6eece27cac23ef8203a2f23b241174c8 nutrients_a2021v13p2779.pdf 2e91da3259cd569b762294672ecafc95bcc9d5e2 nutrients_a2021v13p2779.pdf 285680209060a958dc8af8765acb3d507a715e00d01e820608118c24538b5a56 nutrients_a2021v13p2779.pdf Title: Metabolic, Affective and Neurocognitive Characterization of Metabolic Syndrome Patients with and without Food Addiction. Implications for Weight Progression Subject: According to the food addiction (FA) model, the consumption of certain types of food could be potentially addictive and can lead to changes in intake regulation. We aimed to describe metabolic parameters, dietary characteristics, and affective and neurocognitive vulnerabilities of individuals with and without FA, and to explore its influences on weight loss progression. The sample included 448 adults (55–75 years) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus cognition sub-study. Cognitive and psychopathological assessments, as well as dietary, biochemical, and metabolic measurements, were assessed at baseline. Weight progression was evaluated after a 3-year follow up. The presence of FA was associated with higher depressive symptomatology, neurocognitive decline, low quality of life, high body mass index (BMI), and high waist circumference, but not with metabolic comorbidities. No differences were observed in the dietary characteristics except for the saturated and monounsaturated fatty acids consumption. After three years, the presence of FA at baseline resulted in a significantly higher weight regain. FA is associated with worse psychological and neurocognitive state and higher weight regain in adults with metabolic syndrome. This condition could be an indicator of bad prognosis in the search for a successful weight loss process. Keywords: food addiction; metabolic syndrome; neurocognitive state; depression; quality of life Author: Lucía Camacho-Barcia, Lucero Munguía, Ignacio Lucas, Rafael de la Torre, Jordi Salas-Salvadó, Xavier Pintó, Dolores Corella, Roser Granero, Susana Jiménez-Murcia, Inmaculada González-Monje, Virginia Esteve-Luque, Aida Cuenca-Royo, Carlos Gómez-Martínez, Indira Paz-Graniel, Laura Forcano and Fernando Fernández-Aranda Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Aug 18 06:20:14 2021 CEST ModDate: Wed Aug 18 06:28:33 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 519027 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IBTYZX+VnURWPalladioL Type 1 Custom yes yes no 10 0 KEJLKR+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 IFPGFO+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 NLVUQM+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 MSSEIU+CMSY10 Type 1 Builtin yes yes no 78 0 NLSOBY+EURM10 Type 1 Builtin yes yes no 85 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 95 0 FNBDBI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 114 0 FNBDBJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 117 0 FNBDBK+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 FNBDCM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 126 0 FNBGJJ+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 129 0 NJWNDJ+VnURWPalladioL-Italic Type 1 Custom yes yes no 152 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:17:23 CEST RepresentationInformation: nutrients_a2021v13p2779.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:37 CEST Size: 519027 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 384 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Dietary Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Biochemical, Anthropometric and Blood Pressure Measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Psychometric Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Cognitive Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Descriptive for the Sample Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Comparison of Metabolic and Dietary Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Comparison of Psychological and Neuropsychological Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Evolution of the BMI during the Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: Metabolic, Affective and Neurocognitive Characterization of Metabolic Syndrome Patients with and without Food Addiction. Implications for Weight Progression Author: Lucía Camacho-Barcia, Lucero Munguía, Ignacio Lucas, Rafael de la Torre, Jordi Salas-Salvadó, Xavier Pintó, Dolores Corella, Roser Granero, Susana Jiménez-Murcia, Inmaculada González-Monje, Virginia Esteve-Luque, Aida Cuenca-Royo, Carlos Gómez-Martínez, Indira Paz-Graniel, Laura Forcano and Fernando Fernández-Aranda Subject: According to the food addiction (FA) model, the consumption of certain types of food could be potentially addictive and can lead to changes in intake regulation. We aimed to describe metabolic parameters, dietary characteristics, and affective and neurocognitive vulnerabilities of individuals with and without FA, and to explore its influences on weight loss progression. The sample included 448 adults (55 75 years) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus cognition sub-study. Cognitive and psychopathological assessments, as well as dietary, biochemical, and metabolic measurements, were assessed at baseline. Weight progression was evaluated after a 3-year follow up. The presence of FA was associated with higher depressive symptomatology, neurocognitive decline, low quality of life, high body mass index (BMI), and high waist circumference, but not with metabolic comorbidities. No differences were observed in the dietary characteristics except for the saturated and monounsaturated fatty acids consumption. After three years, the presence of FA at baseline resulted in a significantly higher weight regain. FA is associated with worse psychological and neurocognitive state and higher weight regain in adults with metabolic syndrome. This condition could be an indicator of bad prognosis in the search for a successful weight loss process. Keywords: food addiction; metabolic syndrome; neurocognitive state; depression; quality of life Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Aug 18 06:20:14 CEST 2021 ModDate: Wed Aug 18 06:28:33 CEST 2021 ID: 0x1178ab0d8a15aecc6329762f67556b37, 0x1178ab0d8a15aecc6329762f67556b37 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: IFPGFO+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 134 FontDescriptor: FontName: IFPGFO+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NLSOBY+EURM10 FontSubset: true FirstChar: 11 LastChar: 31 FontDescriptor: FontName: NLSOBY+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: NLVUQM+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: NLVUQM+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NJWNDJ+VnURWPalladioL-Italic FontSubset: true FirstChar: 189 LastChar: 226 FontDescriptor: FontName: NJWNDJ+VnURWPalladioL-Italic Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IBTYZX+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: IBTYZX+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JYPLJJ+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 226 FontDescriptor: FontName: JYPLJJ+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MSSEIU+CMSY10 FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: MSSEIU+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: KEJLKR+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 174 FontDescriptor: FontName: KEJLKR+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 35, 759, 169, 795 Annotation: Subtype: Link Rect: 515, 759, 560, 795 Annotation: Subtype: Link Rect: 149, 641, 160, 654 Annotation: Subtype: Link Rect: 252, 641, 263, 654 Annotation: Subtype: Link Rect: 335, 641, 347, 654 Annotation: Subtype: Link Rect: 450, 641, 461, 654 Annotation: Subtype: Link Rect: 150, 628, 161, 642 Annotation: Subtype: Link Rect: 240, 628, 251, 642 Annotation: Subtype: Link Rect: 343, 628, 354, 642 Annotation: Subtype: Link Rect: 441, 628, 452, 642 Annotation: Subtype: Link Rect: 163, 616, 174, 629 Annotation: Subtype: Link Rect: 441, 616, 452, 629 Annotation: Subtype: Link Rect: 536, 604, 547, 617 Annotation: Subtype: Link Rect: 65, 346, 154, 355 Annotation: Subtype: Link Rect: 35, 336, 73, 343 Annotation: Subtype: Link Rect: 35, 162, 97, 184 Annotation: Subtype: Link Rect: 153, 89, 154, 98 Annotation: Subtype: Link Rect: 35, 77, 147, 86 Annotation: Subtype: Link Rect: 121, 17, 255, 28 Annotation: Subtype: Link Rect: 402, 17, 558, 28 Annotation: Subtype: Link Rect: 35, 482, 87, 501 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 494, 665, 501, 674 ActionDest: 145 Annotation: Subtype: Link Rect: 300, 640, 307, 649 ActionDest: 145 Annotation: Subtype: Link Rect: 277, 627, 284, 636 ActionDest: 145 Annotation: Subtype: Link Rect: 538, 615, 545, 624 ActionDest: 145 Annotation: Subtype: Link Rect: 548, 615, 555, 624 ActionDest: 145 Annotation: Subtype: Link Rect: 359, 602, 366, 611 ActionDest: 145 Annotation: Subtype: Link Rect: 369, 602, 381, 611 ActionDest: 145 Annotation: Subtype: Link Rect: 203, 539, 215, 548 ActionDest: 145 Annotation: Subtype: Link Rect: 263, 464, 275, 473 ActionDest: 145 Annotation: Subtype: Link Rect: 429, 439, 441, 448 ActionDest: 145 Annotation: Subtype: Link Rect: 449, 426, 456, 435 ActionDest: 145 Annotation: Subtype: Link Rect: 535, 426, 547, 435 ActionDest: 145 Annotation: Subtype: Link Rect: 397, 401, 403, 410 ActionDest: 145 Annotation: Subtype: Link Rect: 404, 401, 416, 410 ActionDest: 145 Annotation: Subtype: Link Rect: 419, 401, 431, 410 ActionDest: 145 Annotation: Subtype: Link Rect: 475, 401, 486, 410 ActionDest: 145 Annotation: Subtype: Link Rect: 219, 388, 231, 398 ActionDest: 145 Annotation: Subtype: Link Rect: 218, 376, 230, 385 ActionDest: 149 Annotation: Subtype: Link Rect: 230, 376, 242, 385 ActionDest: 149 Annotation: Subtype: Link Rect: 256, 363, 268, 372 ActionDest: 145 Annotation: Subtype: Link Rect: 268, 364, 280, 372 ActionDest: 145 Annotation: Subtype: Link Rect: 280, 364, 292, 372 ActionDest: 149 Annotation: Subtype: Link Rect: 293, 363, 305, 372 ActionDest: 149 Annotation: Subtype: Link Rect: 359, 338, 371, 347 ActionDest: 149 Annotation: Subtype: Link Rect: 507, 338, 519, 347 ActionDest: 149 Annotation: Subtype: Link Rect: 519, 338, 531, 347 ActionDest: 149 Annotation: Subtype: Link Rect: 379, 313, 391, 322 ActionDest: 149 Annotation: Subtype: Link Rect: 515, 313, 527, 322 ActionDest: 149 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 201, 672, 213, 681 ActionDest: 149 Annotation: Subtype: Link Rect: 360, 669, 487, 681 Annotation: Subtype: Link Rect: 314, 471, 326, 480 ActionDest: 149 Annotation: Subtype: Link Rect: 327, 471, 339, 480 ActionDest: 149 Annotation: Subtype: Link Rect: 544, 345, 556, 354 ActionDest: 149 Annotation: Subtype: Link Rect: 340, 294, 347, 304 ActionDest: 145 Annotation: Subtype: Link Rect: 537, 294, 544, 304 ActionDest: 145 Annotation: Subtype: Link Rect: 495, 269, 507, 278 ActionDest: 149 Annotation: Subtype: Link Rect: 377, 194, 389, 203 ActionDest: 149 Annotation: Subtype: Link Rect: 222, 182, 234, 191 ActionDest: 149 Annotation: Subtype: Link Rect: 356, 156, 368, 166 ActionDest: 149 Annotation: Subtype: Link Rect: 365, 106, 377, 115 ActionDest: 149 Annotation: Subtype: Link Rect: 188, 94, 200, 103 ActionDest: 149 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 378, 684, 390, 693 ActionDest: 149 Annotation: Subtype: Link Rect: 220, 596, 232, 605 ActionDest: 149 Annotation: Subtype: Link Rect: 448, 559, 460, 567 ActionDest: 149 Annotation: Subtype: Link Rect: 376, 471, 388, 480 ActionDest: 149 Annotation: Subtype: Link Rect: 389, 471, 401, 480 ActionDest: 149 Annotation: Subtype: Link Rect: 409, 433, 421, 442 ActionDest: 149 Annotation: Subtype: Link Rect: 449, 395, 461, 404 ActionDest: 149 Annotation: Subtype: Link Rect: 461, 395, 473, 404 ActionDest: 149 Annotation: Subtype: Link Rect: 214, 304, 221, 316 ActionDest: 92 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 213, 196, 220, 208 ActionDest: 99 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 213, 717, 220, 729 ActionDest: 102 Annotation: Subtype: Link Rect: 218, 442, 225, 454 ActionDest: 102 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 428, 697, 440, 706 ActionDest: 149 Annotation: Subtype: Link Rect: 253, 634, 265, 643 ActionDest: 149 Annotation: Subtype: Link Rect: 378, 609, 389, 618 ActionDest: 149 Annotation: Subtype: Link Rect: 241, 572, 253, 581 ActionDest: 156 Annotation: Subtype: Link Rect: 226, 521, 238, 530 ActionDest: 149 Annotation: Subtype: Link Rect: 238, 521, 250, 530 ActionDest: 156 Annotation: Subtype: Link Rect: 251, 521, 263, 530 ActionDest: 156 Annotation: Subtype: Link Rect: 313, 446, 325, 455 ActionDest: 156 Annotation: Subtype: Link Rect: 544, 396, 556, 405 ActionDest: 156 Annotation: Subtype: Link Rect: 188, 295, 200, 304 ActionDest: 156 Annotation: Subtype: Link Rect: 272, 270, 284, 279 ActionDest: 156 Annotation: Subtype: Link Rect: 366, 233, 378, 242 ActionDest: 156 Annotation: Subtype: Link Rect: 381, 233, 393, 242 ActionDest: 156 Annotation: Subtype: Link Rect: 237, 220, 249, 229 ActionDest: 145 Annotation: Subtype: Link Rect: 249, 220, 261, 229 ActionDest: 145 Annotation: Subtype: Link Rect: 262, 220, 273, 229 ActionDest: 149 Annotation: Subtype: Link Rect: 274, 220, 286, 229 ActionDest: 149 Annotation: Subtype: Link Rect: 249, 195, 261, 204 ActionDest: 156 Annotation: Subtype: Link Rect: 486, 195, 493, 204 ActionDest: 145 Annotation: Subtype: Link Rect: 349, 182, 361, 192 ActionDest: 145 Annotation: Subtype: Link Rect: 254, 170, 266, 179 ActionDest: 156 Annotation: Subtype: Link Rect: 484, 157, 496, 166 ActionDest: 156 Annotation: Subtype: Link Rect: 497, 157, 509, 166 ActionDest: 156 Annotation: Subtype: Link Rect: 518, 132, 530, 141 ActionDest: 149 Annotation: Subtype: Link Rect: 484, 82, 496, 91 ActionDest: 149 Annotation: Subtype: Link Rect: 499, 82, 511, 91 ActionDest: 149 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 231, 710, 243, 719 ActionDest: 145 Annotation: Subtype: Link Rect: 544, 697, 556, 706 ActionDest: 156 Annotation: Subtype: Link Rect: 419, 634, 431, 643 ActionDest: 156 Annotation: Subtype: Link Rect: 251, 609, 263, 618 ActionDest: 156 Annotation: Subtype: Link Rect: 256, 584, 268, 593 ActionDest: 156 Annotation: Subtype: Link Rect: 292, 496, 304, 505 ActionDest: 156 Annotation: Subtype: Link Rect: 307, 496, 319, 505 ActionDest: 156 Annotation: Subtype: Link Rect: 226, 459, 233, 468 ActionDest: 145 Annotation: Subtype: Link Rect: 280, 409, 292, 417 ActionDest: 156 Annotation: Subtype: Link Rect: 292, 408, 304, 417 ActionDest: 156 Annotation: Subtype: Link Rect: 439, 371, 451, 380 ActionDest: 149 Annotation: Subtype: Link Rect: 419, 68, 560, 79 Annotation: Subtype: Link Rect: 166, 56, 254, 68 Page: Sequence: 10 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 201, 661, 239, 672 Annotation: Subtype: Link Rect: 245, 661, 281, 672 Annotation: Subtype: Link Rect: 194, 638, 232, 649 Annotation: Subtype: Link Rect: 238, 638, 274, 649 Annotation: Subtype: Link Rect: 59, 615, 97, 626 Annotation: Subtype: Link Rect: 419, 592, 456, 603 Annotation: Subtype: Link Rect: 215, 558, 253, 568 Annotation: Subtype: Link Rect: 318, 522, 355, 533 Annotation: Subtype: Link Rect: 388, 499, 425, 510 Annotation: Subtype: Link Rect: 131, 466, 169, 476 Annotation: Subtype: Link Rect: 175, 466, 211, 476 Annotation: Subtype: Link Rect: 237, 442, 275, 453 Annotation: Subtype: Link Rect: 281, 442, 317, 453 Annotation: Subtype: Link Rect: 156, 408, 193, 418 Annotation: Subtype: Link Rect: 374, 384, 411, 395 Annotation: Subtype: Link Rect: 418, 384, 454, 395 Annotation: Subtype: Link Rect: 273, 362, 311, 372 Annotation: Subtype: Link Rect: 59, 328, 97, 338 Annotation: Subtype: Link Rect: 450, 304, 487, 315 Annotation: Subtype: Link Rect: 494, 304, 530, 315 Annotation: Subtype: Link Rect: 308, 281, 345, 292 Annotation: Subtype: Link Rect: 357, 246, 395, 257 Annotation: Subtype: Link Rect: 179, 224, 217, 234 Annotation: Subtype: Link Rect: 223, 224, 259, 234 Annotation: Subtype: Link Rect: 86, 178, 123, 188 Annotation: Subtype: Link Rect: 517, 167, 555, 177 Annotation: Subtype: Link Rect: 262, 143, 300, 154 Annotation: Subtype: Link Rect: 475, 120, 512, 131 Annotation: Subtype: Link Rect: 519, 120, 555, 131 Annotation: Subtype: Link Rect: 360, 97, 397, 108 Annotation: Subtype: Link Rect: 404, 97, 440, 108 Annotation: Subtype: Link Rect: 519, 74, 557, 85 Annotation: Subtype: Link Rect: 59, 63, 95, 73 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 420, 721, 457, 732 Annotation: Subtype: Link Rect: 179, 699, 217, 709 Annotation: Subtype: Link Rect: 370, 676, 408, 686 Annotation: Subtype: Link Rect: 190, 640, 228, 651 Annotation: Subtype: Link Rect: 149, 607, 186, 617 Annotation: Subtype: Link Rect: 363, 583, 400, 594 Annotation: Subtype: Link Rect: 406, 583, 442, 594 Annotation: Subtype: Link Rect: 248, 548, 285, 559 Annotation: Subtype: Link Rect: 216, 525, 253, 536 Annotation: Subtype: Link Rect: 260, 525, 296, 536 Annotation: Subtype: Link Rect: 177, 491, 215, 502 Annotation: Subtype: Link Rect: 59, 423, 97, 433 Annotation: Subtype: Link Rect: 103, 423, 139, 433 Annotation: Subtype: Link Rect: 211, 308, 248, 318 Annotation: Subtype: Link Rect: 95, 250, 133, 260 Annotation: Subtype: Link Rect: 440, 226, 478, 237 Annotation: Subtype: Link Rect: 339, 215, 402, 226 Annotation: Subtype: Link Rect: 353, 192, 390, 203 Annotation: Subtype: Link Rect: 480, 180, 517, 191 Annotation: Subtype: Link Rect: 398, 157, 436, 168 Annotation: Subtype: Link Rect: 122, 123, 160, 134 Annotation: Subtype: Link Rect: 339, 100, 377, 111 Annotation: Subtype: Link Rect: 59, 66, 97, 76 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 317, 721, 355, 732 Annotation: Subtype: Link Rect: 175, 699, 212, 709 Annotation: Subtype: Link Rect: 59, 664, 97, 674 Annotation: Subtype: Link Rect: 221, 641, 259, 651 Annotation: Subtype: Link Rect: 265, 641, 301, 651 Annotation: Subtype: Link Rect: 462, 629, 500, 640 Annotation: Subtype: Link Rect: 506, 629, 542, 640 Annotation: Subtype: Link Rect: 127, 607, 164, 617 Annotation: Subtype: Link Rect: 171, 607, 207, 617 Annotation: Subtype: Link Rect: 520, 594, 557, 605 Annotation: Subtype: Link Rect: 474, 571, 511, 582 Annotation: Subtype: Link Rect: 181, 548, 219, 559 Annotation: Subtype: Link Rect: 225, 548, 261, 559 Annotation: Subtype: Link Rect: 104, 515, 142, 525 Annotation: Subtype: Link Rect: 458, 491, 496, 502 Annotation: Subtype: Link Rect: 399, 468, 436, 479 Annotation: Subtype: Link Rect: 59, 446, 97, 456 Annotation: Subtype: Link Rect: 103, 446, 139, 456 Annotation: Subtype: Link Rect: 82, 411, 119, 421 Annotation: Subtype: Link Rect: 126, 411, 162, 421 Annotation: Subtype: Link Rect: 326, 376, 364, 387 Annotation: Subtype: Link Rect: 370, 376, 406, 387 Annotation: Subtype: Link Rect: 136, 342, 173, 352 Annotation: Subtype: Link Rect: 59, 308, 97, 318 Annotation: Subtype: Link Rect: 184, 285, 222, 295 Annotation: Subtype: Link Rect: 228, 285, 264, 295 Annotation: Subtype: Link Rect: 377, 261, 414, 272 Annotation: Subtype: Link Rect: 421, 261, 457, 272 Annotation: Subtype: Link Rect: 356, 238, 394, 249 Annotation: Subtype: Link Rect: 338, 215, 375, 226 Annotation: Subtype: Link Rect: 381, 215, 418, 226 Annotation: Subtype: Link Rect: 510, 192, 548, 203 Annotation: Subtype: Link Rect: 278, 169, 315, 180 Annotation: Subtype: Link Rect: 321, 169, 357, 180 Checksum: c94ae08d Type: CRC32 Checksum: 6eece27cac23ef8203a2f23b241174c8 Type: MD5 Checksum: 2e91da3259cd569b762294672ecafc95bcc9d5e2 Type: SHA-1