64438b355905dd1ff63a8182ac65e11f 269717.pdf 8bc199b763ab76772ffe0a36140e82a61e1e41c4 269717.pdf 12efde5bac1bbb9e0ac0c8ea335abfa8cce639dbfbf74096a1a0d2146e50fba3 269717.pdf Title: Alternative C3 Complement System: Lipids and Atherosclerosis Subject: Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque progression remains unknown. The aim of the study was to investigate by a systems biology approach the role of C3 in relation to lipoprotein levels during atherosclerosis (AT) progression and to gain a better understanding on the effects of C3 products on the phenotype and function of human lipid-loaded vascular smooth muscle cells (VSMCs). By mass spectrometry and differential proteomics, we found the extracellular matrix (ECM) of human aortas to be enriched in active components of the C3 complement system, with a significantly different proteomic signature in AT segments. Thus, C3 products were more abundant in AT-ECM than in macroscopically normal segments. Furthermore, circulating C3 levels were significantly elevated in FH patients with subclinical coronary AT, evidenced by computed tomographic angiography. However, no correlation was identified between circulating C3 levels and the increase in plaque burden, indicating a local regulation of the C3 in AT arteries. In cell culture studies of human VSMCs, we evidenced the expression of C3, C3aR (anaphylatoxin receptor) and the integrin M2 receptor for C3b/iC3b (RT-PCR and Western blot). C3mRNA was up-regulated in lipid-loaded human VSMCs, and C3 protein significantly increased in cell culture supernatants, indicating that the C3 products in the AT-ECM have a local vessel-wall niche. Interestingly, C3a and iC3b (C3 active fragments) have functional effects on VSMCs, significantly reversing the inhibition of VSMC migration induced by aggregated LDL and stimulating cell spreading, organization of F-actin stress fibers and attachment during the adhesion of lipid-loaded human VSMCs. This study, by using a systems biology approach, identified molecular processes involving the C3 complement system in vascular remodeling and in the progression of advanced human atherosclerotic lesions. Keywords: atherosclerosis; cardiovascular disease; complement system; proteomics; mass spectrometry Author: Maisa Garcia-Arguinzonis, Elisa Diaz-Riera, Esther Peña, Rafael Escate, Oriol Juan-Babot, Pedro Mata, Lina Badimon and Teresa Padro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed May 12 13:30:51 2021 CEST ModDate: Wed May 12 13:30:51 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2221203 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XYUCZP+URWPalladioL-Ital Type 1 Custom yes yes no 137 0 VARREJ+URWPalladioL-Bold Type 1 Custom yes yes no 138 0 UKWQME+URWPalladioL-Roma Type 1 Custom yes yes no 139 0 XAWNGI+VnURWPalladioL Type 1 Custom yes yes no 142 0 VVSYYB+EURM10 Type 1 Builtin yes yes no 143 0 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TrueType WinAnsi yes yes no 303 0 IHGOLJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 304 0 IHGOLK+PalatinoLinotype TrueType WinAnsi yes yes no 305 0 IHGOLM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 306 0 IHGOKJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 411 0 IHGOLJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 412 0 IHGOLK+PalatinoLinotype TrueType WinAnsi yes yes no 413 0 IHGOLM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 414 0 IHHBKM+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 415 0 IHHGDB+SegoeUISymbol CID TrueType Identity-H yes yes yes 416 0 IHGOKJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 454 0 IHGOLK+PalatinoLinotype TrueType WinAnsi yes yes no 455 0 IHGOLM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 456 0 IHHBKM+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 457 0 IHGOKJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 478 0 IHGOLJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 479 0 IHGOLK+PalatinoLinotype TrueType WinAnsi yes yes no 480 0 IHGOLM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 481 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:14:48 CEST RepresentationInformation: 269717.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:44 CEST Size: 2221203 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰うえぜ〴ぜ〰ぐちぴどづのぴぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぃはねばぬづねづのぴぜ〴ぜ〰どのぜ〴ぜ〰ぐちぴどづのぴびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰えべばづひっとはぬづびぴづひはぬづねどちぜ〴ぜ〰ちのつぜ〴ぜ〰こふぢっぬどのどっちぬぜ〴ぜ〰ぁぴとづひはびっぬづひはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰こべびぴづねぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁつぶちのっづつぜ〴ぜ〰ぁぴとづひはびっぬづひはぴどっぜ〴ぜ〰がづびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰ぐちぴとぷちべぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰どのぜ〴ぜ〰ざちびっふぬちひぜ〴ぜ〰しちぬぬぜ〴ぜ〰げづびどつづのぴぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅへはでづのはふびぜ〴ぜ〰ぃ〳ぜ〴ぜ〰ぐひはぴづはぬべぴどっぜ〴ぜ〰ぐひはつふっぴび〬ぜ〴ぜ〰ぁでがいがぜ〴ぜ〰ちのつぜ〴ぜ〰ざこきぃぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰うえぜ〴ぜ〰ぐちぴどづのぴぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぃはねばぬづねづのぴぜ〴ぜ〰どのぜ〴ぜ〰ぐちぴどづのぴびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰えべばづひっとはぬづびぴづひはぬづねどちぜ〴ぜ〰ちのつぜ〴ぜ〰こふぢっぬどのどっちぬぜ〴ぜ〰ぁぴとづひはびっぬづひはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰こべびぴづねぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁつぶちのっづつぜ〴ぜ〰ぁぴとづひはびっぬづひはぴどっぜ〴ぜ〰がづびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰ぐちぴとぷちべぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰どのぜ〴ぜ〰ざちびっふぬちひぜ〴ぜ〰しちぬぬぜ〴ぜ〰げづびどつづのぴぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅへはでづのはふびぜ〴ぜ〰ぃ〳ぜ〴ぜ〰ぐひはぴづはぬべぴどっぜ〴ぜ〰ぐひはつふっぴび〬ぜ〴ぜ〰ぁでがいがぜ〴ぜ〰ちのつぜ〴ぜ〰ざこきぃぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃ〳ぜ〴ぜ〰ぃはねばぬづねづのぴぜ〴ぜ〰どのぜ〴ぜ〰ぐちぴどづのぴびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰えべばづひっとはぬづびぴづひはぬづねどちぜ〴ぜ〰ちのつぜ〴ぜ〰こふぢっぬどのどっちぬぜ〴ぜ〰ぁぴとづひはびっぬづひはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰こべびぴづねぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁつぶちのっづつぜ〴ぜ〰ぁぴとづひはびっぬづひはぴどっぜ〴ぜ〰がづびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰ぐちぴとぷちべぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰どのぜ〴ぜ〰ざちびっふぬちひぜ〴ぜ〰しちぬぬぜ〴ぜ〰げづびどつづのぴぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅへはでづのはふびぜ〴ぜ〰ぃ〳ぜ〴ぜ〰ぐひはぴづはぬべぴどっぜ〴ぜ〰ぐひはつふっぴび〬ぜ〴ぜ〰ぁでがいがぜ〴ぜ〰ちのつぜ〴ぜ〰ざこきぃぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰こべびぴづねぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁつぶちのっづつぜ〴ぜ〰ぁぴとづひはびっぬづひはぴどっぜ〴ぜ〰がづびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰ぐちぴとぷちべぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰どのぜ〴ぜ〰ざちびっふぬちひぜ〴ぜ〰しちぬぬぜ〴ぜ〰げづびどつづのぴぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅへはでづのはふびぜ〴ぜ〰ぃ〳ぜ〴ぜ〰ぐひはぴづはぬべぴどっぜ〴ぜ〰ぐひはつふっぴび〬ぜ〴ぜ〰ぁでがいがぜ〴ぜ〰ちのつぜ〴ぜ〰ざこきぃぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃ〳ぜ〴ぜ〰ぁぬぴづひのちぴどぶづぜ〴ぜ〰ぐちぴとぷちべぜ〴ぜ〰ぃはねばはのづのぴびぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰どのぜ〴ぜ〰ざちびっふぬちひぜ〴ぜ〰しちぬぬぜ〴ぜ〰げづびどつづのぴぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅへはでづのはふびぜ〴ぜ〰ぃ〳ぜ〴ぜ〰ぐひはぴづはぬべぴどっぜ〴ぜ〰ぐひはつふっぴび〬ぜ〴ぜ〰ぁでがいがぜ〴ぜ〰ちのつぜ〴ぜ〰ざこきぃぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅへはでづのはふびぜ〴ぜ〰ぃ〳ぜ〴ぜ〰ぐひはぴづはぬべぴどっぜ〴ぜ〰ぐひはつふっぴび〬ぜ〴ぜ〰ぁでがいがぜ〴ぜ〰ちのつぜ〴ぜ〰ざこきぃぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰えふねちのぜ〴ぜ〰こちねばぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸱⸱ Children: Item: Title: えふねちのぜ〴ぜ〰こちねばぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸱⸱ Children: Item: Title: こふぢなづっぴびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰うちねどぬどちぬぜ〴ぜ〰えべばづひっとはぬづびぴづひはぬづねどちぜ〴ぜ〰ちのつぜ〴ぜ〰えづちぬぴとべぜ〴ぜ〰ざはぬふのぴづづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸱⸲ Item: Title: ぁはひぴちびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃはひはのちひべぜ〴ぜ〰ぁひぴづひどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸱⸳ Item: Title: ざこきぃぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰がいがぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ごどびびふづぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぅぃきぜ〴ぜ〰ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰〲いぜ〴ぜ〰ぅぬづっぴひはばとはひづびどび〯きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅがぉこぁぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げぎぁぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぁつとづびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しはふのつ〭えづちぬどのでぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ごどびびふづぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぅぃきぜ〴ぜ〰ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰〲いぜ〴ぜ〰ぅぬづっぴひはばとはひづびどび〯きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅがぉこぁぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げぎぁぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぁつとづびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しはふのつ〭えづちぬどのでぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: 〲いぜ〴ぜ〰ぅぬづっぴひはばとはひづびどび〯きちびびぜ〴ぜ〰こばづっぴひはねづぴひべぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅがぉこぁぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げぎぁぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぁつとづびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しはふのつ〭えづちぬどのでぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ちのつぜ〴ぜ〰ぅがぉこぁぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げぎぁぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぁつとづびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しはふのつ〭えづちぬどのでぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: げぎぁぜ〴ぜ〰ぅへぴひちっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづちぬ〭ごどねづぜ〴ぜ〰ぐぃげぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぁつとづびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しはふのつ〭えづちぬどのでぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぃづぬぬぜ〴ぜ〰ぁつとづびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰しはふのつ〭えづちぬどのでぜ〴ぜ〰ぁびびちべびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぃはのてはっちぬぜ〴ぜ〰うはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: 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