1c566ad73b81d56319ce708477ba94a1 269693.pdf a5c7f16fbf02f8d6fce9b14ab21ebbb0af700228 269693.pdf 2291fc59db37d41904198ea432135e01658e88389d7a02133f84cade2e0a301f 269693.pdf Title: Different Approaches to Analyze Muscle Fat Replacement With Dixon MRI in Pompe Disease Subject: Quantitative MRI is an increasingly used method to monitor disease progression in muscular disorders due to its ability to measure changes in muscle fat content (reported as fat fraction) over a short period. Keywords: quantitative MRI, Dixon, Pompe, fat replacement, outcome measures Author: Jordi Dı́az-Manera Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jul 3 08:29:45 2021 CEST ModDate: Sat Jul 3 09:24:16 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1199422 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TWJYTV+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 36 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 49 0 DLYMVP+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 51 0 BTWQXN+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 56 0 WBORZA+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 31 0 MXNYRC+MinionPro-Regular Type 1C Custom yes yes no 64 0 TDPGMR+MinionPro-It Type 1C Custom yes yes no 78 0 ARNWRS+MTSY Type 1C Custom yes yes yes 80 0 CVJJBP+RMTMI Type 1C Custom yes yes yes 84 0 TXAPVB+MinionPro-Bold Type 1C Custom yes yes no 95 0 YGZXPE+MTSYB Type 1C Custom yes yes no 150 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:15:22 CEST RepresentationInformation: 269693.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:42 CEST Size: 1199422 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 208 FreeObjects: 13 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Different Approaches to Analyze Muscle Fat Replacement With Dixon MRI in Pompe Disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Cohort and Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: MRI Acquisition and Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Muscle Function Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Clinical Features of Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Differences in Fat Fraction Among the Three Methods of Analysis at Baseline and Visit 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Fat Fraction Changes After 1 Year of Follow-Up and Differences Among the Three Methods of Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Correlation With Muscle Function Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Info: Title: Different Approaches to Analyze Muscle Fat Replacement With Dixon MRI in Pompe Disease Author: Jordi Dı́az-Manera Subject: Quantitative MRI is an increasingly used method to monitor disease progression in muscular disorders due to its ability to measure changes in muscle fat content (reported as fat fraction) over a short period. Keywords: quantitative MRI, Dixon, Pompe, fat replacement, outcome measures Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jul 03 08:59:45 CEST 2021 ModDate: Sat Jul 03 09:54:16 CEST 2021 ID: 0xf91661430545d56ce01f35bf9b592143, 0x3fc40ee60511e347b94cee49cab4a966 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 945 ImageHeight: 735 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 900 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 945 ImageHeight: 792 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1926 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: MXNYRC+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: MXNYRC+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ARNWRS+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: ARNWRS+MTSY Flags: Symbolic FontBBox: 0, -209, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DLYMVP+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 242 FontDescriptor: FontName: DLYMVP+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: TWJYTV+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 233 FontDescriptor: FontName: TWJYTV+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CVJJBP+RMTMI FontSubset: true FirstChar: 49 LastChar: 62 FontDescriptor: FontName: CVJJBP+RMTMI Flags: Symbolic FontBBox: 0, 0, 735, 657 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YGZXPE+MTSYB FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: YGZXPE+MTSYB Flags: Symbolic FontBBox: 0, 0, 696, 297 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BTWQXN+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 241 FontDescriptor: FontName: BTWQXN+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -49, -205, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: TDPGMR+MinionPro-It FontSubset: true FirstChar: 19 LastChar: 241 FontDescriptor: FontName: TDPGMR+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: WBORZA+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: WBORZA+HelveticaNeueLTStd-Bd Flags: Serif, Symbolic FontBBox: -9, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: TXAPVB+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: TXAPVB+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 660, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-07-03T11:59:45+05:30 LaTeX with hyperref package + hypdvips 2021-07-03T12:54:16+05:30 2021-07-03T12:54:16+05:30 application/pdf Quantitative MRI is an increasingly used method to monitor disease progression in muscular disorders due to its ability to measure changes in muscle fat content (reported as fat fraction) over a short period. Jordi Dı́az-Manera Different Approaches to Analyze Muscle Fat Replacement With Dixon MRI in Pompe Disease quantitative MRI Dixon Pompe fat replacement outcome measures quantitative MRI, Dixon, Pompe, fat replacement, outcome measures dvips + MiKTeX GPL Ghostscript 9.0 uuid:81aba3a6-6beb-41fd-8c27-06acdff76e06 uuid:5cce84e5-44c6-4b94-8462-3e3c20a5a796 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 144, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 477, 728, 520, 736 Annotation: Subtype: Link Rect: 520, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 111, 38 Annotation: Subtype: Link Rect: 114, 30, 174, 38 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 450, 160, 460 Annotation: Subtype: Link Rect: 53, 302, 160, 311 Annotation: Subtype: Link Rect: 74, 83, 160, 90 Annotation: Subtype: Link Rect: 176, 530, 551, 597 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 80, 630, 86, 642 Destination: External Annotation: Subtype: Link Rect: 252, 573, 258, 584 Destination: External Annotation: Subtype: Link Rect: 261, 573, 268, 584 Destination: External Annotation: Subtype: Link Rect: 156, 527, 162, 538 Destination: External Annotation: Subtype: Link Rect: 166, 527, 173, 538 Destination: External Annotation: Subtype: Link Rect: 99, 481, 106, 493 Destination: External Annotation: Subtype: Link Rect: 109, 481, 116, 493 Destination: External Annotation: Subtype: Link Rect: 47, 435, 53, 447 Destination: External Annotation: Subtype: Link Rect: 56, 435, 63, 447 Destination: External Annotation: Subtype: Link Rect: 256, 367, 267, 378 Destination: External Annotation: Subtype: Link Rect: 274, 158, 285, 170 Destination: External Annotation: Subtype: Link Rect: 216, 124, 227, 135 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 189, 672, 224, 682 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 171, 522, 222, 532 Annotation: Subtype: Link Rect: 226, 525, 238, 536 Destination: External Annotation: Subtype: Link Rect: 161, 415, 191, 424 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 43, 706, 78, 716 Destination: External Annotation: Subtype: Link Rect: 78, 450, 113, 460 Destination: External Annotation: Subtype: Link Rect: 214, 373, 221, 385 Destination: External Annotation: Subtype: Link Rect: 479, 695, 513, 705 Destination: External Annotation: Subtype: Link Rect: 453, 639, 483, 648 Destination: External Annotation: Subtype: Link Rect: 374, 468, 380, 479 Destination: External Annotation: Subtype: Link Rect: 384, 468, 391, 479 Destination: External Annotation: Subtype: Link Rect: 395, 468, 406, 479 Destination: External Annotation: Subtype: Link Rect: 410, 468, 421, 479 Destination: External Annotation: Subtype: Link Rect: 468, 422, 479, 433 Destination: External Annotation: Subtype: Link Rect: 438, 342, 449, 353 Destination: External Annotation: Subtype: Link Rect: 516, 135, 527, 147 Destination: External Annotation: Subtype: Link Rect: 307, 87, 341, 98 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 381, 637, 468, 648 Annotation: Subtype: Link Rect: 70, 502, 175, 509 Annotation: Subtype: Link Rect: 70, 462, 163, 471 Annotation: Subtype: Link Rect: 100, 424, 193, 434 Annotation: Subtype: Link Rect: 133, 397, 237, 405 Annotation: Subtype: Link Rect: 292, 348, 56, 368 Annotation: Subtype: Link Rect: 190, 322, 248, 329 Annotation: Subtype: Link Rect: 70, 284, 155, 291 Annotation: Subtype: Link Rect: 213, 208, 273, 216 Annotation: Subtype: Link Rect: 368, 539, 457, 547 Annotation: Subtype: Link Rect: 459, 511, 548, 518 Annotation: Subtype: Link Rect: 412, 473, 469, 481 Annotation: Subtype: Link Rect: 356, 443, 485, 453 Annotation: Subtype: Link Rect: 433, 397, 518, 405 Annotation: Subtype: Link Rect: 331, 359, 430, 367 Annotation: Subtype: Link Rect: 331, 331, 397, 339 Annotation: Subtype: Link Rect: 458, 236, 484, 243 Annotation: Subtype: Link Rect: 484, 236, 516, 243 Annotation: Subtype: Link Rect: 515, 236, 551, 244 Annotation: Subtype: Link Rect: 304, 227, 327, 234 Annotation: Subtype: Link Rect: 327, 226, 354, 234 Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 433, 28, 551, 37 Checksum: 3f266bb7 Type: CRC32 Checksum: 1c566ad73b81d56319ce708477ba94a1 Type: MD5 Checksum: a5c7f16fbf02f8d6fce9b14ab21ebbb0af700228 Type: SHA-1