fcdebc8d5055058a215bd4edd56b250a macromol_a2021m3v1n1p49.pdf 3ba8b90df84dcd9ab509f00226108f86cdf29e59 macromol_a2021m3v1n1p49.pdf 1b7bc339c9bd3413176ffb108b13836e1a9a77adbe39a9df3f65788cd3f86a00 macromol_a2021m3v1n1p49.pdf Title: Bottom-Up Development of Nanoimprinted PLLA Composite Films with Enhanced Antibacterial Properties for Smart Packaging Applications Subject: In this work, polymer nanocomposite films based on poly(L-lactic acid) (PLLA) were reinforced with mesoporous silica nanoparticles, mesoporous cellular foam (MCF) and Santa Barbara amorphous-15 (SBA). PLLA is a biobased aliphatic polyester, that possesses excellent thermomechanical properties, and has already been commercialized for packaging applications. The aim was to utilize nanoparticles that have already been established as nanocarriers to enhance the mechanical and thermal properties of PLLA. Since the introduction of antibacterial properties has become an emerging trend in packaging applications, to achieve an effective antimicrobial activity, micro/nano 3D micropillars decorated with cone- and needle-shaped nanostructures were implemented on the surface of the films by means of thermal nanoimprint lithography (t-NIL), a novel and feasible fabrication technique with multiple industrial applications. The materials were characterized regarding their composition and crystallinity using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), respectively, and their thermal properties using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Their mechanical properties were examined by the nanoindentation technique, while the films’ antimicrobial activity against the bacteria Escherichia coli and Staphylococcus aureus strains was tested in vitro. The results demonstrated the successful production of nanocomposite PLLA films, which exhibited improved mechanical and thermal properties compared to the pristine material, as well as notable antibacterial activity, setting new groundwork for the potential development of biobased smart packaging materials. Keywords: poly(L-lactic acid); biobased polymers; mesoporous silica; nanocomposite films; nanoimprint lithography; antibacterial properties; smart packaging Author: Eleni Psochia, Lazaros Papadopoulos, Dimitrios J. Gkiliopoulos, Achille Francone, Maria-Eirini Grigora, Dimitrios Tzetzis, Joana Vieira de Castro, Nuno M. Neves, Konstantinos S. Triantafyllidis, Clivia M. Sotomayor Torres, Nikolaos Kehagias and Dimitrios N. Bikiaris Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 26 04:35:41 2021 CET ModDate: Fri Mar 26 04:45:27 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3383108 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HSNIKI+VnURWPalladioL Type 1 Custom yes yes no 10 0 WMOSOC+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 WMDFGB+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 OMDYPU+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 SVVJCD+Rpxr Type 1 Builtin yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 69 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 73 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 77 0 WWQLWV+Pxsy Type 1 Builtin yes yes no 87 0 IZJBLV+EURM10 Type 1 Builtin yes yes 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Item: Title: Experimental Section Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Synthesis of MCF and SBA-15 Silica Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Nanocomposite Preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Preparation of Films by Spin-Coating Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Patterning of PLLA Nanocomposite Films by NIL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Nanoparticle Characterization Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Fourier Transform-Infrared Spectroscopy (FT-IR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: N2 Porosimetry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Thermogravimetric Analysis (TGA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Characterization of the Prepared Films Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Scanning Electron Microscopy (SEM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: X-ray Diffraction (XRD) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Differential Scanning Calorimetry (DSC) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Nanoindentation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Antibacterial Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Results and Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: Nanoparticle Characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: FT-IR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Porosity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: TGA Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Characterization of the Imprinted Nanocomposite Films Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Morphological Study of Micro- and Nanosized Topographies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Fourier Transform-Infrared Spectroscopy (FT-IR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: X-ray Diffraction (XRD) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Differential Scanning Calorimetry (DSC) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Thermogravimetric Analysis (TGA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Nanoindentation Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Antibacterial Activity Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Info: Title: Bottom-Up Development of Nanoimprinted PLLA Composite Films with Enhanced Antibacterial Properties for Smart Packaging Applications Author: Eleni Psochia, Lazaros Papadopoulos, Dimitrios J. Gkiliopoulos, Achille Francone, Maria-Eirini Grigora, Dimitrios Tzetzis, Joana Vieira de Castro, Nuno M. Neves, Konstantinos S. Triantafyllidis, Clivia M. Sotomayor Torres, Nikolaos Kehagias and Dimitrios N. Bikiaris Subject: In this work, polymer nanocomposite films based on poly(L-lactic acid) (PLLA) were reinforced with mesoporous silica nanoparticles, mesoporous cellular foam (MCF) and Santa Barbara amorphous-15 (SBA). PLLA is a biobased aliphatic polyester, that possesses excellent thermomechanical properties, and has already been commercialized for packaging applications. The aim was to utilize nanoparticles that have already been established as nanocarriers to enhance the mechanical and thermal properties of PLLA. Since the introduction of antibacterial properties has become an emerging trend in packaging applications, to achieve an effective antimicrobial activity, micro/nano 3D micropillars decorated with cone- and needle-shaped nanostructures were implemented on the surface of the films by means of thermal nanoimprint lithography (t-NIL), a novel and feasible fabrication technique with multiple industrial applications. The materials were characterized regarding their composition and crystallinity using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), respectively, and their thermal properties using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Their mechanical properties were examined by the nanoindentation technique, while the films’ antimicrobial activity against the bacteria Escherichia coli and Staphylococcus aureus strains was tested in vitro. The results demonstrated the successful production of nanocomposite PLLA films, which exhibited improved mechanical and thermal properties compared to the pristine material, as well as notable antibacterial activity, setting new groundwork for the potential development of biobased smart packaging materials. 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