37aea4bc7c7d55b888a45e867da4255c  270216.pdf
eb4031e096ea03728bafbc8882516dbd628fca34  270216.pdf
514c75055250569c36c510e7f2e545f1543781eaa7d413b0ef98b29cd3c459cf  270216.pdf

Title:          Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis
Subject:        JHEP Reports, 3 (2021) . doi:10.1016/j.jhepr.2021.100368
Author:         Ana Garcia Garcia de Paredes
Creator:        Elsevier
CreationDate:   Thu Nov 18 02:49:53 2021 CET
ModDate:        Thu Nov 18 03:02:04 2021 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      298997 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GLKOCN+AdvOTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     266  0
GLKOCO+AdvOT863180fb                 Type 1C           WinAnsi          yes yes no     267  0
GLKOEO+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     272  0
GLKOEP+ArialMT                       Type 1C           WinAnsi          yes yes no     273  0
GLKOIP+AdvP4C4E74                    Type 1C           Custom           yes yes no     277  0
GLKOJA+AdvOT863180fb+fb              Type 1C           Custom           yes yes yes    278  0
GLKOCN+AdvOTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     188  0
GLKOCO+AdvOT863180fb                 Type 1C           WinAnsi          yes yes no     193  0
ONILEK+AdvOTb92eb7df.I               Type 1C           WinAnsi          yes yes no     177  0
ONILEL+AdvOTb92eb7df.I+20            Type 1C           WinAnsi          yes yes no     199  0
ONILFM+AdvOT863180fb+20              Type 1C           WinAnsi          yes yes no     200  0
GLKOJA+AdvOT863180fb+fb              Type 1C           Custom           yes yes yes    181  0
ONIMBJ+AdvOT863180fb+22              Type 1C           Custom           yes yes no     212  0
ONIMBK+AdvPS3F4C13                   Type 1C           WinAnsi          yes yes no     208  0
GLKOIP+AdvP4C4E74                    Type 1C           WinAnsi          yes yes no     209  0
ONIMCM+AdvPSMP13                     Type 1C           WinAnsi          yes yes no     214  0
ONIMDM+ArialMT                       Type 1C           Custom           yes yes yes    215  0
ONIMDN+Arial-ItalicMT                Type 1C           WinAnsi          yes yes no     216  0
ONIMHN+AdvOTb83ee1dd.B+fb            Type 1C           Custom           yes yes yes    217  0
ONIMHO+AdvOTb83ee1dd.B+20            Type 1C           WinAnsi          yes yes no     218  0
ONIMHP+AdvOTb92eb7df.I+fb            Type 1C           Custom           yes yes yes    219  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-27 03:11:24 CEST
 RepresentationInformation: 270216.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-31 12:04:51 CEST
  Size: 298997
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found
   Offset: 285201
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found
   Offset: 285201
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 359
   FreeObjects: 14
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4
       Item: 
        Title: Patients and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034
        Children: 
         Item: 
          Title: Patients and study design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
         Item: 
          Title: miRNA signature determination in serum samples
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
         Item: 
          Title: Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
        Children: 
         Item: 
          Title: Patient characteristics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
         Item: 
          Title: Serum miRNA levels and ascites formation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
         Item: 
          Title: Serum miRNAs levels and the hemodynamic response to NSBB
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: Financial support
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Conflicts of interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: Authors' contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: Data availability statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
       Item: 
        Title: Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
   Info: 
    Title: Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis
    Author: Ana Garcia Garcia de Paredes
    Subject: JHEP Reports, 3 (2021) . doi:10.1016/j.jhepr.2021.100368
    Creator: Elsevier
    CreationDate: Thu Nov 18 03:19:53 CET 2021
    ModDate: Thu Nov 18 03:32:04 CET 2021
   ID: 0x3f11b0f44653f8419ae943a3d809919f, 0x7513b2051ba2e64a8fc711d73f76824a
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 74
      ImageHeight: 54
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 107
      ImageHeight: 27
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 395
      ImageHeight: 26
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 397
      ImageHeight: 28
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 55
      ImageHeight: 24
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 57
      ImageHeight: 26
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 28
      ImageHeight: 72
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 28
      ImageHeight: 72
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 261
      ImageHeight: 26
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 264
      ImageHeight: 28
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 97
      ImageHeight: 90
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 17
      ImageHeight: 44
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 18
      ImageHeight: 44
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 74
      ImageHeight: 65
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 79
      ImageHeight: 60
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 220
      ImageHeight: 41
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 218
      ImageHeight: 39
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 98
      ImageHeight: 39
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 97
      ImageHeight: 90
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 105
      ImageHeight: 25
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 100
      ImageHeight: 41
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
   Fonts: 
    Type1: 
     Font: 
      BaseFont: GLKOCO+AdvOT863180fb
      FontSubset: true
      FirstChar: 35
      LastChar: 243
      FontDescriptor: 
       FontName: GLKOCO+AdvOT863180fb
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONILEL+AdvOTb92eb7df.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: ONILEL+AdvOTb92eb7df.I+20
       Flags: Nonsymbolic
       FontBBox: -41, -208, 885, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONILFM+AdvOT863180fb+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: ONILFM+AdvOT863180fb+20
       Flags: Nonsymbolic
       FontBBox: 9, -208, 947, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GLKOCN+AdvOTb83ee1dd.B
      FontSubset: true
      FirstChar: 45
      LastChar: 119
      FontDescriptor: 
       FontName: GLKOCN+AdvOTb83ee1dd.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GLKOCO+AdvOT863180fb
      FontSubset: true
      FirstChar: 40
      LastChar: 241
      FontDescriptor: 
       FontName: GLKOCO+AdvOT863180fb
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GLKOEO+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: GLKOEO+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONIMBK+AdvPS3F4C13
      FontSubset: true
      FirstChar: 68
      LastChar: 68
      FontDescriptor: 
       FontName: ONIMBK+AdvPS3F4C13
       Flags: Nonsymbolic
       FontBBox: 0, -291, 875, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GLKOEP+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: GLKOEP+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONILEK+AdvOTb92eb7df.I
      FontSubset: true
      FirstChar: 40
      LastChar: 242
      FontDescriptor: 
       FontName: ONILEK+AdvOTb92eb7df.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GLKOIP+AdvP4C4E74
      FontSubset: true
      FirstChar: 106
      LastChar: 106
      FontDescriptor: 
       FontName: GLKOIP+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONIMBJ+AdvOT863180fb+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: ONIMBJ+AdvOT863180fb+22
       Flags: Nonsymbolic
       FontBBox: -20, -208, 770, 885
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: GLKOIP+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GLKOIP+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: GLKOJA+AdvOT863180fb+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: GLKOJA+AdvOT863180fb+fb
       Flags: Symbolic
       FontBBox: 40, 0, 895, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GLKOJA+AdvOT863180fb+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GLKOJA+AdvOT863180fb+fb
       Flags: Symbolic
       FontBBox: 40, 0, 895, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ONIMCM+AdvPSMP13
      FontSubset: true
      FirstChar: 113
      LastChar: 113
      FontDescriptor: 
       FontName: ONIMCM+AdvPSMP13
       Flags: Nonsymbolic
       FontBBox: 0, -302, 958, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONIMDM+ArialMT
      FontSubset: true
      FirstChar: 2
      LastChar: 118
      FontDescriptor: 
       FontName: ONIMDM+ArialMT
       Flags: Symbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ONIMDN+Arial-ItalicMT
      FontSubset: true
      FirstChar: 112
      LastChar: 112
      FontDescriptor: 
       FontName: ONIMDN+Arial-ItalicMT
       Flags: Nonsymbolic, Italic
       FontBBox: -517, -325, 1359, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONIMHN+AdvOTb83ee1dd.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ONIMHN+AdvOTb83ee1dd.B+fb
       Flags: Symbolic
       FontBBox: 19, 0, 947, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ONIMHO+AdvOTb83ee1dd.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: ONIMHO+AdvOTb83ee1dd.B+20
       Flags: Nonsymbolic
       FontBBox: 9, -208, 1125, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ONIMHP+AdvOTb92eb7df.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ONIMHP+AdvOTb92eb7df.I+fb
       Flags: Symbolic
       FontBBox: -114, -208, 833, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GLKOCN+AdvOTb83ee1dd.B
      FontSubset: true
      FirstChar: 38
      LastChar: 122
      FontDescriptor: 
       FontName: GLKOCN+AdvOTb83ee1dd.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jhepr.2021.100368</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Ana Garcia Garcia de Paredes</rdf:li>
               <rdf:li>Càndid Villanueva</rdf:li>
               <rdf:li>Carolina Blanco</rdf:li>
               <rdf:li>Joan Genescà</rdf:li>
               <rdf:li>Nicolo Manicardi</rdf:li>
               <rdf:li>Juan Carlos Garcia-Pagan</rdf:li>
               <rdf:li>Jose Luis Calleja</rdf:li>
               <rdf:li>Carlos Aracil</rdf:li>
               <rdf:li>Rosa M. Morillas</rdf:li>
               <rdf:li>Maria Poca</rdf:li>
               <rdf:li>Beatriz Peñas</rdf:li>
               <rdf:li>Salvador Augustin</rdf:li>
               <rdf:li>Juan G. Abraldes</rdf:li>
               <rdf:li>Eldimar Alvarado</rdf:li>
               <rdf:li>Félix Royo</rdf:li>
               <rdf:li>Maria Laura Garcia-Bermejo</rdf:li>
               <rdf:li>Juan Manuel Falcon-Perez</rdf:li>
               <rdf:li>Rafael Bañares</rdf:li>
               <rdf:li>Jaime Bosch</rdf:li>
               <rdf:li>Jordi Gracia-Sancho</rdf:li>
               <rdf:li>Agustin Albillos</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Ascites</rdf:li>
               <rdf:li>beta-blockers</rdf:li>
               <rdf:li>cirrhosis</rdf:li>
               <rdf:li>microRNA</rdf:li>
               <rdf:li>portal hypertension</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">JHEP Reports, 3 (2021) . doi:10.1016/j.jhepr.2021.100368</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>JHEP Reports</prism:publicationName>
         <prism:copyright>© 2021 The Authors. Published by Elsevier. All rights reserved.</prism:copyright>
         <prism:issn>2589-5559</prism:issn>
         <prism:volume>3</prism:volume>
         <prism:number>6</prism:number>
         <prism:coverDisplayDate>December 2021</prism:coverDisplayDate>
         <prism:pageRange>100368</prism:pageRange>
         <prism:startingPage>100368</prism:startingPage>
         <prism:doi>10.1016/j.jhepr.2021.100368</prism:doi>
         <prism:url>http://dx.doi.org/10.1016/j.jhepr.2021.100368</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jhepr.2021.100368</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:robots>noindex</pdfx:robots>
         <ZtV1wzgr8z.z-m.iGndqNyLNNnMeOlt6NzdiGz.uJn.mJnwr9ndmPo9ePnMuKntmPndiTma/>
         <pdfx:doi>10.1016/j.jhepr.2021.100368</pdfx:doi>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2021-11-18T07:19:53+05:30</xap:CreateDate>
         <xap:ModifyDate>2021-11-18T07:32:04+05:30</xap:ModifyDate>
         <xap:MetadataDate>2021-11-18T07:32:04+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:8cf9bb20-f905-4618-a204-407be1ba9831</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:85c141a3-138e-4610-8428-e65634503353</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 550, 157, 562
      Annotation: 
       Subtype: Link
       Rect: 45, 35, 208, 44
      Annotation: 
       Subtype: Link
       Rect: 161, 788, 168, 792
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 409, 617, 413, 626
       Name: 19f5183a-b916-4ad8-9eec-1a92b28cb396
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 491, 617, 491, 626
       Name: 5a2df8b4-c4f2-4e96-9288-76cd351b78bd
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 491, 617, 491, 626
       Name: 3af19b35-34b4-412b-bf53-b1244af79152
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 491, 617, 495, 626
       Name: b204a973-718b-4049-88ae-917a56cd3faa
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 496, 617, 501, 626
       Name: cbee700c-3ec4-4b9c-a37d-8c4c914f6f4e
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 123, 436, 298, 445
       Name: dfab913d-98c6-40bc-85e5-9a5510a470fb
      Annotation: 
       Subtype: Link
       Rect: 259, 213, 468, 222
       Name: c7681585-c769-4e85-9feb-5aaa0a252f3c
      Annotation: 
       Subtype: Link
       Rect: 369, 188, 372, 197
       Name: 6ec0b1bb-def2-483d-a2c4-9072c4e5ee0d
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 373, 188, 376, 197
       Name: 0982a7b4-db6c-488b-a9ca-3152cdddc668
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 394, 111, 398, 120
       Name: aad5e374-13a8-41a0-b5da-0e5a20272a1d
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 88, 82, 155, 88
       Name: a91f029a-9d64-48bc-9020-6334f18e1db4
      Annotation: 
       Subtype: Link
       Rect: 524, 677, 552, 704
       Name: 9f2d0ef8-791e-4e4d-aaf4-8281498b7794
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 701, 131, 710
       Name: 87ead259-fb63-45de-904f-69f6010e1161
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 266, 669, 270, 677
       Name: 3bf83274-2366-4a14-8669-ede0732b17a9
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 132, 636, 135, 644
       Name: 40da0ae6-4805-4955-801b-24d731b334e3
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 129, 570, 133, 578
       Name: 561b72f4-ac7d-4ae5-820b-3543dbb5cd3f
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 206, 548, 210, 557
       Name: 2de6b281-9b09-477d-b99f-d61ea92ea49c
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 101, 395, 104, 404
       Name: 4404c004-0540-4cb1-bdd8-1639e5c98956
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 101, 286, 104, 294
       Name: b4e5820c-1014-4b53-9184-427caa40ae9c
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 235, 175, 239, 184
       Name: 4f38cb76-892f-4821-a024-8a9923e367c4
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 435, 723, 439, 732
       Name: 74fcbc9e-fe77-4ee0-b79e-15179c17b37c
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 534, 647, 537, 655
       Name: 9b83de06-02ba-4f16-8f4b-f747438a086b
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 357, 518, 385, 526
       Name: 5fb5b22b-df12-456e-9b01-7ff9e5d8908e
       Destination: 45
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 643, 147, 651
       Name: 443028a9-9bb2-4809-8377-f60aed2f3fd2
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 382, 591, 389, 600
       Name: 27467006-a02a-463a-b342-28107aa62687
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 336, 580, 339, 589
       Name: 59dee124-064f-49c4-9914-118bc670544a
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 340, 580, 347, 589
       Name: d51002ca-8504-479a-bdb2-6bf285912e53
       Destination: null
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 181, 625, 188, 633
       Name: 40f141c0-db3b-4828-a42f-62b71827806b
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 131, 614, 137, 622
       Name: ea653cc1-c50e-420f-81fa-9fb16f62868d
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 86, 603, 92, 611
       Name: 110bad5c-300b-42d6-ac12-5987bdf89dfc
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 83, 581, 86, 589
       Name: aa36652f-4f2a-4131-9e7a-e72775fe20a0
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 270, 559, 274, 567
       Name: 0e1952da-e60b-4b9b-ba74-68720d874ffd
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 77, 515, 81, 524
       Name: 070d3d42-4575-4a43-b37e-eb7458a4bc10
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 82, 515, 86, 524
       Name: 1e6c2919-23c0-4ee5-a7f6-b3f509fce97d
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 87, 515, 93, 524
       Name: 8fba88b3-1cd4-4c17-8093-c4514b60cf86
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 95, 515, 101, 524
       Name: 9083c490-ef5f-463f-989e-f226c2c90921
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 271, 493, 274, 502
       Name: 0cb5f365-3d32-44bf-aaa4-f4c1e7984c14
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 276, 493, 291, 502
       Name: 8041519c-c0b0-4c8e-93de-cbba9bb15437
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 235, 427, 238, 436
       Name: 3286b258-a125-4f94-94e2-02aaf76df727
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 403, 614, 407, 622
       Name: beb8b5d6-a1b3-418c-b32c-5083276be65b
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 496, 259, 552, 266
       Name: a60f64f4-947d-4414-bfa2-bffb28b8ffd5
      Annotation: 
       Subtype: Link
       Rect: 303, 249, 393, 257
       Name: 2c27463e-8901-419a-b04a-c5eea62b1c3f
      Annotation: 
       Subtype: Link
       Rect: 419, 176, 550, 183
       Name: 761666ba-c06a-4cd8-9d02-e08443960e65
      Annotation: 
       Subtype: Link
       Rect: 428, 131, 552, 138
       Name: 28acf994-f67a-4381-86f6-9106bfb0a058
      Annotation: 
       Subtype: Link
       Rect: 319, 122, 345, 129
       Name: 47fe9d0a-69ff-47a4-b275-6e52684e92ad
      Annotation: 
       Subtype: Link
       Rect: 392, 86, 531, 93
       Name: e974cf19-b7f0-4e1b-96ce-0a02e410b0de
      Annotation: 
       Subtype: Link
       Rect: 477, 59, 552, 66
       Name: 94007e73-860d-4d19-9516-b3bfbed1c0e6
      Annotation: 
       Subtype: Link
       Rect: 319, 50, 349, 57
       Name: 02e98c25-c736-4b20-99b7-63ea877f7240
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 234, 703, 291, 710
       Name: dd4c239b-7159-4837-8525-c3fa15139dd2
      Annotation: 
       Subtype: Link
       Rect: 58, 694, 113, 701
       Name: 6185bdbf-a5c5-41f8-a054-550a5b2ebe89
      Annotation: 
       Subtype: Link
       Rect: 256, 667, 291, 674
       Name: 654e55ab-5ab0-41e6-abdd-faafcc213599
      Annotation: 
       Subtype: Link
       Rect: 58, 658, 131, 665
       Name: 48cac5e5-da2f-4cbc-96aa-5361596c5c5f
      Annotation: 
       Subtype: Link
       Rect: 58, 649, 291, 656
       Name: 8b5be417-7356-486e-b74f-978b7e49cc4d
      Annotation: 
       Subtype: Link
       Rect: 58, 640, 291, 647
       Name: 45e10604-8850-4645-81ef-329a28ddbbde
      Annotation: 
       Subtype: Link
       Rect: 58, 631, 162, 638
       Name: 9418268f-cc69-4916-90c4-1d6b0332ad89
      Annotation: 
       Subtype: Link
       Rect: 129, 596, 243, 603
       Name: b1337f9b-3773-49ab-bed4-3fa8bc7d0d4a
      Annotation: 
       Subtype: Link
       Rect: 58, 569, 214, 576
       Name: 0c7bcdd4-11ae-4887-aad7-589d929da524
      Annotation: 
       Subtype: Link
       Rect: 58, 542, 181, 549
       Name: 46846104-076b-4870-8117-eafe4699246d
      Annotation: 
       Subtype: Link
       Rect: 136, 506, 278, 513
       Name: acb4c25a-b961-4672-96a4-09746170bb6f
      Annotation: 
       Subtype: Link
       Rect: 256, 479, 291, 486
       Name: 21815f91-77bb-4edb-b739-451df46b8159
      Annotation: 
       Subtype: Link
       Rect: 58, 470, 165, 477
       Name: b1e7a512-11dd-44f2-ad29-8ee254a77f23
      Annotation: 
       Subtype: Link
       Rect: 438, 703, 552, 710
       Name: f01cb1c0-86dc-47ff-b510-c51cd89001ac
      Annotation: 
       Subtype: Link
       Rect: 319, 694, 345, 701
       Name: c0a45155-1f4f-44f6-81e7-73619eec71b5
      Annotation: 
       Subtype: Link
       Rect: 319, 658, 471, 665
       Name: 891d07bf-58d1-44a6-b78a-e4aa22230c76
      Annotation: 
       Subtype: Link
       Rect: 495, 631, 552, 638
       Name: d1e031f6-5d04-4df3-a8b6-09c454e8fce6
      Annotation: 
       Subtype: Link
       Rect: 319, 622, 400, 629
       Name: 0e814634-b2ad-418d-aace-3fc7958c0dd2
      Annotation: 
       Subtype: Link
       Rect: 517, 605, 552, 612
       Name: 83947e9d-130e-47cc-a6b7-794f4ff05167
      Annotation: 
       Subtype: Link
       Rect: 319, 596, 428, 603
       Name: f082a09c-b89a-40ac-997b-5e7005a1bd23
      Annotation: 
       Subtype: Link
       Rect: 517, 569, 552, 576
       Name: 6040d4a1-08ab-4c85-b71a-3fcc5bd9e9c5
      Annotation: 
       Subtype: Link
       Rect: 319, 560, 422, 567
       Name: 5a9f66df-5da0-4ac3-99fa-0cda62a4bf23
      Annotation: 
       Subtype: Link
       Rect: 439, 524, 552, 531
       Name: 180bce48-d33d-4029-806f-eccde6f58e82
      Annotation: 
       Subtype: Link
       Rect: 319, 515, 360, 522
       Name: c657a260-2934-43a4-9c0e-4a2949cc719a
      Annotation: 
       Subtype: Link
       Rect: 435, 479, 552, 486
       Name: 0e8dca94-95eb-4295-9596-f02d65b0f42e
      Annotation: 
       Subtype: Link
       Rect: 319, 470, 331, 477
       Name: 3acbf641-93f6-49d8-9367-30b195b06b81
  Checksum: 36718ca1
   Type: CRC32
  Checksum: 37aea4bc7c7d55b888a45e867da4255c
   Type: MD5
  Checksum: eb4031e096ea03728bafbc8882516dbd628fca34
   Type: SHA-1