e65848b33858c331dbf8ba959ce89359 270245.pdf 3bfdbffd371a9590d0c1aa7123385a6752fdde0d 270245.pdf 926b98efc78635c65cd95789543c5cc69b505f79aee61c1661775a8ad721aa85 270245.pdf Title: A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data Subject: Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Keywords: Parkinson's disease, alpha-synuclein (α-syn), prasinezumab, monoclonal antibodies, disease progression, MDS-UPDRS = Movement Disorder Society—Unified Parkinson's Disease Rating Scale, Phase II clinical trial, disease modification treatments Author: Gennaro Pagano Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Dec 18 05:24:06 2021 CET ModDate: Sat Dec 18 09:24:06 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1544150 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LJBWBZ+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 45 0 YEKYQR+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 50 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 63 0 ICIZUL+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 65 0 DCJBCW+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 70 0 GBNQTY+MTSY Type 1C Custom yes yes no 72 0 ZVVQAX+MinionPro-It Type 1C Custom yes yes no 97 0 GBKXCW+MTGUB Type 1C Custom yes yes no 80 0 UADLTO+MTSYB Type 1C Custom yes yes no 82 0 VPOHSR+MinionPro-Regular Type 1C Custom yes yes no 84 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 149 0 UFYNUW+MinionPro-Bold Type 1C Custom yes yes no 155 0 IBLQEL+HelveticaNeueLTStd-Md Type 1C Custom yes yes no 167 0 Times-Roman Type 1 Standard no no no 183 0 GBKXCW+MTGU Type 1C Custom yes yes no 211 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:11:06 CEST RepresentationInformation: 270245.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:52 CEST Size: 1544150 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 465 FreeObjects: 22 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Desi最渀Ⰰ 愀渀搀 䈀愀猀攀氀椀渀攀 䐀愀琀愩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㌷‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸳㌯䅣瑩潮⽇潔漯偲敶″㘠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Objectives and Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Primary Endpoint Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Secondary Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Exploratory Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: PASADENA Digital Motor Score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Standard Protocol Approvals, Registrations, and Patient Consents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Sample Size Justification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Covariate Adjustment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Statistical Analyses of Primary Efficacy Endpoint Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Statistical Analyses of Secondary and Exploratory Efficacy Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Subgroup Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Inclusion Criteria for the PPMI Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Statistical Comparisons Between PASADENA and PPMI Cohorts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results of Baseline Data Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Baseline PASADENA Demographics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: MAO-B Inhibitor-Treated vs. Treatment-Naïve Patients in the PASADENA Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: PASADENA Population vs. PPMI Cohort, Selected Using PASADENA Eligibility Criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: PASADENA Investigators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: PRASINEZUMAB Study Group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data Author: Gennaro Pagano Subject: Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Keywords: Parkinson's disease, alpha-synuclein (α-syn), prasinezumab, monoclonal antibodies, disease progression, MDS-UPDRS = Movement 䐀椀猀漀爀搀攀爀 匀漀挀椀攀琀礠᐀唀渀椀昀椀攀搀 倀愀爀欀椀渀猀漀渀✀猀 䐀椀猀攀愀猀攀 刀愀琀椀渀最 匀挀愀氀攀Ⰰ 倀栀愀猀攀 䤀䤀 挀氀椀渀椀挀愀氀 琀爀椀愀氀Ⰰ 搀椀猀攀愀猀攀 洀漀搀椀昀椀挀愀琀椀漀渀 琀爀攀愀琀洀攀渀琀猩⽐牯摵捥爨摶楰猠⬠䵩䭔敘⁇偌⁇桯獴獣物灴†㤮〩⽍潤䑡瑥⡄㨲〲ㄱ㈱㠱㌵㐰㘫〵✳〧 Creator: LaTeX with hyperref package + hypdvips CreationDate: Sat Dec 18 05:54:06 CET 2021 ID: 0x5d78f5c269fb9c14fccc01c353f3d4d0, 0xa397cfefe8135c47a86c9d32a8a1b585 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1011 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1061 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 478 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 936 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: ICIZUL+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 246 FontDescriptor: FontName: ICIZUL+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ZVVQAX+MinionPro-It FontSubset: true FirstChar: 19 LastChar: 169 FontDescriptor: FontName: ZVVQAX+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DCJBCW+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 122 FontDescriptor: FontName: DCJBCW+HelveticaNeueLTStd-MdIt Flags: Serif, Nonsymbolic FontBBox: -64, -205, 995, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBLQEL+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 0 LastChar: 122 FontDescriptor: FontName: IBLQEL+HelveticaNeueLTStd-Md Flags: Symbolic FontBBox: -22, -205, 815, 731 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GBNQTY+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: GBNQTY+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 583 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LJBWBZ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 239 FontDescriptor: FontName: LJBWBZ+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -41, -214, 870, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GBKXCW+MTGUB FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: GBKXCW+MTGUB Flags: Symbolic FontBBox: 0, -13, 581, 462 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YEKYQR+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 239 FontDescriptor: FontName: YEKYQR+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UADLTO+MTSYB FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: UADLTO+MTSYB Flags: Symbolic, AllCap FontBBox: 0, 0, 724, 387 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GBKXCW+MTGU FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: GBKXCW+MTGU Flags: Symbolic FontBBox: 0, -10, 519, 460 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VPOHSR+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: VPOHSR+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 794 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Times-Roman Font: BaseFont: UFYNUW+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: UFYNUW+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 823, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding XMP: 2021-12-18T09:54:06+05:30 LaTeX with hyperref package + hypdvips 2021-12-18T13:54:06+05:30 2021-12-18T13:54:06+05:30 application/pdf Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Gennaro Pagano A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data Parkinson's disease alpha-synuclein (α-syn) prasinezumab monoclonal antibodies disease progression MDS-UPDRS = Movement Disorder Society—Unified Parkinson's Disease Rating Scale Phase II clinical trial disease modification treatments Parkinson's disease, alpha-synuclein (α-syn), prasinezumab, monoclonal antibodies, disease progression, MDS-UPDRS = Movement Disorder Society—Unified Parkinson's Disease Rating Scale, Phase II clinical trial, disease modification treatments dvips + MiKTeX GPL Ghostscript 9.0 uuid:fab172a3-0436-4ee4-9097-ae74bbbe774a uuid:cb45e88b-4d18-4538-981b-a2fd6980c5dc Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 144, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 464, 728, 507, 736 Annotation: Subtype: Link Rect: 507, 729, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 111, 38 Annotation: Subtype: Link Rect: 114, 30, 174, 38 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 493, 160, 503 Annotation: Subtype: Link Rect: 71, 345, 160, 354 Annotation: Subtype: Link Rect: 74, 66, 160, 73 Annotation: Subtype: Link Rect: 176, 537, 551, 646 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 229, 398, 235, 409 Destination: External Annotation: Subtype: Link Rect: 238, 398, 245, 409 Destination: External Annotation: Subtype: Link Rect: 146, 352, 153, 363 Destination: External Annotation: Subtype: Link Rect: 158, 352, 164, 363 Destination: External Annotation: Subtype: Link Rect: 131, 318, 137, 329 Destination: External Annotation: Subtype: Link Rect: 140, 318, 147, 329 Destination: External Annotation: Subtype: Link Rect: 269, 283, 276, 295 Destination: External Annotation: Subtype: Link Rect: 279, 283, 285, 295 Destination: External Annotation: Subtype: Link Rect: 171, 249, 182, 260 Destination: External Annotation: Subtype: Link Rect: 247, 226, 258, 237 Destination: External Annotation: Subtype: Link Rect: 261, 226, 272, 237 Destination: External Annotation: Subtype: Link Rect: 102, 169, 113, 180 Destination: External Annotation: Subtype: Link Rect: 116, 169, 127, 180 Destination: External Annotation: Subtype: Link Rect: 47, 146, 58, 157 Destination: External Annotation: Subtype: Link Rect: 63, 146, 74, 157 Destination: External Annotation: Subtype: Link Rect: 122, 77, 133, 88 Destination: External Annotation: Subtype: Link Rect: 136, 77, 147, 88 Destination: External Annotation: Subtype: Link Rect: 488, 407, 499, 419 Destination: External Annotation: Subtype: Link Rect: 502, 407, 513, 419 Destination: External Annotation: Subtype: Link Rect: 516, 407, 527, 419 Destination: External Annotation: Subtype: Link Rect: 503, 361, 514, 373 Destination: External Annotation: Subtype: Link Rect: 516, 361, 527, 373 Destination: External Annotation: Subtype: Link Rect: 530, 361, 541, 373 Destination: External Annotation: Subtype: Link Rect: 403, 327, 414, 339 Destination: External Annotation: Subtype: Link Rect: 358, 304, 370, 316 Destination: External Annotation: Subtype: Link Rect: 372, 304, 384, 316 Destination: External Annotation: Subtype: Link Rect: 430, 293, 441, 304 Destination: External Annotation: Subtype: Link Rect: 307, 247, 318, 258 Destination: External Annotation: Subtype: Link Rect: 522, 201, 533, 212 Destination: External Annotation: Subtype: Link Rect: 537, 201, 548, 212 Destination: External Annotation: Subtype: Link Rect: 307, 178, 318, 190 Destination: External Annotation: Subtype: Link Rect: 321, 178, 333, 190 Destination: External Annotation: Subtype: Link Rect: 376, 121, 387, 132 Destination: External Annotation: Subtype: Link Rect: 389, 121, 401, 132 Destination: External Annotation: Subtype: Link Rect: 414, 75, 425, 86 Destination: External Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 421, 28, 551, 37 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 109, 605, 120, 617 Destination: External Annotation: Subtype: Link Rect: 122, 605, 133, 617 Destination: External Annotation: Subtype: Link Rect: 136, 605, 147, 617 Destination: External Annotation: Subtype: Link Rect: 153, 559, 164, 571 Destination: External Annotation: Subtype: Link Rect: 168, 559, 179, 571 Destination: External Annotation: Subtype: Link Rect: 183, 559, 194, 571 Destination: External Annotation: Subtype: Link Rect: 197, 559, 209, 571 Destination: External Annotation: Subtype: Link Rect: 47, 536, 58, 548 Destination: External Annotation: Subtype: Link Rect: 64, 536, 75, 548 Destination: External Annotation: Subtype: Link Rect: 81, 536, 92, 548 Destination: External Annotation: Subtype: Link Rect: 247, 422, 258, 433 Destination: External Annotation: Subtype: Link Rect: 260, 422, 271, 433 Destination: External Annotation: Subtype: Link Rect: 274, 422, 285, 433 Destination: External Annotation: Subtype: Link Rect: 235, 365, 246, 376 Destination: External Annotation: Subtype: Link Rect: 219, 284, 230, 296 Destination: External Annotation: Subtype: Link Rect: 232, 284, 244, 296 Destination: External Annotation: Subtype: Link Rect: 164, 239, 175, 250 Destination: External Annotation: Subtype: Link Rect: 98, 204, 109, 216 Destination: External Annotation: Subtype: Link Rect: 86, 170, 97, 181 Destination: External Annotation: Subtype: Link Rect: 216, 135, 227, 147 Destination: External Annotation: Subtype: Link Rect: 428, 640, 439, 651 Destination: External Annotation: Subtype: Link Rect: 330, 559, 341, 571 Destination: External Annotation: Subtype: Link Rect: 340, 339, 374, 350 Destination: External Annotation: Subtype: Link Rect: 473, 135, 484, 147 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 304, 193, 409, 204 Destination: External Annotation: Subtype: Link Rect: 438, 146, 476, 156 Destination: External Annotation: Subtype: Link Rect: 482, 148, 489, 156 Destination: External Annotation: Subtype: Link Rect: 371, 125, 382, 137 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 47, 147, 58, 158 Destination: External Annotation: Subtype: Link Rect: 307, 283, 400, 294 Destination: External Annotation: Subtype: Link Rect: 441, 124, 452, 135 Destination: External Annotation: Subtype: Link Rect: 437, 110, 472, 121 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 43, 194, 136, 205 Destination: External Annotation: Subtype: Link Rect: 232, 94, 243, 105 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 109, 628, 120, 640 Destination: External Annotation: Subtype: Link Rect: 85, 181, 96, 193 Destination: External Annotation: Subtype: Link Rect: 100, 181, 111, 193 Destination: External Annotation: Subtype: Link Rect: 448, 697, 459, 708 Destination: External Annotation: Subtype: Link Rect: 461, 697, 472, 708 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 79, 330, 90, 341 Destination: External Annotation: Subtype: Link Rect: 375, 299, 386, 310 Destination: External Annotation: Subtype: Link Rect: 390, 299, 401, 310 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 274, 685, 285, 697 Destination: External Annotation: Subtype: Link Rect: 81, 175, 111, 184 Destination: External Annotation: Subtype: Link Rect: 128, 173, 225, 184 Destination: External Annotation: Subtype: Link Rect: 503, 559, 534, 568 Destination: External Annotation: Subtype: Link Rect: 304, 546, 401, 556 Destination: External Annotation: Subtype: Link Rect: 439, 365, 450, 376 Destination: External Annotation: Subtype: Link Rect: 333, 319, 344, 330 Destination: External Annotation: Subtype: Link Rect: 348, 319, 359, 330 Destination: External Annotation: Subtype: Link Rect: 481, 204, 492, 216 Destination: External Annotation: Subtype: Link Rect: 307, 158, 318, 170 Destination: External Annotation: Subtype: Link Rect: 322, 158, 333, 170 Destination: External Annotation: Subtype: Link Rect: 431, 124, 442, 135 Destination: External Annotation: Subtype: Link Rect: 446, 124, 457, 135 Destination: External Annotation: Subtype: Link Rect: 307, 67, 318, 78 Destination: External Annotation: Subtype: Link Rect: 320, 67, 331, 78 Destination: External Annotation: Subtype: Link Rect: 334, 67, 345, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Rotate: 90 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 259, 617, 270, 628 Destination: External Annotation: Subtype: Link Rect: 274, 617, 285, 628 Destination: External Annotation: Subtype: Link Rect: 86, 582, 97, 594 Destination: External Annotation: Subtype: Link Rect: 274, 365, 285, 376 Destination: External Annotation: Subtype: Link Rect: 264, 90, 275, 101 Destination: External Annotation: Subtype: Link Rect: 356, 651, 367, 662 Destination: External Annotation: Subtype: Link Rect: 372, 651, 383, 662 Destination: External Annotation: Subtype: Link Rect: 485, 628, 496, 640 Destination: External Annotation: Subtype: Link Rect: 339, 594, 350, 605 Destination: External Annotation: Subtype: Link Rect: 348, 559, 359, 571 Destination: External Annotation: Subtype: Link Rect: 364, 559, 375, 571 Destination: External Annotation: Subtype: Link Rect: 379, 559, 390, 571 Destination: External Annotation: Subtype: Link Rect: 394, 559, 406, 571 Destination: External Annotation: Subtype: Link Rect: 409, 479, 420, 491 Destination: External Annotation: Subtype: Link Rect: 534, 445, 546, 456 Destination: External Annotation: Subtype: Link Rect: 397, 399, 408, 410 Destination: External Annotation: Subtype: Link Rect: 412, 399, 423, 410 Destination: External Annotation: Subtype: Link Rect: 488, 307, 499, 319 Destination: External Annotation: Subtype: Link Rect: 502, 307, 513, 319 Destination: External Annotation: Subtype: Link Rect: 507, 261, 518, 273 Destination: External Annotation: Subtype: Link Rect: 444, 193, 455, 204 Destination: External Annotation: Subtype: Link Rect: 432, 90, 443, 101 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 99, 697, 110, 708 Destination: External Annotation: Subtype: Link Rect: 150, 605, 161, 617 Destination: External Annotation: Subtype: Link Rect: 163, 559, 174, 571 Destination: External Annotation: Subtype: Link Rect: 177, 559, 188, 571 Destination: External Annotation: Subtype: Link Rect: 56, 388, 67, 399 Destination: External Annotation: Subtype: Link Rect: 47, 365, 58, 376 Destination: External Annotation: Subtype: Link Rect: 156, 342, 167, 353 Destination: External Annotation: Subtype: Link Rect: 169, 342, 181, 353 Destination: External Annotation: Subtype: Link Rect: 140, 296, 151, 307 Destination: External Annotation: Subtype: Link Rect: 162, 216, 173, 227 Destination: External Annotation: Subtype: Link Rect: 179, 216, 190, 227 Destination: External Annotation: Subtype: Link Rect: 244, 67, 255, 78 Destination: External Annotation: Subtype: Link Rect: 478, 685, 490, 697 Destination: External Annotation: Subtype: Link Rect: 383, 491, 394, 502 Destination: External Annotation: Subtype: Link Rect: 375, 240, 439, 251 Annotation: Subtype: Link Rect: 487, 229, 551, 240 Annotation: Subtype: Link Rect: 304, 219, 396, 228 Annotation: Subtype: Link Rect: 500, 194, 551, 205 Annotation: Subtype: Link Rect: 304, 183, 546, 194 Annotation: Subtype: Link Rect: 304, 171, 534, 183 Annotation: Subtype: Link Rect: 307, 137, 382, 148 Annotation: Subtype: Link Rect: 322, 125, 377, 137 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 552, 269, 303, 293 Annotation: Subtype: Link Rect: 146, 184, 225, 192 Annotation: Subtype: Link Rect: 104, 157, 165, 164 Annotation: Subtype: Link Rect: 70, 128, 128, 136 Annotation: Subtype: Link Rect: 224, 109, 287, 117 Annotation: Subtype: Link Rect: 70, 81, 182, 88 Annotation: Subtype: Link Rect: 331, 204, 410, 212 Annotation: Subtype: Link Rect: 385, 183, 464, 193 Annotation: Subtype: Link Rect: 364, 157, 436, 164 Annotation: Subtype: Link Rect: 386, 117, 445, 126 Annotation: Subtype: Link Rect: 331, 81, 391, 89 Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 421, 28, 551, 37 Page: Label: 15 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 292, 658, 56, 679 Annotation: Subtype: Link Rect: 100, 621, 193, 631 Annotation: Subtype: Link Rect: 292, 592, 56, 613 Annotation: Subtype: Link Rect: 292, 546, 56, 565 Annotation: Subtype: Link Rect: 122, 519, 181, 526 Annotation: Subtype: Link Rect: 70, 481, 155, 488 Annotation: Subtype: Link Rect: 70, 434, 159, 441 Annotation: Subtype: Link Rect: 70, 405, 116, 413 Annotation: Subtype: Link Rect: 292, 355, 56, 376 Annotation: Subtype: Link Rect: 108, 318, 177, 327 Annotation: Subtype: Link Rect: 70, 282, 146, 289 Annotation: Subtype: Link Rect: 292, 232, 56, 253 Annotation: Subtype: Link Rect: 70, 196, 126, 204 Annotation: Subtype: Link Rect: 70, 158, 150, 166 Annotation: Subtype: Link Rect: 292, 109, 56, 130 Annotation: Subtype: Link Rect: 70, 72, 161, 81 Annotation: Subtype: Link Rect: 331, 678, 421, 687 Annotation: Subtype: Link Rect: 552, 631, 316, 650 Annotation: Subtype: Link Rect: 552, 593, 316, 612 Annotation: Subtype: Link Rect: 357, 566, 433, 573 Annotation: Subtype: Link Rect: 552, 526, 316, 546 Annotation: Subtype: Link Rect: 331, 489, 398, 498 Annotation: Subtype: Link Rect: 442, 471, 527, 479 Annotation: Subtype: Link Rect: 480, 452, 540, 460 Annotation: Subtype: Link Rect: 552, 414, 316, 432 Annotation: Subtype: Link Rect: 412, 386, 464, 394 Annotation: Subtype: Link Rect: 552, 337, 316, 357 Annotation: Subtype: Link Rect: 331, 300, 430, 309 Annotation: Subtype: Link Rect: 331, 262, 431, 271 Annotation: Subtype: Link Rect: 552, 223, 316, 243 Annotation: Subtype: Link Rect: 331, 177, 439, 185 Annotation: Subtype: Link Rect: 331, 131, 416, 138 Annotation: Subtype: Link Rect: 341, 91, 428, 101 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 16 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 292, 688, 56, 707 Annotation: Subtype: Link Rect: 70, 651, 131, 659 Annotation: Subtype: Link Rect: 57, 631, 144, 640 Annotation: Subtype: Link Rect: 104, 594, 165, 602 Annotation: Subtype: Link Rect: 215, 564, 291, 574 Annotation: Subtype: Link Rect: 57, 555, 252, 564 Annotation: Subtype: Link Rect: 70, 500, 131, 508 Annotation: Subtype: Link Rect: 70, 462, 155, 469 Annotation: Subtype: Link Rect: 108, 415, 197, 422 Annotation: Subtype: Link Rect: 70, 377, 125, 384 Annotation: Subtype: Link Rect: 292, 328, 56, 348 Annotation: Subtype: Link Rect: 70, 299, 170, 309 Annotation: Subtype: Link Rect: 70, 262, 161, 271 Annotation: Subtype: Link Rect: 292, 204, 56, 225 Annotation: Subtype: Link Rect: 70, 178, 159, 186 Annotation: Subtype: Link Rect: 192, 159, 252, 167 Annotation: Subtype: Link Rect: 70, 121, 174, 129 Annotation: Subtype: Link Rect: 70, 93, 193, 101 Annotation: Subtype: Link Rect: 331, 689, 406, 696 Annotation: Subtype: Link Rect: 411, 651, 497, 659 Annotation: Subtype: Link Rect: 438, 631, 513, 640 Annotation: Subtype: Link Rect: 331, 594, 395, 602 Annotation: Subtype: Link Rect: 382, 576, 477, 583 Annotation: Subtype: Link Rect: 331, 538, 399, 545 Annotation: Subtype: Link Rect: 390, 481, 450, 489 Annotation: Subtype: Link Rect: 331, 443, 416, 450 Annotation: Subtype: Link Rect: 368, 367, 428, 375 Annotation: Subtype: Link Rect: 552, 289, 316, 309 Annotation: Subtype: Link Rect: 331, 263, 432, 271 Annotation: Subtype: Link Rect: 552, 224, 316, 243 Annotation: Subtype: Link Rect: 331, 186, 430, 195 Annotation: Subtype: Link Rect: 346, 150, 432, 157 Annotation: Subtype: Link Rect: 552, 120, 316, 139 Annotation: Subtype: Link Rect: 552, 92, 316, 111 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 17 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 70, 689, 170, 696 Annotation: Subtype: Link Rect: 318, 594, 344, 601 Annotation: Subtype: Link Rect: 347, 594, 379, 601 Annotation: Subtype: Link Rect: 382, 594, 418, 602 Annotation: Subtype: Link Rect: 421, 594, 444, 601 Annotation: Subtype: Link Rect: 447, 593, 477, 602 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Checksum: fec15fc1 Type: CRC32 Checksum: e65848b33858c331dbf8ba959ce89359 Type: MD5 Checksum: 3bfdbffd371a9590d0c1aa7123385a6752fdde0d Type: SHA-1