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Title:          Clinical consequences of BRCA2 hypomorphism
Subject:        npj Breast Cancer, doi:10.1038/s41523-021-00322-9
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      Title: Clinical consequences of BRCA2 hypomorphism
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       Item: 
        Title: Introduction
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        Title: Results
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          Title: Biallelic BRCA2-FA disorder diagnosis
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          Title: Patient fibroblasts retain partial DNA damage response
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         Item: 
          Title: Evidencing the in trans position of BRCA2 c.1813dup and c.7796nobreak nobreakA > G variants
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          Title: The hypomorphic missense p.(Glu2599Gly) variant displays 37–nobreak54% of HRR activity
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        Title: Methods
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          Title: Cell lines and cultures
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          Title: Chromosome fragility assays and G2/M cell cycle arrest
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          Title: RAD51 foci formation
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          Title: RAD51 on formalin-fixed paraffin-embedded (FFPE) samples
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          Title: PARPi survival assays
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         Item: 
          Title: BRCA2 mutant cell line generation
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         Item: 
          Title: BRCA2 plasmids
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          Title: Plasmid transfection
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          Title: Western blot antibodies
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          Title: HRR assay
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          Title: Generation of PDX models
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          Title: BRCA2 mRNA expression
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          Title: In silico prediction tools
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          Title: DNA extraction and genetic variant screening
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          Title: RNA extraction, reverse transcription and cDNA amplification
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          Title: DNA copy number analysis by multiplex ligation-dependent probe assay (MLPA)
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          Title: Ethics approval
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          Title: Consent to participate
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          Title: Reporting summary
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       Item: 
        Title: DATA AVAILABILITY
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        Title: References
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        Title: Acknowledgements
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        Title: Author contributions
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        Title: Competing interests
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        Title: ADDITIONAL INFORMATION
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Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
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Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
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                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
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                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
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