a7b744c49283b3fce34a9a1741e19eb1 269943.pdf f6d98f7ea6cd57958441fb26d781955e86b1f201 269943.pdf 93f0d4a45d2edbb7c79602f16d9bb4c7ad96365e5a010e93c978a566061116cd 269943.pdf Title: Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women Subject: Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13–3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms. Keywords: SARS-CoV-2; pregnancy; coronavirus; asymptomatic infection; perinatal outcomes; delivery; maternal complications Author: Monica Cruz-Lemini, Elena Ferriols Perez, Maria Luisa de la Cruz Conty, Africa Caño Aguilar, Maria Begoña Encinas Pardilla, Pilar Prats Rodríguez, Marta Muner Hernando, Laura Forcen Acebal, Pilar Pintado Recarte, Maria del Carmen Medina Mallen, Noelia Perez Perez, Judit Canet Rodriguez, Ana Villalba Yarza, Olga Nieto Velasco, Pablo Guillermo del Barrio Fernandez, Carmen Maria Orizales Lago, Beatriz Marcos Puig, Begoña Muñoz Abellana, Laura Fuentes Ricoy, Agueda Rodriguez Vicente, Maria Jesus Janeiro Freire, Macarena Alferez Alvarez-Mallo, Cristina Casanova Pedraz, Onofre Alomar Mateu, Cristina Lesmes Heredia, Juan Carlos Wizner de Alva, Alma Posadas San Juan, Montserrat Macia Badia, Cristina Alvarez Colomo, Antonio Sanchez Muñoz, Laia Pratcorona Alicart, Ruben Alonso Saiz, Monica Lopez Rodriguez, Maria Carmen Barbancho Lopez, Marta Ruth Meca Casbas, Oscar Vaquerizo Ruiz, Eva Moran Antolin, Maria Jose Nuñez Valera, Camino Fernandez Fernandez, Albert Tubau Navarra, Alejandra Maria Cano Garcia, Susana Soldevilla Perez, Irene Gattaca Abasolo, Jose Adanez Garcia, Alberto Puertas Prieto, Rosa Ostos Serna, Maria del Pilar Guadix Martin, Monica Catalina Coello, Silvia Espuelas Malon, Jose Antonio Sainz Bueno, Maria Reyes Granell Escobar, Sara Cruz Melguizo, Oscar Martinez Perez and on behalf of the Spanish Obstetric Emergency Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jan 15 12:41:25 2021 CET ModDate: Fri Jan 15 14:06:18 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 643186 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Obstetric Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Neonatal Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Multivariable Logistic Model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Info: Title: Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women Author: Monica Cruz-Lemini, Elena Ferriols Perez, Maria Luisa de la Cruz Conty, Africa Caño Aguilar, Maria Begoña Encinas Pardilla, Pilar Prats Rodríguez, Marta Muner Hernando, Laura Forcen Acebal, Pilar Pintado Recarte, Maria del Carmen Medina Mallen, Noelia Perez Perez, Judit Canet Rodriguez, Ana Villalba Yarza, Olga Nieto Velasco, Pablo Guillermo del Barrio Fernandez, Carmen Maria Orizales Lago, Beatriz Marcos Puig, Begoña Muñoz Abellana, Laura Fuentes Ricoy, Agueda Rodriguez Vicente, Maria Jesus Janeiro Freire, Macarena Alferez Alvarez-Mallo, Cristina Casanova Pedraz, Onofre Alomar Mateu, Cristina Lesmes Heredia, Juan Carlos Wizner de Alva, Alma Posadas San Juan, Montserrat Macia Badia, Cristina Alvarez Colomo, Antonio Sanchez Muñoz, Laia Pratcorona Alicart, Ruben Alonso Saiz, Monica Lopez Rodriguez, Maria Carmen Barbancho Lopez, Marta Ruth Meca Casbas, Oscar Vaquerizo Ruiz, Eva Moran Antolin, Maria Jose Nuñez Valera, Camino Fernandez Fernandez, Albert Tubau Navarra, Alejandra Maria Cano Garcia, Susana Soldevilla Perez, Irene Gattaca Abasolo, Jose Adanez Garcia, Alberto Puertas Prieto, Rosa Ostos Serna, Maria del Pilar Guadix Martin, Monica Catalina Coello, Silvia Espuelas Malon, Jose Antonio Sainz Bueno, Maria Reyes Granell Escobar, Sara Cruz Melguizo, Oscar Martinez Perez and on behalf of the Spanish Obstetric Emergency Group Subject: Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13 3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms. 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