b6883a608306b35c0131dd8eaa075e75 270214.pdf 6bbcbaf06ef5cf0c9d9db57338f40af4a99acff4 270214.pdf 8c7745129b0554f34fe3def928b3fb03c0aa83630fa5a084a9b7c08809920a14 270214.pdf Title: Management of Localized Muscle-Invasive Bladder Cancer from a Multidisciplinary Perspective: Current Position of the Spanish Oncology Genitourinary (SOGUG) Working Group Subject: This review presents challenges and recommendations on different aspects related to the management of patients with localized muscle-invasive bladder cancer (MIBC), which were discussed by a group of experts of a Spanish Oncology Genitourinary (SOGUG) Working Group within the framework of the Genitourinary Alliance project (12GU). It is necessary to clearly define which patients are candidates for radical cystectomy and which are candidates for undergoing bladder-sparing procedures. In older patients, it is necessary to include a geriatric assessment and evaluation of comorbidities. The pathological report should include a classification of the histopathological variant of MIBC, particularly the identification of subtypes with prognostic, molecular and therapeutic implications. Improvement of clinical staging, better definition of prognostic groups based on molecular subtypes, and identification of biomarkers potentially associated with maximum benefit from neoadjuvant chemotherapy are areas for further research. A current challenge in the management of MIBC is improving the selection of patients likely to be candidates for immunotherapy with checkpoint inhibitors in the neoadjuvant setting. Optimization of FDG-PET/CT reliability in staging of MIBC and the selection of patients is necessary, as well as the design of prospective studies aimed to compare the value of different imaging techniques in parallel. Keywords: muscle-invasive bladder cancer; neoadjuvant chemotherapy; molecular subtypes; bladder preservation; radical cystectomy; immunotherapy; checkpoint inhibitors Author: Antonio Gómez Caamaño, Ana M. García Vicente, Pablo Maroto, Alfredo Rodríguez Antolín, Julián Sanz, María Almudena Vera González, Miguel Ángel Climent and on behalf of the Spanish Oncology Genitourinary (SOGUG) Multisiciplinary Working Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Dec 3 11:32:12 2021 CET ModDate: Fri Dec 3 13:02:22 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1055717 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BKONWJ+VnURWPalladioL Type 1 Custom yes yes no 10 0 EHTBZR+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 JUXZFW+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 DHZDGH+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 WIPXQR+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 ALRLBO+CMSY10 Type 1 Builtin yes yes no 84 0 GMCLPN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 91 0 GMCMAO+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 97 0 GMCMAP+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 103 0 GMCMBA+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 109 0 GMCMBB+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 112 0 GMCMCB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 115 0 GMCNKJ+SymbolMT CID TrueType Identity-H yes yes yes 118 0 GMCNKK+ArialMT CID TrueType Identity-H yes yes yes 124 0 CBSRZX+EURM10 Type 1 Builtin yes yes no 143 0 GMCLPN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 156 0 GMCMAO+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 162 0 GMCMAP+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 168 0 GMCMBA+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 174 0 GMCMBB+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 177 0 GMCMCB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 180 0 GMCNKJ+SymbolMT CID TrueType Identity-H yes yes yes 183 0 GMCNKK+ArialMT CID TrueType Identity-H yes yes yes 189 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:11:26 CEST RepresentationInformation: 270214.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:51 CEST Size: 1055717 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 482 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Subclassification of Urothelial Carcinoma in Different Molecular Groups Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Integrated Assessment of Patient Candidates for Radical Cystectomy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Bladder Preservation and New Molecular Classifications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Neoadjuvant Chemotherapy and Integration of Immunotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Role of Imaging Techniques in Staging, Assessment of Response, and Follow-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Nuclear Medicine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Radiology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: Management of Localized Muscle-Invasive Bladder Cancer from a Multidisciplinary Perspective: Current Position of the Spanish Oncology Genitourinary (SOGUG) Working Group Author: Antonio Gómez Caamaño, Ana M. García Vicente, Pablo Maroto, Alfredo Rodríguez Antolín, Julián Sanz, María Almudena Vera González, Miguel Ángel Climent and on behalf of the Spanish Oncology Genitourinary (SOGUG) Multisiciplinary Working Group Subject: This review presents challenges and recommendations on different aspects related to the management of patients with localized muscle-invasive bladder cancer (MIBC), which were discussed by a group of experts of a Spanish Oncology Genitourinary (SOGUG) Working Group within the framework of the Genitourinary Alliance project (12GU). It is necessary to clearly define which patients are candidates for radical cystectomy and which are candidates for undergoing bladder-sparing procedures. In older patients, it is necessary to include a geriatric assessment and evaluation of comorbidities. The pathological report should include a classification of the histopathological variant of MIBC, particularly the identification of subtypes with prognostic, molecular and therapeutic implications. Improvement of clinical staging, better definition of prognostic groups based on molecular subtypes, and identification of biomarkers potentially associated with maximum benefit from neoadjuvant chemotherapy are areas for further research. A current challenge in the management of MIBC is improving the selection of patients likely to be candidates for immunotherapy with checkpoint inhibitors in the neoadjuvant setting. Optimization of FDG-PET/CT reliability in staging of MIBC and the selection of patients is necessary, as well as the design of prospective studies aimed to compare the value of different imaging techniques in parallel. 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