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Destination: 1 Children: Item: Title: Introduction Destination: 1 Item: Title: Methods Destination: 1 Children: Item: Title: Design Destination: 1 Item: Title: Participants Destination: 1 Item: Title: Intervention Destination: 1 Item: Title: Sample and data collection Destination: 1 Item: Title: Study variables Destination: 1 Item: Title: Data analysis Destination: 1 Item: Title: Results Destination: 1 Item: Title: Discussion Destination: 1 Item: Title: Key points Destination: 1 Children: Item: Title: What is already known on this topic? Destination: 1 Item: Title: What this study adds? 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778, 170, 784 Annotation: Subtype: Link Rect: 172, 778, 182, 784 Annotation: Subtype: Link Rect: 185, 778, 222, 784 Annotation: Subtype: Link Rect: 224, 778, 231, 784 Annotation: Subtype: Link Rect: 233, 778, 253, 784 Annotation: Subtype: Link Rect: 255, 778, 267, 784 Annotation: Subtype: Link Rect: 270, 778, 305, 784 Annotation: Subtype: Link Rect: 308, 778, 330, 784 Annotation: Subtype: Link Rect: 106, 768, 120, 773 Annotation: Subtype: Link Rect: 123, 768, 128, 774 Annotation: Subtype: Link Rect: 131, 768, 149, 774 Annotation: Subtype: Link Rect: 151, 767, 177, 774 Annotation: Subtype: Link Rect: 180, 768, 211, 774 Annotation: Subtype: Link Rect: 213, 768, 229, 774 Annotation: Subtype: Link Rect: 232, 768, 239, 773 Annotation: Subtype: Link Rect: 242, 767, 266, 774 Annotation: Subtype: Link Rect: 268, 767, 307, 774 Annotation: Subtype: Link Rect: 309, 767, 328, 774 Annotation: Subtype: Link Rect: 328, 768, 329, 770 Annotation: Subtype: Link Rect: 105, 757, 125, 764 Annotation: 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Annotation: Subtype: Link Rect: 246, 707, 270, 715 Annotation: Subtype: Link Rect: 274, 709, 296, 715 Annotation: Subtype: Link Rect: 301, 707, 330, 714 Annotation: Subtype: Link Rect: 106, 697, 131, 703 Annotation: Subtype: Link Rect: 134, 699, 138, 703 Annotation: Subtype: Link Rect: 141, 699, 165, 704 Annotation: Subtype: Link Rect: 165, 699, 166, 700 Annotation: Subtype: Link Rect: 170, 699, 181, 704 Annotation: Subtype: Link Rect: 183, 699, 186, 704 Annotation: Subtype: Link Rect: 190, 699, 211, 705 Annotation: Subtype: Link Rect: 214, 699, 239, 705 Annotation: Subtype: Link Rect: 243, 697, 273, 705 Annotation: Subtype: Link Rect: 274, 699, 290, 705 Annotation: Subtype: Link Rect: 291, 701, 292, 701 Annotation: Subtype: Link Rect: 292, 701, 293, 701 Annotation: Subtype: Link Rect: 293, 701, 294, 701 Annotation: Subtype: Link Rect: 295, 699, 303, 704 Annotation: Subtype: Link Rect: 304, 699, 305, 700 Annotation: Subtype: Link Rect: 106, 689, 146, 695 Annotation: Subtype: Link Rect: 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Subtype: Link Rect: 132, 669, 150, 675 Annotation: Subtype: Link Rect: 154, 667, 177, 675 Annotation: Subtype: Link Rect: 180, 669, 202, 673 Annotation: Subtype: Link Rect: 205, 667, 231, 675 Annotation: Subtype: Link Rect: 236, 669, 240, 675 Annotation: Subtype: Link Rect: 244, 669, 263, 675 Annotation: Subtype: Link Rect: 267, 667, 312, 675 Annotation: Subtype: Link Rect: 316, 667, 330, 673 Annotation: Subtype: Link Rect: 106, 659, 133, 665 Annotation: Subtype: Link Rect: 136, 659, 140, 665 Annotation: Subtype: Link Rect: 141, 659, 151, 663 Annotation: Subtype: Link Rect: 154, 659, 168, 665 Annotation: Subtype: Link Rect: 171, 657, 201, 665 Annotation: Subtype: Link Rect: 205, 657, 235, 665 Annotation: Subtype: Link Rect: 236, 659, 244, 665 Annotation: Subtype: Link Rect: 245, 661, 246, 662 Annotation: Subtype: Link Rect: 246, 661, 247, 662 Annotation: Subtype: Link Rect: 247, 661, 248, 662 Annotation: Subtype: Link Rect: 249, 659, 256, 665 Annotation: Subtype: Link Rect: 258, 659, 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Annotation: Subtype: Link Rect: 288, 509, 330, 515 Annotation: Subtype: Link Rect: 106, 498, 121, 504 Annotation: Subtype: Link Rect: 125, 499, 150, 505 Annotation: Subtype: Link Rect: 154, 499, 163, 505 Annotation: Subtype: Link Rect: 167, 498, 216, 505 Annotation: Subtype: Link Rect: 220, 499, 247, 505 Annotation: Subtype: Link Rect: 251, 499, 259, 504 Annotation: Subtype: Link Rect: 263, 499, 283, 505 Annotation: Subtype: Link Rect: 288, 499, 329, 505 Annotation: Subtype: Link Rect: 106, 488, 135, 495 Annotation: Subtype: Link Rect: 137, 489, 147, 495 Annotation: Subtype: Link Rect: 149, 491, 151, 492 Annotation: Subtype: Link Rect: 150, 491, 152, 492 Annotation: Subtype: Link Rect: 151, 491, 153, 492 Annotation: Subtype: Link Rect: 154, 489, 158, 495 Annotation: Subtype: Link Rect: 159, 489, 160, 491 Annotation: Subtype: Link Rect: 105, 450, 315, 456 Flags: Print Annotation: Subtype: Link Rect: 105, 440, 230, 446 Flags: Print Annotation: Subtype: Link Rect: 265, 420, 330, 426 Flags: Print Annotation: Subtype: Link Rect: 105, 410, 299, 416 Flags: Print Annotation: Subtype: Link Rect: 106, 390, 121, 396 Annotation: Subtype: Link Rect: 124, 388, 130, 396 Annotation: Subtype: Link Rect: 134, 390, 155, 396 Annotation: Subtype: Link Rect: 159, 390, 163, 396 Annotation: Subtype: Link Rect: 162, 388, 163, 391 Annotation: Subtype: Link Rect: 168, 390, 171, 396 Annotation: Subtype: Link Rect: 172, 390, 192, 396 Annotation: Subtype: Link Rect: 196, 388, 203, 396 Annotation: Subtype: Link Rect: 207, 390, 238, 396 Annotation: Subtype: Link Rect: 241, 388, 247, 396 Annotation: Subtype: Link Rect: 251, 390, 277, 396 Annotation: Subtype: Link Rect: 280, 388, 287, 396 Annotation: Subtype: Link Rect: 291, 390, 306, 396 Annotation: Subtype: Link Rect: 310, 388, 330, 396 Annotation: Subtype: Link Rect: 106, 379, 113, 386 Annotation: Subtype: Link Rect: 117, 380, 124, 385 Annotation: Subtype: Link Rect: 128, 380, 136, 386 Annotation: Subtype: Link Rect: 141, 380, 177, 386 Annotation: Subtype: Link Rect: 181, 380, 188, 386 Annotation: Subtype: Link Rect: 191, 380, 194, 384 Annotation: Subtype: Link Rect: 198, 378, 237, 386 Annotation: Subtype: Link Rect: 241, 378, 269, 384 Annotation: Subtype: Link Rect: 273, 380, 280, 385 Annotation: Subtype: Link Rect: 284, 380, 308, 386 Annotation: Subtype: Link Rect: 311, 380, 330, 386 Annotation: Subtype: Link Rect: 106, 370, 119, 376 Annotation: Subtype: Link Rect: 123, 370, 129, 376 Annotation: Subtype: Link Rect: 133, 370, 151, 376 Annotation: Subtype: Link Rect: 155, 368, 178, 376 Annotation: Subtype: Link Rect: 182, 370, 195, 376 Annotation: Subtype: Link Rect: 199, 370, 206, 375 Annotation: Subtype: Link Rect: 209, 370, 255, 376 Annotation: Subtype: Link Rect: 259, 370, 288, 376 Annotation: Subtype: Link Rect: 293, 370, 306, 376 Annotation: Subtype: Link Rect: 310, 370, 329, 376 Annotation: Subtype: Link Rect: 106, 359, 135, 366 Annotation: Subtype: Link Rect: 137, 360, 149, 366 Annotation: Subtype: Link Rect: 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299, 188, 306 Annotation: Subtype: Link Rect: 191, 299, 230, 306 Annotation: Subtype: Link Rect: 232, 300, 259, 306 Annotation: Subtype: Link Rect: 262, 300, 265, 306 Annotation: Subtype: Link Rect: 268, 300, 291, 306 Annotation: Subtype: Link Rect: 293, 300, 305, 306 Annotation: Subtype: Link Rect: 308, 300, 328, 306 Annotation: Subtype: Link Rect: 328, 300, 329, 301 Annotation: Subtype: Link Rect: 106, 289, 135, 296 Annotation: Subtype: Link Rect: 137, 290, 143, 296 Annotation: Subtype: Link Rect: 145, 292, 147, 293 Annotation: Subtype: Link Rect: 146, 292, 148, 293 Annotation: Subtype: Link Rect: 147, 292, 149, 293 Annotation: Subtype: Link Rect: 150, 290, 158, 296 Annotation: Subtype: Link Rect: 159, 290, 160, 291 Annotation: Subtype: Link Rect: 106, 279, 138, 286 Annotation: Subtype: Link Rect: 141, 280, 147, 286 Annotation: Subtype: Link Rect: 150, 280, 175, 286 Annotation: Subtype: Link Rect: 178, 280, 185, 286 Annotation: Subtype: Link Rect: 188, 280, 199, 286 Annotation: Subtype: Link Rect: 202, 279, 228, 286 Annotation: Subtype: Link Rect: 231, 280, 253, 286 Annotation: Subtype: Link Rect: 256, 279, 306, 286 Annotation: Subtype: Link Rect: 310, 280, 316, 286 Annotation: Subtype: Link Rect: 317, 280, 330, 286 Annotation: Subtype: Link Rect: 106, 270, 118, 275 Annotation: Subtype: Link Rect: 122, 270, 151, 276 Annotation: Subtype: Link Rect: 154, 270, 193, 276 Annotation: Subtype: Link Rect: 196, 270, 206, 276 Annotation: Subtype: Link Rect: 209, 270, 250, 276 Annotation: Subtype: Link Rect: 253, 270, 257, 276 Annotation: Subtype: Link Rect: 257, 269, 287, 276 Annotation: Subtype: Link Rect: 291, 270, 309, 276 Annotation: Subtype: Link Rect: 106, 260, 110, 266 Annotation: Subtype: Link Rect: 110, 259, 132, 266 Annotation: Subtype: Link Rect: 135, 260, 145, 266 Annotation: Subtype: Link Rect: 144, 259, 145, 261 Annotation: Subtype: Link Rect: 149, 260, 172, 266 Annotation: Subtype: Link Rect: 175, 259, 186, 266 Annotation: Subtype: Link Rect: 190, 260, 212, 266 Annotation: Subtype: Link Rect: 216, 259, 230, 266 Annotation: Subtype: Link Rect: 233, 260, 238, 266 Annotation: Subtype: Link Rect: 238, 260, 251, 266 Annotation: Subtype: Link Rect: 255, 259, 260, 266 Annotation: Subtype: Link Rect: 264, 260, 269, 266 Annotation: Subtype: Link Rect: 268, 260, 286, 267 Annotation: Subtype: Link Rect: 289, 260, 300, 266 Annotation: Subtype: Link Rect: 304, 260, 330, 266 Annotation: Subtype: Link Rect: 106, 250, 130, 256 Annotation: Subtype: Link Rect: 133, 250, 169, 256 Annotation: Subtype: Link Rect: 172, 250, 188, 256 Annotation: Subtype: Link Rect: 191, 249, 227, 256 Annotation: Subtype: Link Rect: 230, 250, 242, 256 Annotation: Subtype: Link Rect: 246, 249, 279, 256 Annotation: Subtype: Link Rect: 282, 250, 308, 256 Annotation: Subtype: Link Rect: 311, 250, 330, 256 Annotation: Subtype: Link Rect: 106, 240, 114, 245 Annotation: Subtype: Link Rect: 117, 240, 128, 246 Annotation: Subtype: Link Rect: 131, 240, 157, 246 Annotation: Subtype: 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Subtype: Link Rect: 513, 539, 525, 545 Annotation: Subtype: Link Rect: 528, 539, 559, 545 Annotation: Subtype: Link Rect: 562, 539, 585, 545 Annotation: Subtype: Link Rect: 585, 539, 586, 540 Annotation: Subtype: Link Rect: 362, 528, 382, 535 Annotation: Subtype: Link Rect: 384, 529, 402, 535 Annotation: Subtype: Link Rect: 405, 529, 422, 535 Annotation: Subtype: Link Rect: 426, 528, 455, 535 Annotation: Subtype: Link Rect: 457, 529, 468, 535 Annotation: Subtype: Link Rect: 470, 531, 471, 532 Annotation: Subtype: Link Rect: 471, 531, 472, 532 Annotation: Subtype: Link Rect: 471, 531, 473, 532 Annotation: Subtype: Link Rect: 474, 529, 482, 535 Annotation: Subtype: Link Rect: 483, 529, 484, 530 Annotation: Subtype: Link Rect: 363, 519, 367, 525 Annotation: Subtype: Link Rect: 367, 519, 385, 525 Annotation: Subtype: Link Rect: 394, 518, 405, 525 Annotation: Subtype: Link Rect: 414, 519, 425, 525 Annotation: Subtype: Link Rect: 434, 518, 444, 525 Annotation: Subtype: Link Rect: 454, 519, 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Annotation: Subtype: Link Rect: 426, 468, 452, 475 Annotation: Subtype: Link Rect: 460, 469, 482, 475 Annotation: Subtype: Link Rect: 490, 469, 495, 475 Annotation: Subtype: Link Rect: 502, 469, 514, 475 Annotation: Subtype: Link Rect: 522, 469, 556, 475 Annotation: Subtype: Link Rect: 564, 468, 587, 475 Annotation: Subtype: Link Rect: 363, 460, 376, 465 Annotation: Subtype: Link Rect: 380, 458, 410, 465 Annotation: Subtype: Link Rect: 411, 460, 423, 465 Annotation: Subtype: Link Rect: 424, 462, 426, 462 Annotation: Subtype: Link Rect: 425, 462, 427, 462 Annotation: Subtype: Link Rect: 426, 462, 427, 462 Annotation: Subtype: Link Rect: 429, 460, 436, 465 Annotation: Subtype: Link Rect: 437, 460, 438, 461 Annotation: Subtype: Link Rect: 363, 448, 402, 456 Annotation: Subtype: Link Rect: 406, 448, 411, 455 Annotation: Subtype: Link Rect: 415, 450, 420, 455 Annotation: Subtype: Link Rect: 420, 450, 432, 456 Annotation: Subtype: Link Rect: 436, 448, 443, 455 Annotation: Subtype: Link Rect: 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Link Rect: 418, 388, 460, 396 Annotation: Subtype: Link Rect: 465, 390, 469, 394 Annotation: Subtype: Link Rect: 473, 388, 510, 396 Annotation: Subtype: Link Rect: 515, 390, 538, 396 Annotation: Subtype: Link Rect: 538, 390, 539, 391 Annotation: Subtype: Link Rect: 544, 390, 560, 396 Annotation: Subtype: Link Rect: 564, 390, 587, 396 Annotation: Subtype: Link Rect: 362, 380, 387, 386 Annotation: Subtype: Link Rect: 391, 379, 416, 386 Annotation: Subtype: Link Rect: 418, 380, 420, 386 Annotation: Subtype: Link Rect: 422, 382, 424, 383 Annotation: Subtype: Link Rect: 423, 382, 425, 383 Annotation: Subtype: Link Rect: 424, 382, 426, 383 Annotation: Subtype: Link Rect: 427, 380, 434, 386 Annotation: Subtype: Link Rect: 435, 380, 437, 381 Annotation: Subtype: Link Rect: 363, 370, 406, 376 Annotation: Subtype: Link Rect: 411, 369, 418, 376 Annotation: Subtype: Link Rect: 424, 370, 451, 376 Annotation: Subtype: Link Rect: 456, 369, 463, 376 Annotation: Subtype: Link Rect: 469, 370, 490, 376 Annotation: Subtype: Link Rect: 495, 369, 501, 376 Annotation: Subtype: Link Rect: 507, 368, 539, 376 Annotation: Subtype: Link Rect: 545, 369, 550, 376 Annotation: Subtype: Link Rect: 556, 370, 577, 376 Annotation: Subtype: Link Rect: 582, 370, 586, 376 Annotation: Subtype: Link Rect: 585, 369, 586, 371 Annotation: Subtype: Link Rect: 363, 360, 390, 366 Annotation: Subtype: Link Rect: 395, 360, 400, 366 Annotation: Subtype: Link Rect: 406, 360, 419, 366 Annotation: Subtype: Link Rect: 424, 360, 471, 366 Annotation: Subtype: Link Rect: 476, 360, 483, 366 Annotation: Subtype: Link Rect: 488, 358, 527, 366 Annotation: Subtype: Link Rect: 532, 358, 576, 365 Annotation: Subtype: Link Rect: 581, 360, 587, 366 Annotation: Subtype: Link Rect: 363, 348, 384, 356 Annotation: Subtype: Link Rect: 388, 350, 409, 356 Annotation: Subtype: Link Rect: 413, 350, 460, 356 Annotation: Subtype: Link Rect: 463, 350, 473, 356 Annotation: Subtype: Link Rect: 476, 348, 526, 356 Annotation: Subtype: Link Rect: 530, 348, 555, 354 Annotation: Subtype: Link Rect: 559, 350, 563, 354 Annotation: Subtype: Link Rect: 567, 350, 587, 355 Annotation: Subtype: Link Rect: 363, 338, 392, 346 Annotation: Subtype: Link Rect: 396, 340, 410, 346 Annotation: Subtype: Link Rect: 413, 340, 434, 346 Annotation: Subtype: Link Rect: 438, 340, 463, 346 Annotation: Subtype: Link Rect: 466, 339, 496, 346 Annotation: Subtype: Link Rect: 498, 340, 500, 346 Annotation: Subtype: Link Rect: 502, 342, 503, 343 Annotation: Subtype: Link Rect: 503, 342, 504, 343 Annotation: Subtype: Link Rect: 504, 342, 505, 343 Annotation: Subtype: Link Rect: 506, 340, 514, 346 Annotation: Subtype: Link Rect: 515, 340, 516, 341 Annotation: Subtype: Link Rect: 385, 300, 532, 306 Flags: Print Annotation: Subtype: Link Rect: 363, 290, 384, 296 Annotation: Subtype: Link Rect: 388, 290, 391, 296 Annotation: Subtype: Link Rect: 391, 289, 392, 291 Annotation: Subtype: Link Rect: 396, 290, 400, 296 Annotation: Subtype: Link Rect: 400, 290, 420, 297 Annotation: Subtype: Link Rect: 424, 289, 433, 296 Annotation: Subtype: Link Rect: 438, 290, 461, 296 Annotation: Subtype: Link Rect: 464, 289, 470, 296 Annotation: Subtype: Link Rect: 474, 290, 505, 296 Annotation: Subtype: Link Rect: 508, 289, 514, 296 Annotation: Subtype: Link Rect: 518, 290, 537, 297 Annotation: Subtype: Link Rect: 540, 289, 547, 296 Annotation: Subtype: Link Rect: 551, 290, 587, 297 Annotation: Subtype: Link Rect: 362, 279, 369, 286 Annotation: Subtype: Link Rect: 374, 280, 381, 286 Annotation: Subtype: Link Rect: 384, 280, 393, 286 Annotation: Subtype: Link Rect: 397, 280, 432, 286 Annotation: Subtype: Link Rect: 435, 280, 453, 286 Annotation: Subtype: Link Rect: 456, 280, 466, 286 Annotation: Subtype: Link Rect: 470, 280, 491, 286 Annotation: Subtype: Link Rect: 496, 280, 519, 286 Annotation: Subtype: Link Rect: 523, 279, 544, 286 Annotation: Subtype: Link Rect: 548, 279, 587, 286 Annotation: Subtype: Link Rect: 363, 270, 370, 276 Annotation: Subtype: Link Rect: 372, 269, 400, 276 Annotation: Subtype: Link Rect: 403, 270, 423, 276 Annotation: Subtype: Link Rect: 426, 270, 447, 276 Annotation: Subtype: Link Rect: 451, 269, 492, 276 Annotation: Subtype: Link Rect: 495, 269, 521, 276 Annotation: Subtype: Link Rect: 524, 269, 587, 276 Annotation: Subtype: Link Rect: 363, 260, 412, 266 Annotation: Subtype: Link Rect: 415, 260, 428, 266 Annotation: Subtype: Link Rect: 431, 260, 451, 266 Annotation: Subtype: Link Rect: 454, 260, 473, 266 Annotation: Subtype: Link Rect: 476, 260, 499, 266 Annotation: Subtype: Link Rect: 500, 259, 519, 266 Annotation: Subtype: Link Rect: 519, 259, 530, 266 Annotation: Subtype: Link Rect: 531, 260, 560, 266 Annotation: Subtype: Link Rect: 363, 250, 394, 256 Annotation: Subtype: Link Rect: 398, 249, 405, 256 Annotation: Subtype: Link Rect: 410, 249, 450, 256 Annotation: Subtype: Link Rect: 455, 249, 462, 256 Annotation: Subtype: Link Rect: 467, 250, 483, 256 Annotation: Subtype: Link Rect: 487, 250, 495, 256 Annotation: Subtype: Link Rect: 501, 250, 547, 256 Annotation: Subtype: Link Rect: 551, 250, 558, 256 Annotation: Subtype: Link Rect: 563, 250, 587, 256 Annotation: Subtype: Link Rect: 363, 240, 382, 246 Annotation: Subtype: Link Rect: 386, 240, 415, 246 Annotation: Subtype: Link Rect: 418, 240, 431, 246 Annotation: Subtype: Link Rect: 434, 240, 468, 246 Annotation: Subtype: Link Rect: 472, 239, 494, 245 Annotation: Subtype: Link Rect: 497, 240, 516, 246 Annotation: Subtype: Link Rect: 519, 239, 544, 246 Annotation: Subtype: Link Rect: 548, 240, 556, 245 Annotation: Subtype: Link Rect: 559, 239, 587, 246 Annotation: Subtype: Link Rect: 363, 230, 376, 236 Annotation: Subtype: Link Rect: 379, 230, 402, 236 Annotation: Subtype: Link Rect: 402, 230, 404, 232 Annotation: Subtype: Link Rect: 408, 230, 423, 236 Annotation: Subtype: Link Rect: 426, 230, 437, 236 Annotation: Subtype: Link Rect: 440, 230, 456, 236 Annotation: Subtype: Link Rect: 459, 229, 499, 236 Annotation: Subtype: Link Rect: 499, 230, 500, 232 Annotation: Subtype: Link Rect: 504, 229, 533, 236 Annotation: Subtype: Link Rect: 535, 230, 547, 236 Annotation: Subtype: Link Rect: 547, 232, 549, 233 Annotation: Subtype: Link Rect: 548, 232, 550, 233 Annotation: Subtype: Link Rect: 549, 232, 551, 233 Annotation: Subtype: Link Rect: 552, 230, 560, 236 Annotation: Subtype: Link Rect: 561, 230, 562, 232 Annotation: Subtype: Link Rect: 363, 220, 394, 226 Annotation: Subtype: Link Rect: 397, 219, 404, 226 Annotation: Subtype: Link Rect: 407, 220, 428, 226 Annotation: Subtype: Link Rect: 431, 221, 435, 226 Annotation: Subtype: Link Rect: 435, 219, 436, 222 Annotation: Subtype: Link Rect: 440, 221, 443, 226 Annotation: Subtype: Link Rect: 444, 219, 473, 226 Annotation: Subtype: Link Rect: 476, 220, 482, 226 Annotation: Subtype: Link Rect: 486, 221, 489, 226 Annotation: Subtype: Link Rect: 490, 219, 523, 226 Annotation: Subtype: Link Rect: 526, 220, 545, 226 Annotation: Subtype: Link Rect: 548, 220, 578, 226 Annotation: Subtype: 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