Dufouil Caroline Graff Catarina B. Ferreira Caterina Chillotti Chandra A. Reynolds Chiara Fenoglio Christine Van Broeckhoven Christopher Clark Claudia Pisanu Claudia L. Satizabal Clive Holmes Dolores Buiza-Rueda Dag Aarsland Dan Rujescu Daniel Alcolea Daniela Galimberti David Wallon Davide Seripa Edna Grünblatt Efthimios Dardiotis Emrah Düzel Elio Scarpini Elisa Conti Elisa Rubino Ellen Gelpi Eloy Rodriguez-Rodriguez Emmanuelle Duron Eric Boerwinkle Evelyn Ferri Fabrizio Tagliavini Fahri Küçükali Florence Pasquier Florentino Sanchez-Garcia Francesca Mangialasche Frank Jessen Gaël Nicolas Geir Selbæk Gemma Ortega Geneviève Chêne Georgios Hadjigeorgiou Giacomina Rossi Gianfranco Spalletta Giorgio Giaccone Giulia Grande Giuliano Binetti Goran Papenberg Harald Hampel Henri Bailly Henrik Zetterberg Hilkka Soininen Ida K. Karlsson Ignacio Alvarez Ildebrando Appollonio Ina Giegling Ingmar Skoog Ingvild Saltvedt Innocenzo Rainero Irene Rosas Allende Jakub Hort Janine Diehl-Schmid Jasper Van Dongen Jean-Sebastien Vidal Jenni Lehtisalo Jens Wiltfang Jesper Qvist Thomassen Johannes Kornhuber Jonathan L. Haines Jonathan Vogelgsang Juan A. Pineda Juan Fortea Julius Popp Jürgen Deckert Katharina Buerger Kevin Morgan Klaus Fließbach Kristel Sleegers Laura Molina-Porcel Lena Kilander Leonie Weinhold Lindsay A. Farrer Li-San Wang Luca Kleineidam Lucia Farotti Lucilla Parnetti Lucio Tremolizzo Lucrezia Hausner Luisa Benussi Lutz Froelich M. Arfan Ikram M. Candida Deniz-Naranjo Magda Tsolaki Maitée Rosende-Roca Malin Löwenmark Marc Hulsman Marco Spallazzi Margaret A. Pericak-Vance Margaret Esiri María Bernal Sánchez-Arjona Maria Carolina Dalmasso María Teresa Martínez-Larrad Marina Arcaro Markus M. Nöthen Marta Fernández-Fuertes Martin Dichgans Martin Ingelsson Martin J. Herrmann Martin Scherer Martin Vyhnalek Mary H. Kosmidis Mary Yannakoulia Matthias Schmid Michael Ewers Michael T. Heneka Michael Wagner Michela Scamosci Miia Kivipelto Mikko Hiltunen Miren Zulaica Montserrat Alegret Myriam Fornage Natalia Roberto Natasja M. van Schoor Nazib M. Seidu Nerisa Banaj Nicola J. Armstrong Nikolaos Scarmeas Norbert Scherbaum Oliver Goldhardt Oliver Hanon Oliver Peters Olivia Anna Skrobot Olivier Quenez Ondrej Lerch Paola Bossù Paolo Caffarra Paolo Dionigi Rossi Paraskevi Sakka Per Hoffmann Peter A. Holmans Peter Fischer Peter Riederer Qiong Yang Rachel Marshall Rajesh N. Kalaria Richard Mayeux Rik Vandenberghe Roberta Cecchetti Roberta Ghidoni Ruth Frikke-Schmidt Sandro Sorbi Sara Hägg Sebastiaan Engelborghs Seppo Helisalmi Sigrid Botne Sando Silke Kern Silvana Archetti Silvia Boschi Silvia Fostinelli Silvia Gil Silvia Mendoza Simon Mead Simona Ciccone Srdjan Djurovic Stefanie Heilmann-Heimbach Steffi Riedel-Heller Teemu Kuulasmaa Teodoro del Ser Thibaud Lebouvier Thomas Polak Tiia Ngandu Timo Grimmer Valentina Bessi Valentina Escott-Price Vilmantas Giedraitis Vincent Deramecourt Wolfgang Maier Xueqiu Jian Yolande A. L. Pijnenburg A. David Smith Aldo Saenz Alessandra Bizzarro Alessandra Lauria Alessandro Vacca Alina Solomon Anna Anastasiou Anna Richardson Anne Boland Anne Koivisto Antonio Daniele Antonio Greco Arnaoutoglou Marianthi Bernadette McGuinness Bertrand Fin Camilla Ferrari Carlo Custodero Carlo Ferrarese Carlos Ingino Carlos Mangone Carlos Reyes Toso Carmen Martínez Carolina Cuesta Carolina Muchnik Catharine Joachim Cecilia Ortiz Céline Besse Charlotte Johansson Chiara Paola Zoia Christoph Laske Costas Anastasiou Dana Lis Palacio Daniel G. Politis Daniel Janowitz David Craig David M. Mann David Neary Deckert Jürgen Delphine Daian Diyana Belezhanska Eduardo Kohler Eduardo M. Castaño Effrosyni Koutsouraki Elena Chipi Ellen De Roeck Emanuele Costantini Emma R. L. C. Vardy Fabrizio Piras Fausto Roveta Federica Piras Federico Ariel Prestia Francesca Assogna Francesca Salani Gessica Sala Giordano Lacidogna Gisela Novack Gordon Wilcock Håkan Thonberg Heike Kölsch Heike Weber Henning Boecker Ignacio Etchepareborda Irene Piaceri Jaakko Tuomilehto Jaana Lindström Jan Laczo Janet Johnston Jean-François Deleuze Jenny Harris Jonathan M. Schott Josef Priller Juan Ignacio Bacha Julie Snowden Julieta Lisso Kalina Yonkova Mihova Latchezar Traykov Laura Morelli Luis Ignacio Brusco Malik Rainer Mari Takalo Maria Bjerke Maria Del Zompo Maria Serpente Mariana Sanchez Abalos Mario Rios Markku Peltonen Martin J. Herrman Mary H. Kosmidis Matias Kohler Matias Rojo Matthew Jones Michela Orsini Nancy Medel Natividad Olivar Nick C. Fox Nicola Salvadori Nigel M. Hooper Pablo Galeano Patricia Solis Patrizia Bastiani Patrizia Mecocci Peter Passmore Reinhard Heun Riitta Antikainen Robert Olaso Robert Perneczky Sandra Germani Sara López-García Seth Love Shima Mehrabian Silvia Bagnoli Silvia Kochen Simona Andreoni Stefan Teipel Stephen Todd Stuart Pickering-Brown Teemu Natunen Thomas Tegos Tiina Laatikainen Timo Strandberg Tuomo M. Polvikoski Vaclav Matoska Valentina Ciullo Valeria Cores Vincenzo Solfrizzi Viviana Lisetti Zulma Sevillano C. Abdelnour N. Aguilera E. Alarcon M. Alegret A. Benaque M. Boada M. Buendia P. Cañabate A. Carracedo A. Corbatón-Anchuelo I. de Rojas S. Diego A. Espinosa A. Gailhajenet P. García-González S. Gil M. Guitart A. González-Pérez I. Hernández M. Ibarria A. Lafuente J. Macias O. Maroñas E. Martín M. T. Martínez M. Marquié A. Mauleón L. Montrreal S. Moreno-Grau M. Moreno A. Orellana G. Ortega A. Pancho E. Pelejá A. Pérez-Cordon J. A. Pineda S. Preckler I. Quintela L. M. Real M. Rosende-Roca A. Ruiz M. E. Sáez A. Sanabria M. Serrano-Rios O. Sotolongo-Grau L. Tárraga S. Valero L. Vargas A. D. Adarmes-Gómez E. Alarcón-Martín M. D. Alonso I. Álvarez V. Álvarez G. Amer-Ferrer M. Antequera C. Antúnez M. Baquero M. Bernal R. Blesa M. Boada D. Buiza-Rueda M. J. Bullido J. A. Burguera M. Calero F. Carrillo M. Carrión-Claro M. J. Casajeros J. Clarimón J. M. Cruz-Gamero M. M. de Pancorbo I. de Rojas T. del Ser M. Diez-Fairen R. Escuela L. Garrote-Espina J. Fortea E. Franco-Macías A. Frank-García J. M. García-Alberca S. Garcia Madrona G. Garcia-Ribas P. Gómez-Garre I. Hernández S. Hevilla S. Jesús M. A. Labrador Espinosa C. Lage A. Legaz A. Lleó A. Lopez de Munain S. López-García D. Macias-García S. Manzanares M. Marín J. Marín-Muñoz T. Marín M. Marquié A. Martín Montes B. Martínez C. Martínez V. Martínez P. Martínez-Lage Álvarez M. Medina M. Mendioroz Iriarte M. Menéndez-González P. Mir J. L. Molinuevo P. Pastor J. Pérez Tur T. Periñán-Tocino R. Pineda-Sanchez G. Piñol-Ripoll A. Rábano D. Real de Asúa S. Rodrigo E. Rodríguez-Rodríguez J. L. Royo A. Ruiz R. Sanchez del Valle Díaz P. Sánchez-Juan I. Sastre S. Valero M. P. Vicente R. Vigo-Ortega L. Vivancos C. Macleod C. McCracken Carol Brayne Catherine Bresner Detelina Grozeva Eftychia Bellou Ewen W. Sommerville F. Matthews Ganna Leonenko Georgina Menzies Gill Windle Janet Harwood Judith Phillips K. Bennett Lauren Luckuck Linda Clare Robert Woods Salha Saad Vanessa Burholt Iris E. Jansen Arvid Rongve Patrick Gavin Kehoe Guillermo Garcia-Ribas Pascual Sánchez-Juan Pau Pastor Jordi Pérez-Tur Gerard Piñol-Ripoll Adolfo Lopez de Munain Jose María García-Alberca María J. Bullido Victoria Álvarez Alberto Lleó Luis M. Real Pablo Mir Miguel Medina Philip Scheltens Henne Holstege Marta Marquié María Eugenia Sáez Ángel Carracedo Philippe Amouyel Gerard D. Schellenberg Julie Williams Sudha Seshadri Cornelia M. van Duijn Karen A. Mather Raquel Sánchez-Valle Manuel Serrano-Ríos Adelina Orellana Lluís Tárraga Kaj Blennow Martijn Huisman Ole A. Andreassen Danielle Posthuma Jordi Clarimón Mercè Boada Wiesje M. van der Flier Alfredo Ramirez Jean-Charles Lambert Sven J. van der Lee Agustín Ruiz Springer US Nature Communications, doi:10.1038/s41467-021-22491-8 10.1038/s41467-021-22491-8 http://dx.doi.org/10.1038/s41467-021-22491-8 journal Nature Communications © 2021, The Author(s) 2041-1723 10.1038/s41467-021-22491-8 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-021-22491-8 springer.com springerlink.com Springer 2021-06-01T18:08:54+02:00 2021-05-31T16:02:26+05:30 2021-06-01T18:08:54+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:54117ddb-a491-4653-9e7e-6ba5006b170a uuid:60302e7e-4d22-4cf6-a780-730c433f1068 default 1 converted uuid:aa9e8e87-d48e-4798-817b-506a5627e844 converted to PDF/A-2b pdfToolbox 2021-05-31T16:03:59+05:30 2 B Itziar Rojas http://orcid.org/0000-0002-2148-381X Najada Stringa http://orcid.org/0000-0001-6350-452X Anna Zettergren http://orcid.org/0000-0002-7182-8417 Rick M. 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OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 473, 640, 475, 671 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 473, 643, 508, 674 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link 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