dd92024922ebb2dc70a07af8dcd053de 269933.pdf 41900bb958f7ab413c439e855f1cfcfcbe0ff65b 269933.pdf 006423b5e45a53226afac96f242d0243b937edccf7bc7f7b41ca27f26be86016 269933.pdf Title: First-Line Maintenance Treatment in Metastatic Colorectal Cancer (mCRC): Quality and Clinical Benefit Overview Subject: Different strategies of maintenance therapy (sequential CT, intermittent CT, intermittent CT and MAbs, or de-escalation MAbs monotherapy) after first-line treatment are undertaken. Many randomized clinical trials (RCT), which evaluated these approaches, suffer from incorrect design, heterogenous primary endpoints, inadequate size, and other methodology flaws. Drawing any conclusions becomes challenging and recommendations are mainly vague. We evaluated those studies from another perspective, focusing on the design quality and the clinical benefit measure with a more objective and accurate methodology. These data allowed a clearer and more exact overview of the statement in maintenance treatment. Keywords: maintenance treatment; sequential; continuous; intermittent treatment Author: Marta Martín-Richard and Maria Tobeña Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jan 26 13:52:11 2021 CET ModDate: Tue Jan 26 14:54:40 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 260445 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- URUSTZ+URWPalladioL-Ital Type 1 Custom yes yes no 10 0 MXPEYZ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 CFHZHC+URWPalladioL-Roma Type 1 Custom yes yes no 19 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 ECJKOI+VnURWPalladioL Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 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and Maria Tobeña Subject: Different strategies of maintenance therapy (sequential CT, intermittent CT, intermittent CT and MAbs, or de-escalation MAbs monotherapy) after first-line treatment are undertaken. Many randomized clinical trials (RCT), which evaluated these approaches, suffer from incorrect design, heterogenous primary endpoints, inadequate size, and other methodology flaws. Drawing any conclusions becomes challenging and recommendations are mainly vague. We evaluated those studies from another perspective, focusing on the design quality and the clinical benefit measure with a more objective and accurate methodology. These data allowed a clearer and more exact overview of the statement in maintenance treatment. 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