8b69877608db479697eb4f344cbf7a54  nanotoxicology_a2021v15n4p558.pdf
e94be7272d926ae99d0faa499e67cfff7a96cfc7  nanotoxicology_a2021v15n4p558.pdf
6ced9dafebfc0a70bd8013636da88611d086f48ce2cda02b6155957b08057ae2  nanotoxicology_a2021v15n4p558.pdf

Title:          Interaction of nanoparticles with endotoxin Importance in nanosafety testing and exploitation for en
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          20
Encrypted:      no
Page size:      634.32 x 833.04 pts
Page rot:       0
File size:      3451754 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EBJGEJ+OpenSans-SemiboldItalic       CID TrueType      Identity-H       yes yes yes    795  0
EBJGEI+OpenSans-Semibold             CID TrueType      Identity-H       yes yes yes    796  0
EBJGFA+ArialUnicodeMS                CID TrueType      Identity-H       yes yes yes    797  0
EBJGFB+ArialUnicodeMSItalic          CID TrueType      Identity-H       yes yes yes    798  0
EBJGFC+OpenSans                      CID TrueType      Identity-H       yes yes yes    799  0
PBEJAO+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     806  0
PBEJOB+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     807  0
PBEJOC+AdvOTc20ddc96                 Type 1C           WinAnsi          yes yes no     808  0
PBEKHP+AdvT001                       Type 1C           Custom           yes yes no     809  0
PBEJJL+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no     810  0
PBEJJM+AdvOT56309c18.I               Type 1C           WinAnsi          yes yes no     811  0
PBEJJN+AdvP4C4E74                    Type 1C           Custom           yes yes yes    812  0
PBEJMN+AdvOT5fcf1b24                 Type 1C           WinAnsi          yes yes no     813  0
PBEJMO+AdvOT5fcf1b24+20              Type 1C           WinAnsi          yes yes no     814  0
PBEJMP+AdvP4C4E59                    Type 1C           Custom           yes yes no     815  0
PBEJNA+AdvOT2bda31c3.B               Type 1C           WinAnsi          yes yes no     816  0
PBEJNB+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     817  0
PBEKNO+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     835  0
PBEOIH+AdvPSMP13                     Type 1C           WinAnsi          yes yes no     838  0
PBEPNA+AdvPi1                        Type 1C           WinAnsi          yes yes no     847  0
PBEPOA+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     848  0
PBFAFO+AdvOTd0125be5.BI              Type 1C           WinAnsi          yes yes no     851  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-27 03:19:03 CEST
 RepresentationInformation: nanotoxicology_a2021v15n4p558.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-31 11:59:31 CEST
  Size: 3451754
  Format: PDF
  Version: 1.5
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-87
  InfoMessage: File header gives version as 1.5, but catalog dictionary gives version as 1.4
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1017
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
       Item: 
        Title: LPS structure and signaling
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
       Item: 
        Title: Biological effects of endotoxin
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
       Item: 
        Title: Current methods for LPS detection
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: Endotoxin contamination of NPs
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: Assessing endotoxin contamination in NP preparations
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Function-independent methods for detecting LPS contamination on NPs
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
        Children: 
         Item: 
          Title: Dynamic light scattering
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: Transmission electron microscopy
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: Surface-enhanced Raman spectroscopy
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: NPs for detection and quantitation of LPS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
        Children: 
         Item: 
          Title: NP colorimetric assays (optical assays)
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: NP electrochemical assays
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: NP fluorescence assays
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: Conclusions and future perspective
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: Disclosure statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
       Item: 
        Title: Funding
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: Orcid
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
   Info: 
    Title: Interaction of nanoparticles with endotoxin Importance in nanosafety testing and exploitation for en
   ID: 0xd15e1a9c2c64c42b0a0e24f97c753d85, 0xd15e1a9c2c64c42b0a0e24f97c753d85
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im10
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im13
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im14
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im11
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im12
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im15
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im16
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 200
      ImageHeight: 255
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Name: Im1
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im3
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 3150
      ImageHeight: 746
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im2
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im5
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im4
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im7
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im6
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im9
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im8
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1700
      ImageHeight: 956
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1950
      ImageHeight: 2126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1975
      ImageHeight: 1167
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1975
      ImageHeight: 1781
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
   Fonts: 
    Type0: 
     Font: 
      BaseFont: EBJGEJ+OpenSans-SemiboldItalic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EBJGEI+OpenSans-Semibold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EBJGFA+ArialUnicodeMS
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EBJGFB+ArialUnicodeMSItalic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EBJGFC+OpenSans
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: PBEKNO+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: PBEKNO+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: -9, -205, 1126, 868
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJAO+AdvOT46dcae81
      FontSubset: true
      FirstChar: 37
      LastChar: 177
      FontDescriptor: 
       FontName: PBEJAO+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -46, -250, 838, 879
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEOIH+AdvPSMP13
      FontSubset: true
      FirstChar: 97
      LastChar: 109
      FontDescriptor: 
       FontName: PBEOIH+AdvPSMP13
       Flags: Nonsymbolic
       FontBBox: 0, -302, 958, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJOB+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: PBEJOB+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -112, -250, 894, 873
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJOC+AdvOTc20ddc96
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: PBEJOC+AdvOTc20ddc96
       Flags: Nonsymbolic
       FontBBox: -39, -250, 796, 886
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEKHP+AdvT001
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: PBEKHP+AdvT001
       Flags: Symbolic
       FontBBox: -197, -260, 1000, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: PBEJJL+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 73
      LastChar: 120
      FontDescriptor: 
       FontName: PBEJJL+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -42, -250, 858, 889
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJJM+AdvOT56309c18.I
      FontSubset: true
      FirstChar: 73
      LastChar: 121
      FontDescriptor: 
       FontName: PBEJJM+AdvOT56309c18.I
       Flags: Nonsymbolic
       FontBBox: -103, -250, 914, 882
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJJN+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: PBEJJN+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PBEJMN+AdvOT5fcf1b24
      FontSubset: true
      FirstChar: 38
      LastChar: 184
      FontDescriptor: 
       FontName: PBEJMN+AdvOT5fcf1b24
       Flags: Nonsymbolic
       FontBBox: -40, -250, 777, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJMO+AdvOT5fcf1b24+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: PBEJMO+AdvOT5fcf1b24+20
       Flags: Nonsymbolic
       FontBBox: -128, -205, 1059, 861
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJMP+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: PBEJMP+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: PBEPNA+AdvPi1
      FontSubset: true
      FirstChar: 109
      LastChar: 109
      FontDescriptor: 
       FontName: PBEPNA+AdvPi1
       Flags: Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJNA+AdvOT2bda31c3.B
      FontSubset: true
      FirstChar: 65
      LastChar: 89
      FontDescriptor: 
       FontName: PBEJNA+AdvOT2bda31c3.B
       Flags: Nonsymbolic
       FontBBox: -44, -250, 892, 905
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEPOA+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: PBEPOA+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBEJNB+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 45
      LastChar: 120
      FontDescriptor: 
       FontName: PBEJNB+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -39, -250, 875, 897
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PBFAFO+AdvOTd0125be5.BI
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: PBFAFO+AdvOTd0125be5.BI
       Flags: Nonsymbolic
       FontBBox: -95, -250, 930, 889
       FontFile3: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: EBJGEJ+OpenSans-SemiboldItalic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBJGEJ+OpenSans-SemiboldItalic
       Flags: FixedPitch, Nonsymbolic, Italic
       FontBBox: -249, -240, 965, 931
       FontFile2: true
     Font: 
      BaseFont: EBJGEI+OpenSans-Semibold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBJGEI+OpenSans-Semibold
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -583, -282, 1261, 1048
       FontFile2: true
     Font: 
      BaseFont: EBJGFA+ArialUnicodeMS
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBJGFA+ArialUnicodeMS
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -1011, -329, 2260, 1078
       FontFile2: true
     Font: 
      BaseFont: EBJGFB+ArialUnicodeMSItalic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBJGFB+ArialUnicodeMSItalic
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -670, -329, 2260, 1078
       FontFile2: true
     Font: 
      BaseFont: EBJGFC+OpenSans
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EBJGFC+OpenSans
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -549, -270, 1204, 1047
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP toolkit 3.0.1-30, framework 1.6">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
            xmlns:iX="http://ns.adobe.com/iX/1.0/">
      <rdf:Description xmlns:pdf="http://ns.adobe.com/pdf/1.3/" rdf:about="">
         <pdf:Producer>Adobe LiveCycle PDFG ES</pdf:Producer>
         <pdf:Keywords/>
      </rdf:Description>
      <rdf:Description xmlns:photoshop="http://ns.adobe.com/photoshop/1.0/" rdf:about=""/>
      <rdf:Description xmlns:tiff="http://ns.adobe.com/tiff/1.0/" rdf:about=""/>
      <rdf:Description xmlns:xap="http://ns.adobe.com/xap/1.0/" rdf:about="">
         <xap:CreateDate>2021-04-24T15:36:54+05:30</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher</xap:CreatorTool>
         <xap:ModifyDate>2021-04-24T15:36:54+05:30</xap:ModifyDate>
         <xap:MetadataDate>2021-04-24T15:36:54+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/" rdf:about="">
         <xapMM:DocumentID>uuid:8addd02c-2a8d-4824-a074-0375b52bef83</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:9735c38c-787b-4f5b-aca7-e8422204bc96</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" rdf:about="">
         <prism:aggregationType>Journal</prism:aggregationType>
         <prism:publicationName>Nanotoxicology</prism:publicationName>
         <prism:copyright>© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group.</prism:copyright>
         <prism:issn/>
         <prism:eissn/>
         <prism:volume>15</prism:volume>
         <prism:number>4</prism:number>
         <prism:issueName/>
         <prism:coverDate/>
         <prism:pageRange>558-576</prism:pageRange>
         <prism:startingPage>558</prism:startingPage>
         <prism:endingPage>576</prism:endingPage>
         <prism:doi>10.1080/17435390.2021.1898690</prism:doi>
         <prism:url>https://doi.org/10.1080/17435390.2021.1898690</prism:url>
      </rdf:Description>
      <rdf:Description xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:about="">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1080/17435390.2021.1898690</dc:identifier>
         <dc:language>en-US</dc:language>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Interaction of nanoparticles with endotoxin  Importance in nanosafety testing and exploitation for endotoxin binding</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Taylor &amp; Francis</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nanotoxicology, 2021. doi: 10.1080/17435390.2021.1898690</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Mangini Maria</rdf:li>
               <rdf:li>Verde Alessandro</rdf:li>
               <rdf:li>Boraschi Diana</rdf:li>
               <rdf:li>Puntes Victor F.</rdf:li>
               <rdf:li>Italiani Paola</rdf:li>
               <rdf:li>De Luca Anna Chiara</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Nanoparticles</rdf:li>
               <rdf:li>endotoxin</rdf:li>
               <rdf:li>inflammation</rdf:li>
               <rdf:li>LPS sensors</rdf:li>
               <rdf:li>SERS</rdf:li>
            </rdf:Bag>
         </dc:subject>
      </rdf:Description>
      <rdf:Description xmlns:jav="http://www.niso.org/schemas/jav/1.0/" rdf:about="">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description xmlns:crossmark="http://crossref.org/crossmark/1.0/" rdf:about="">
         <crossmark:DOI>10.1080/17435390.2021.1898690</crossmark:DOI>
         <crossmark:MajorVersionDate>2021-03-30</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>www.tandfonline.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" rdf:about="">
         <pdfx:doi>10.1080/17435390.2021.1898690</pdfx:doi>
         <pdfx:CrossmarkMajorVersionDate>2021-03-30</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>True</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>www.tandfonline.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 42, 478, 51
      Annotation: 
       Subtype: Link
       Rect: 283, 688, 438, 696
      Annotation: 
       Subtype: Link
       Rect: 97, 474, 247, 483
      Annotation: 
       Subtype: Link
       Rect: 202, 454, 427, 464
      Annotation: 
       Subtype: Link
       Rect: 106, 312, 124, 321
      Annotation: 
       Subtype: Link
       Rect: 131, 312, 286, 321
      Annotation: 
       Subtype: Link
       Rect: 106, 222, 122, 231
      Annotation: 
       Subtype: Link
       Rect: 131, 226, 230, 235
      Annotation: 
       Subtype: Link
       Rect: 106, 176, 125, 185
      Annotation: 
       Subtype: Link
       Rect: 131, 183, 232, 192
    Page: 
     Label: 1
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 635, 127, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 127, 635, 132, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 229, 635, 233, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 233, 635, 239, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 310, 635, 315, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 391, 635, 394, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 396, 635, 400, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 402, 635, 406, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 469, 635, 473, 645
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 154, 623, 158, 633
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 191, 257, 213, 267
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 483, 364, 504, 375
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 487, 703, 549, 715
      Annotation: 
       Subtype: Link
       Rect: 136, 635, 146, 645
      Annotation: 
       Subtype: Link
       Rect: 439, 62, 549, 69
      Annotation: 
       Subtype: Link
       Rect: 59, 54, 88, 61
      Annotation: 
       Subtype: Link
       Rect: 447, 727, 549, 751
    Page: 
     Label: 2
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 203, 629, 225, 640
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 466, 687, 487, 698
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 340, 602, 361, 612
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 371, 602, 409, 612
       Destination: 10
    Page: 
     Label: 3
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 674, 81, 684
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 150, 674, 171, 684
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 116, 645, 138, 656
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 125, 574, 147, 585
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 235, 489, 256, 500
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 85, 475, 106, 485
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 93, 280, 114, 291
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 151, 124, 172, 134
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 447, 688, 469, 699
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 313, 576, 335, 587
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 378, 576, 400, 587
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 520, 380, 547, 390
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 313, 366, 341, 376
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 399, 310, 421, 320
       Destination: 25
    Page: 
     Label: 4
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 157, 100, 179, 110
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 147, 71, 169, 82
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 355, 716, 376, 727
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 496, 674, 517, 685
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 425, 660, 446, 671
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 490, 660, 511, 671
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 342, 646, 363, 657
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 412, 646, 433, 657
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 313, 604, 335, 615
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 391, 534, 413, 545
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 484, 492, 505, 503
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 425, 226, 447, 236
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 381, 71, 403, 82
       Destination: 25
    Page: 
     Label: 5
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 85, 603, 106, 614
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 177, 142, 199, 153
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 244, 142, 265, 153
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 146, 128, 167, 138
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 340, 630, 362, 641
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 417, 430, 438, 440
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 525, 430, 547, 440
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 456, 415, 478, 426
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 522, 329, 544, 340
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 313, 201, 335, 211
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 487, 201, 508, 211
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 313, 186, 335, 197
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 352, 129, 374, 140
       Destination: 25
    Page: 
     Label: 6
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 85, 590, 106, 601
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 259, 548, 281, 559
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 87, 534, 109, 545
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 159, 478, 181, 489
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 265, 352, 286, 362
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 208, 184, 229, 194
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 416, 702, 437, 713
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 451, 590, 472, 601
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 414, 520, 436, 531
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 522, 450, 544, 460
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 342, 380, 364, 390
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 313, 141, 348, 152
       Destination: 15
    Page: 
     Label: 7
     Sequence: 8
    Page: 
     Label: 8
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 189, 466, 211, 476
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 128, 128, 149, 139
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 114, 72, 135, 82
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 313, 730, 365, 741
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 325, 294, 358, 304
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 455, 170, 477, 180
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 369, 114, 424, 124
       Destination: 17
    Page: 
     Label: 9
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 415, 148, 433, 158
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 103, 104, 121, 114
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 527, 60, 545, 70
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 177, 38, 195, 48
       Destination: 25
    Page: 
     Label: 10
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 576, 92, 586
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 127, 409, 149, 420
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 230, 409, 251, 420
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 89, 395, 110, 406
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 181, 395, 202, 406
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 167, 283, 189, 293
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 170, 226, 192, 237
       Destination: 27
      Annotation: 
       Subtype: Link
       Rect: 135, 170, 156, 180
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 115, 114, 164, 124
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 240, 114, 262, 124
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 90, 100, 112, 110
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 316, 604, 355, 614
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 461, 575, 511, 586
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 313, 561, 334, 572
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 430, 561, 452, 572
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 523, 561, 544, 572
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 459, 477, 480, 487
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 313, 406, 334, 417
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 398, 406, 419, 417
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 426, 350, 459, 360
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 349, 156, 370, 167
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 442, 156, 463, 167
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 429, 71, 451, 82
       Destination: 26
    Page: 
     Label: 11
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 256, 162, 267
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 170, 155, 203, 166
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 406, 300, 427, 311
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 394, 257, 415, 268
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 341, 143, 362, 153
       Destination: 27
      Annotation: 
       Subtype: Link
       Rect: 415, 143, 436, 153
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 494, 143, 515, 153
       Destination: 27
      Annotation: 
       Subtype: Link
       Rect: 316, 86, 338, 96
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 367, 422, 385, 432
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 437, 422, 455, 432
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 119, 389, 137, 399
       Destination: 24
      Annotation: 
       Subtype: Link
       Rect: 220, 389, 237, 399
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 299, 389, 317, 399
       Destination: 25
    Page: 
     Label: 12
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 411, 687, 461, 698
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 474, 616, 524, 626
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 418, 516, 440, 526
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 384, 315, 405, 326
       Destination: 25
    Page: 
     Label: 13
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 129, 477, 162, 487
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 59, 421, 81, 431
       Destination: 27
      Annotation: 
       Subtype: Link
       Rect: 181, 114, 202, 124
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 494, 673, 544, 684
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 436, 630, 457, 641
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 522, 530, 544, 541
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 339, 229, 361, 240
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 521, 201, 549, 211
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 313, 186, 330, 197
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 339, 115, 388, 125
       Destination: 17
    Page: 
     Label: 14
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 226, 702, 248, 713
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 152, 406, 189, 417
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 425, 688, 446, 699
       Destination: 27
      Annotation: 
       Subtype: Link
       Rect: 342, 520, 364, 530
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 375, 520, 425, 530
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 316, 393, 366, 404
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 464, 127, 497, 137
       Destination: 20
    Page: 
     Label: 15
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 499, 80, 528, 90
       Destination: 20
    Page: 
     Label: 16
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 254, 616, 292, 627
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 369, 558, 388, 567
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 373, 509, 392, 518
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 374, 460, 498, 469
      Annotation: 
       Subtype: Link
       Rect: 380, 448, 399, 457
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 393, 423, 503, 432
      Annotation: 
       Subtype: Link
       Rect: 529, 399, 547, 408
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 413, 350, 515, 359
      Annotation: 
       Subtype: Link
       Rect: 352, 326, 370, 335
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 516, 301, 549, 310
      Annotation: 
       Subtype: Link
       Rect: 323, 289, 395, 298
      Annotation: 
       Subtype: Link
       Rect: 323, 265, 342, 274
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 409, 253, 501, 262
      Annotation: 
       Subtype: Link
       Rect: 323, 216, 342, 225
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 453, 192, 525, 201
      Annotation: 
       Subtype: Link
       Rect: 454, 180, 472, 189
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 374, 155, 443, 164
      Annotation: 
       Subtype: Link
       Rect: 489, 131, 507, 140
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 377, 94, 490, 103
      Annotation: 
       Subtype: Link
       Rect: 371, 82, 390, 91
       Destination: 18
    Page: 
     Label: 17
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 720, 158, 728
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 69, 695, 131, 704
      Annotation: 
       Subtype: Link
       Rect: 170, 670, 189, 679
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 230, 658, 295, 667
      Annotation: 
       Subtype: Link
       Rect: 69, 646, 90, 655
      Annotation: 
       Subtype: Link
       Rect: 69, 621, 88, 630
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 83, 597, 205, 606
      Annotation: 
       Subtype: Link
       Rect: 178, 572, 196, 581
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 83, 535, 158, 544
      Annotation: 
       Subtype: Link
       Rect: 204, 511, 222, 520
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 198, 474, 271, 483
      Annotation: 
       Subtype: Link
       Rect: 182, 450, 201, 459
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 212, 425, 289, 434
      Annotation: 
       Subtype: Link
       Rect: 237, 413, 256, 422
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 69, 364, 148, 373
      Annotation: 
       Subtype: Link
       Rect: 275, 339, 293, 348
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 131, 302, 224, 311
      Annotation: 
       Subtype: Link
       Rect: 177, 290, 196, 299
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 69, 254, 88, 263
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 143, 229, 279, 238
      Annotation: 
       Subtype: Link
       Rect: 187, 217, 206, 226
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 263, 192, 295, 201
      Annotation: 
       Subtype: Link
       Rect: 69, 180, 147, 189
      Annotation: 
       Subtype: Link
       Rect: 188, 168, 207, 177
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 147, 143, 248, 152
      Annotation: 
       Subtype: Link
       Rect: 275, 131, 293, 140
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 158, 82, 276, 91
      Annotation: 
       Subtype: Link
       Rect: 108, 70, 127, 79
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 499, 732, 549, 741
      Annotation: 
       Subtype: Link
       Rect: 323, 720, 365, 729
      Annotation: 
       Subtype: Link
       Rect: 476, 708, 494, 717
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 374, 672, 481, 681
      Annotation: 
       Subtype: Link
       Rect: 436, 660, 455, 669
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 383, 623, 465, 632
      Annotation: 
       Subtype: Link
       Rect: 418, 612, 441, 621
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 416, 575, 439, 584
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 362, 527, 380, 536
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 457, 491, 549, 500
      Annotation: 
       Subtype: Link
       Rect: 323, 479, 351, 488
      Annotation: 
       Subtype: Link
       Rect: 484, 455, 502, 464
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 517, 407, 549, 416
      Annotation: 
       Subtype: Link
       Rect: 323, 395, 415, 404
      Annotation: 
       Subtype: Link
       Rect: 413, 359, 431, 368
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 500, 323, 549, 332
      Annotation: 
       Subtype: Link
       Rect: 323, 310, 365, 319
      Annotation: 
       Subtype: Link
       Rect: 529, 298, 547, 307
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 517, 250, 549, 259
      Annotation: 
       Subtype: Link
       Rect: 323, 238, 380, 247
      Annotation: 
       Subtype: Link
       Rect: 516, 226, 535, 235
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 374, 190, 491, 199
      Annotation: 
       Subtype: Link
       Rect: 323, 154, 342, 163
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 499, 118, 549, 127
      Annotation: 
       Subtype: Link
       Rect: 323, 106, 390, 115
      Annotation: 
       Subtype: Link
       Rect: 472, 94, 490, 103
       Destination: 13
    Page: 
     Label: 18
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 707, 141, 716
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 247, 683, 295, 692
      Annotation: 
       Subtype: Link
       Rect: 69, 671, 101, 680
      Annotation: 
       Subtype: Link
       Rect: 173, 646, 191, 655
       Destination: 21
      Annotation: 
       Subtype: Link
       Rect: 224, 597, 295, 606
      Annotation: 
       Subtype: Link
       Rect: 69, 585, 94, 594
      Annotation: 
       Subtype: Link
       Rect: 214, 561, 232, 570
       Destination: 14
      Annotation: 
       Subtype: Link
       Rect: 113, 512, 200, 521
      Annotation: 
       Subtype: Link
       Rect: 189, 488, 207, 497
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 284, 463, 295, 472
      Annotation: 
       Subtype: Link
       Rect: 69, 451, 137, 460
      Annotation: 
       Subtype: Link
       Rect: 175, 427, 194, 436
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 284, 390, 295, 399
      Annotation: 
       Subtype: Link
       Rect: 69, 378, 143, 387
      Annotation: 
       Subtype: Link
       Rect: 189, 366, 208, 375
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 205, 329, 224, 338
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 120, 305, 236, 314
      Annotation: 
       Subtype: Link
       Rect: 199, 293, 218, 302
       Destination: 22
      Annotation: 
       Subtype: Link
       Rect: 284, 256, 295, 265
      Annotation: 
       Subtype: Link
       Rect: 69, 244, 141, 253
      Annotation: 
       Subtype: Link
       Rect: 157, 220, 176, 229
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 159, 195, 232, 204
      Annotation: 
       Subtype: Link
       Rect: 205, 183, 224, 192
       Destination: 21
      Annotation: 
       Subtype: Link
       Rect: 284, 159, 295, 168
      Annotation: 
       Subtype: Link
       Rect: 69, 146, 136, 155
      Annotation: 
       Subtype: Link
       Rect: 235, 122, 253, 131
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 111, 73, 224, 82
      Annotation: 
       Subtype: Link
       Rect: 485, 719, 503, 728
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 337, 694, 409, 703
      Annotation: 
       Subtype: Link
       Rect: 364, 682, 383, 691
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 516, 657, 549, 666
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 413, 654
      Annotation: 
       Subtype: Link
       Rect: 529, 620, 547, 629
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 349, 582, 441, 591
      Annotation: 
       Subtype: Link
       Rect: 529, 570, 547, 579
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 374, 533, 466, 542
      Annotation: 
       Subtype: Link
       Rect: 420, 521, 439, 530
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 374, 496, 481, 505
      Annotation: 
       Subtype: Link
       Rect: 415, 471, 434, 480
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 538, 446, 549, 455
      Annotation: 
       Subtype: Link
       Rect: 323, 433, 417, 442
      Annotation: 
       Subtype: Link
       Rect: 439, 421, 457, 430
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 508, 384, 526, 393
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 517, 347, 549, 356
      Annotation: 
       Subtype: Link
       Rect: 323, 334, 362, 343
      Annotation: 
       Subtype: Link
       Rect: 432, 309, 451, 319
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 433, 272, 517, 281
      Annotation: 
       Subtype: Link
       Rect: 323, 247, 342, 256
       Destination: 12
      Annotation: 
       Subtype: Link
       Rect: 323, 198, 342, 207
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 516, 185, 549, 194
      Annotation: 
       Subtype: Link
       Rect: 323, 173, 389, 182
      Annotation: 
       Subtype: Link
       Rect: 377, 135, 395, 144
       Destination: 11
      Annotation: 
       Subtype: Link
       Rect: 420, 110, 475, 119
      Annotation: 
       Subtype: Link
       Rect: 529, 98, 547, 107
       Destination: 14
    Page: 
     Label: 19
     Sequence: 20
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 263, 732, 295, 741
      Annotation: 
       Subtype: Link
       Rect: 69, 720, 130, 729
      Annotation: 
       Subtype: Link
       Rect: 186, 696, 205, 705
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 122, 648, 231, 657
      Annotation: 
       Subtype: Link
       Rect: 215, 624, 234, 633
       Destination: 18
      Annotation: 
       Subtype: Link
       Rect: 383, 720, 501, 729
      Annotation: 
       Subtype: Link
       Rect: 352, 696, 370, 705
       Destination: 19
      Annotation: 
       Subtype: Link
       Rect: 354, 660, 459, 669
      Annotation: 
       Subtype: Link
       Rect: 350, 636, 369, 645
       Destination: 22
      Annotation: 
       Subtype: Link
       Rect: 365, 612, 458, 621
  Checksum: 1d7f55fc
   Type: CRC32
  Checksum: 8b69877608db479697eb4f344cbf7a54
   Type: MD5
  Checksum: e94be7272d926ae99d0faa499e67cfff7a96cfc7
   Type: SHA-1