94f02359ccfa07d3bfcbb47c2889fd4c 270262.pdf 938fc0dd4ab7ca2c2252b3d22165d11b048f1ed9 270262.pdf 905f32090ba64505356beb2a467783eab204c6c2cac9d99b9e2c7a075e440ca6 270262.pdf Title: Non-muscle-invasive bladder cancer: An overview of potential new treatment options Subject: Urologic Oncology: Seminars and Original Investigations, 39 (2021) 642-663. doi:10.1016/j.urolonc.2021.05.015 Keywords: "BCG"; "Bladder cancer"; "Immune checkpoint inhibitors"; "Non-muscle-invasive"; "Targeted therapy" Author: Neal D. Shore M.D. Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Mon Aug 30 02:32:19 2021 CEST ModDate: Mon Aug 30 02:32:46 2021 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 593.972 x 792 pts Page rot: 0 File size: 1113719 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OLDFJD+AdvTT488bbd95+22 Type 1C Custom yes yes no 1090 0 OLCODB+AdvP6F01 Type 1C WinAnsi yes yes no 1094 0 OLCODC+AdvP697C Type 1C Custom yes yes no 1097 0 OLCOBO+AdvP6F00 Type 1C MacRoman yes yes no 1101 0 OLCOCA+AdvP6F0B Type 1C MacRoman yes yes no 1104 0 OLCOBP+AdvP4C4E59 Type 1C Custom yes yes yes 1107 0 OLDGAC+AdvOTb0c9bf5d+22 Type 1C Custom yes yes yes 816 0 OLDFPB+AdvP4C9543 Type 1C WinAnsi yes yes no 821 0 OLECHB+AdvP4C4E74 Type 1C Custom yes yes no 824 0 OLECHC+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 828 0 OLECID+AdvP6F09 Type 1C WinAnsi yes yes no 831 0 OLECJD+AdvP4A5FDB Type 1C WinAnsi yes yes no 834 0 OLEJCJ+AdvTT488bbd95+20 Type 1C WinAnsi yes yes no 261 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:10:34 CEST RepresentationInformation: 270262.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:54 CEST Size: 1113719 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1197 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Non-muscle-invasive bladder cancer: An overview of potential new treatment options Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: 1.1. Treatment guidelines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 1.2. Histological variants in NMIBC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 1.3. BCG strains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2. Completed and ongoing clinical trials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: 2.1. BCG-naïve Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: 2.1.1. Immune checkpoint inhibitors (ICIs)/immunomodulators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.1.2. Targeted therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.1.3. Gene therapy, vaccines, viral-, and bacterial-based therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.1.4. Chemotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.2. BCG-recurrent Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: 2.2.1. ICIs/immunomodulators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.2.2. Targeted therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.2.3. Chemotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.3. BCG-unresponsive Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: 2.3.1. ICIs/immunomodulators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.3.2. Targeted therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.3.3. Gene therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.3.4. Chemotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.4. Future and potential targets in NMIBC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 3. Intravesical drug delivery systems Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 4. Lesion detection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 5. Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Author contribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Disclosure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Info: Title: Non-muscle-invasive bladder cancer: An overview of potential new treatment options Author: Neal D. 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Urologic Oncology: Seminars and Original Investigations, 39 (2021) 642-663. doi:10.1016/j.urolonc.2021.05.015 BCG Bladder cancer Immune checkpoint inhibitors Non-muscle-invasive Targeted therapy Non-muscle-invasive bladder cancer: An overview of potential new treatment options Neal D. Shore M.D. Joan Palou Redorta M.D. Gregoire Robert M.D. Thomas E. Hutson M.D. Rossano Cesari Pharm.D. Subramanian Hariharan M.D. Óscar Rodríguez Faba M.D. Alberto Briganti M.D. Gary D. Steinberg M.D. uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:adad430c-6503-4e34-aa10-aa9af614b026 journal © 2021 Pfizer Inc. and the Author(s). Elsevier Inc. 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383, 271 Annotation: Subtype: Link Rect: 329, 254, 547, 261 Annotation: Subtype: Link Rect: 329, 244, 547, 252 Annotation: Subtype: Link Rect: 329, 234, 547, 242 Annotation: Subtype: Link Rect: 329, 224, 516, 232 Annotation: Subtype: Link Rect: 329, 214, 547, 222 Annotation: Subtype: Link Rect: 329, 204, 547, 212 Annotation: Subtype: Link Rect: 329, 194, 387, 202 Annotation: Subtype: Link Rect: 329, 184, 547, 192 Annotation: Subtype: Link Rect: 329, 174, 357, 182 Annotation: Subtype: Link Rect: 361, 174, 386, 182 Annotation: Subtype: Link Rect: 389, 174, 547, 182 Annotation: Subtype: Link Rect: 329, 164, 521, 172 Annotation: Subtype: Link Rect: 329, 154, 547, 162 Annotation: Subtype: Link Rect: 329, 144, 547, 152 Annotation: Subtype: Link Rect: 329, 134, 547, 142 Annotation: Subtype: Link Rect: 329, 124, 547, 132 Annotation: Subtype: Link Rect: 329, 114, 503, 122 Annotation: Subtype: Link Rect: 329, 104, 547, 112 Annotation: Subtype: Link Rect: 329, 94, 547, 102 Annotation: Subtype: Link Rect: 329, 84, 547, 92 Annotation: Subtype: Link Rect: 329, 74, 379, 82 Checksum: df68e2b1 Type: CRC32 Checksum: 94f02359ccfa07d3bfcbb47c2889fd4c Type: MD5 Checksum: 938fc0dd4ab7ca2c2252b3d22165d11b048f1ed9 Type: SHA-1