fcb7b5a710b66c40a2130f2dd30aaf14 FIM_a2021.pdf e6041c2db72d7ac17a5b995aa39f9ece6c3fb43d FIM_a2021.pdf 35e3aff1519f22dde99977024f948e8df43f8f7f8ff63f44e5c6c1ac0d7d98d6 FIM_a2021.pdf Title: Epstein–Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report Subject: EBV-specific T cells have been recently described to be involved in fatal encephalitis and myocarditis in cancer patients after immune checkpoint therapies. Keywords: Epstein–Barr virus, B cells, T cells, breast cancer, TCR—T-cell receptor Author: Andrea Aran Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Nov 12 05:38:23 2021 CET ModDate: Fri Nov 12 05:57:06 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2961586 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FKHCPP+AdvPSA323 Type 1C WinAnsi yes yes no 606 0 FKHCMF+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 588 0 FKHCMG+AdvOT34fe1490.B+20 Type 1C WinAnsi yes yes no 589 0 FKHCMH+AdvOT01861455.I Type 1C WinAnsi yes yes no 590 0 FKHCMI+AdvPSA18C Type 1C WinAnsi yes yes no 591 0 FKHCMJ+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 592 0 FKHCMK+AdvOT1deab444.I Type 1C WinAnsi yes yes no 593 0 FKHCML+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 594 0 FKHCNL+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 587 0 FKHCNM+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 595 0 FKHCON+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 607 0 FKHCPO+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 608 0 FKHDDO+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 349 0 FKHDDP+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 355 0 FKHDEA+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 350 0 FKHDFB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 351 0 FKHDFC+AdvOTf94803d4 Type 1C WinAnsi yes yes no 352 0 FKHDGC+AdvOTd877c31c+21 Type 1C WinAnsi yes yes no 360 0 FKHDGD+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 361 0 FKHDGE+AdvOTd877c31c+20 Type 1C Custom yes yes yes 362 0 FKHDHF+AdvOTf94803d4+fb Type 1C Custom yes yes yes 370 0 FKHDHG+AdvOTf94803d4+20 Type 1C WinAnsi yes yes no 365 0 FKHDIG+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 371 0 FKHDJH+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 377 0 FKHDJI+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 375 0 FKHEBG+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 379 0 FKHFEP+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 380 0 FKHLMF+AdvOT1ef757c0+01 Type 1C Custom yes yes no 386 0 FKHLMG+AdvTT58d178b9+03 Type 1C Custom yes yes yes 387 0 FKHLPG+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 391 0 FKHLPH+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 393 0 FKHMAI+AdvTT02dee1cd.I+03 Type 1C Custom yes yes yes 394 0 FKHMAJ+AdvOT7d6df7ab.I+01 Type 1C MacRoman yes yes no 392 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:24:53 CEST RepresentationInformation: FIM_a2021.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:59:11 CEST Size: 2961586 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B25' cannot be found Offset: 2938686 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B24' cannot be found Offset: 2938686 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B77' cannot be found Offset: 2938686 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 682 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Epstein–Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2 Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: 2.1 Samples and Cell Cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 2.1.1 TNBC Biopsy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.1.2 XABCL Generation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.1.3 XABCL-LCL Culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.1.4 TNBC-T Cells and XABCL-LCL Co-Cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.2 Tumoral and T- and B-Cell Presence in the Biopsy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 2.2.1 Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.3 Characterization of XABCL-LCL and TNBC-T Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 2.3.1 Phenotypic Characterization of T and B Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.3.2 BCR and TCR High-Throughput Sequencing of TNBC, XABCL, TNBC-T Cells, and XABCL-LCL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.3.3 TCR and BCR Repertoire Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.4 Characterization of the HLA-Associated Peptide Repertoire From the XABCL-LCL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 2.4.1 Purification of Peptide–HLA Complexes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.4.2 Peptide Identification by Mass Spectrometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.4.3 HLA-Derived Peptide Repertoire Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.4.4 Identification of Proteins in the XABCL-LCL HLA Peptide Repertoire Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: 3.4 HLA-Associated Peptides Presented by the XABCL-LCL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 3.2 XABCL B Cells Can Maintain Tumor-Infiltrating T Cells In Vivo and In Vitro Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 3.3 Previously Reported TCR Sequences Are Maintained by XABCL B Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3.4 HLA-Associated Peptides Presented by the XABCL-LCL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Epstein–Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report Author: Andrea Aran Subject: EBV-specific T cells have been recently described to be involved in fatal encephalitis and myocarditis in cancer patients after immune checkpoint therapies. 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FKHFEP+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 65 LastChar: 69 FontDescriptor: FontName: FKHFEP+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding XMP: Acrobat Distiller 7.0 (Windows) Epstein–Barr virus, B cells, T cells, breast cancer, TCR—T-cell receptor 2021-11-12T12:57:06+08:00 2021-11-12T12:38:23+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2021-11-12T12:57:06+08:00 application/pdf Epstein–Barr Virus+ B Cells in Breast Cancer Immune Response: A Case Report Andrea Aran Vicente Peg Rosa Maria Rabanal Cristina Bernad&oacute Esther Zamora Elisa Molina Yago A. Arribas Joaqu&iacute n Arribas José Pérez Carme Roura-Mir Montserrat Carrascal Javier Cortés Merc&egrave Mart&iacute EBV-specific T cells have been recently described to be involved in fatal encephalitis and myocarditis in cancer patients after immune checkpoint therapies. 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524, 482, 549, 489 Annotation: Subtype: Link Rect: 318, 472, 403, 480 Annotation: Subtype: Link Rect: 524, 444, 549, 451 Annotation: Subtype: Link Rect: 318, 434, 366, 442 Annotation: Subtype: Link Rect: 392, 406, 489, 413 Annotation: Subtype: Link Rect: 523, 377, 549, 385 Annotation: Subtype: Link Rect: 318, 368, 376, 375 Annotation: Subtype: Link Rect: 524, 311, 549, 318 Annotation: Subtype: Link Rect: 318, 301, 370, 309 Annotation: Subtype: Link Rect: 363, 263, 426, 271 Annotation: Subtype: Link Rect: 407, 130, 548, 138 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 408, 29, 549, 36 Checksum: e387a842 Type: CRC32 Checksum: fcb7b5a710b66c40a2130f2dd30aaf14 Type: MD5 Checksum: e6041c2db72d7ac17a5b995aa39f9ece6c3fb43d Type: SHA-1