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Storm Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Dec 13 15:12:29 2021 CET ModDate: Tue Dec 14 18:30:17 2021 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1263460 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OPACFC+AdvOTf23bb480 Type 1C WinAnsi yes yes no 547 0 OPACFD+AdvOTf23bb480+fb Type 1C Custom yes yes yes 554 0 OPACGE+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 77 0 OPABDD+AdvOTea1a7398 Type 1C WinAnsi yes yes no 79 0 OPABHC+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 110 0 OPACBP+AdvTT2876772e+27 Type 1C Custom yes yes yes 523 0 OPACCA+AdvOTea1a7398+fb Type 1C Custom yes yes yes 111 0 OPACCB+AdvOTcb88df00 Type 1C WinAnsi yes yes no 85 0 Arial-BoldMT Type 1C WinAnsi yes no no 770 0 OPACJD+AdvOT125c650c Type 1C WinAnsi yes yes no 75 0 OPACJE+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 76 0 OPACKL+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 78 0 OPACKJ+AdvTTab7e17fd Type 1C WinAnsi yes yes no 80 0 OPACKK+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 81 0 OPACJH+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 82 0 OPACJI+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 83 0 OPACJF+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 84 0 OPACJG+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 86 0 OPAFJL+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 143 0 OPAFIK+AdvOTcb88df00+fb Type 1C Custom yes yes yes 144 0 OPAFML+AdvMacMthSyN Type 1C Custom yes yes yes 185 0 OPAFMM+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 186 0 OPAFMN+AdvP4C4E51 Type 1C WinAnsi yes yes no 187 0 OPAHLD+AdvOTe75a9404.I Type 1C WinAnsi yes yes no 282 0 OPAHLE+AdvOT8608a8d1+27 Type 1C Custom yes yes yes 283 0 OPAHLC+AdvOTcb88df00+20 Type 1C WinAnsi yes yes no 284 0 OPAIBF+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 441 0 OPAHPE+AdvTTab7e17fd+22 Type 1C Custom yes yes no 442 0 OPAHPF+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 443 0 OPAIDF+AdvOT7d6df7ab.I+20 Type 1C WinAnsi yes yes no 485 0 OPAIFG+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 522 0 OPAIPD+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 546 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:24:12 CEST RepresentationInformation: 264453.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:59:15 CEST Size: 1263460 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bm_CR61' cannot be found Offset: 925162 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 925162 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 925162 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 925162 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 925162 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 925162 MIMEtype: application/pdf PDFMetadata: Objects: 852 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Mimicking medications with expression quantitative trait loci Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Discovery phase identifies 31 potential drug targets to prevent PD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 15 potential preventative agents replicate in an independent PD case-control cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: MR quality control suggests that CD38, CTSB, GPNMB and’MAP3K12 have the most robust MR evidence for PD risk Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Four potential targets for preventative drugs may also affect PD age at onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: There is little overlap between drug targets to prevent PD and reduce PD progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Protein quantitative trait locus data provide further genetic evidence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Exposure data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Outcome data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Mendelian randomization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Colocalization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome Author: Catherine S. 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Storm Demis A. Kia Mona M. Almramhi Sara Bandres-Ciga Chris Finan Alastair J. Noyce Rauan Kaiyrzhanov Ben Middlehurst Manuela Tan Henry Houlden Huw R. Morris Helene Plun-Favreau Peter Holmans John Hardy Daniah Trabzuni John Quinn Vivien Bubb Kin Y. Mok Kerri J. Kinghorn Patrick Lewis Sebastian R. Schreglmann Ruth Lovering Lea R’Bibo Claudia Manzoni Mie Rizig Mina Ryten Sebastian Guelfi Valentina Escott-Price Viorica Chelban Thomas Foltynie Nigel Williams Karen E. Morrison Carl Clarke Kirsten Harvey Benjamin M. Jacobs Alexis Brice Fabrice Danjou Suzanne Lesage Jean-Christophe Corvol Maria Martinez Claudia Schulte Kathrin Brockmann Javier Simón-Sánchez Peter Heutink Patrizia Rizzu Manu Sharma Thomas Gasser Susanne A. Schneider Mark R. Cookson Cornelis Blauwendraat David W. Craig Kimberley Billingsley Mary B. Makarious Derek P. Narendra Faraz Faghri J. Raphael Gibbs Dena G. Hernandez Kendall Van Keuren-Jensen Joshua M. Shulman Hirotaka Iwaki Hampton L. Leonard Mike A. Nalls Laurie Robak Jose Bras Rita Guerreiro Steven Lubbe Timothy Troycoco Steven Finkbeiner Niccolo E. Mencacci Codrin Lungu Andrew B. Singleton Sonja W. Scholz Xylena Reed Ryan J. Uitti Owen A. Ross Francis P. Grenn Anni Moore Roy N. Alcalay Zbigniew K. Wszolek Ziv Gan-Or Guy A. Rouleau Lynne Krohn Kheireddin Mufti Jacobus J. van Hilten Johan Marinus Astrid D. Adarmes-Gómez Miquel Aguilar Ignacio Alvarez Victoria Alvarez Francisco Javier Barrero Jesús Alberto Bergareche Yarza Inmaculada Bernal-Bernal Marta Blazquez Marta Bonilla-Toribio Juan A. Botía María Teresa Boungiorno Dolores Buiza-Rueda Ana Cámara Fátima Carrillo Mario Carrión-Claro Debora Cerdan Jordi Clarimón Yaroslau Compta Monica Diez-Fairen Oriol Dols-Icardo Jacinto Duarte Raquel Duran Francisco Escamilla-Sevilla Mario Ezquerra Cici Feliz Manel Fernández Rubén Fernández-Santiago Ciara Garcia Pedro García-Ruiz Pilar Gómez-Garre Maria Jose Gomez Heredia Isabel Gonzalez-Aramburu Ana Gorostidi Pagola Janet Hoenicka Jon Infante Silvia Jesús Adriano Jimenez-Escrig Jaime Kulisevsky Miguel A. Labrador-Espinosa Jose Luis Lopez-Sendon Adolfo López de Munain Arregui Daniel Macias Irene Martínez Torres Juan Marín Maria Jose Marti Juan Carlos Martínez-Castrillo Carlota Méndez-del-Barrio Manuel Menéndez González Marina Mata Adolfo Mínguez Pablo Mir Elisabet Mondragon Rezola Esteban Muñoz Javier Pagonabarraga Pau Pastor Francisco Perez Errazquin Teresa Periñán-Tocino Javier Ruiz-Martínez Clara Ruz Antonio Sanchez Rodriguez María Sierra Esther Suarez-Sanmartin Cesar Tabernero Juan Pablo Tartari Cristina Tejera-Parrado Eduard Tolosa Francesc Valldeoriola Laura Vargas-González Lydia Vela Francisco Vives Alexander Zimprich Lasse Pihlstrom Mathias Toft Pille Taba Sulev Koks Sharon Hassin-Baer Kari Majamaa Ari Siitonen Pentti Tienari Njideka U. Okubadejo Oluwadamilola O. Ojo Chingiz Shashkin Nazira Zharkinbekova Vadim Akhmetzhanov Gulnaz Kaishybayeva Altynay Karimova Talgat Khaibullin Timothy L. Lynch Aroon D. Hingorani Nicholas W. 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