ed1fc1e1fea5bbacfac918373fb138cc chemosensors_a2021m7v9n7p162.pdf 40a7bbdbad44b26472ef4c5b7407f759fb4cfdde chemosensors_a2021m7v9n7p162.pdf 3b04ce448f1d3c5e3b6aff55f3e7cdb2ce6d981b80967b9d635d64530621e605 chemosensors_a2021m7v9n7p162.pdf Title: Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review Subject: Electrochemical immunosensors (EI) have been widely investigated in the last several years. Among them, immunosensors based on low-dimensional materials (LDM) stand out, as they could provide a substantial gain in fabricating point-of-care devices, paving the way for fast, precise, and sensitive diagnosis of numerous severe illnesses. The high surface area available in LDMs makes it possible to immobilize a high density of bioreceptors, improving the sensitivity in biorecognition events between antibodies and antigens. If on the one hand, many works present promising results in using LDMs as a sensing material in EIs, on the other hand, very few of them discuss the fundamental interactions involved at the interfaces. Understanding the fundamental Chemistry and Physics of the interactions between the surface of LDMs and the bioreceptors, and how the operating conditions and biorecognition events affect those interactions, is vital when proposing new devices. Here, we present a review of recent works on EIs, focusing on devices that use LDMs (1D and 2D) as the sensing substrate. To do so, we highlight both experimental and theoretical aspects, bringing to light the fundamental aspects of the main interactions occurring at the interfaces and the operating mechanisms in which the detections are based. Keywords: immunosensor; electrochemical; FET; low-dimensional materials Author: Ernane de Freitas Martins, Luis Francisco Pinotti, Cecilia de Carvalho Castro Silva and Alexandre Reily Rocha Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 29 08:38:05 2021 CEST ModDate: Tue Jun 29 08:41:21 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 30 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 6383948 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZFUDTW+VnURWPalladioL Type 1 Custom yes yes no 10 0 KGFEIQ+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 AIWYSS+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 EATHOO+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 QOQMCA+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 32 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 54 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 58 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 62 0 CZKGAS+CMR10 Type 1 Builtin yes yes no 86 0 VFNYCD+CMSY10 Type 1 Builtin yes yes no 90 0 QIELJB+CMMI10 Type 1 Builtin yes yes no 94 0 ZYZFAV+EURM10 Type 1 Builtin yes yes no 98 0 HYYHEA+CMBSY10 Type 1 Builtin yes yes no 114 0 MEAFGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 129 0 MEAFGK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 132 0 MEAFGL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 138 0 MEAFGM+PalatinoLinotype CID TrueType Identity-H yes yes yes 141 0 MEAFGN+PalatinoLinotype TrueType WinAnsi yes yes no 147 0 MEAFGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 167 0 MEAFGK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 170 0 MEAFGL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 176 0 MEAFGM+PalatinoLinotype CID TrueType Identity-H yes yes yes 179 0 MEAFGN+PalatinoLinotype TrueType WinAnsi yes yes no 185 0 MEAFGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 205 0 MEAFGK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 208 0 MEAFGL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 214 0 MEAFGM+PalatinoLinotype CID TrueType Identity-H yes yes yes 217 0 MEAFGN+PalatinoLinotype TrueType WinAnsi yes yes no 223 0 MEAFGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 243 0 MEAFGK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 246 0 MEAFGL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 252 0 MEAFGM+PalatinoLinotype CID TrueType Identity-H yes yes yes 255 0 MEAFGN+PalatinoLinotype TrueType WinAnsi yes yes no 261 0 MEAFGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 281 0 MEAFGK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 284 0 MEAFGL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 290 0 MEAFGM+PalatinoLinotype CID TrueType Identity-H yes yes yes 293 0 MEAFGN+PalatinoLinotype TrueType WinAnsi yes yes no 299 0 MEAFGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 319 0 MEAFGK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 322 0 MEAFGL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 328 0 MEAFGM+PalatinoLinotype CID TrueType Identity-H yes yes yes 331 0 MEAFGN+PalatinoLinotype TrueType WinAnsi yes yes no 337 0 WMGRYN+CMEX10 Type 1 Builtin yes yes no 349 0 EAZYED+PazoMath-Italic Type 1 Builtin yes yes no 353 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:18:55 CEST RepresentationInformation: chemosensors_a2021m7v9n7p162.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:59:31 CEST Size: 6383948 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 964 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Fundamentals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: From Biosensors to Immunosensors: Definitions and Type of Transduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Field-Effect Transistors as Biosensors Principles of Operation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: LDM Semiconductors in FET-Based Immunosensors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: FET Based on 1D and 2D Materials: Detection Mechanisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Recent Applications towards Biosensing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: 1D Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Carbon Nanotubes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Nanowires Silicon and Beyond Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: 2D Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Children: Item: Title: Graphene Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Transition Metal Dichalcogenides Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Black Phosphorus and MXenes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Theory and Simulation of Biosensing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Outlook and Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Info: Title: Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review Author: Ernane de Freitas Martins, Luis Francisco Pinotti, Cecilia de Carvalho Castro Silva and Alexandre Reily Rocha Subject: Electrochemical immunosensors (EI) have been widely investigated in the last several years. Among them, immunosensors based on low-dimensional materials (LDM) stand out, as they could provide a substantial gain in fabricating point-of-care devices, paving the way for fast, precise, and sensitive diagnosis of numerous severe illnesses. The high surface area available in LDMs makes it possible to immobilize a high density of bioreceptors, improving the sensitivity in biorecognition events between antibodies and antigens. If on the one hand, many works present promising results in using LDMs as a sensing material in EIs, on the other hand, very few of them discuss the fundamental interactions involved at the interfaces. Understanding the fundamental Chemistry and Physics of the interactions between the surface of LDMs and the bioreceptors, and how the operating conditions and biorecognition events affect those interactions, is vital when proposing new devices. Here, we present a review of recent works on EIs, focusing on devices that use LDMs (1D and 2D) as the sensing substrate. To do so, we highlight both experimental and theoretical aspects, bringing to light the fundamental aspects of the main interactions occurring at the interfaces and the operating mechanisms in which the detections are based. Keywords: immunosensor; electrochemical; FET; low-dimensional materials Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 29 08:38:05 CEST 2021 ModDate: Tue Jun 29 08:41:21 CEST 2021 ID: 0x1841608cb807a699ede7d874c42710ec, 0x1841608cb807a699ede7d874c42710ec Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: EAZYED+PazoMath-Italic FontSubset: true FirstChar: 35 LastChar: 108 FontDescriptor: FontName: EAZYED+PazoMath-Italic Flags: Symbolic FontBBox: -70, -277, 902, 733 FontFile: true Font: BaseFont: ZYZFAV+EURM10 FontSubset: true FirstChar: 11 LastChar: 34 FontDescriptor: FontName: ZYZFAV+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: HYYHEA+CMBSY10 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: HYYHEA+CMBSY10 Flags: Symbolic FontBBox: -26, -940, 1332, 825 FontFile: true Font: BaseFont: AIWYSS+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: AIWYSS+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CZKGAS+CMR10 FontSubset: true FirstChar: 40 LastChar: 61 FontDescriptor: FontName: CZKGAS+CMR10 Flags: Symbolic FontBBox: -40, -250, 1009, 750 FontFile: true Font: BaseFont: EATHOO+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: EATHOO+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZFUDTW+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 226 FontDescriptor: FontName: ZFUDTW+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VFNYCD+CMSY10 FontSubset: true FirstChar: 0 LastChar: 20 FontDescriptor: FontName: VFNYCD+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: WMGRYN+CMEX10 FontSubset: true FirstChar: 115 LastChar: 115 FontDescriptor: FontName: WMGRYN+CMEX10 Flags: Symbolic FontBBox: -24, -2960, 1454, 772 FontFile: true Font: BaseFont: QIELJB+CMMI10 FontSubset: true FirstChar: 62 LastChar: 62 FontDescriptor: FontName: QIELJB+CMMI10 Flags: Symbolic FontBBox: -32, -250, 1048, 750 FontFile: true Font: BaseFont: KGFEIQ+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: KGFEIQ+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 35, 759, 174, 795 Annotation: Subtype: Link Rect: 515, 759, 560, 795 Annotation: Subtype: Link Rect: 165, 644, 176, 656 Annotation: Subtype: Link Rect: 443, 644, 454, 656 Annotation: Subtype: Link Rect: 172, 630, 183, 644 Annotation: Subtype: Link Rect: 117, 359, 154, 367 Annotation: Subtype: Link Rect: 35, 346, 154, 355 Annotation: Subtype: Link Rect: 35, 336, 104, 343 Annotation: Subtype: Link Rect: 35, 162, 97, 184 Annotation: Subtype: Link Rect: 153, 89, 154, 98 Annotation: Subtype: Link Rect: 35, 77, 147, 86 Annotation: Subtype: Link Rect: 253, 135, 260, 144 ActionDest: 416 Annotation: Subtype: Link Rect: 290, 85, 297, 94 ActionDest: 416 Annotation: Subtype: Link Rect: 410, 72, 417, 82 ActionDest: 416 Annotation: Subtype: Link Rect: 420, 73, 432, 82 ActionDest: 419 Annotation: Subtype: Link Rect: 126, 17, 296, 28 Annotation: Subtype: Link Rect: 385, 17, 558, 28 Annotation: Subtype: Link Rect: 35, 446, 87, 465 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 498, 711, 505, 721 ActionDest: 416 Annotation: Subtype: Link Rect: 506, 674, 518, 683 ActionDest: 419 Annotation: Subtype: Link Rect: 521, 674, 533, 683 ActionDest: 419 Annotation: Subtype: Link Rect: 341, 548, 353, 557 ActionDest: 419 Annotation: Subtype: Link Rect: 394, 511, 406, 520 ActionDest: 419 Annotation: Subtype: Link Rect: 407, 511, 419, 520 ActionDest: 419 Annotation: Subtype: Link Rect: 199, 423, 211, 432 ActionDest: 419 Annotation: Subtype: Link Rect: 211, 423, 223, 432 ActionDest: 419 Annotation: Subtype: Link Rect: 392, 398, 404, 407 ActionDest: 419 Annotation: Subtype: Link Rect: 407, 398, 419, 407 ActionDest: 419 Annotation: Subtype: Link Rect: 254, 322, 266, 331 ActionDest: 419 Annotation: Subtype: Link Rect: 269, 322, 281, 331 ActionDest: 419 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 244, 672, 256, 681 ActionDest: 419 Annotation: Subtype: Link Rect: 259, 672, 271, 681 ActionDest: 419 Annotation: Subtype: Link Rect: 203, 634, 215, 643 ActionDest: 419 Annotation: Subtype: Link Rect: 218, 634, 230, 643 ActionDest: 419 Annotation: Subtype: Link Rect: 493, 622, 505, 631 ActionDest: 419 Annotation: Subtype: Link Rect: 505, 622, 517, 631 ActionDest: 419 Annotation: Subtype: Link Rect: 478, 534, 490, 543 ActionDest: 419 Annotation: Subtype: Link Rect: 493, 534, 505, 543 ActionDest: 419 Annotation: Subtype: Link Rect: 530, 471, 542, 480 ActionDest: 419 Annotation: Subtype: Link Rect: 545, 471, 557, 480 ActionDest: 419 Annotation: Subtype: Link Rect: 236, 459, 248, 468 ActionDest: 422 Annotation: Subtype: Link Rect: 251, 459, 263, 468 ActionDest: 422 Annotation: Subtype: Link Rect: 531, 421, 543, 430 ActionDest: 422 Annotation: Subtype: Link Rect: 544, 421, 556, 430 ActionDest: 422 Annotation: Subtype: Link Rect: 381, 383, 393, 392 ActionDest: 422 Annotation: Subtype: Link Rect: 393, 383, 405, 392 ActionDest: 422 Annotation: Subtype: Link Rect: 544, 371, 556, 380 ActionDest: 422 Annotation: Subtype: Link Rect: 386, 320, 398, 330 ActionDest: 422 Annotation: Subtype: Link Rect: 399, 320, 411, 330 ActionDest: 422 Annotation: Subtype: Link Rect: 297, 233, 309, 242 ActionDest: 419 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 259, 717, 266, 729 ActionDest: 77 Annotation: Subtype: Link Rect: 481, 691, 488, 703 ActionDest: 77 Annotation: Subtype: Link Rect: 428, 679, 435, 691 ActionDest: 77 Annotation: Subtype: Link Rect: 245, 669, 257, 678 ActionDest: 422 Annotation: Subtype: Link Rect: 332, 606, 344, 615 ActionDest: 422 Annotation: Subtype: Link Rect: 360, 204, 371, 213 ActionDest: 422 Annotation: Subtype: Link Rect: 310, 133, 322, 142 ActionDest: 422 Annotation: Subtype: Link Rect: 544, 108, 556, 117 ActionDest: 422 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 196, 707, 203, 719 ActionDest: 83 Annotation: Subtype: Link Rect: 463, 694, 470, 706 ActionDest: 83 Annotation: Subtype: Link Rect: 480, 263, 491, 271 ActionDest: 422 Annotation: Subtype: Link Rect: 428, 225, 439, 233 ActionDest: 422 Annotation: Subtype: Link Rect: 546, 212, 557, 220 ActionDest: 422 Annotation: Subtype: Link Rect: 186, 199, 197, 207 ActionDest: 422 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 218, 685, 230, 694 ActionDest: 422 Annotation: Subtype: Link Rect: 266, 632, 273, 644 ActionDest: 77 Annotation: Subtype: Link Rect: 425, 594, 432, 606 ActionDest: 77 Annotation: Subtype: Link Rect: 216, 559, 223, 568 ActionDest: 416 Annotation: Subtype: Link Rect: 223, 559, 235, 568 ActionDest: 419 Annotation: Subtype: Link Rect: 237, 546, 249, 556 ActionDest: 422 Annotation: Subtype: Link Rect: 340, 546, 351, 556 ActionDest: 422 Annotation: Subtype: Link Rect: 215, 534, 227, 543 ActionDest: 422 Annotation: Subtype: Link Rect: 308, 534, 320, 543 ActionDest: 422 Annotation: Subtype: Link Rect: 375, 534, 387, 543 ActionDest: 422 Annotation: Subtype: Link Rect: 458, 534, 470, 543 ActionDest: 422 Annotation: Subtype: Link Rect: 221, 283, 233, 292 ActionDest: 422 Annotation: Subtype: Link Rect: 318, 232, 330, 241 ActionDest: 422 Annotation: Subtype: Link Rect: 365, 230, 372, 242 ActionDest: 111 Annotation: Subtype: Link Rect: 219, 132, 231, 141 ActionDest: 419 Annotation: Subtype: Link Rect: 450, 82, 462, 91 ActionDest: 419 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 227, 685, 239, 694 ActionDest: 422 Annotation: Subtype: Link Rect: 463, 672, 475, 681 ActionDest: 422 Annotation: Subtype: Link Rect: 239, 647, 251, 656 ActionDest: 419 Annotation: Subtype: Link Rect: 412, 597, 424, 606 ActionDest: 425 Annotation: Subtype: Link Rect: 453, 509, 465, 518 ActionDest: 419 Annotation: Subtype: Link Rect: 335, 431, 342, 443 ActionDest: 77 Annotation: Subtype: Link Rect: 300, 421, 312, 430 ActionDest: 425 Annotation: Subtype: Link Rect: 394, 371, 406, 380 ActionDest: 425 Annotation: Subtype: Link Rect: 194, 333, 206, 342 ActionDest: 419 Annotation: Subtype: Link Rect: 277, 308, 289, 317 ActionDest: 425 Annotation: Subtype: Link Rect: 302, 283, 314, 292 ActionDest: 422 Annotation: Subtype: Link Rect: 368, 258, 380, 267 ActionDest: 419 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 211, 377, 222, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 312, 377, 323, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 418, 377, 429, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 538, 377, 549, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 644, 377, 655, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 754, 378, 765, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 765, 377, 776, 386 ActionDest: 425 Annotation: Subtype: Link Rect: 205, 359, 216, 367 ActionDest: 425 Annotation: Subtype: Link Rect: 308, 359, 319, 367 ActionDest: 425 Annotation: Subtype: Link Rect: 424, 359, 435, 367 ActionDest: 425 Annotation: Subtype: Link Rect: 532, 359, 543, 367 ActionDest: 425 Annotation: Subtype: Link Rect: 642, 359, 653, 367 ActionDest: 425 Annotation: Subtype: Link Rect: 765, 359, 776, 367 ActionDest: 425 Annotation: Subtype: Link Rect: 203, 333, 214, 342 ActionDest: 425 Annotation: Subtype: Link Rect: 313, 334, 324, 343 ActionDest: 425 Annotation: Subtype: Link Rect: 423, 333, 434, 342 ActionDest: 425 Annotation: Subtype: Link Rect: 539, 333, 549, 342 ActionDest: 425 Annotation: Subtype: Link Rect: 643, 333, 653, 342 ActionDest: 425 Annotation: Subtype: Link Rect: 785, 333, 796, 342 ActionDest: 425 Annotation: Subtype: Link Rect: 213, 312, 224, 321 ActionDest: 425 Annotation: Subtype: Link Rect: 329, 312, 340, 321 ActionDest: 425 Annotation: Subtype: Link Rect: 425, 313, 436, 321 ActionDest: 422 Annotation: Subtype: Link Rect: 551, 312, 562, 321 ActionDest: 425 Annotation: Subtype: Link Rect: 770, 313, 781, 321 ActionDest: 425 Annotation: Subtype: Link Rect: 203, 297, 214, 305 ActionDest: 425 Annotation: Subtype: Link Rect: 313, 297, 324, 305 ActionDest: 425 Annotation: Subtype: Link Rect: 423, 297, 434, 305 ActionDest: 425 Annotation: Subtype: Link Rect: 556, 297, 567, 305 ActionDest: 425 Annotation: Subtype: Link Rect: 643, 297, 653, 305 ActionDest: 425 Annotation: Subtype: Link Rect: 203, 282, 214, 290 ActionDest: 425 Annotation: Subtype: Link Rect: 336, 282, 347, 290 ActionDest: 425 Annotation: Subtype: Link Rect: 425, 282, 436, 290 ActionDest: 425 Annotation: Subtype: Link Rect: 547, 282, 558, 290 ActionDest: 425 Annotation: Subtype: Link Rect: 645, 282, 656, 290 ActionDest: 425 Annotation: Subtype: Link Rect: 769, 282, 780, 290 ActionDest: 425 Annotation: Subtype: Link Rect: 195, 246, 206, 254 ActionDest: 422 Annotation: Subtype: Link Rect: 342, 247, 353, 255 ActionDest: 422 Annotation: Subtype: Link Rect: 415, 246, 426, 254 ActionDest: 422 Annotation: Subtype: Link Rect: 554, 251, 565, 260 ActionDest: 422 Annotation: Subtype: Link Rect: 676, 256, 687, 265 ActionDest: 422 Annotation: Subtype: Link Rect: 760, 252, 771, 260 ActionDest: 422 Annotation: Subtype: Link Rect: 224, 213, 235, 221 ActionDest: 422 Annotation: Subtype: Link Rect: 335, 222, 346, 231 ActionDest: 422 Annotation: Subtype: Link Rect: 444, 213, 455, 221 ActionDest: 422 Annotation: Subtype: Link Rect: 557, 222, 568, 231 ActionDest: 422 Annotation: Subtype: Link Rect: 667, 222, 678, 231 ActionDest: 422 Annotation: Subtype: Link Rect: 776, 218, 787, 226 ActionDest: 422 Annotation: Subtype: Link Rect: 218, 123, 229, 131 ActionDest: 425 Annotation: Subtype: Link Rect: 305, 142, 316, 151 ActionDest: 425 Annotation: Subtype: Link Rect: 438, 123, 449, 131 ActionDest: 425 Annotation: Subtype: Link Rect: 565, 195, 576, 203 ActionDest: 425 Annotation: Subtype: Link Rect: 525, 127, 536, 135 ActionDest: 425 Annotation: Subtype: Link Rect: 658, 142, 669, 151 ActionDest: 422 Annotation: Subtype: Link Rect: 760, 141, 771, 149 ActionDest: 425 Annotation: Subtype: Link Rect: 222, 99, 233, 107 ActionDest: 422 Annotation: Subtype: Link Rect: 305, 99, 316, 107 ActionDest: 425 Annotation: Subtype: Link Rect: 442, 99, 453, 107 ActionDest: 419 Annotation: Subtype: Link Rect: 553, 104, 564, 112 ActionDest: 425 Annotation: Subtype: Link Rect: 635, 99, 646, 107 ActionDest: 419 Annotation: Subtype: Link Rect: 770, 104, 781, 112 ActionDest: 425 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 544, 490, 556, 500 ActionDest: 425 Annotation: Subtype: Link Rect: 458, 453, 470, 462 ActionDest: 425 Annotation: Subtype: Link Rect: 450, 378, 461, 387 ActionDest: 419 Annotation: Subtype: Link Rect: 254, 352, 266, 361 ActionDest: 425 Annotation: Subtype: Link Rect: 300, 264, 312, 274 ActionDest: 425 Annotation: Subtype: Link Rect: 286, 189, 298, 198 ActionDest: 419 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 495, 582, 507, 591 ActionDest: 425 Annotation: Subtype: Link Rect: 197, 544, 209, 553 ActionDest: 425 Annotation: Subtype: Link Rect: 408, 519, 425, 528 ActionDest: 428 Annotation: Subtype: Link Rect: 382, 507, 399, 516 ActionDest: 428 Annotation: Subtype: Link Rect: 433, 507, 450, 516 ActionDest: 428 Annotation: Subtype: Link Rect: 501, 507, 518, 516 ActionDest: 428 Annotation: Subtype: Link Rect: 197, 494, 214, 503 ActionDest: 428 Annotation: Subtype: Link Rect: 214, 494, 231, 503 ActionDest: 428 Annotation: Subtype: Link Rect: 342, 494, 354, 503 ActionDest: 419 Annotation: Subtype: Link Rect: 355, 494, 367, 503 ActionDest: 422 Annotation: Subtype: Link Rect: 367, 494, 384, 503 ActionDest: 428 Annotation: Subtype: Link Rect: 385, 494, 401, 503 ActionDest: 428 Annotation: Subtype: Link Rect: 472, 444, 489, 453 ActionDest: 428 Annotation: Subtype: Link Rect: 211, 394, 228, 403 ActionDest: 428 Annotation: Subtype: Link Rect: 287, 381, 304, 390 ActionDest: 428 Annotation: Subtype: Link Rect: 209, 281, 226, 290 ActionDest: 428 Annotation: Subtype: Link Rect: 220, 193, 237, 202 ActionDest: 428 Annotation: Subtype: Link Rect: 364, 80, 381, 89 ActionDest: 428 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 488, 622, 505, 631 ActionDest: 428 Annotation: Subtype: Link Rect: 463, 597, 480, 606 ActionDest: 428 Annotation: Subtype: Link Rect: 483, 597, 500, 606 ActionDest: 428 Annotation: Subtype: Link Rect: 251, 521, 268, 530 ActionDest: 428 Annotation: Subtype: Link Rect: 373, 469, 380, 481 ActionDest: 364 Annotation: Subtype: Link Rect: 224, 421, 241, 430 ActionDest: 428 Annotation: Subtype: Link Rect: 323, 408, 340, 417 ActionDest: 428 Annotation: Subtype: Link Rect: 514, 381, 521, 393 ActionDest: 364 Annotation: Subtype: Link Rect: 228, 368, 235, 380 ActionDest: 364 Annotation: Subtype: Link Rect: 251, 320, 268, 330 ActionDest: 428 Annotation: Subtype: Link Rect: 431, 305, 438, 317 ActionDest: 364 Annotation: Subtype: Link Rect: 268, 280, 275, 292 ActionDest: 364 Annotation: Subtype: Link Rect: 272, 255, 279, 267 ActionDest: 364 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 541, 306, 557, 314 ActionDest: 428 Annotation: Subtype: Link Rect: 289, 271, 306, 280 ActionDest: 428 Annotation: Subtype: Link Rect: 224, 255, 230, 268 ActionDest: 364 Annotation: Subtype: Link Rect: 331, 255, 338, 268 ActionDest: 364 Annotation: Subtype: Link Rect: 482, 230, 489, 242 ActionDest: 364 Annotation: Subtype: Link Rect: 466, 205, 473, 217 ActionDest: 364 Annotation: Subtype: Link Rect: 522, 107, 534, 116 ActionDest: 419 Annotation: Subtype: Link Rect: 315, 82, 332, 91 ActionDest: 428 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 324, 722, 336, 731 ActionDest: 425 Annotation: Subtype: Link Rect: 244, 697, 251, 706 ActionDest: 416 Annotation: Subtype: Link Rect: 293, 685, 310, 694 ActionDest: 428 Annotation: Subtype: Link Rect: 387, 685, 404, 694 ActionDest: 428 Annotation: Subtype: Link Rect: 239, 672, 251, 681 ActionDest: 419 Annotation: Subtype: Link Rect: 252, 672, 269, 681 ActionDest: 428 Annotation: Subtype: Link Rect: 404, 622, 421, 631 ActionDest: 428 Annotation: Subtype: Link Rect: 507, 597, 518, 606 ActionDest: 425 Annotation: Subtype: Link Rect: 373, 572, 390, 581 ActionDest: 428 Annotation: Subtype: Link Rect: 201, 506, 208, 518 ActionDest: 370 Annotation: Subtype: Link Rect: 349, 205, 364, 213 ActionDest: 428 Annotation: Subtype: Link Rect: 541, 167, 557, 175 ActionDest: 428 Annotation: Subtype: Link Rect: 333, 64, 348, 72 ActionDest: 428 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 345, 710, 357, 719 ActionDest: 425 Annotation: Subtype: Link Rect: 357, 710, 374, 719 ActionDest: 428 Annotation: Subtype: Link Rect: 219, 697, 236, 706 ActionDest: 428 Annotation: Subtype: Link Rect: 298, 609, 315, 618 ActionDest: 428 Annotation: Subtype: Link Rect: 219, 597, 236, 606 ActionDest: 428 Annotation: Subtype: Link Rect: 358, 581, 365, 594 ActionDest: 370 Annotation: Subtype: Link Rect: 336, 496, 353, 505 ActionDest: 431 Annotation: Subtype: Link Rect: 459, 494, 466, 506 ActionDest: 370 Annotation: Subtype: Link Rect: 516, 469, 523, 481 ActionDest: 370 Annotation: Subtype: Link Rect: 426, 421, 443, 430 ActionDest: 428 Annotation: Subtype: Link Rect: 226, 383, 243, 392 ActionDest: 431 Annotation: Subtype: Link Rect: 295, 258, 312, 267 ActionDest: 431 Annotation: Subtype: Link Rect: 448, 182, 465, 192 ActionDest: 431 Annotation: Subtype: Link Rect: 472, 120, 484, 129 ActionDest: 422 Annotation: Subtype: Link Rect: 198, 107, 215, 116 ActionDest: 431 Annotation: Subtype: Link Rect: 218, 107, 235, 116 ActionDest: 431 Annotation: Subtype: Link Rect: 446, 82, 463, 91 ActionDest: 431 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 213, 722, 225, 731 ActionDest: 422 Annotation: Subtype: Link Rect: 328, 534, 345, 543 ActionDest: 431 Annotation: Subtype: Link Rect: 341, 509, 348, 518 ActionDest: 416 Annotation: Subtype: Link Rect: 348, 509, 365, 518 ActionDest: 431 Annotation: Subtype: Link Rect: 460, 496, 477, 505 ActionDest: 431 Annotation: Subtype: Link Rect: 217, 406, 224, 418 ActionDest: 382 Annotation: Subtype: Link Rect: 337, 408, 354, 417 ActionDest: 431 Annotation: Subtype: Link Rect: 218, 280, 225, 292 ActionDest: 382 Annotation: Subtype: Link Rect: 334, 268, 341, 280 ActionDest: 382 Annotation: Subtype: Link Rect: 350, 243, 357, 255 ActionDest: 382 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 286, 446, 301, 454 ActionDest: 431 Annotation: Subtype: Link Rect: 442, 384, 459, 393 ActionDest: 431 Annotation: Subtype: Link Rect: 491, 359, 508, 368 ActionDest: 431 Annotation: Subtype: Link Rect: 304, 334, 321, 343 ActionDest: 431 Annotation: Subtype: Link Rect: 256, 321, 273, 330 ActionDest: 431 Annotation: Subtype: Link Rect: 464, 271, 481, 280 ActionDest: 431 Annotation: Subtype: Link Rect: 274, 171, 291, 180 ActionDest: 431 Annotation: Subtype: Link Rect: 365, 171, 382, 180 ActionDest: 431 Annotation: Subtype: Link Rect: 245, 70, 262, 79 ActionDest: 431 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 301, 685, 318, 694 ActionDest: 431 Annotation: Subtype: Link Rect: 213, 572, 230, 581 ActionDest: 431 Annotation: Subtype: Link Rect: 245, 547, 262, 556 ActionDest: 431 Annotation: Subtype: Link Rect: 519, 484, 536, 493 ActionDest: 431 Annotation: Subtype: Link Rect: 345, 421, 361, 430 ActionDest: 431 Annotation: Subtype: Link Rect: 238, 383, 255, 392 ActionDest: 431 Annotation: Subtype: Link Rect: 244, 270, 261, 279 ActionDest: 431 Annotation: Subtype: Link Rect: 495, 92, 502, 104 ActionDest: 391 Annotation: Subtype: Link Rect: 223, 82, 235, 91 ActionDest: 422 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 284, 682, 291, 694 ActionDest: 391 Annotation: Subtype: Link Rect: 378, 581, 385, 595 ActionDest: 391 Annotation: Subtype: Link Rect: 334, 199, 345, 207 ActionDest: 422 Annotation: Subtype: Link Rect: 493, 113, 510, 122 ActionDest: 431 Annotation: Subtype: Link Rect: 294, 100, 311, 109 ActionDest: 431 Annotation: Subtype: Link Rect: 343, 63, 355, 72 ActionDest: 422 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 255, 735, 272, 744 ActionDest: 431 Annotation: Subtype: Link Rect: 331, 722, 343, 731 ActionDest: 425 Annotation: Subtype: Link Rect: 279, 634, 296, 643 ActionDest: 431 Annotation: Subtype: Link Rect: 325, 572, 342, 581 ActionDest: 431 Annotation: Subtype: Link Rect: 525, 459, 542, 468 ActionDest: 431 Annotation: Subtype: Link Rect: 360, 258, 377, 267 ActionDest: 431 Annotation: Subtype: Link Rect: 415, 255, 422, 267 ActionDest: 400 Annotation: Subtype: Link Rect: 318, 217, 324, 229 ActionDest: 400 Annotation: Subtype: Link Rect: 301, 155, 308, 167 ActionDest: 400 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 475, 386, 491, 395 ActionDest: 431 Annotation: Subtype: Link Rect: 307, 288, 319, 297 ActionDest: 422 Annotation: Subtype: Link Rect: 524, 273, 531, 285 ActionDest: 111 Annotation: Subtype: Link Rect: 324, 250, 335, 259 ActionDest: 425 Annotation: Subtype: Link Rect: 442, 213, 454, 222 ActionDest: 422 Annotation: Subtype: Link Rect: 302, 75, 319, 84 ActionDest: 431 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 421, 559, 433, 568 ActionDest: 425 Annotation: Subtype: Link Rect: 539, 559, 556, 568 ActionDest: 431 Annotation: Subtype: Link Rect: 256, 509, 268, 518 ActionDest: 425 Annotation: Subtype: Link Rect: 360, 496, 377, 505 ActionDest: 431 Annotation: Subtype: Link Rect: 539, 207, 556, 216 ActionDest: 431 Annotation: Subtype: Link Rect: 307, 170, 324, 179 ActionDest: 428 Annotation: Subtype: Link Rect: 324, 170, 341, 179 ActionDest: 434 Annotation: Subtype: Link Rect: 342, 170, 359, 179 ActionDest: 434 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 481, 672, 498, 681 ActionDest: 434 Annotation: Subtype: Link Rect: 244, 647, 261, 656 ActionDest: 434 Annotation: Subtype: Link Rect: 328, 647, 345, 656 ActionDest: 434 Annotation: Subtype: Link Rect: 512, 572, 529, 581 ActionDest: 434 Annotation: Subtype: Link Rect: 255, 446, 272, 455 ActionDest: 434 Annotation: Subtype: Link Rect: 459, 408, 475, 417 ActionDest: 434 Annotation: Subtype: Link Rect: 522, 408, 539, 417 ActionDest: 434 Annotation: Subtype: Link Rect: 351, 308, 363, 317 ActionDest: 425 Annotation: Subtype: Link Rect: 364, 308, 381, 317 ActionDest: 434 Annotation: Subtype: Link Rect: 384, 308, 401, 317 ActionDest: 434 Annotation: Subtype: Link Rect: 539, 308, 556, 317 ActionDest: 434 Annotation: Subtype: Link Rect: 403, 270, 420, 279 ActionDest: 434 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 320, 720, 334, 732 ActionDest: 346 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 251, 302, 288, 313 Annotation: Subtype: Link Rect: 86, 279, 124, 290 Annotation: Subtype: Link Rect: 291, 256, 328, 267 Annotation: Subtype: Link Rect: 59, 222, 97, 232 Annotation: Subtype: Link Rect: 244, 198, 282, 209 Annotation: Subtype: Link Rect: 288, 198, 324, 209 Annotation: Subtype: Link Rect: 465, 175, 502, 186 Annotation: Subtype: Link Rect: 327, 152, 364, 163 Annotation: Subtype: Link Rect: 198, 130, 236, 140 Annotation: Subtype: Link Rect: 519, 106, 557, 117 Annotation: Subtype: Link Rect: 59, 95, 95, 105 Annotation: Subtype: Link Rect: 230, 71, 267, 82 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 411, 721, 448, 732 Annotation: Subtype: Link Rect: 342, 698, 380, 709 Annotation: Subtype: Link Rect: 386, 698, 422, 709 Annotation: Subtype: Link Rect: 485, 687, 522, 697 Annotation: Subtype: Link Rect: 59, 664, 97, 674 Annotation: Subtype: Link Rect: 118, 641, 155, 651 Annotation: Subtype: Link Rect: 162, 641, 198, 651 Annotation: Subtype: Link Rect: 59, 607, 97, 617 Annotation: Subtype: Link Rect: 103, 607, 139, 617 Annotation: Subtype: Link Rect: 403, 583, 440, 594 Annotation: Subtype: Link Rect: 471, 571, 560, 582 Annotation: Subtype: Link Rect: 56, 560, 142, 571 Annotation: Subtype: Link Rect: 91, 538, 128, 548 Annotation: Subtype: Link Rect: 157, 515, 194, 525 Annotation: Subtype: Link Rect: 333, 491, 370, 502 Annotation: Subtype: Link Rect: 232, 468, 270, 479 Annotation: Subtype: Link Rect: 219, 446, 257, 456 Annotation: Subtype: Link Rect: 364, 433, 401, 444 Annotation: Subtype: Link Rect: 455, 410, 493, 421 Annotation: Subtype: Link Rect: 499, 410, 535, 421 Annotation: Subtype: Link Rect: 176, 388, 214, 398 Annotation: Subtype: Link Rect: 161, 365, 198, 375 Annotation: Subtype: Link Rect: 426, 341, 464, 352 Annotation: Subtype: Link Rect: 417, 330, 454, 341 Annotation: Subtype: Link Rect: 462, 318, 500, 329 Annotation: Subtype: Link Rect: 506, 318, 542, 329 Annotation: Subtype: Link Rect: 197, 296, 234, 306 Annotation: Subtype: Link Rect: 475, 261, 512, 272 Annotation: Subtype: Link Rect: 456, 215, 493, 226 Annotation: Subtype: Link Rect: 95, 192, 133, 203 Annotation: Subtype: Link Rect: 502, 181, 540, 191 Annotation: Subtype: Link Rect: 391, 169, 428, 180 Annotation: Subtype: Link Rect: 170, 135, 208, 145 Annotation: Subtype: Link Rect: 243, 100, 280, 111 Annotation: Subtype: Link Rect: 59, 66, 97, 76 Annotation: Subtype: Link Rect: 103, 66, 139, 76 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 407, 721, 445, 732 Annotation: Subtype: Link Rect: 325, 698, 362, 709 Annotation: Subtype: Link Rect: 368, 698, 405, 709 Annotation: Subtype: Link Rect: 189, 676, 226, 686 Annotation: Subtype: Link Rect: 296, 652, 333, 663 Annotation: Subtype: Link Rect: 475, 629, 512, 640 Annotation: Subtype: Link Rect: 519, 629, 555, 640 Annotation: Subtype: Link Rect: 136, 595, 173, 605 Annotation: Subtype: Link Rect: 519, 583, 557, 594 Annotation: Subtype: Link Rect: 518, 571, 555, 582 Annotation: Subtype: Link Rect: 172, 549, 209, 559 Annotation: Subtype: Link Rect: 216, 549, 252, 559 Annotation: Subtype: Link Rect: 296, 525, 334, 536 Annotation: Subtype: Link Rect: 122, 503, 159, 513 Annotation: Subtype: Link Rect: 166, 503, 202, 513 Annotation: Subtype: Link Rect: 394, 479, 432, 490 Annotation: Subtype: Link Rect: 490, 468, 527, 479 Annotation: Subtype: Link Rect: 380, 456, 418, 467 Annotation: Subtype: Link Rect: 267, 423, 304, 433 Annotation: Subtype: Link Rect: 59, 400, 97, 410 Annotation: Subtype: Link Rect: 182, 365, 219, 375 Annotation: Subtype: Link Rect: 225, 365, 262, 375 Annotation: Subtype: Link Rect: 224, 342, 262, 352 Annotation: Subtype: Link Rect: 82, 308, 119, 318 Annotation: Subtype: Link Rect: 454, 284, 491, 295 Annotation: Subtype: Link Rect: 113, 250, 151, 260 Annotation: Subtype: Link Rect: 118, 215, 155, 226 Annotation: Subtype: Link Rect: 234, 192, 271, 203 Annotation: Subtype: Link Rect: 300, 169, 337, 180 Annotation: Subtype: Link Rect: 255, 146, 293, 157 Annotation: Subtype: Link Rect: 299, 146, 335, 157 Annotation: Subtype: Link Rect: 196, 123, 234, 134 Annotation: Subtype: Link Rect: 240, 123, 276, 134 Annotation: Subtype: Link Rect: 95, 100, 133, 111 Annotation: Subtype: Link Rect: 258, 77, 296, 88 Annotation: Subtype: Link Rect: 302, 77, 338, 88 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 193, 722, 230, 732 Annotation: Subtype: Link Rect: 313, 698, 350, 709 Annotation: Subtype: Link Rect: 312, 675, 350, 686 Annotation: Subtype: Link Rect: 332, 653, 369, 663 Annotation: Subtype: Link Rect: 517, 629, 554, 640 Annotation: Subtype: Link Rect: 192, 606, 230, 617 Annotation: Subtype: Link Rect: 398, 583, 435, 594 Annotation: Subtype: Link Rect: 305, 560, 343, 571 Annotation: Subtype: Link Rect: 349, 560, 385, 571 Annotation: Subtype: Link Rect: 59, 538, 97, 548 Annotation: Subtype: Link Rect: 103, 538, 139, 548 Annotation: Subtype: Link Rect: 267, 514, 305, 525 Annotation: Subtype: Link Rect: 311, 514, 347, 525 Annotation: Subtype: Link Rect: 444, 503, 482, 513 Annotation: Subtype: Link Rect: 481, 479, 519, 490 Annotation: Subtype: Link Rect: 122, 457, 160, 467 Annotation: Subtype: Link Rect: 476, 445, 513, 456 Annotation: Subtype: Link Rect: 178, 423, 215, 433 Annotation: Subtype: Link Rect: 402, 399, 439, 410 Annotation: Subtype: Link Rect: 109, 377, 146, 387 Annotation: Subtype: Link Rect: 59, 342, 97, 352 Annotation: Subtype: Link Rect: 103, 342, 139, 352 Annotation: Subtype: Link Rect: 143, 319, 181, 329 Annotation: Subtype: Link Rect: 187, 319, 223, 329 Annotation: Subtype: Link Rect: 411, 307, 448, 318 Annotation: Subtype: Link Rect: 255, 284, 292, 295 Annotation: Subtype: Link Rect: 145, 250, 182, 260 Annotation: Subtype: Link Rect: 417, 238, 455, 249 Annotation: Subtype: Link Rect: 312, 215, 349, 226 Annotation: Subtype: Link Rect: 356, 215, 392, 226 Annotation: Subtype: Link Rect: 149, 192, 187, 203 Annotation: Subtype: Link Rect: 224, 169, 262, 180 Annotation: Subtype: Link Rect: 268, 169, 304, 180 Annotation: Subtype: Link Rect: 322, 146, 360, 157 Annotation: Subtype: Link Rect: 366, 146, 402, 157 Annotation: Subtype: Link Rect: 400, 123, 437, 134 Annotation: Subtype: Link Rect: 275, 100, 313, 111 Annotation: Subtype: Link Rect: 356, 88, 394, 99 Annotation: Subtype: Link Rect: 209, 66, 246, 76 Annotation: Subtype: Link Rect: 253, 66, 289, 76 Page: Sequence: 28 Annotations: Annotation: Subtype: Link Rect: 182, 721, 220, 732 Annotation: Subtype: Link Rect: 127, 699, 164, 709 Annotation: Subtype: Link Rect: 445, 676, 482, 686 Annotation: Subtype: Link Rect: 490, 653, 528, 663 Annotation: Subtype: Link Rect: 202, 630, 240, 640 Annotation: Subtype: Link Rect: 396, 606, 433, 617 Annotation: Subtype: Link Rect: 430, 583, 468, 594 Annotation: Subtype: Link Rect: 519, 560, 557, 571 Annotation: Subtype: Link Rect: 59, 549, 95, 559 Annotation: Subtype: Link Rect: 345, 537, 560, 548 Annotation: Subtype: Link Rect: 56, 526, 118, 536 Annotation: Subtype: Link Rect: 381, 479, 418, 490 Annotation: Subtype: Link Rect: 358, 456, 396, 467 Annotation: Subtype: Link Rect: 402, 456, 438, 467 Annotation: Subtype: Link Rect: 276, 433, 313, 444 Annotation: Subtype: Link Rect: 320, 433, 356, 444 Annotation: Subtype: Link Rect: 228, 410, 266, 421 Annotation: Subtype: Link Rect: 104, 377, 142, 387 Annotation: Subtype: Link Rect: 391, 353, 429, 364 Annotation: Subtype: Link Rect: 95, 331, 132, 341 Annotation: Subtype: Link Rect: 232, 307, 270, 318 Annotation: Subtype: Link Rect: 363, 272, 401, 283 Annotation: Subtype: Link Rect: 514, 249, 551, 260 Annotation: Subtype: Link Rect: 430, 226, 468, 237 Annotation: Subtype: Link Rect: 474, 226, 510, 237 Annotation: Subtype: Link Rect: 176, 204, 214, 214 Annotation: Subtype: Link Rect: 220, 204, 256, 214 Annotation: Subtype: Link Rect: 302, 180, 339, 191 Annotation: Subtype: Link Rect: 270, 157, 307, 168 Annotation: Subtype: Link Rect: 221, 123, 259, 134 Annotation: Subtype: Link Rect: 109, 100, 146, 111 Annotation: Subtype: Link Rect: 162, 66, 200, 76 Page: Sequence: 29 Annotations: Annotation: Subtype: Link Rect: 177, 722, 215, 732 Annotation: Subtype: Link Rect: 221, 722, 257, 732 Annotation: Subtype: Link Rect: 59, 699, 97, 709 Annotation: Subtype: Link Rect: 294, 675, 332, 686 Annotation: Subtype: Link Rect: 463, 652, 500, 663 Annotation: Subtype: Link Rect: 507, 652, 543, 663 Annotation: Subtype: Link Rect: 486, 640, 523, 651 Annotation: Subtype: Link Rect: 451, 617, 488, 628 Annotation: Subtype: Link Rect: 136, 584, 173, 594 Annotation: Subtype: Link Rect: 443, 571, 481, 582 Annotation: Subtype: Link Rect: 309, 548, 346, 559 Annotation: Subtype: Link Rect: 352, 548, 388, 559 Annotation: Subtype: Link Rect: 113, 526, 150, 536 Annotation: Subtype: Link Rect: 413, 502, 451, 513 Annotation: Subtype: Link Rect: 374, 479, 411, 490 Annotation: Subtype: Link Rect: 197, 457, 234, 467 Annotation: Subtype: Link Rect: 241, 457, 277, 467 Annotation: Subtype: Link Rect: 171, 433, 208, 444 Annotation: Subtype: Link Rect: 464, 410, 502, 421 Annotation: Subtype: Link Rect: 260, 377, 298, 387 Annotation: Subtype: Link Rect: 118, 342, 155, 352 Annotation: Subtype: Link Rect: 299, 318, 336, 329 Annotation: Subtype: Link Rect: 342, 318, 378, 329 Annotation: Subtype: Link Rect: 90, 296, 128, 306 Annotation: Subtype: Link Rect: 429, 272, 467, 283 Annotation: Subtype: Link Rect: 274, 249, 312, 260 Annotation: Subtype: Link Rect: 503, 226, 540, 237 Annotation: Subtype: Link Rect: 478, 203, 515, 214 Annotation: Subtype: Link Rect: 521, 203, 557, 214 Annotation: Subtype: Link Rect: 519, 180, 557, 191 Annotation: Subtype: Link Rect: 59, 169, 95, 180 Annotation: Subtype: Link Rect: 383, 111, 420, 122 Annotation: Subtype: Link Rect: 445, 88, 482, 99 Annotation: Subtype: Link Rect: 218, 66, 255, 76 Page: Sequence: 30 Annotations: Annotation: Subtype: Link Rect: 420, 721, 457, 732 Annotation: Subtype: Link Rect: 520, 698, 557, 709 Annotation: Subtype: Link Rect: 59, 687, 95, 697 Annotation: Subtype: Link Rect: 449, 663, 486, 674 Annotation: Subtype: Link Rect: 492, 663, 528, 674 Annotation: Subtype: Link Rect: 256, 640, 293, 651 Annotation: Subtype: Link Rect: 402, 617, 440, 628 Annotation: Subtype: Link Rect: 459, 594, 497, 605 Annotation: Subtype: Link Rect: 297, 571, 334, 582 Annotation: Subtype: Link Rect: 127, 549, 164, 559 Annotation: Subtype: Link Rect: 394, 525, 431, 536 Annotation: Subtype: Link Rect: 59, 492, 97, 502 Annotation: Subtype: Link Rect: 329, 468, 366, 479 Annotation: Subtype: Link Rect: 346, 445, 384, 456 Annotation: Subtype: Link Rect: 431, 422, 469, 433 Checksum: 656a756a Type: CRC32 Checksum: ed1fc1e1fea5bbacfac918373fb138cc Type: MD5 Checksum: 40a7bbdbad44b26472ef4c5b7407f759fb4cfdde Type: SHA-1